Citation Impact
Citing Papers
Spectrum of Phosphatidylinositol 3-Kinase Pathway Gene Alterations in Bladder Cancer
2009
PIK3R1 (p85α) Is Somatically Mutated at High Frequency in Primary Endometrial Cancer
2011
The Phosphoinositide 3-Kinase Regulatory Subunit p85α Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling
2010
Coexistence of PIK3CA and Other Oncogene Mutations in Lung Adenocarcinoma–Rationale for Comprehensive Mutation Profiling
2011
Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-Kinase
2009
The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations
2007 Science
Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235
2008
Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1
2017
The Intracellular Juxtamembrane Domain of the Epidermal Growth Factor (EGF) Receptor Is Responsible for the Allosteric Regulation of EGF Binding
2009
Hallmarks of Cancer: The Next Generation
2011 Standout
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Crystal Structure of the Human Monoacylglycerol Lipase, a Key Actor in Endocannabinoid Signaling
2009
The Regulation of Class IA PI 3-Kinases by Inter-Subunit Interactions
2010
A Phospholipid Substrate Molecule Residing in the Membrane Surface Mediates Opening of the Lid Region in Group IVA Cytosolic Phospholipase A2
2008
Modifying enzyme activity and selectivity by immobilization
2012 Standout
Enzyme immobilisation in biocatalysis: why, what and how
2013 Standout
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
2012 StandoutNobel
Green Chemistry: Principles and Practice
2009 Standout
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Class I PI3K in oncogenic cellular transformation
2008
Sphingolipids and their metabolism in physiology and disease
2017 Standout
Synergy in activating class I PI3Ks
2015
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Biocatalysts: application and engineering for industrial purposes
2014
PI3K pathway alterations in cancer: variations on a theme
2008
Insights into the oncogenic effects of /PIK3CA/ mutations from the structure of p110α/p85α
2008
Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing
2017 Standout
Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase
2003
The molecular biology of head and neck cancer
2010 Standout
Targeting phosphoinositide 3-kinase—Moving towards therapy
2007
Targeting the phosphoinositide 3-kinase pathway in cancer
2009 Standout
Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition
2017
Fibroblast growth factor signalling: from development to cancer
2010 Standout
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
The ADAM metalloproteinases
2008
Lipid signalling in disease
2008
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
Lipases at interfaces: A review
2008
Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30/Autophagy-related Protein 6 and Its Specific Role in Autophagy
2012 StandoutNobel
The emerging mechanisms of isoform-specific PI3K signalling
2010
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
2014 Standout
Small-molecule inhibition of APT1 affects Ras localization and signaling
2010
Design of activated serine–containing catalytic triads with atomic-level accuracy
2014 StandoutNobel
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
2014
Survey of the year 2003 commercial optical biosensor literature
2004
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Dysregulated pH: a perfect storm for cancer progression
2011 Standout
Targeting ferroptosis as a vulnerability in cancer
2022 Standout
AKT/PKB Signaling: Navigating the Network
2017 Standout
Hydrolysis of triacetin catalyzed by immobilized lipases: Effect of the immobilization protocol and experimental conditions on diacetin yield
2011
The functions and regulation of the PTEN tumour suppressor
2012 Standout
The PI3K Pathway in Human Disease
2017 Standout
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
Enzyme immobilization for biodiesel production
2011
Obstructive sleep apnoea and its cardiovascular consequences
2008 Standout
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
Simple and efficient immobilization of lipase B from Candida antarctica on porous styrene–divinylbenzene beads
2011
Immunogenic cell death and DAMPs in cancer therapy
2012 Standout
Improved reactivation of immobilized-stabilized lipase from Thermomyces lanuginosus by its coating with highly hydrophilic polymers
2009
Lipase from Rhizomucor miehei as a biocatalyst in fats and oils modification
2010
The regulation and function of Class III PI3Ks: novel roles for Vps34
2008
The Structure of p85ni in Class IA Phosphoinositide 3-Kinase Exhibits Interdomain Disorder
2010
Food waste as a valuable resource for the production of chemicals, materials and fuels. Current situation and global perspective
2012 Standout
Chitosan—A versatile semi-synthetic polymer in biomedical applications
2011 Standout
Dynamic Combinatorial Chemistry
2006 Standout
Reactivation of covalently immobilized lipase from Thermomyces lanuginosus
2009
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Chitin and chitosan polymers: Chemistry, solubility and fiber formation
2009 Standout
General Trend of Lipase to Self-Assemble Giving Bimolecular Aggregates Greatly Modifies the Enzyme Functionality
2003
Positive effects of the multipoint covalent immobilization in the reactivation of partially inactivated derivatives of lipase from Thermomyces lanuginosus
2009
Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation
2017 StandoutNobel
Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase
2007
Contributions of Amino Acid Side Chains to the Kinetics and Thermodynamics of the Bivalent Binding of Protein L to Ig κ Light Chain
2004 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
2013
Cancer-derived mutations in the regulatory subunit p85α of phosphoinositide 3-kinase function through the catalytic subunit p110α
2010
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Class 1A PI3K regulates vessel integrity during development and tumorigenesis
2008
Multimerization of an Alcohol Dehydrogenase by Fusion to a Designed Self-Assembling Protein Results in Enhanced Bioelectrocatalytic Operational Stability
2019 StandoutNobel
Morphing Activity between Structurally Similar Enzymes: From Heme-Free Bromoperoxidase to Lipase
2009
Modulation of Mucor miehei lipase properties via directed immobilization on different hetero-functional epoxy resins
2003
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity
2013 StandoutNobel
Potential of Different Enzyme Immobilization Strategies to Improve Enzyme Performance
2011 Standout
Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine
2010 Standout
Interfacial adsorption of lipases on very hydrophobic support (octadecyl–Sepabeads): immobilization, hyperactivation and stabilization of the open form of lipases
2002
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
Tissue- and Organ-Selective Biodistribution of NIR Fluorescent Quantum Dots
2009 StandoutNobel
Chitin and chitosan: Properties and applications
2006 Standout
LIPASES AND LIPASE-CATALYZED ESTERIFICATION REACTIONS IN NONAQUEOUS MEDIA
2002
Chitosan Chemistry and Pharmaceutical Perspectives
2004 Standout
Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α ( PIK3CA )
2012
Glutaraldehyde Cross-Linking of Lipases Adsorbed on Aminated Supports in the Presence of Detergents Leads to Improved Performance
2006
Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
2008
Immobilization of lipases for non-aqueous synthesis
2006
Works of Nabil Miled being referenced
Electrostatic interactions of peptides flanking the tyrosine kinase domain in the epidermal growth factor receptor provides a model for intracellular dimerization and autophosphorylation
2005
A thermoactive uropygial esterase from chicken: Purification, characterisation and synthesis of flavour esters
2012
Crystal Structure of the Open Form of Dog Gastric Lipase in Complex with a Phosphonate Inhibitor
2002
Cleavage of the human thyrotropin receptor by ADAM10 is regulated by thyrotropin
2007
Phosphorylation of Thr654 but not Thr669 within the juxtamembrane domain of the EGF receptor inhibits calmodulin binding
2006
Importance of the lid and cap domains for the catalytic activity of gastric lipases
2003
Digestive lipases: From three-dimensional structure to physiology
2000
N‐terminal peptide of Rhizopus oryzae lipase is important for its catalytic properties
2005
Immobilization studies and biochemical properties of free and immobilized Rhizopus oryzae lipase onto CaCO3: A comparative study
2007
Interfacial catalysis by lipases
2001
Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit
2007 Science