Citation Impact
Citing Papers
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
2004
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness
1979 StandoutNobel
Regulation of the Cell Cycle at the G1–S Transition by Proteolysis of Cyclin E and p27Kip1
2001
Hallmarks of Cancer: The Next Generation
2011 Standout
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome
1997 Nature
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
2002 Standout
LIN-23-Mediated Degradation of β-Catenin Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Nerve Cord of C. elegans
2005
p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
1999
A question of balance: the role of cyclin-kinase inhibitors in development and tumorigenesis
1996
Mechanism of action of a new macromolecular antitumor antibiotic, C-1027.
1990
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Treatment triumphs
2014 StandoutNatureNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Regulation of the Cdk inhibitor p27 and its deregulation in cancer
2000
Deregulated degradation of the cdk inhibitor p27 and malignant transformation
2002
A Cyclin-Dependent Kinase Inhibitor, Dacapo, Is Necessary for Timely Exit from the Cell Cycle during Drosophila Embryogenesis
1996
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
2002 Standout
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Roles of Axin in the Wnt Signalling Pathway
1999
Wnt/β-Catenin Signaling Induces the Expression and Activity of βTrCP Ubiquitin Ligase Receptor
2000
Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast
2000
Key interactions in neocarzinostatin, a protein of the immunoglobulin fold family
2002
Recognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase
2004
Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1
2008
Regulation of β-Catenin Signaling in the Wnt Pathway
2000
Kedarcidin, a new chromoprotein antitumor antibiotic. II. Isolation, purification and physico-chemical properties.
1992
Axin Directly Interacts with Plakoglobin and Regulates Its Stability
1999
Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex
2002 Nature
Regulation of Nuclear Transport and Degradation of the Xenopus Cyclin-dependent Kinase Inhibitor, p27Xic1
2001
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
A GSK3β Phosphorylation Site in Axin Modulates Interaction with β-Catenin and Tcf-Mediated Gene Expression
1999
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
2012
The Bcl2 family: regulators of the cellular life-or-death switch
2002 Standout
Regulation of G1 Phase
1998
Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication
2000
Control of Meiotic and Mitotic Progression by the F Box Protein β-Trcp1 In Vivo
2003
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
2005 StandoutNobel
HEPATITIS C VIRUS ANTIBODIES AMONG RISK GROUPS IN SPAIN
1989 StandoutNobel
Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system
2000 StandoutNobel
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27
1996
Detection of Antibody to Hepatitis C Virus in Prospectively Followed Transfusion Recipients with Acute and Chronic Non-A, Non-B Hepatitis
1989 StandoutNobel
Activating the Wnt/β-Catenin Pathway for the Treatment of Melanoma – Application of LY2090314, a Novel Selective Inhibitor of Glycogen Synthase Kinase-3
2015
Control of β-Catenin Stability
2000
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1
1997
Neurogenesis and the Cell Cycle
2003
Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1
1997
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Delving deeper: MCL-1's contributions to normal and cancer biology
2012
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Dacapo, a Cyclin-Dependent Kinase Inhibitor, Stops Cell Proliferation during Drosophila Development
1996
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
1999 StandoutNobel
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
Transcriptional regulation and transformation by Myc proteins
2005
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Role of p27Kip1 in human intestinal cell differentiation
2001
The BCL-2 protein family: opposing activities that mediate cell death
2007 Standout
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Modes of regulation of ubiquitin-mediated protein degradation
2000 StandoutNobel
p21CIP1 and p57KIP2 control muscle differentiation at the myogenin step
1999
Pathway-specific tumor suppression
2002
CHIP is a chaperone‐dependent E3 ligase that ubiquitylates unfolded protein
2001
Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein.
2003
A NEW ANTIBIOTIC, MACROMOMYCIN, EXHIBITING ANTITUMOR AND ANTIMICROBIAL ACTIVITY
1968
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
The mouse T cell receptor: Structural heterogeneity of molecules of normal T cells defined by Xenoantiserum
1983 StandoutNobel
p21 Is a Critical CDK2 Regulator Essential for Proliferation Control in Rb-deficient Cells
1998
Binding of Hepatitis C Virus to CD81
1998 StandoutScienceNobel
Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin
2005 Standout
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family
1985 StandoutNobel
An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis
1989 StandoutScienceNobel
Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322
1979 Nature
Identification of a Conserved Negative Regulatory Sequence That Influences the Leukemogenic Activity of NOTCH1
2006
Cyclin E-CDK2 is a regulator of p27Kip1.
1997
Cancer Cell Cycles
1996 StandoutScience
The agents of non-A, non-B viral hepatitis
1985
The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice
2001
Hepatitis B virus genes and their expression in E. coli
1979 StandoutNatureNobel
Structure, sequence and expression of the hepatitis delta (δ) viral genome
1986 StandoutNatureNobel
The molecular logic of Notch signaling – a structural and biochemical perspective
2008
Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival
1999
The Prognostic Significance of Altered Cyclin-Dependent Kinase Inhibitors in Human Cancer
1999
Non-A, non-B hepatitis. I. Recognition, epidemiology, and clinical features
1983
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.
1990
Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice
2012
Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli
1979 Nature
The hepatitis B virus
1985 Nature
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to γ-secretase inhibitors
2007
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia
2007
Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα
2001
Apoptosis Signaling
2000
Primary structure of macromomycin, an antitumor antibiotic protein.
1983
The Role of Caspases in Development, Immunity, and Apoptotic Signal Transduction
1999
Localization on the viral genome and nucleotide sequence of the gene coding for the two major polypeptides of the Hepatitis B surface antigen (HBs Ag)
1979
Viruses in Human Cancers
1991 StandoutScienceNobel
Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA
1997 StandoutScienceNobel
Novel TCR-Mediated Mechanisms of Notch Activation and Signaling
2017
Induction of p18INK4c and its predominant association with CDK4 and CDK6 during myogenic differentiation.
1996
Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans
1998 StandoutNobel
Myc and Max Homologs in Drosophila
1996 Science
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
1999
The Ubiquitin Ligase SCF Fbw7 Antagonizes Apoptotic JNK Signaling
2004 Science
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Regulation of S33/S37 phosphorylated β-catenin in normal and transformed cells
2002
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Transforming Growth Factor β Stabilizes p15INK4B Protein, Increases p15INK4B-cdk4 Complexes, and Inhibits Cyclin D1-cdk4 Association in Human Mammary Epithelial Cells
1997
Biological activity of macromomycin.
1979
Developmental Control of Cell Cycle Regulators: A Fly's Perspective
1996 Science
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Posttransfusion Non-A, Non-B Hepatitis: Physicochemical Properties of Two Distinct Agents
1983
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome
1989 StandoutScienceNobel
Isolation of a non-protein component and a protein component from neocarzinostatin (NCS) and their biological activities.
1980
Works of N. Ishida being referenced
Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors
1996
Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development
2004
Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7
2004
Characterization of a Mouse Gene (Fbxw6) That Encodes a Homologue of Caenorhabditis elegans SEL-10
2001
U Box Proteins as a New Family of Ubiquitin-Protein Ligases
2001
Neocarzinostatin: Selective tryptophan oxidation and neocarzinostatin-chromophore binding to apo-neocarzinostatin.
1991
Phosphorylation of p27 on Serine 10 Is Required for Its Binding to CRM1 and Nuclear Export
2002
An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin
1999
Down-regulation of p27 by Two Mechanisms, Ubiquitin-mediated Degradation and Proteolytic Processing
1999
Phosphorylation at Serine 10, a Major Phosphorylation Site of p27 , Increases Its Protein Stability
2000
The Specific Reduction of a and d Antigenic Determinants after Periodate Treatment of Hepatitis B Surface Antigen (HBsAg)
1978
Specific G2 block in HeLa-S3 cells by neocarzinostatin
1975
Carbohydrate Composition of Hepatitis B Surface Antigen
1977
NEOCARZINOSTATIN, AN ANTITUMOR ANTIBIOTIC OF HIGH MOLECULAR WEIGHT. ISOLATION, PHYSIOCHEMICAL PROPERTIES AND BIOLOGICAL ACTIVITIES.
1965
Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2–related A1 Gene
1998
Effect of Antilymphocyte Serum on Influenza Virus Infection in Mice
1974
Non-B Hepatitis in Japanese Recipients of Blood Transfusions: Clinical and Serologic Studies after the Introduction of Laboratory Screening of Donor Blood for Hepatitis B Surface Antigen
1979
Immunological and Morphological Properties of HBeAg Subtypes (HBeAg/1 and HBeAg/2) in Hepatitis B Virus Core Particles
1984
Demonstration of Hepatitis B e Antigen (HBeAg) in Association with Intact Dane Particles
1979