M.K. Williamson

γ-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase

Comprehensive proteomic analysis of mineral nanoparticles derived from human body fluids and analyzed by liquid chromatography–tandem mass spectrometry

Pharmacology and Management of the Vitamin K Antagonists

Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues

The warfarin embryopathy: A rat model showing maxillonasal hypoplasia and other skeletal disturbances

Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

Concurrent Assays of Circulating Bone Gla-Protein and Bone Alkaline Phosphatase: Effects of Sex, Age, and Metabolic Bone Disease*

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

Transcriptional Regulation of Osteocalcin Production by Transforming Growth Factor-β in Rat Osteoblast-Like Cells

NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata

Association Between CYP2C9 Genetic Variants and Anticoagulation-Related Outcomes During Warfarin Therapy

Effect of Calcium and Vitamin D Supplementation on Bone Density in Men and Women 65 Years of Age or Older

Oral Anticoagulant Therapy

Emergency Hospitalizations for Adverse Drug Events in Older Americans

The molecular basis of blood coagulation

Bone Quality — The Material and Structural Basis of Bone Strength and Fragility

Osteoporosis: now and the future

Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Effects of Raloxifene on Bone Mineral Density, Serum Cholesterol Concentrations, and Uterine Endometrium in Postmenopausal Women

WNT signaling in bone homeostasis and disease: from human mutations to treatments

Discovery of a High Molecular Weight Complex of Calcium, Phosphate, Fetuin, and Matrix γ-Carboxyglutamic Acid Protein in the Serum of Etidronate-treated Rats

Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

Antithrombotic Therapy for VTE Disease

Biology of Incretins: GLP-1 and GIP

Human Growth Hormone and Human Aging

Endothelial Cells Modulate Osteogenesis in Calcifying Vascular Cells

Developmental expression of 44-kDa bone phosphoprotein (osteopontin) and bone γ-carboxyglutamic acid (Gla)-containing protein (osteocalcin) in calcifying tissues of rat

Oral Anticoagulants

Endocrine Regulation of Energy Metabolism by the Skeleton

Resistance to Activated Protein C as a Basis for Venous Thrombosis

Oral Anticoagulants: Mechanism of Action, Clinical Effectiveness, and Optimal Therapeutic Range

Capturing complex 3D tissue physiology in vitro

Rivaroxaban versus Enoxaparin for Thromboprophylaxis after Hip Arthroplasty

Matrix GLA Protein Modulates Differentiation Induced by Bone Morphogenetic Protein-2 in C3H10T1/2 Cells

Metastasis to bone: causes, consequences and therapeutic opportunities

The Physiology of Glucagon-like Peptide 1

Biochemical Characterization of the Serum Fetuin-Mineral Complex

Gla-Containing Proteins of Bone

Markers of bone turnover for the management of patients with bone metastases from prostate cancer

The serum protein α2–Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification

Calumenin, a Ca2+-binding Protein Retained in the Endoplasmic Reticulum with a Novel Carboxyl-terminal Sequence, HDEF

Biomolecular coronas provide the biological identity of nanosized materials

Mechanisms of Bone Metastasis

Serum Levels of the Fetuin-Mineral Complex Correlate with Artery Calcification in the Rat

The Pharmacology and Management of the Vitamin K Antagonists

Effect of Fluoride Treatment on the Fracture Rate in Postmenopausal Women with Osteoporosis

Biochemical Markers of Bone Metabolism: An Overview

Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes

Dissociation of bone formation markers in bone metastasis of prostate cancer

Denosumab and bisphosphonates: Different mechanisms of action and effects

Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats

Molecular cloning and expression of human hepatocyte growth factor

Vitamin K-dependent carboxylase: possible role of the substrate "propeptide" as an intracellular recognition site.

Matrix Metalloproteinase Inhibition Attenuates Aortic Calcification

Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial

Involutional Osteoporosis

Warfarin Causes Rapid Calcification of the Elastic Lamellae in Rat Arteries and Heart Valves

Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide

Vitamin K-dependent carboxylase. Control of enzyme activity by the “propeptide” region of factor X.

The identification of matrix Gla protein in cartilage.

Primary Biliary Cirrhosis

Molecular cloning of matrix Gla protein: implications for substrate recognition by the vitamin K-dependent gamma-carboxylase.

Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats

American Heart Association/American College of Cardiology Foundation Guide to Warfarin Therapy

Assessment of the serum levels of bone alkaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease.

Aggregation-Induced Emission: Together We Shine, United We Soar!

Warfarin-Induced Artery Calcification Is Accelerated by Growth and Vitamin D

Functional glass slides for in vitro evaluation of interactions between osteosarcoma TE85 cells and mineral-binding ligands

ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease

SERUM BONE GLA-PROTEIN: A SPECIFIC MARKER FOR BONE FORMATION IN POSTMENOPAUSAL OSTEOPOROSIS

American Heart Association/American College of Cardiology Foundation guide to warfarin therapy11The American Heart Association makes every effort to avoid any actual or potential conflicts of interest that may arise as a result of an outside relationship or a personal, professional, or business interest of a member of the writing panel. Specifically, all members of the writing group are required to complete and submit a Disclosure Questionnaire showing all such relationships that might be perceived as real or potential conflicts of interest.This statement has been co-published in the April 1, 2003, issue of Circulation.This statement was approved by the American Heart Association Science Advisory and Coordinating Committee in October 2002 and by the American College of Cardiology Board of Trustees in February 2003. A single reprint is available by calling 800-242-8721 (US only) or writing the American Heart Association, Public Information, 7272 Greenville Ave, Dallas, TX 75231-4596. Ask for reprint No. 71-0254. To purchase additional reprints: up to 999 copies, call 800-611-6083 (US only) or fax 413-665-2671; 1000 or more copies, call 410-528-4426, fax 410-528-4264, or e-mail klbradle@lww.com. To make photocopies for personal or educational use, call the Copyright Clearance Center, 978-750-8400.

The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development

Bone Loss and Reduced Osteoblast Function in Primary Biliary Cirrhosis

Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins

Novel Regulators of Bone Formation: Molecular Clones and Activities

The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression.

Recognition site directing vitamin K-dependent γ-carboxylation resides on the propeptide of factor IX

Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage [published erratum appears in J Cell Biol 1995 Feb;128(4):following 713]

Role of Gastrointestinal Hormones in Postprandial Reduction of Bone Resorption

2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

DIFFERENCES IN SERUM BONE GLA PROTEIN WITH AGE AND SEX

cDNA and deduced amino acid sequence of mouse matrix gla protein: One of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence

γ-Glutamyl carboxylation: An extracellular posttranslational modification that antedates the divergence of molluscs, arthropods, and chordates

Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones.

cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family.

Vascular Calcification

The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors.

Increase in serum bone gamma-carboxyglutamic acid protein with aging in women. Implications for the mechanism of age-related bone loss.

Chemotactic activity of theγ-carboxyglutamic acid containing protein in bone

The Amino Bisphosphonate Ibandronate Prevents Calciphylaxis in the Rat at Doses that Inhibit Bone Resorption

Effects of warfarin on bone. Studies on the vitamin K-dependent protein of rat bone.

Carboxyl-terminal proteolytic processing of matrix Gla protein.

The putative RGD-dependent cell adhesion activity of matrix Gla protein is due to higher molecular weight contaminants.

Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein.

Sequence of the precursor to rat bone gamma-carboxyglutamic acid protein that accumulates in warfarin-treated osteosarcoma cells.

Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and bone.

Excessive mineralization with growth plate closure in rats on chronic warfarin treatment.