Citation Impact
Citing Papers
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
2011 StandoutNobel
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
Molecular Determinants of Vanilloid Sensitivity in TRPV1
2004
Proinflammatory Mediators Modulate the Heat-Activated Ion Channel TRPV1 via the Scaffolding Protein AKAP79/150
2008
Calcium Plays a Central Role in the Sensitization of TRPV3 Channel to Repetitive Stimulations
2008
TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs.
2006
Calmodulin is responsible for Ca2+-dependent regulation of TRPA1 Channels
2017
Regulation of the Mouse Epithelial Ca2+ Channel TRPV6 by the Ca2+-sensor Calmodulin
2004
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Desensitization of Capsaicin-activated Currents in the Vanilloid Receptor TRPV1 Is Decreased by the Cyclic AMP-dependent Protein Kinase Pathway
2003
TRPV1 Gene Required for Thermosensory Transduction and Anticipatory Secretion from Vasopressin Neurons during Hyperthermia
2008
Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization
2007
Thermodynamics of Heat Activation of Single Capsaicin Ion Channels VR1
2003
Novel class of pain drugs based on antagonism of NGF
2005
Inflammatory Pain: The Cellular Basis of Heat Hyperalgesia
2006
NGF rapidly increases membrane expression of TRPV1 heat‐gated ion channels
2005
Involvement of capsaicin-sensitive afferent nerves in the proteinase-activated receptor 2–mediated vasodilatation in the rat dura mater
2009
TRPV1: a therapeutic target for novel analgesic drugs?
2006
Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials
2007 Standout
Multiple roles of calmodulin and other Ca2+-binding proteins in the functional regulation of TRP channels
2005
Voltage is a partial activator of rat thermosensitive TRP channels
2007
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Transient receptor potential ion channels as participants in thermosensation and thermoregulation
2006
Regulation of Ca2+-dependent Desensitization in the Vanilloid Receptor TRPV1 by Calcineurin and cAMP-dependent Protein Kinase
2005
TRPV1 shows dynamic ionic selectivity during agonist stimulation
2008
ThermoTRP channels and beyond: mechanisms of temperature sensation
2003 StandoutNobel
Activin Acutely Sensitizes Dorsal Root Ganglion Neurons and Induces Hyperalgesia via PKC-Mediated Potentiation of Transient Receptor Potential Vanilloid I
2007
Asymmetric Disulfonimide‐Catalyzed Synthesis of δ‐Amino‐β‐Ketoester Derivatives by Vinylogous Mukaiyama–Mannich Reactions
2014 StandoutNobel
Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice
2006
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
2009 StandoutNobel
Zebrafish TRPA1 Channels Are Required for Chemosensation But Not for Thermosensation or Mechanosensory Hair Cell Function
2008 StandoutNobel
Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1
2007
Anandamide and vanilloid TRPV1 receptors
2003
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice
2005
Downregulation of Transient Receptor Potential Melastatin 8 by Protein Kinase C-Mediated Dephosphorylation
2005
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors
2007
Protease‐activated receptor 2 sensitizes TRPV1 by protein kinase Cɛ‐ and A‐dependent mechanisms in rats and mice
2006
Structure–functional intimacies of transient receptor potential channels
2009
Small molecule vanilloid TRPV1 receptor antagonists approaching drug status: can they live up to the expectations?
2006
Targeting TRP channels for pain relief
2013
Transient receptor potential channels: targeting pain at the source
2008 StandoutNobel
Integration of Phosphoinositide- and Calmodulin-Mediated Regulation of TRPC6
2007
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
Tissue-Specific Regulation of Microvascular Diameter: Opposite Functional Roles of Neuronal and Smooth Muscle Located Vanilloid Receptor-1
2008
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
2007 Standout
Biochemistry and pharmacology of endovanilloids
2007
Posttranslational mechanisms of peripheral sensitization
2004
Phosphoinositide Sensitivity of Ion Channels, a Functional Perspective
2012
Restriction of Transient Receptor Potential Vanilloid-1 to the Peptidergic Subset of Primary Afferent Neurons Follows Its Developmental Downregulation in Nonpeptidergic Neurons
2011 StandoutNobel
International Union of Basic and Clinical Pharmacology. LXXVI. Current Progress in the Mammalian TRP Ion Channel Family
2010
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs
2007 StandoutNobel
The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4
2015
TRPV1 Is Activated by Both Acidic and Basic pH
2009 StandoutNobel
Coiled Coils Direct Assembly of a Cold-Activated TRP Channel
2006 StandoutNobel
Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation
2009
Agonist Recognition Sites in the Cytosolic Tails of Vanilloid Receptor 1
2002
Ca2+-dependent PKC activation mediates menthol-induced desensitization of transient receptor potential M8
2005
Proteinase-Activated Receptor 2-Mediated Potentiation of Transient Receptor Potential Vanilloid Subfamily 1 Activity Reveals a Mechanism for Proteinase-Induced Inflammatory Pain
2004
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
A-Kinase Anchoring Protein 150 Mediates Transient Receptor Potential Family V Type 1 Sensitivity to Phosphatidylinositol-4,5-Bisphosphate
2011
An Alternative Splicing Product of the Murine trpv1 Gene Dominant Negatively Modulates the Activity of TRPV1 Channels
2004
Structure–activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1)
2008
Functional aspects and mechanisms of TRPV1 involvement in neurogenic inflammation that leads to thermal hyperalgesia
2005
TRP channels as cellular sensors
2003 StandoutNature
Functional Recovery from Desensitization of Vanilloid Receptor TRPV1 Requires Resynthesis of Phosphatidylinositol 4,5-Bisphosphate
2005
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
TRPV1
2014
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism
2005
The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity
2007
The TRPV1 receptor and nociception
2006
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Contribution of transient receptor potential vanilloid subfamily 1 to endothelin-1-induced thermal hyperalgesia
2008
Phosphoinositide regulation of TRPV1 revisited
2015
Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels
2006
Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice
2004
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1‐directed internalization
2007
ThermoTRP channels as modular proteins with allosteric gating
2007
Persistent postsurgical pain: risk factors and prevention
2006 Standout
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Identification of a Tetramerization Domain in the C Terminus of the Vanilloid Receptor
2004
Potentiation of TRPV3 channel function by unsaturated fatty acids
2006
Intracellular Signaling in Primary Sensory Neurons and Persistent Pain
2008
Biphasic Currents Evoked by Chemical or Thermal Activation of the Heat-gated Ion Channel, TRPV3
2005
Endovanilloids
2004
Pain TRPs
2005
Polyamines Are Potent Ligands for the Capsaicin Receptor TRPV1
2006
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
2007 Standout
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells
2011 StandoutNobel
Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six
2014 StandoutNobel
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating
2008 StandoutNobel
Peripheral TGF-β1 Signaling Is a Critical Event in Bone Cancer-Induced Hyperalgesia in Rodents
2013
The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans
2007
TRP channels and analgesia
2012
The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel
2004 StandoutNobel
Localization of the PIP2 Sensor of TRPV1 Ion Channels
2011
Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites
2005
Phosphorylation of Vanilloid Receptor 1 by Ca2+/Calmodulin-dependent Kinase II Regulates Its Vanilloid Binding
2004
Regulation of the Ca2+ Sensitivity of the Nonselective Cation Channel TRPM4
2004
DrosophilaPainless Is a Ca2+-Requiring Channel Activated by Noxious Heat
2008
The TRPV4 Channel Contributes to Intercellular Junction Formation in Keratinocytes
2010
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin
2011 StandoutNobel
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
2003
Signaling Pathways in Sensitization: Toward a Nociceptor Cell Biology
2007
Ca2+/Calmodulin Modulates TRPV1 Activation by Capsaicin
2003
Modulation of Thermoreceptor TRPM8 by Cooling Compounds
2012
Pain regulation by non-neuronal cells and inflammation
2016 StandoutScience
Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels
2019
Pungent products from garlic activate the sensory ion channel TRPA1
2005 StandoutNobel
The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin
2006
Phosphoinositide 3-Kinase Binds to TRPV1 and Mediates NGF-stimulated TRPV1 Trafficking to the Plasma Membrane
2006
High‐resolution structures of transient receptor potential vanilloid channels: Unveiling a functionally diverse group of ion channels
2020
TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids
2013 StandoutNobel
Structure–function relationship of the TRP channel superfamily
2006
TRP Channels and Pain
2013 StandoutNobel
Sensitization and Translocation of TRPV1 by Insulin and IGF-I
2005
Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation
2005
TRPM8 acute desensitization is mediated by calmodulin and requires PIP2: distinction from tachyphylaxis
2011
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
Distinct properties of Ca2+–calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel
2012
TRPA1 mediates formalin-induced pain
2007 StandoutNobel
Sensitization of TRPV1 by EP1 and IP Reveals Peripheral Nociceptive Mechanism of Prostaglandins
2005
Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management
2004
Emerging Targets in Photopharmacology
2016 StandoutNobel
Structural insight into TRPV5 channel function and modulation
2019 StandoutNobel
Structural and Biochemical Consequences of Disease-Causing Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Channel
2012
Trigeminal Nociceptors Express TLR-4 and CD14: a Mechanism for Pain due to Infection
2006
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release
2017 StandoutNobel
Ca2+ Regulation of TRP Ion Channels
2018
Works of Mitsuko Numazaki being referenced
Nociception and TRP Channels
2004
DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src‐dependent manner
2004
Direct Phosphorylation of Capsaicin Receptor VR1 by Protein Kinase Cε and Identification of Two Target Serine Residues
2002
Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels
2004
Increased sensitivity of desensitized TRPV1 by PMA occurs through PKCε-mediated phosphorylation at S800
2006
Regulation Mechanisms of Vanilloid Receptors
2004
Structural determinant of TRPV1 desensitization interacts with calmodulin
2003