Standout Papers
Citation Impact
Citing Papers
The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2
2008
Hypothalamic mTOR Signaling Regulates Food Intake
2006 Science
mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
2006 Standout
eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
2012
Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions
2014 Science
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
2007
TOR Signaling in Growth and Metabolism
2006 Standout
Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-α gene transcription by the liver X receptor agonist T0-901317
2007
The Critical Role of Metabolic Pathways in Aging
2012
mTOR signaling: implications for cancer and anticancer therapy
2005
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate
2013
PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
2011
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Insulin and Metabolic Stress Stimulate Multisite Serine/Threonine Phosphorylation of Insulin Receptor Substrate 1 and Inhibit Tyrosine Phosphorylation
2014
Linking mitochondrial bioenergetics to insulin resistance via redox biology
2012
Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34
2008
Beyond the Sympathetic Tone: The New Brown Fat Activators
2013
mTOR Signaling in Growth Control and Disease
2012 Standout
Inflammation and metabolic disorders
2006 StandoutNature
Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels
2010
Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase
2016
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
2007
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
2005 Standout
S6K1 Plays a Critical Role in Early Adipocyte Differentiation
2010
FXR signaling in metabolic disease
2007
Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity
2012
mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
2011
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Mice with a Targeted Deletion of the Type 2 Deiodinase Are Insulin Resistant and Susceptible to Diet Induced Obesity
2011
Plasma Bile Acids Are Associated with Energy Expenditure and Thyroid Function in Humans
2011
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
2013
The genetics of ageing
2010 StandoutNature
Modulation of insulin action by dietary proteins and amino acids: role of the mammalian target of rapamycin nutrient sensing pathway
2005
mTOR and cancer: many loops in one pathway
2009
Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
2011
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
2009
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
2008 Standout
New Modes of Translational Control in Development, Behavior, and Disease
2007
Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis
2008
PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms
2007
Rapamycin, an mTOR inhibitor, disrupts triglyceride metabolism in guinea pigs
2006
Targeting mammalian target of rapamycin (mTOR) for health and diseases
2006
Expanding mTOR signaling
2007
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function
2011
Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis
2008
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
2009 Standout
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
2012
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
2007
Retinoid X receptors: common heterodimerization partners with distinct functions
2010
Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats
2011
Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
2011
mTOR and the control of whole body metabolism
2009
EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice
2017 Nature
Irs1 Serine 307 Promotes Insulin Sensitivity in Mice
2010
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
2010
Disruption of BCATm in Mice Leads to Increased Energy Expenditure Associated with the Activation of a Futile Protein Turnover Cycle
2007
Mitochondrial longevity pathways
2010
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
2010
RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice
2014
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
2009
Anatomical Profiling of Nuclear Receptor Expression Reveals a Hierarchical Transcriptional Network
2006
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
2013
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
2011
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
2008
Perspectives on tight junction research
2012
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Activation and inactivation of thyroid hormone by deiodinases: Local action with general consequences
2007
Brown adipose tissue clinical impact of a re-discovered thermogenic organ
2013
A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility
2017
Bile acids: regulation of synthesis
2009
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12
2012
Lipid signalling in disease
2008
Insulin Receptor Signaling in Normal and Insulin-Resistant States
2014
Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR
2007
Biochemical and cellular properties of insulin receptor signalling
2017
Branched-chain amino acids in metabolic signalling and insulin resistance
2014
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
2006
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
2006
Claudins and Other Tight Junction Proteins
2012
Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes
2009
Diet rapidly and reproducibly alters the human gut microbiome
2013 StandoutNature
Endocrine Regulation of Energy Metabolism by the Skeleton
2007 Standout
Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism
2011
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
2006 Standout
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
2005
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
2010
Increased Activation of the Mammalian Target of Rapamycin Pathway in Liver and Skeletal Muscle of Obese Rats: Possible Involvement in Obesity-Linked Insulin Resistance
2004
Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex
2017
Signalling and autophagy regulation in health, aging and disease
2006
Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
2009
An expanding role for mTOR in cancer
2005
Metabolic Networks of Longevity
2010
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
2006
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate
2011
Defining the Role of mTOR in Cancer
2007 Standout
What We Talk About When We Talk About Fat
2014 Standout
Nuclear Receptors Reverse McGarry's Vicious Cycle to Insulin Resistance
2012
PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans
2011
S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover
2007
AKT/PKB Signaling: Navigating the Network
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr-1/SHP/EID1 network
2014
Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2
2007
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
2006 Standout
mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer
2007
The functions and regulation of the PTEN tumour suppressor
2012 Standout
The Hallmarks of Aging
2013 Standout
Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling
2014
Energy Metabolism in the Liver
2014 Standout
S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2
2008
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression
2012 Standout
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
2004
Regulation of mTORC1 and its impact on gene expression at a glance
2013
PRR5, a Novel Component of mTOR Complex 2, Regulates Platelet-derived Growth Factor Receptor β Expression and Signaling
2007
Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation
2009
Global quantification of mammalian gene expression control
2011 StandoutNature
Role of AMP‐activated protein kinase in the metabolic syndrome and in heart disease
2007
Rapamycin passes the torch: a new generation of mTOR inhibitors
2011
The Aging Stress Response
2010
mTOR is a key modulator of ageing and age-related disease
2013 Nature
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
2008
Mammalian target of rapamycin complex 1 (mTORC1) signaling in energy balance and obesity
2009
Inhibitor hijacking of Akt activation
2009
Retinoid X Receptor Heterodimers in the Metabolic Syndrome
2005
Restraining PI3K: mTOR signalling goes back to the membrane
2004
Claudin-17 forms tight junction channels with distinct anion selectivity
2012
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans
2006
Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: Neuronal involvement in food-intake regulation
2006
Molecular mechanisms of mTOR-mediated translational control
2009 Standout
Insulin signalling mechanisms for triacylglycerol storage
2013
Deficiency of Claudin-18 Causes Paracellular H+ Leakage, Up-regulation of Interleukin-1β, and Atrophic Gastritis in Mice
2011
Insulin signaling to hepatic lipid metabolism in health and disease
2011
With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
2010
TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1
2009
The Multiple Facets of the Fat Tissue
2008
Links between Thyroid Hormone Action, Oxidative Metabolism, and Diabetes Risk?
2008
Bile Acids and the Membrane Bile Acid Receptor TGR5—Connecting Nutrition and Metabolism
2008
Thyroid Hormone as a Determinant of Energy Expenditure and the Basal Metabolic Rate
2008
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Ubiquitination-Induced Conformational Change within the Deiodinase Dimer Is a Switch Regulating Enzyme Activity
2007
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
2007
AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
2011
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Nutrients Suppress Phosphatidylinositol 3-Kinase/Akt Signaling via Raptor-Dependent mTOR-Mediated Insulin Receptor Substrate 1 Phosphorylation
2005
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
2005
Disruption of Tsc2 in pancreatic β cells induces β cell mass expansion and improved glucose tolerance in a TORC1-dependent manner
2008
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
2008
Type II iodothyronine deiodinase provides intracellular 3,5,3′-triiodothyronine to normal and regenerating mouse skeletal muscle
2011
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Biosynthesis of the Caenorhabditis elegans dauer pheromone
2009 StandoutNobel
Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle
2008
Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
2007
Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
2017 Science
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Thyronamines—Past, Present, and Future
2011
Turnover of the Active Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine Phosphorylation in Cell Culture Models of Tuberous Sclerosis
2006
Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
2018 Standout
Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice
2005
Interplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle Cells
2008
Balancing Akt with S6K
2004
Type 2 deiodinase at the crossroads of thyroid hormone action
2011
Poly(ADP-Ribose)Polymerase-1 (PARP1) Controls Adipogenic Gene Expression and Adipocyte Function
2011
Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice
2008
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1
2012 Standout
Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes
2011
Thyroid Hormone Regulation of Metabolism
2014 Standout
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Drosophila Melted Modulates FOXO and TOR Activity
2005
Thyroid Hormones and the Metabolic Syndrome
2013
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
2008 Standout
Ser/Thr Phosphorylation of IRS Proteins: A Molecular Basis for Insulin Resistance
2005
Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
2010
Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells
2010
mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes
2008
Class IA Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy
2005
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
2006
The molecular machinery of autophagy: unanswered questions
2004
A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle
2010 StandoutNobel
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Claudins and the Modulation of Tight Junction Permeability
2013 Standout
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
2007
mTOR: a pharmacologic target for autophagy regulation
2015 Standout
NOX4 Pathway as a Source of Selective Insulin Resistance and Responsiveness
2012
Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
2009
mTOR Pathway as a Target in Tissue Hypertrophy
2006
The gut microbiota and metabolic disease: current understanding and future perspectives
2016
Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
2010
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3‐L1 Adipocytes
2010
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Dysregulation of the TSC-mTOR pathway in human disease
2004 Standout
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Caenorhabditis elegans responses to bacteria from its natural habitats
2016 StandoutNobel
Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage
2010
Works of Mitsuhiro Watanabe being referenced
TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
2012
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
2006 StandoutNature
Endocrine functions of bile acids
2006
Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders
2013
Impaired pancreatic growth, β cell mass, and β cell function in E2F1 –/– mice
2004
Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure
2011
Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure
2012
Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis
2008
Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine
2010
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
2004 Nature
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
2004
Ligand‐dependent contribution of RXRβ to cholesterol homeostasis in Sertoli cells
2004
Peroxisome Proliferator-activated Receptor (PPAR)-2 Controls Adipocyte Differentiation and Adipose Tissue Function through the Regulation of the Activity of the Retinoid X Receptor/PPARγ Heterodimer
2007
Vegetarian diets and glycemic control in diabetes: a systematic review and meta-analysis.
2014