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Citing Papers
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
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Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Hallmarks of Cancer: The Next Generation
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Pharmacology of LY315920/S-5920, [[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1 H-indol-4-yl]oxy]acetate, a Potent and Selective Secretory Phospholipase A2Inhibitor: A New Class of Anti-Inflammatory Drugs, SPI
1999
Phospholipase A2 subclasses in acute respiratory distress syndrome
2009
Group II phospholipase A2 mRNA synthesis is stimulated by two distinct mechanisms in rat vascular smooth muscle cells
1990
KIN‐29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC
2006
Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity
2003
Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2
2001
Biology of Secretory Phospholipase A2
2008
Enzyme-Catalyzed Activation of Anticancer Prodrugs
2004
Gene Expression of Group Ii Phospholipase A2 in Intestine in Crohn's Disease
1999
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
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Biaryl diacid inhibitors of human s-PLA2 with anti-inflammatory activity
2000
The genetics of ageing
2010 StandoutNature
On the specificity of pig adrenal ferredoxin (adrenodoxin) and spinach ferredoxin in electron‐transfer reactions
1988 StandoutNobel
A novel phospholipase A2 associated with nuclear matrix: stimulation of the activity and modulation of the Ca2+ dependency by polyphosphoinositides
1989
The role of Asp‐49 and other conserved amino acids in phospholipases A2 and their importance for enzymatic activity
1989
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
1995 StandoutNatureNobel
The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia
1995
Defective Fasciculata Zone Function as the Mechanism of Glucocorticoid-Remediable Aldosteronism*
1990
Role of group IIA phospholipase A2 in rat colitis induced by dextran sulfate sodium
2003
Human epidermis is a novel site of phospholipase B expression
2002
Flavonoids as Phospholipase A2 Inhibitors: Importance of Their Structure for Selective Inhibition of Group II Phospholipase A2
1997
Vitamin D Deficiency
2007 Standout
Mechanism of Inhibition of Human Nonpancreatic Secreted Phospholipase A2 by the Anti-inflammatory Agent BMS-181162*
1995
A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis
2005
Lessons from Hereditary Colorectal Cancer
1996 Standout
Expression of human group II PLA2 in transgenic mice results in epidermal hyperplasia in the absence of inflammatory infiltrate.
1996
Translocation of phospholipase A2 from cytosol to membranes in rat brain induced by calcium ions
1990
The Formation of Ceramide-1-phosphate during Neutrophil Phagocytosis and Its Role in Liposome Fusion
1998 StandoutNobel
Inactivation of human synovial fluid phospholipase a2 by the marine natural product, manoalide
1990
Modulation of transcription factor function by O-GlcNAc modification
2010
An unusual yet strongly conserved flavoprotein reductase in bacteria and mammals
1991
Purification and characterization of rabbit platelet cytosolic phospholipase A2
1991
PLA2 (group IIA phospholipase A2) as a prognostic determinant in stage II colorectal carcinoma
2009
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid production without activation of cytosolic phospholipase A2 alpha
2005
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
2014 StandoutNature
Suppression of murine endotoxic shock by sPLA2 inhibitor, indoxam, through group IIA sPLA2-independent mechanisms
1999
Sequential Synthesis of Coordination Polymersomes
2014 StandoutNobel
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
2009
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
The multifaceted Paneth cell
2002
Secretory phospholipase A2 of group IIA: Is it an offensive or a defensive player during atherosclerosis and other inflammatory diseases?
2005
Calmodulin Suppresses Synaptotagmin-2 Transcription in Cortical Neurons*
2010 StandoutNobel
Thielocin B3, a novel antiinflammatory human group II phospholipase A2 specific inhibitor from ascomycetes.
1994
Oncogenes and signal transduction
1991 Standout
LKB1; linking cell structure and tumor suppression
2008
Enhanced Phagocytosis through Inhibition of de Novo Ceramide Synthesis
2003 StandoutNobel
Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes
2015
Purified Group X Secretory Phospholipase A2 Induced Prominent Release of Arachidonic Acid from Human Myeloid Leukemia Cells
1999
Compensatory phospholipid digestion is required for cholesterol absorption in pancreatic phospholipase A2–Deficient mice
2001
Cross-talk between calcium and cAMP-dependent intracellular signaling pathways. Implications for synergistic secretion in T84 colonic epithelial cells and rat pancreatic acinar cells.
1995 StandoutNobel
Groups IV, V, and X Phospholipases A2s in Human Neutrophils
2002
Roles of secretory phospholipases A2 in inflammatory diseases and trauma
2000
Secretory phospholipase A2: A multifaceted family of proatherogenic enzymes
2009
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
1991 Standout
The Hallmarks of Aging
2013 Standout
Atherosclerosis
2000 StandoutNature
Phospholipase A2 engineering: Design, synthesis, and expression of a gene for bovine (pro)phospholipase A2
1989
Calcium Signaling
2007 Standout
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
2011 Nature
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
Inactivating Mutations in the 25-Hydroxyvitamin D31α-Hydroxylase Gene in Patients with Pseudovitamin D–Deficiency Rickets
1998
A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension
1992 StandoutNature
Wnt signalling in stem cells and cancer
2005 StandoutNature
Antimicrobial peptides of multicellular organisms
2002 StandoutNature
Bactericidal properties of murine intestinal phospholipase A2.
1995
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Effect of a Selective Inhibitor of Secretory Phospholipase A2, S-5920/LY315920Na, on Experimental Acute Pancreatitis in Rats
2004
Structure of gene coding for rat group II phospholipase A2
1990
Phospholipase A2 enzymes
2002
An 100‐kDa arachidonate‐mobilizing phospholipase A2 in mouse spleen and the macrophage cell line J774
1991
Enhanced expression of group II phospholipase A2 gene in the tissues of endotoxin shock rats and its suppression by glucocorticoid
1990
Therapeutic time-window of a group IIA phospholipase A2 inhibitor in rabbit acute lung injury: Correlation with lung surfactant protection
2001
Potent Modification of Low Density Lipoprotein by Group X Secretory Phospholipase A2 Is Linked to Macrophage Foam Cell Formation
2002
Structure and Properties of a Human Non-pancreatic Phospholipase A2
1989
Predicting the orientation of eukaryotic membrane-spanning proteins.
1989
Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction
2006
Aldosterone synthase cytochrome P-450 expressed in the adrenals of patients with primary aldosteronism
1991
Metabolic cross-talk allows labeling of O-linked β- N -acetylglucosamine-modified proteins via the N -acetylgalactosamine salvage pathway
2011 StandoutNobel
Tumor Necrosis Factor (TNF)
1985 StandoutScience
Constitutive synthesis of tumor necrosis factor in the thymus.
1992 StandoutNobel
Biochemistry and Physiology of Mammalian Secreted Phospholipases A2
2008
Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. 1. Indole-3-acetamides
1996
Cachectin and tumour necrosis factor as two sides of the same biological coin
1986 StandoutNatureNobel
Identification of chromophore binding domains of yeast DNA photolyase.
1992 StandoutNobel
DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.
1986
Platelet-activating factor.
1990 Standout
Protection against diet-induced obesity and obesity- related insulin resistance in Group 1B PLA2-deficient mice
2002
Kinetic properties of a high molecular mass arachidonoyl-hydrolyzing phospholipase A2 that exhibits lysophospholipase activity
1991
Macrophage-mediated cytotoxicity: role of a soluble macrophage cytotoxic factor similar to lymphotoxin and tumor necrosis factor.
1983
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Cytochrome P450 may regulate plasma membrane Ca 2+ permeability according to the filling state of the intracellular Ca 2+ stores
1992
Lymphotoxin: Properties, role and mode of action
1981
Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages
1992 StandoutScience
Characterization of a novel inhibitor of cytosolic phospholipase A2α, pyrrophenone
2002
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
1991 StandoutNobel
Dicarboxylic acid inhibitors of phospholipase A2
1997
Interfacial Catalysis: the Mechanism of Phospholipase A 2
1990 StandoutScience
PKD2 , a Gene for Polycystic Kidney Disease That Encodes an Integral Membrane Protein
1996 StandoutScience
Lymphotoxin ? An immunologic hormone with anticarcinogenic and antitumor activity
1982
A fundamental system of cellular energy homeostasis regulated by PGC-1α
2007
Localization of phospholipase A2 in normal and ras-transformed cells.
1988
Secretory Phospholipases A2 Induce β-Glucuronidase Release and IL-6 Production from Human Lung Macrophages
2000
Expression of porcine pancreatic phospholipase A2. Generation of active enzyme by sequence-specific cleavage of a hybrid protein fromEscherichia coli
1987
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
Tumor Suppression by LKB1: SIK-ness Prevents Metastasis
2009
Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis
1989 StandoutScience
Glucocorticoids suppress group II phospholipase A2 production by blocking mRNA synthesis and post-transcriptional expression.
1990
Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).
1989
Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro
1985 StandoutScience
Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. 3. Indole-3-glyoxamides
1996
Characterization of Two Genes Encoding Human Steroid 11β-Hydroxylase (P-45011β)
1989
Secretory Phospholipase A 2 Is the Principal Bactericide for Staphylococci and Other Gram-Positive Bacteria in Human Tears
1998
Enteric β-Defensin: Molecular Cloning and Characterization of a Gene with Inducible Intestinal Epithelial Cell Expression Associated with Cryptosporidium parvum Infection
1998
Autophagy and Metabolism
2010 StandoutScience
Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism
1990
Phospholipase A2 inhibitors in inflammation
2001
Approaches to the study of mammalian cellular phospholipases.
1985
Leukoregulin, a direct-acting anticancer immunological hormone that is distinct from lymphotoxin and interferon.
1985
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
Inflammatory factors stimulate expression of group II phospholipase A2 in rat cultured astrocytes. Two distinct pathways of the gene expression
1991
Molecular cloning of pancreatic group I phospholipase A2 receptor.
1994
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Inhibition of Secreted Phospholipase A2. 4-Glycerol Derivatives of 4,5-Dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with Broad Activities
2007
Hepatic Glucose Sensing via the CREB Coactivator CRTC2
2008 Science
Pancreatic phospholipase A 2 via its receptor regulates the expression of key enzymes of phospholipid and sphingolipid metabolism
2001
Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by .beta.-chloroalanine
1988
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Cloning and Recombinant Expression of Phospholipase A2 Present in Rheumatoid Arthritic Synovial Fluid
1989
Purification of a high-molecular-mass form of phospholipase A2 from rat kidney activated at physiological calcium concentrations
1990
Circulating Levels of Secretory Type II Phospholipase A 2 Predict Coronary Events in Patients with Coronary Artery Disease
1999
Cytochrome P-450 may link intracellular Ca2+ stores with plasma membrane Ca2+ influx
1991
Glyco-seek: Ultrasensitive Detection of Protein-Specific Glycosylation by Proximity Ligation Polymerase Chain Reaction
2016 StandoutNobel
Works of Mitsuhiro Okamoto being referenced
Increased group II phospholipase A2 in colonic mucosa of patients with Crohn's disease and ulcerative colitis.
1994
Raised serum activity of phospholipase A2 immunochemically related to group II enzyme in inflammatory bowel disease: its correlation with disease activity of Crohn's disease and ulcerative colitis.
1992
Reverse-phase high-performance liquid chromatographic assay of phospholipases: application of spectrophotometric detection to rat phospholipase A2 isozymes
1993
Salt-inducible kinase in steroidogenesis and adipogenesis
2003
Group II phospholipase A2 induced by interleukin‐1β in cultured rat gingival fibroblasts
1992
Purification and Characterization of a Catalytic Domain of Rat Intestinal Phospholipase B/Lipase Associated with Brush Border Membranes
1998
cDNA cloning and sequence determination of rat membrane-associated phospholipase A2
1989
Molecular cloning and sequence analysis of cDNA encoding rat adrenal cytochrome P‐45011β
1989
Preferential distribution of group‐II‐like phospholipase A2 in mononuclear phagocytic cells in rat spleen and liver
1991
Group II phospholipase A2 as an autocrine growth factor mediating interleukin-1 action on mesangial cells
1997
Increased intestinal phospholipase A2 activity catalyzed by phospholipase B/lipase in WBN/Kob rats with pancreatic insufficiency
2000
Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects: a study based on coronary angiography
2001
Molecular cloning and expression of cDNAs encoding rat aldosterone synthase: Variants of cytochrome P-45011β
1990
Presence of pancreatic-type phospholipase A2 mRNA in rat gastric mucosa and lung
1989
Adipose-specific Expression, Phosphorylation of Ser794 in Insulin Receptor Substrate-1, and Activation in Diabetic Animals of Salt-inducible Kinase-2
2003
Cloning and expression of phospholipase A2 from guinea pig gastric mucosa, its induction by carbachol and secretion in vivo
1993
The primary structure of a membrane-associated phospholipase A2 from human spleen
1989
A pancreatic-type phospholipase A2 in rat gastric mucosa
1988
Enzymatic Activities of P-450(llβ)s Expressed by Two cDNAs in COS-7 Cells1
1990
The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector
2004
Cloning of a novel kinase (SIK) of the SNF1/AMPK family from high salt diet‐treated rat adrenal1
1999
Identification of Essential Residues for Catalysis of Rat Intestinal Phospholipase B/Lipase
2001
Studies on the Mechanism of Action of Guinea Pig Lymphotoxin
1978
Aldosterone biosynthesis in mitochondria of isolated zones of adrenal cortex
1988
Synthesis of Aldosterone by a Reconstituted System of Cytochrome P-45011β from Bovine Adrenocortical Mitochondria1
1985
Rat Pancreatic Phospholipase A2: Purification, Characterization, and N-Terminal Amino Acid Sequence1
1984
Purification and characterization of a phospholipase A2 from human ileal mucosa
1993
Molecular Cloning and Sequence Analysis of Full-Length cDNA for Rabbit Liver NADPH-Cytochrome P-450 Reductase mRNA1
1986
19-Hydroxylation of 18-hydroxy-11-deoxycorticosterone catalyzed by cytochrome P-45011 beta of bovine adrenocortex.
1983
Aldosterone biosynthesis by a reconstituted cytochrome P-45011β system
1984
Studies on the Mechanism of Action of Guinea Pig Lymphotoxin
1978
Elevation of phospholipase A2 protein in sera of patients with Crohn's disease and ulcerative colitis.
1993
Molecular cloning and sequence analysis of full-length cDNA for mRNA of adrenodoxin oxidoreductase from bovine adrenal cortex
1987
Aldosterone biosynthesis and cytochrome P-45011β: evidence for two different forms of the enzyme in rats
1987
Purification and Characterization of Human Pancreatic Phospholipase A2 and Development of a Radioimmunoassay1
1983
Identification of Functional Domains of Rat Intestinal Phospholipase B/Lipase
1998
Purification and Some Properties of Rat Spleen Phospholipase A21
1983
Effect of Calinodulin on Aldosterone Synthesis by a Cytoclirome P-45011β-Reconstituted System from Bovine Adrenocortical Mitochondria1
1986
Immunochemical relatedness between secretory phospholipase A2 and intracellular·phospholipase A2
1985
Dog and Rat Pancreatic Phospholipases A2: Complete Amino Acid Sequences Deduced from Complementary DNAs
1986
Purification of intracellular phospholipase A2 from rat spleen supernatant by reverse-phase high-performance liquid chromatography
1984
Cytochrome P-450-Dependent Oxidative Cleavage of 1-(Tetrahydro-2-Furanyl)-5-Fluorouracil to 5-Fluorouracil
1984
Studies on the mechanism of action of guinea pig lymphotoxin. I. Membrane active substances prevent target cell lysis by lymphotoxin.
1978
Studies on the mechanism of action of guinea pig lymphotoxin. II. Increase of calcium uptake rate in LT-damaged target cells.
1978
A phospholipase A2 in the supernatant fraction of rat spleen. Its similarity to rat pancreatic phospholipase A2.
1988
Purification and characterization of a membrane-associated phospholipase A2 from rat spleen. Its comparison with a cytosolic phospholipase A2 S-1.
1988
Labeling of the active site of cytoplasmic aspartate aminotransferase by β-chloro-L-alanine
1973