Standout Papers
Citation Impact
Citing Papers
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Southern African ancient genomes estimate modern human divergence to 350,000 to 260,000 years ago
2017 Science
Limits of long-term selection against Neandertal introgression
2019 StandoutNobel
Meta-hallmarks of aging and cancer
2023
Gut microbiota as the key controllers of “healthy” aging of elderly people
2021
Metabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
2019
Role of mitochondria and C‐terminal membrane anchor of Bcl‐2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae
1996
Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms
2022
The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies
2016
Improved age determination of blood and teeth samples using a selected set of DNA methylation markers
2015
Senescence-associated genes in normal human oral keratinocytes
2003
Inflamm‐aging of the stem cell niche: Breast cancer as a paradigmatic example
2011
Chronic inflammation in the etiology of disease across the life span
2019 Standout
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
The genetics of ageing
2010 StandoutNature
ATP-dependent chromatin remodelers in ageing and age-related disorders
2020
Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites
2013
Effect of age on chronic inflammation and responsiveness to bacterial and viral challenges
2017
Development of a forensically useful age prediction method based on DNA methylation analysis
2015
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
2014 Standout
Apoptosis by Death Factor
1997 Standout
Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?
2008
Hallmarks of aging: An expanding universe
2023 Standout
Longevity in Mice Is Promoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production
2011
Forensic age prediction for dead or living samples by use of methylation-sensitive high resolution melting
2016
Tracing the Route of Modern Humans out of Africa by Using 225 Human Genome Sequences from Ethiopians and Egyptians
2015
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
2018 Standout
Systemic infection and delirium: when cytokines and acetylcholine collide
2010
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Inflammaging: should this term be suitable for age related macular degeneration too?
2013
Epigenetic age signatures in the forensically relevant body fluid of semen: a preliminary study
2015
Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms
2011
Age-dependent alteration in muscle regeneration: the critical role of tissue niche
2013
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
The brain and immune system prompt energy shortage in chronic inflammation and ageing
2017
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
2012
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
2019 Standout
Flow cytometric analysis of apoptotic subpopulations with a combination of Annexin V-FITC, propidium iodide, and SYTO 17
2001
Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging
2017
Long-term ambient particle exposures and blood DNA methylation age: findings from the VA normative aging study
2016
Inflammation–Nature's Way to Efficiently Respond to All Types of Challenges: Implications for Understanding and Managing “the Epidemic” of Chronic Diseases
2018
Role of the Microbiota in Immunity and Inflammation
2014 Standout
The complexity of NF-κB signaling in inflammation and cancer
2013 Standout
Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques
2020
Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice
2017
Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
2013
Apoptosis and Its Role in Human Disease
1994
Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
2000
Nrk, an X-linked Protein Kinase in the Germinal Center Kinase Family, Is Required for Placental Development and Fetoplacental Induction of Labor
2011 StandoutNobel
Taking a “good” look at free radicals in the aging process
2011
Aging of the innate immune system
2010
Stem cells, ageing and the quest for immortality
2006 StandoutNature
The aging gut microbiota: New perspectives
2011
Oxidative stress and the ageing endocrine system
2013
Cellular senescence: putting the paradoxes in perspective
2010
Gut metagenome in European women with normal, impaired and diabetic glucose control
2013 StandoutNature
Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
2012
Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice
2022
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
The immunology of exceptional individuals: the lesson of centenarians
1995
Two faces of p53: aging and tumor suppression
2007
Puzzles, promises and a cure for ageing
2008 Nature
Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly
2012
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
1998 Standout
The Complicated Nature of Somatic mtDNA Mutations in Aging
2022
What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?
2004
Subjective wellbeing, health, and ageing
2014 StandoutNobel
The Fas Death Factor
1995 StandoutScience
Loss of Function of Cytochrome c in Jurkat Cells Undergoing Fas-mediated Apoptosis
1996
Hallmarks of T cell aging
2021
Crystallin γB-I4F Mutant Protein Binds to α-Crystallin and Affects Lens Transparency
2005 StandoutNobel
The quest to slow ageing through drug discovery
2020
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
2018 Standout
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
2019
Immunosenescence: what does it mean to health outcomes in older adults?
2009
Making sense of the ageing methylome
2022
The impact of CMV infection on survival in older humans
2012
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
2013
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology
2021
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study
2007
The role of senescent cells in ageing
2014 StandoutNature
Cytoplasmic DNA: sources, sensing, and role in aging and disease
2021
Geroscience: Linking Aging to Chronic Disease
2014 Standout
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
2010
The Hallmarks of Aging
2013 Standout
Diversity, stability and resilience of the human gut microbiota
2012 StandoutNature
The Search for Antiaging Interventions: From Elixirs to Fasting Regimens
2014
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
Defining trained immunity and its role in health and disease
2020 Standout
Role of Reactive Oxygen Species and p53 in Chromium(VI)-induced Apoptosis
1999 Standout
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
1999 StandoutNature
Molecular damage in aging
2021
Distinctive Biological Correlates of Positive Psychological Well-Being in Older Men and Women
2012
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
2015 Standout
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Frailty in elderly people
2013 Standout
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
2018 Standout
Inflammatory networks during cellular senescence: causes and consequences
2010
SARS-CoV-2 vaccines in development
2020 StandoutNature
The gut microbiome as a modulator of healthy ageing
2022
HaploGrep 2: mitochondrial haplogroup classification in the era of high-throughput sequencing
2016
Microglial dysfunction in brain aging and Alzheimer's disease
2014
Age‐associated elevation in TLR5 leads to increased inflammatory responses in the elderly
2011
Inflammaging: disturbed interplay between autophagy and inflammasomes
2012
Forensic DNA methylation profiling from evidence material for investigative leads
2016
Siglec receptors impact mammalian lifespan by modulating oxidative stress
2015
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
2016 Standout
Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice
2008
EAGER: efficient ancient genome reconstruction
2016
Ancient Ethiopian genome reveals extensive Eurasian admixture in Eastern Africa
2015 StandoutScience
Signaling Recognition Events with Fluorescent Sensors and Switches
1997 Standout
Lymphocyte Homing and Homeostasis
1996 StandoutScience
Caspase 3 Cleavage of the Ste20-Related Kinase SLK Releases and Activates an Apoptosis-Inducing Kinase Domain and an Actin-Disassembling Region
2000
Cell nucleus and DNA fragmentation are not required for apoptosis.
1994
Accelerated epigenetic aging in Werner syndrome
2017
Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity
2017
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Biological mechanisms of aging predict age‐related disease co‐occurrence in patients
2022
Biodemographic Trajectories of Longevity
1998 Science
Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels
2016
Oxidation Proteomics: The Role of Thiol Modifications
2009
Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations
2018 StandoutScienceNobel
The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies
2021 Standout
Spermidine in health and disease
2018 StandoutScience
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
2020
Four faces of cellular senescence
2011 Standout
Broken Limits to Life Expectancy
2002 StandoutScience
Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice
2007
Aging of the Immune System as a Prognostic Factor for Human Longevity
2008
Genomic Diversity and Admixture Differs for Stone-Age Scandinavian Foragers and Farmers
2014 Science
Fluorescent Sensors for Zn2+Based on a Fluorescein Platform: Synthesis, Properties and Intracellular Distribution
2001 StandoutNobel
Exercise and Toll-like receptors.
2006
Acceleration of leukocytes’ epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer
2017
The cerebellum ages slowly according to the epigenetic clock
2015
Genetic legacy of state centralization in the Kuba Kingdom of the Democratic Republic of the Congo
2018 StandoutNobel
N-glycomic biomarkers of biological aging and longevity: A link with inflammaging
2012
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
2005 StandoutNature
Epigenetic estimation of age in humpback whales
2014
Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II)
1993
An epigenetic biomarker of aging for lifespan and healthspan
2018 Standout
A New Cell-Permeable Fluorescent Probe for Zn2+
2000 StandoutNobel
Global analyses revealed age‐related alterations in innate immune responses after stimulation of pathogen recognition receptors
2015
Chromatin Degradation in Differentiating Fiber Cells of the Eye Lens
1997
Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring
2015
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
2013
Works of Miriam Capri being referenced
The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans
2016
Gut Microbiota and Extreme Longevity
2016
Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges
2013
Human longevity within an evolutionary perspective: The peculiar paradigm of a post-reproductive genetics
2007
Circulating miR-21, miR-146a and Fas ligand respond to postmenopausal estrogen-based hormone replacement therapy – A study with monozygotic twin pairs
2014
Mitochondrial Modifications during Rat Thymocyte Apoptosis: A Study at the Single Cell Level
1994
Actin Cytoskeleton as a Target for 2-Chloro Adenosine: Evidence for Induction of Apoptosis in C2C12 Myoblastic Cells
1997
Immunosenescence and Immunogenetics of Human Longevity
2008
The Genetics of Human Longevity
2006
Genes, ageing and longevity in humans: Problems, advantages and perspectives
2006
Charting the NF-κB Pathway Interactome Map
2012
Inhibition of apoptosis by zinc: A reappraisal
1992
Cell Proliferation and Cell Death in Immunosenescencea
1992
The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death
2004
Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans
2006 Standout
Systems Biology and Longevity: An Emerging Approach to Identify Innovative Anti- Aging Targets and Strategies
2010
The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates
2018
mtDNA mutations in human aging and longevity: Controversies and new perspectives opened by high-throughput technologies
2014
Ecoimmunology: is there any room for the neuroendocrine system?
2008
MicroRNAs linking inflamm-aging, cellular senescence and cancer
2013
Immunosenescence in Humans: Deterioration or Remodelling?
1995
Mitochondrial DNA involvement in human longevity
2006
Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians
2001
Immune parameters identify Italian centenarians with a longer five-year survival independent of their health and functional status
2014
Inflammaging and ‘Garb-aging’
2016
Complexity of Anti‐immunosenescence Strategies in Humans
2006
Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53
2009
Gut microbiota changes in the extreme decades of human life: a focus on centenarians
2017
Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians
2004
Conserved and species-specific molecular denominators in mammalian skeletal muscle aging
2017
Inflamm-Aging, Cytokines and Aging: State of the Art, New Hypotheses on the Role of Mitochondria and New Perspectives from Systems Biology
2006
Age-Related Inflammation: the Contribution of Different Organs, Tissues and Systems. How to Face it for Therapeutic Approaches
2010
Mitochondria, aging and longevity – a new perspective
2001
Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity
2017
Methylation of ELOVL 2 gene as a new epigenetic marker of age
2012
Cell‐free DNA as a biomarker of aging
2018
Inflammaging and Cancer: A Challenge for the Mediterranean Diet
2015
HAPLOFIND: A New Method for High-Throughput mtDNA Haplogroup Assignment
2013
Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity
2014
Mediterranean diet and inflammaging within the hormesis paradigm
2017
A meta-analysis on age-associated changes in blood DNA methylation: results from an original analysis pipeline for Infinium 450k data
2015
Calorie restriction in humans inhibits the PI 3K /AKT pathway and induces a younger transcription profile
2013
Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans
2006
Shotgun Metagenomics of Gut Microbiota in Humans with up to Extreme Longevity and the Increasing Role of Xenobiotic Degradation
2020
Plasma N-Glycome Signature of Down Syndrome
2015