Standout Papers
Citation Impact
Citing Papers
Phospholipid Scramblase 1 Potentiates the Antiviral Activity of Interferon
2004
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
UBE1L causes lung cancer growth suppression by targeting cyclin D1
2008
Selective blockade of the inhibitory Fcγ receptor (FcγRIIB) in human dendritic cells and monocytes induces a type I interferon response program
2007 StandoutNobel
IFN-α Is Not Sufficient to Drive Th1 Development Due to Lack of Stable T-bet Expression
2007
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation
2015 StandoutNobel
Activation of Double-stranded RNA-activated Protein Kinase (PKR) by Interferon-stimulated Gene 15 (ISG15) Modification Down-regulates Protein Translation
2012
Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C
2010
Interferons as pathogenic effectors in autoimmunity
2005
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
Treatment triumphs
2014 StandoutNatureNobel
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
2007 StandoutNobel
Persistence of Leukemia-Initiating Cells in a Conditional Knockin Model of an Imatinib-Responsive Myeloproliferative Disorder
2009
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
2016 Standout
ISG15, a ubiquitin-like interferon-stimulated gene, promotes hepatitis C virus production in vitro: implications for chronic infection and response to treatment
2009
ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP
2007
Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme
2005
The protein kinase IKKε can inhibit HCV expression independently of IFN and its own expression is downregulated in HCV-infected livers
2006
DUB-3, a Cytokine-inducible Deubiquitinating Enzyme That Blocks Proliferation
2004
Brucella requires a functional Type IV secretion system to elicit innate immune responses in mice
2007
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity
2006
Psoriasis
2021 Standout
A Genomic and Functional Inventory of Deubiquitinating Enzymes
2005 Standout
Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo
2011
IFNs, ISGylation and cancer: Cui prodest?
2012
Silencing of USP18 Potentiates the Antiviral Activity of Interferon Against Hepatitis C Virus Infection
2006 StandoutNobel
Genomic and Metabolic Studies of the Impact of Probiotics on a Model Gut Symbiont and Host
2006
Antiviral resistance of stem cells
2018 StandoutNobel
Mouse models of human AML accurately predict chemotherapy response
2009
The interferon stimulated gene 15 functions as a proviral factor for the hepatitis C virus and as a regulator of the IFN response
2010
Metazoan MicroRNAs
2018 Standout
Amplification of IFN-α-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors
2004
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Host responses to alphavirus infection
2008
p21 in cancer: intricate networks and multiple activities
2009 Standout
Screen for ISG15-crossreactive Deubiquitinases
2007
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Multiple Interferon Stimulated Genes Synergize with the Zinc Finger Antiviral Protein to Mediate Anti-Alphavirus Activity
2012 StandoutNobel
NOD1 and NOD2 signalling links ER stress with inflammation
2016 StandoutNature
STAT1 as a key modulator of cell death
2006
Regulation of JAK–STAT signalling in the immune system
2003
The ins and outs of hepatitis C virus entry and assembly
2013 StandoutNobel
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
Tuberous sclerosis
2008 Standout
STAT1 Pathway Mediates Amplification of Metastatic Potential and Resistance to Therapy
2009
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage
2013 StandoutNobel
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity
2017 StandoutNobel
Immunity by ubiquitylation: a reversible process of modification
2005
Hepatic Gene Expression Discriminates Responders and Nonresponders in Treatment of Chronic Hepatitis C Viral Infection
2005
Clinical Effect of Point Mutations in Myelodysplastic Syndromes
2011 Standout
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15
2008
USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response
2011
ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response*
2008
Regulation of type I interferon responses
2013 Standout
Genetics of therapy-related myelodysplasia and acute myeloid leukemia
2008
Standardizing immunophenotyping for the Human Immunology Project
2012
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
2011 StandoutNobel
The Interferon-inducible Ubiquitin-protein Isopeptide Ligase (E3) EFP Also Functions as an ISG15 E3 Ligase
2005
Interferon regulated gene (IRG) expression-signature in a mouse model of chikungunya virus neurovirulence
2017
Regulatory Effects of Mammalian Target of Rapamycin-activated Pathways in Type I and II Interferon Signaling
2006
Innate immune responses in hepatitis C virus infection
2012
Bifidobacteria can protect from enteropathogenic infection through production of acetate
2011 StandoutNature
The way forward in HCV treatment — finding the right path
2007 StandoutNobel
Innate Immune Responses to Hepatitis C Virus
2013 StandoutNobel
Hepatitis C Virus Reveals a Novel Early Control in Acute Immune Response
2011
Genomic response to interferon-α in chimpanzees: Implications of rapid downregulation for hepatitis C kinetics
2006
25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end
2013
Tumor Necrosis Factor Inhibits Spread of Hepatitis C Virus Among Liver Cells, Independent From Interferons
2017 StandoutNobel
The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: Friend or foe?☆
2006
Interferon-inducible antiviral effectors
2008 Standout
Dendritic cells require a systemic type I interferon response to mature and induce CD4+ Th1 immunity with poly IC as adjuvant
2009 StandoutNobel
Proteomic identification of proteins conjugated to ISG15 in mouse and human cells
2005
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Flying Under the Radar: The Immunobiology of Hepatitis C
2006 StandoutNobel
Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins
2003
Generalized pustular psoriasis: a review and update on treatment
2018
Proline Rich Motifs as Drug Targets in Immune Mediated Disorders
2012
Identification of Interferon-Stimulated Gene 15 as an Antiviral Molecule during Sindbis Virus Infection In Vivo
2005
Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections
2010
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
2008 StandoutNature
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Signal Transducer and Activator of Transcription 1 Regulates Both Cytotoxic and Prosurvival Functions in Tumor Cells
2007
Reexamination of the Role of Ubiquitin-Like Modifier ISG15 in the Phenotype of UBP43-Deficient Mice
2005
Treg functional stability and its responsiveness to the microenvironment
2014
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
2004 StandoutNobel
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
2007 Standout
Regulation of interferon and Toll‐like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms
2008
Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication
2004
Identification and Characterization of Interferon-Induced Proteins That Inhibit Alphavirus Replication
2007
Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation
2012
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis Virus
2008
ISG15, an Interferon-Stimulated Ubiquitin-Like Protein, Is Not Essential for STAT1 Signaling and Responses against Vesicular Stomatitis and Lymphocytic Choriomeningitis Virus
2005
The mirn23a microRNA cluster antagonizes B cell development
2016
Developmental regulation of myeloerythroid progenitor function by the Lin28b–let-7–Hmga2 axis
2016
Interferon signatures in immune disorders and disease
2012
Stealth and Cunning: Hepatitis B and Hepatitis C Viruses
2005
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Lipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression
2016
ITAM-Coupled Receptors Inhibit IFNAR Signaling and Alter Macrophage Responses to TLR4 and Listeria mono cytogenes
2012
Viral persistence, liver disease, and host response in a hepatitis C–like virus rat model
2017 StandoutNobel
Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of β cells
2007 StandoutNobel
Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15
2006
AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biologic, pathologic, immunophenotypic, and prognostic features
2009
RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates
2006 StandoutScience
Interferon-Inducible Ubiquitin E2, Ubc8, Is a Conjugating Enzyme for Protein ISGylation
2004
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
2016 Standout
Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion
2016 StandoutNobel
Role of the Akt pathway in mRNA translation of interferon-stimulated genes
2008
Works of Ming Yan being referenced
Protein ISGylation modulates the JAK-STAT signaling pathway
2003
Quality assurance of intracellular cytokine staining assays: Analysis of multiple rounds of proficiency testing
2010
SON Protein Regulates GATA-2 through Transcriptional Control of the MicroRNA 23a∼27a∼24-2 Cluster*
2013
Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-rasLA2 mice
2008
Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages
2007
A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis
2006
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection
2004
Clinical profiles of pediatric patients with GPP alone and with different IL36RN genotypes
2016
Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development
2004
Alpha Interferon Induces Long-Lasting Refractoriness of JAK-STAT Signaling in the Mouse Liver through Induction of USP18/UBP43
2009
The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO
2007
Enhanced Antibacterial Potential in UBP43-Deficient Mice against Salmonella typhimurium Infection by Up-Regulating Type I IFN Signaling
2005 StandoutNobel
Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts
2007
Ube1L and Protein ISGylation Are Not Essential for Alpha/Beta Interferon Signaling
2005
Hmga2 is a direct target gene of RUNX1 and regulates expansion of myeloid progenitors in mice
2014
USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1–TAB1 complex
2013
Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling
2007