Citation Impact
Citing Papers
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila
2006 StandoutNobel
Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils
2001 Science
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
Statistical significance for genomewide studies
2003 Standout
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
2002 StandoutNobel
Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
2003
Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: Relevance to Alzheimer's disease
2006
Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy
2005
A Family of Basic Amino Acid Transporters of the Vacuolar Membrane from Saccharomyces cerevisiae
2004 StandoutNobel
Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice
2000
Apoptosis in the nervous system
2000 StandoutNature
The Value of Transgenic Models for the Study of Neurodegenerative Diseases
2000
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases
2000
Inflammation and metabolic disorders
2006 StandoutNature
Genetic effects on gene expression across human tissues
2017 StandoutNature
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
2007 Standout
Age-Dependent Induction of Congophilic Neurofibrillary Tau Inclusions in Tau Transgenic Mice
2001
Dynein mutations impair autophagic clearance of aggregate-prone proteins
2005
Evaluating triggers and enhancers of tau fibrillization
2005
Co-expression networks reveal the tissue-specific regulation of transcription and splicing
2017
Tau protein pathology in neurodegenerative diseases
1998
Glutamate uptake
2001 Standout
Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils
2003
Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration
2003 Nature
C-terminal ECFP Fusion Impairs Synaptotagmin 1 Function
2004 StandoutNobel
Phenotypic variation in hereditary frontotemporal dementia with tau mutations
1999
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
2003
TauGene Mutation K257T Causes a Tauopathy Similar to Pick's Disease
2000
The tau gene in progressive supranuclear palsy: exclusion of mutations in coding exons and exon 10 splice sites, and identification of a new intronic variant of the disease-associated H1 haplotype in Italian cases
1999
Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function
2004
Alternative RNA splicing in the nervous system
2001
Accumulation of Filamentous Tau in the Cerebral Cortex of Human Tau R406W Transgenic Mice
2005
Mutation-dependent aggregation of tau protein and its selective depletion from the soluble fraction in brain of P301L FTDP-17 patients
2000
Complex Regulation of Tau Exon 10, Whose Missplicing Causes Frontotemporal Dementia
2000
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
2007 Standout
A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes
2001
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
2005 StandoutNature
Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes
2000
Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases
2007
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Tau phosphorylation: physiological and pathological consequences
2004
Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein
1999
Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients
2001
Abnormal microtubule packing in processes of SF9 cells expressing the FTDP‐17 V337M tau mutation
1999
Wnt/β-Catenin Signaling and Disease
2012 Standout
Protein folding and misfolding
2003 StandoutNature
Recent Molecular Advances in Mammalian Glutamine Transport
2001
Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia
2001
Autophagy in the Pathogenesis of Disease
2008 Standout
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
2000
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Alzheimer's Disease-Like Tau Neuropathology Leads to Memory Deficits and Loss of Functional Synapses in a Novel Mutated Tau Transgenic Mouse without Any Motor Deficits
2006
Oligodendroglial tau filament formation in transgenic mice expressing G272V tau
2001
Expansion of the eukaryotic proteome by alternative splicing
2010 StandoutNature
A Family of Yeast Proteins Mediating Bidirectional Vacuolar Amino Acid Transport
2001
Listening to silence and understanding nonsense: exonic mutations that affect splicing
2002 Standout
Alternative splicing: multiple control mechanisms and involvement in human disease
2002
A new case of frontotemporal dementia and parkinsonism resulting from an intron 10 +3‐splice site mutation in the tau gene: clinical and pathological features
2000
Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles
2003 Standout
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
FTDP-17 Mutations in tau Transgenic Mice Provoke Lysosomal Abnormalities and Tau Filaments in Forebrain
2001
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
2007
Promotion of Hyperphosphorylation by Frontotemporal Dementia Tau Mutations
2004
Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: A novel action of R406W mutation
2000
Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations
1999
Alzheimer's Disease
2010 Standout
Filamentous nerve cell inclusions in neurodegenerative diseases
1998
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Mutations of Tau Protein in Frontotemporal Dementia Promote Aggregation of Paired Helical Filaments by Enhancing Local β-Structure
2001
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
2012
Abnormal Tau-Containing Filaments in Neurodegenerative Diseases
2000
Neurodegenerative Tauopathies
1999
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.
2000 Standout
Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation
1999
Transgenic animal models of tauopathies
2004
A Decade of Tau Transgenic Animal Models and Beyond
2007
Linking pathways in the developing and aging brain with neurodegeneration
2014
Axonal transport defects: a common theme in neurodegenerative diseases
2005
Induction of Inflammatory Mediators and Microglial Activation in Mice Transgenic for Mutant Human P301S Tau Protein
2004
Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors
2008
Alterations in Glucose Metabolism Induce Hypothermia Leading to Tau Hyperphosphorylation through Differential Inhibition of Kinase and Phosphatase Activities: Implications for Alzheimer's Disease
2004
Transmission and spreading of tauopathy in transgenic mouse brain
2009
Tau pathology in Alzheimer disease and other tauopathies
2004
Tau Filament Formation in Transgenic Mice Expressing P301L Tau
2001
Retarded Axonal Transport of R406W Mutant Tau in Transgenic Mice with a Neurodegenerative Tauopathy
2004
Cloning of an Amino Acid Transporter with Functional Characteristics and Tissue Expression Pattern Identical to That of System A
2000
Frequency oftau mutations in three series of non-Alzheimer's degenerative dementia
1999
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene
2000
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
The molecular pathology of Alzheimer's disease
1991 Standout
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
2009 StandoutNature
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
2003
Reduced Binding of Protein Phosphatase 2A to Tau Protein with Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 Mutations
2000
Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability
2006
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
2000
Determinants of 4-Repeat Tau Expression
2000
Prediction of the structure of symmetrical protein assemblies
2007 StandoutNobel
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?
2005
Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein
2002
Neurodegenerative Tauopathies
2001 Standout
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
Amino acid transport System A resembles System N in sequence but differs in mechanism
2000
A Century of Alzheimer's Disease
2006 StandoutScience
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degenerationin vivo
2005
Mutations causing neurodegenerative tauopathies
2004
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Glycogen Synthase Kinase-3 Mediates Endothelial Cell Activation by Tumor Necrosis Factor-α
2005
Pathways of tau fibrillization
2004
Human tau filaments induce microtubule and synapse loss in an in vivo model of neurofibrillary degenerative disease
2000
Spermidine Protects against Oxidative Stress in Inflammation Models Using Macrophages and Zebrafish
2017
From genetics to pathology: tau and a–synuclein assemblies in neurodegenerative diseases
2001
Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis
2015
Spermidine in health and disease
2018 StandoutScience
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice
2016
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
2004
Intraneuronal amyloid‐β1‐42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death
2004
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
2015
Neurodegeneration with Tau Accumulation in a Transgenic Mouse Expressing V337M Human Tau
2002
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
2005 StandoutScience
Phosphorylated tau can promote tubulin assembly
1999
Uptake of Glutamate into Synaptic Vesicles by an Inorganic Phosphate Transporter
2000 Science
E-Syts, a family of membranous Ca 2+ -sensor proteins with multiple C 2 domains
2007 StandoutNobel
The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer’s and Parkinson’s diseases1,2 11Guest Editors: Mark A. Smith and George Perry 22This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.
2002
Molecular Targets of Lithium Action
2001
A Japanese patient with frontotemporal dementia and parkinsonism by a tau P301S mutation
2000
Tauopathy in Drosophila : Neurodegeneration Without Neurofibrillary Tangles
2001 Science
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons
1999
Current Understanding of the Molecular Actions of Vitamin D
1998
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
2003 StandoutScience
Aberrant Splicing of tau Pre-mRNA Caused by Intronic Mutations Associated with the Inherited Dementia Frontotemporal Dementia with Parkinsonism Linked to Chromosome 17
2000
Glyco-seek: Ultrasensitive Detection of Protein-Specific Glycosylation by Proximity Ligation Polymerase Chain Reaction
2016 StandoutNobel
Works of Ming Hong being referenced
Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3
1997
Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex: Transgenic Mice Provide Insights into Mechanisms Underlying a Common Tauopathy in an Ethnic Minority on Guam
2002
Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform
1999
Transcriptional activation and dimerization functions in the human vitamin D receptor.
1996
Cloning and Functional Identification of a Neuronal Glutamine Transporter
2000
The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases
2016
Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
2000
Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons
1997
A Novel System A Isoform Mediating Na+/Neutral Amino Acid Cotransport
2000
Transgenic Mouse Model of Tauopathies with Glial Pathology and Nervous System Degeneration
2002
Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements
1999
Attenuated Neurodegenerative Disease Phenotype in Tau Transgenic Mouse Lacking Neurofilaments
2001
Distinct FTDP-17 Missense Mutations in Tau Produce Tau Aggregates and Other Pathological Phenotypes in Transfected CHO Cells
2000
Chronic Myeloid Leukemia Patients Sensitive and Resistant to Imatinib Treatment Show Different Metabolic Responses
2010