Citation Impact
Citing Papers
Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages
2005 StandoutNobel
A stomatin-like protein necessary for mechanosensation in C. elegans
1995 StandoutNatureNobel
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes
1998 StandoutNobel
Regulation of protein kinase cascades by protein phosphatase 2A
1999
A Requirement for Phosphatidylinositol 3-Kinase in Pseudopod Extension
1999
Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
1998 Standout
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
1995 Standout
Calmodulin-mediated Activation of Akt Regulates Survival of c-Myc-overexpressing Mouse Mammary Carcinoma Cells
2004
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
1994
Backbone Dynamics of a Free and a Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation
1994 Standout
The oligodendrocyte and its many cellular processes
1993
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
SH2 and SH3 domains
1993
Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-$gamma;1 complexed with a high affinity binding peptide
1994
SH2/SH3 signaling proteins
1994
The Hallmarks of Cancer
2000 Standout
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Src family kinases are required for integrin but not PDGFR signal transduction
1999
Phosphoinositide 3-kinases: A conserved family of signal transducers
1997
Modular binding domains in signal transduction proteins
1995
Phosphatidylinositol 3-Kinase Mediates the Inhibitory Effect of Epidermal Growth Factor on Calcium-dependent Chloride Secretion
1996
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras
1997
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
1997
Signaling—2000 and Beyond
2000 Standout
T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21ras
1995
PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain
2005
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Protein modules and signalling networks
1995 StandoutNature
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
1995 Standout
Phosphatidylinositol 3‐kinase
1994
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
1994
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
1995 Nature
The CD19-CR2-TAPA-1 complex, CD45 and signaling by the antigen receptor of B lymphocytes
1993
Growth factor signaling by receptor tyrosine kinases
1992
Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes
1999
The Growth-Promoting Effect of Low-Density Lipoprotein May Be Mediated by a Pertussis Toxin-Sensitive Mitogen-Activated Protein Kinase Pathway
1997
The B7 and CD28 receptor families
1994
Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells
1998
SH3 domains direct cellular localization of signaling molecules
1993
Negative regulation of activation-induced cytidine deaminase in B cells
2006 StandoutNobel
In vivoblockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
1999 StandoutNobel
Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells.
1994
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase
1994
Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.
1992
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Growth factor-induced binding of dynamin to signal transduction proteins involves sorting to distinct and separate proline-rich dynamin sequences.
1994
Phosphatidylinositol 4-Kinase: Gene Structure and Requirement for Yeast Cell Viability
1993 Science
SH2 domains recognize specific phosphopeptide sequences
1993 Standout
Functional rafts in cell membranes
1997 StandoutNature
The role of p21ras in receptor tyrosine kinase signaling
1995
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
The Structure and Function of P55PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase
1995
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
1993
Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.
1994
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
The Src-family kinase, Fyn, regulates the activation of phosphatidylinositol 3-kinase in an interleukin 2-responsive T cell line.
1994
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
1997 StandoutNobel
MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING
1997
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Targeting G βγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis
1999 StandoutNobel
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
1994
PI 3-kinase: structural and functional analysis of intersubunit interactions.
1994
Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.
1993
Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene
1997 StandoutNobel
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase
1994
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
1994
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Disruption of PDGF Receptor Trafficking by Mutation of Its PI-3 Linase Binding Sites
1994 Science
PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus.
1994
NMR solution structure of the human prion protein
2000 StandoutNobel
Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.
1994
1997 StandoutNobel
THE CROONIAN LECTURE 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease
1998
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.
1993
Structure of the recombinant full-length hamster prion protein PrP(29–231): The N terminus is highly flexible
1997 StandoutNobel
Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase
1995
The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.
1993
Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels
1997 StandoutNobel
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
NMR structure of the bovine prion protein
2000 StandoutNobel
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
1994
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
2012 StandoutNobel
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.
1995
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the β1-adrenergic receptor
1999 StandoutNobel
Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor
1995 Science
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.
1993
Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma.
1994
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.
1994
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
Attenuated T 2 relaxation by mutual cancellation of dipole–dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution
1997 StandoutNobel
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy
1994
Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.
1996 Nobel
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
Works of Mindaugas Valius being referenced
Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
1993
The Platelet-derived Growth Factor β Receptor Triggers Multiple Cytoplasmic Signaling Cascades That Arrive at the Nucleus as Distinguishable Inputs
1997
The CDK inhibitors in cancer research and therapy
2011
Platelet-derived Growth Factor Stimulates Protein Kinase D through the Activation of Phospholipase Cγ and Protein Kinase C
1998
Tyrosines 1021 and 1009 Are Phosphorylation Sites in the Carboxy Terminus of the Platelet-Derived Growth Factor Receptor β Subunit and are Required for Binding of Phospholipase Cγ and a 64-Kilodalton Protein, Respectively
1993
The GTPase-Activating Protein of Ras Suppresses Platelet-Derived Growth Factor β Receptor Signaling by Silencing Phospholipase C-γ1
1995
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.
1992
GTPase-Activating Protein and Phosphatidylinositol 3-Kinase Bind to Distinct Regions of the Platelet-Derived Growth Factor Receptor β Subunit
1992
Platelet-Derived Growth Factor-Dependent Activation of Phosphatidylinositol 3-Kinase Is Regulated by Receptor Binding of SH2-Domain-Containing Proteins Which Influence Ras Activity
1996
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp.
1993
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively.
1993