Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Design of structurally distinct proteins using strategies inspired by evolution
2016 Science
Crystal structure of the CRISPR RNA–guided surveillance complex from Escherichia coli
2014 Science
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
Structure of the 70 S Ribosome Complexed with mRNA and tRNA
2006 StandoutScienceNobel
Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease
2010 StandoutScienceNobel
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction
2010 StandoutScienceNobel
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Structures of the RNA-guided surveillance complex from a bacterial immune system
2011 StandoutNatureNobel
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Double-stranded Endonuclease Activity in Bacillus halodurans Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated Cas2 Protein
2012
Single-crystal x-ray diffraction structures of covalent organic frameworks
2018 StandoutScienceNobel
Inhibitory Mechanism of Escherichia coli RelE-RelB Toxin-Antitoxin Module Involves a Helix Displacement Near an mRNA Interferase Active Site
2009
The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
2009 StandoutNobel
Tuning in to Interference: R-Loops and Cascade Complexes in CRISPR Immunity
2012
The bacterial toxin RelE induces specific mRNA cleavage in the A site of the eukaryote ribosome
2007
Cutting it close: CRISPR-associated endoribonuclease structure and function
2014 StandoutNobel
Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases
2013 StandoutNobel
Tandem repeats in proteins: From sequence to structure
2011
Interaction of the Cas6 Riboendonuclease with CRISPR RNAs: Recognition and Cleavage
2011
Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome Defense
2009 StandoutNobel
Transcription Profile of Thermus thermophilus CRISPR Systems after Phage Infection
2009
High Resolution Structure of the Large Ribosomal Subunit from a Mesophilic Eubacterium
2001 StandoutNobel
Structural and Functional Characterization of an Archaeal Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Complex for Antiviral Defense (CASCADE)
2011
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Conformational Change in the Catalytic Site of the Ribonuclease YoeB Toxin by YefM Antitoxin
2005
Artificial Metalloenzymes as Catalysts in Stereoselective Diels–Alder Reactions
2012
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
CRISPR-based adaptive and heritable immunity in prokaryotes
2009
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Clustered regularly interspaced short palindromic repeats (CRISPRs): the hallmark of an ingenious antiviral defense mechanism in prokaryotes
2011
Denaturant m values and heat capacity changes: Relation to changes in accessible surface areas of protein unfolding
1995 Standout
A short history ofSHELX
2007 Standout
The CRISPR System: Small RNA-Guided Defense in Bacteria and Archaea
2010
Recognition and maturation of effector RNAs in a CRISPR interference pathway
2011
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
Protein folding in the landscape perspective: Chevron plots and non-arrhenius kinetics
1998
Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A
2011 Nature
CRISPR — a widespread system that provides acquired resistance against phages in bacteria and archaea
2007
The coming of age of de novo protein design
2016 StandoutNatureNobel
Enzyme promiscuity: evolutionary and mechanistic aspects
2006
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
2014
DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes
2015 StandoutNobel
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
prlF and yhaV Encode a New Toxin–Antitoxin System in Escherichia coli
2007
Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System
2012
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Structure of the ternary initiation complex aIF2–GDPNP–methionylated initiator tRNA
2012
Improved protein structure prediction using potentials from deep learning
2020 StandoutNatureNobel
CRISPR-based adaptive immune systems
2011
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea
2010
Structural and Functional Studies of RegB, a New Member of a Family of Sequence-specific Ribonucleases Involved in mRNA Inactivation on the Ribosome
2006
A Novel Family of Sequence-specific Endoribonucleases Associated with the Clustered Regularly Interspaced Short Palindromic Repeats
2008
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity
2015 StandoutNobel
The impact of CRISPR repeat sequence on structures of a Cas6 protein–RNA complex
2012
An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3
2011 StandoutNobel
A surprising simplicity to protein folding
2000 StandoutNatureNobel
Binding and cleavage of CRISPR RNA by Cas6
2010
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Nucleases: diversity of structure, function and mechanism
2010
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
CRISPR/Cas System and Its Role in Phage-Bacteria Interactions
2010
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
2001 StandoutNatureNobel
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
2011 StandoutNobel
CRISPR-Cas Systems in Bacteria and Archaea: Versatile Small RNAs for Adaptive Defense and Regulation
2011
Structural insights on the translation initiation complex: ghosts of a universal initiation complex
2006 StandoutNobel
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase
2016 StandoutNobel
Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity
2008
Crystal structure of a CRISPR RNA–guided surveillance complex bound to a ssDNA target
2014 Science
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
CRISPR interference: a structural perspective
2013
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information
2014 StandoutNobel
Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective
2010 Standout
Short motif sequences determine the targets of the prokaryotic CRISPR defence system
2009
CRISPR: New Horizons in Phage Resistance and Strain Identification
2012
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
2003 StandoutScienceNobel
CRISPR-Mediated Adaptive Immune Systems in Bacteria and Archaea
2013
Trapping a transition state in a computationally designed protein bottle
2015 StandoutScienceNobel
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
The Putative Diels−Alderase Macrophomate Synthase is an Efficient Aldolase
2008
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Design and control of gas diffusion process in a nanoporous soft crystal
2019 StandoutScienceNobel
Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes
2008 StandoutScience
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
2014 StandoutNobel
Self-Accelerating CO Sorption in a Soft Nanoporous Crystal
2013 StandoutScienceNobel
Works of Min Yao being referenced
Insight into a natural Diels–Alder reaction from the structure of macrophomate synthase
2003 Nature
Crystal structure of the hypothetical protein ST2072 from Sulfolobus tokodaii
2005
Structure of the type IL -asparaginase from the hyperthermophilic archaeonPyrococcus horikoshiiat 2.16 Å resolution
2005
Crystal structure of hypothetical protein TTHB192 from Thermus thermophilus HB8 reveals a new protein family with an RNA recognition motif‐like domain
2006
Crystal Structure of the Pyrococcus horikoshii Isopropylmalate Isomerase Small Subunit Provides Insight into the Dual Substrate Specificity of the Enzyme
2004
Ribosomal protein L5 has a highly twisted concave surface and flexible arms responsible for rRNA binding
2001
Two distinct regions in Staphylococcus aureus GatCAB guarantee accurate tRNA recognition
2009
Crystal structure of archaeal toxin-antitoxin RelE–RelB complex with implications for toxin activity and antitoxin effects
2005
A Helical String of Alternately Connected Three-Helix Bundles for the Cell Wall-Associated Adhesion Protein Ebh from Staphylococcus aureus
2008
How Valid Are Denaturant-Induced Unfolding Free Energy Measurements? Level of Conformance to Common Assumptions over an Extended Range of Ribonuclease A Stability
1995
Structure of archaeal translational initiation factor 2 βγ–GDP reveals significant conformational change of the β-subunit and switch 1 region
2006
Roll: a new algorithm for the detection of protein pockets and cavities with a rolling probe sphere
2009
In-crystal chemical ligation for lead compound generation
2010