Citation Impact
Citing Papers
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
2003 StandoutNobel
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
2002 StandoutNobel
Ionic events induced by epidermal growth factor. Evidence that hyperpolarization and stimulated cation influx play a role in the stimulation of cell growth.
1991
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex
1990
Tumor-targeting peptides from combinatorial libraries
2016
Specificity in Signal Transduction
2004
Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg
1992 StandoutNobel
Identification of a signal for rapid export of proteins from the nucleus
1995 StandoutNobel
PDGF induction of tyrosine phosphorylation of GTPase activating protein
1989 Nature
Fibronectin and integrins in invasion and metastasis
1995
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
1992 Standout
EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation
2003
Phospholipase C Isozymes: Structural and Functional Similarities
2007
Signaling Pathways Leading to Transcription and Translation Cooperatively Regulate the Transient Increase in Expression of c-Fos Protein
2001 StandoutNobel
Signal transduction by receptors with tyrosine kinase activity
1990 Standout
Regulators and Effectors of ras Proteins
1991
CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
1992 StandoutNatureNobel
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254
1991
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Integrins: Emerging Paradigms of Signal Transduction
1995
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
1991
Structural and Functional Diversity in the FGf Receptor Multigene Family
1992
Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs
1992 Nature
The TRPM7 channel is inactivated by PIP2 hydrolysis
2002
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
1994 StandoutScience
A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)
1992
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Oncogenes and signal transduction
1991 Standout
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
Inositol trisphosphate and calcium signalling
1993 StandoutNature
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis
1992 Nature
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
1991
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
Involvement of growth factor receptors in the mammalian UVC response
1994
Atherosclerosis
2000 StandoutNature
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
1992
Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides
1992 NatureNobel
Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins
1991 Nature
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
1990 Nature
Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis
1992 Nature
Human colony stimulating factor-1 receptor activates the C-raf-1 proto-oncogene kinase
1990
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
1989
Mechanisms of Signal Transduction to the Cell Nucleus
1990
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
1991 StandoutScience
The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein
1996
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene.
1993 StandoutNobel
Insulin activates the kinase activity of the Raf-1 proto-oncogene by increasing its serine phosphorylation.
1990
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
2010 StandoutNobel
The fibronectin gene as a model for splicing and transcription studies
1996
Presence of an SH2 Domain in the Actin-Binding Protein Tensin
1991 Science
Phenotypic consequences of lung-specific inducible expression of FGF-3
2001 StandoutNobel
Interaction between the epidermal growth factor receptor and phosphoinositide kinases.
1991
Blocking Very Late Antigen-4 Integrin Decreases Leukocyte Entry and Fatty Streak Formation in Mice Fed an Atherogenic Diet
1999
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.
1991
Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide
1997 Standout
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.
1991
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.
1990
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.
1991 Nobel
Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.
1992
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
1992
Stimulation of Phospholipase C-γ1 Membrane Association by Epidermal Growth Factor
1990 Science
Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits.
1993 StandoutNobel
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Modified kinetics of platelet-derived growth factor-induced Ca2+ increases in NIH-3T3 cells overexpressing phospholipase Cγ1
1992
Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.
1990
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.
1992
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors
1992
Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation
1993 Science
Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains.
1990
The Actin-Binding Protein Profilin Binds to PIP 2 and Inhibits Its Hydrolysis by Phospholipase C
1990 Science
Effect of Phospholipase C-γ Overexpression on PDGF-induced Second Messengers and Mitogenesis
1990 Science
Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors
1990 Science
Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.
1990
Leukocyte-endothelial adhesion molecules
1994 Standout
EGF Receptor and erb B-2 Tyrosine Kinase Domains Confer Cell Specificity for Mitogenic Signaling
1990 Science
Production of novel polyphosphoinositides in vivo is linked to cell transformation by polyomavirus middle T antigen
1990
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
1993
The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.
1995
Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.
1991 Nobel
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
Expression, purification, and characterization of protein kinase C-epsilon.
1990
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.
1990
Stable expression of truncated inositol 1,4,5-trisphosphate receptor subunits in 3T3 fibroblasts. Coordinate signaling changes and differential suppression of cell growth and transformation.
1994 StandoutNobel
Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.
1990
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.
1990
Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation.
1990
gCap39, a Calcium Ion- and Polyphosphoinositide-Regulated Actin Capping Protein
1990 StandoutScienceNobel
Identification of Trk binding sites for SHC and phosphatidylinositol 3'-kinase and formation of a multimeric signaling complex.
1993
Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product
1989 Science
The tyrosine kinase activity of the epidermal-growth-factor receptor is necessary for phospholipase A2 activation
1990
PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer
1997 StandoutScience
Increase of the Catalytic Activity of Phospholipase C-γ1 by Tyrosine Phosphorylation
1990 Science
Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
1990
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Cell cycle arrest and c-mos
1992 StandoutNatureNobel
A Cell Culture Model for T Lymphocyte Clonal Anergy
1990 StandoutScience
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
1994
Coupling of dual signaling pathways: epidermal growth factor action involves the estrogen receptor.
1992
Inhibitors of human immunodeficiency virus integrase.
1993 StandoutNobel
Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1.
1989
Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex
1990
A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes.
1990
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Src homology region 2 domains direct protein-protein interactions in signal transduction.
1990
Transient up-regulation of P2Y2nucleotide receptor mRNA expression is an immediate early gene response in activated thymocytes
1997 StandoutNobel
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.
1990
Geometric Control of Cell Life and Death
1997 StandoutScience
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins
1990 Science
Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.
1991
SH2 Domains of the p85α Subunit of Phosphatidylinositol 3-Kinase Regulate Binding to Growth Factor Receptors
1992
Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions.
1992
Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain
1989
Epidermal growth factor increases the labeling of phosphatidylinositol 3,4-bisphosphate in MA-10 Leydig tumor cells.
1990
Works of Miljenko Mervič being referenced
EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling
1989
Peptides from multiple regions of the lectin domain of P‐selectin inhibiting neutrophil adhesion
1993
Autophosphorylation of the intracellular domain of the epidermal growth factor receptor results in different effects on its tyrosine kinase activity with various peptide substrates. Phosphorylation of peptides representing Tyr(P) sites of phospholipase C-gamma.
1991
The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine
1991