Mikko Ora

SURVEY AND SUMMARY: Recent advances in the elucidation of the mechanisms of action of ribozymes

Optimization of the β-Elimination/Michael Addition Chemistry on Reversed-Phase Supports for Mass Spectrometry Analysis of O-Linked Protein Modifications

The linkage between ribosomal crystallography, metal ions, heteropolytungstates and functional flexibility

A re-investigation of the thio effect at the hammerhead cleavage site

Associative Versus Dissociative Mechanisms of Phosphate Monoester Hydrolysis: On the Interpretation of Activation Entropies

The chemical repertoire of natural ribozymes

Chemical models for ribozyme action

Are Mixed Explicit/Implicit Solvation Models Reliable for Studying Phosphate Hydrolysis? A Comparative Study of Continuum, Explicit and Mixed Solvation Models

Why nature really chose phosphate

Bisphosphonate conjugation for bone specific drug targeting

Ribozyme catalysis: not different, just worse

Iron Catalysis in Organic Synthesis

Functional Nucleic Acid Sensors

Zn²⁺-Dependent Deoxyribozymes That Form Natural and Unnatural RNA Linkages

A Computational Study of the Hydrolysis of dGTP Analogues with Halomethylene-Modified Leaving Groups in Solution: Implications for the Mechanism of DNA Polymerases

Iron-catalyzed Direct-type Hydroxymethylation of 1,3-Dicarbonyl Compounds in Water

Assessment of heat-sensitive thiophosphate protecting groups in the development of thermolytic DNA oligonucleotide prodrugs

Phosphate ester analogues as probes for understanding enzyme catalysed phosphoryl transfer

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

Addressing Open Questions about Phosphate Hydrolysis Pathways by Careful Free Energy Mapping

Antibody−Dendrimer Conjugates: The Number, Not the Size of the Dendrimers, Determines the Immunoreactivity

Progress in Ab Initio QM/MM Free-Energy Simulations of Electrostatic Energies in Proteins: Accelerated QM/MM Studies of pK_a, Redox Reactions and Solvation Free Energies

2′F-Arabinonucleic acids (2′F-ANA) — History, properties, and new frontiers

Transesterification Thio Effects of Phosphate Diesters:  Free Energy Barriers and Kinetic and Equilibrium Isotope Effects from Density-Functional Theory

Ribozyme Structures and Mechanisms

Ribozyme Structures and Mechanisms

Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment

Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine

Applications of Fluorine in Medicinal Chemistry

Density Functional Study of the In-Line Mechanism of Methanolysis of Cyclic Phosphate and Thiophosphate Esters in Solution:  Insight into Thio Effects in RNA Transesterification

On the Interpretation of the Observed Linear Free Energy Relationship in Phosphate Hydrolysis: A Thorough Computational Study of Phosphate Diester Hydrolysis in Solution

The Hydrolysis of RNA:  From Theoretical Calculations to the Hammerhead Ribozyme-Mediated Cleavage of RNA

Chemical Glycoproteomics

Derivatization of phosphopeptides with mercapto- and amino-functionalized conjugate groups by phosphate elimination and subsequent Michael addition

Hydrolytic stability of nucleoside phosphotriesters derived from bis(hydroxymethyl)-1,3-dicarbonyl compounds and their congeners: towards a novel pro-drug strategy for antisense oligonucleotides

Hydrolytic Reactions of the Phosphorodithioate Analogue of Uridylyl(3‘,5‘)uridine:  Kinetics and Mechanisms for the Cleavage, Desulfurization, and Isomerization of the Internucleosidic Linkage

Phosphoester Hydrolysis and Intramolecular Transesterification of Ribonucleoside 2‘- and 3‘-Phosphoromonothioate Triesters:  Kinetics and Mechanisms for the Reactions of 5‘-O-Methyluridine 2‘- and 3‘-Dimethylphosphoromonothioates

Towards Nucleotide Prodrugs Derived from 2,2-Bis(hydroxymethyl)malonate and Its Congeners: Hydrolytic Cleavage of 2-Cyano-2-(hydroxymethyl)-3-methoxy-3-oxopropyl and 3-(Alkylamino)-2-cyano-2-(hydroxymethyl)-3-oxopropyl Protections from the Internucleosidic Phosphodiester and Phosphorothioate Linkages

Phosphodiester Cleavage of Guanylyl-(3‘,3‘)-(2‘-amino-2‘-deoxyuridine):  Rate Acceleration by the 2‘-Amino Function

ChemInform Abstract: Metal‐Ion‐Promoted Cleavage, Isomerization, and Desulfurization of the Diastereomeric Phosphoromonothioate Analogues of Uridylyl(3′,5′)uridine.

Metal-Ion-Promoted Cleavage, Isomerization, and Desulfurization of the Diastereomeric Phosphoromonothioate Analogues of Uridylyl(3‘,5‘)uridine

Bisphosphonate Derivatives of Nucleoside Antimetabolites: Hydrolytic Stability and Hydroxyapatite Adsorption of 5′-β,γ-Methylene and 5′-β,γ-(1-Hydroxyethylidene) Triphosphates of 5-Fluorouridine and ara-Cytidine

Hydrolytic Reactions of the Diastereomeric Phosphoromonothioate Analogs of Uridylyl(3',5')uridine: Kinetics and Mechanisms for Desulfurization, Phosphoester Hydrolysis, and Transesterification to the 2',5'-Isomers

Hydrolytic Reactions of Guanosyl-(3‘,3‘)-uridine and Guanosyl-(3‘,3‘)-(2‘,5‘-di-O-methyluridine)

Hydrolysis and Desulfurization of the Diastereomeric Phosphoromonothioate Analogs of Uridine 2‘,3‘-Cyclic Monophosphate