Citation Impact
Citing Papers
Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus
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Structural Basis of Transcription Initiation
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Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
2009 StandoutScienceNobel
Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
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Mouse models of acute and chronic hepacivirus infection
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Donation of catalytic residues to RNA polymerase active center by transcription factor Gre
2003
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
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CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Identification of a Decay in Transcription Potential That Results in Elongation Factor Dependence of RNA Polymerase II
1995
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Nucleotide Sequence Context Effect of a Cyclobutane Pyrimidine Dimer upon RNA Polymerase II Transcription
1997
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Characterization of the structure, function, and mechanism of B2 RNA, an ncRNA repressor of RNA polymerase II transcription
2007
Allosteric Binding of Nucleoside Triphosphates to RNA Polymerase Regulates Transcription Elongation
2001
Structural Basis of Transcription
2004 StandoutNobel
Histone H2A/H2B Dimer Exchange by ATP-Dependent Chromatin Remodeling Activities
2003
Functions of DNA methylation: islands, start sites, gene bodies and beyond
2012 Standout
Genome-wide Map of Nucleosome Acetylation and Methylation in Yeast
2005
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
2006 StandoutNobel
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
The RNA–DNA Hybrid Maintains the Register of Transcription by Preventing Backtracking of RNA Polymerase
1997
Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II
2006
Insights into transcription: structure and function of single-subunit DNA-dependent RNA polymerases
2000 StandoutNobel
Forward Translocation Is the Natural Pathway of RNA Release at an Intrinsic Terminator
2004
Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity
2015
RNA Polymerase Slides Home: Pause and Termination Site Recognition
1997
Transcript cleavage factors GreA and GreB act as transient catalytic components of RNA polymerase
2003
Crystal Structure of Thermus aquaticus Core RNA Polymerase at 3.3 Å Resolution
1999
Direct observation of base-pair stepping by RNA polymerase
2005 Nature
Variation in the Size of Nascent RNA Cleavage Products as a Function of Transcript Length and Elongation Competence
1995
Three-dimensional structure of E. coil core RNA polymerase: Promoter binding and elongation conformations of the enzyme
1995
Single-molecule imaging reveals mechanisms of protein disruption by a DNA translocase
2010 Nature
Downstream DNA Selectively Affects a Paused Conformation of Human RNA Polymerase II
2004
Characterization of structural features important for T7 RNAP elongation complex stability reveals competing complex conformations and a role for the non-template strand in RNA displacement
1999
Structure-activity relationship analysis of mitochondrial toxicity caused by antiviral ribonucleoside analogs
2017
Initially Transcribed Sequences Strongly Affect the Extent of Abortive Initiation by RNA Polymerase II
1999
Yeast RNA Polymerase II at 5 Å Resolution
1999 StandoutNobel
The Role of the Transcription Bubble and TFIIB in Promoter Clearance by RNA Polymerase II
2005
de FACTo Nucleosome Dynamics
2006
Functionally interacting telomerase RNAs in the yeast telomerase complex
1997 StandoutNobel
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
DNA methylation: roles in mammalian development
2013 Standout
Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase
2003
Mutations of Bacterial RNA Polymerase Leading to Resistance to Microcin J25
2002
Formation and Crystallization of Yeast RNA Polymerase II Elongation Complexes
1997 StandoutNobel
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
Nucleosome displacement in transcription: Figure 1.
2006
Abortive Cycling and the Release of Polymerase for Elongation at the σ54-dependent glnAp2 Promoter
1995
Promoting elongation with transcript cleavage stimulatory factors
2002
Determination of lysine residues affinity labeled in the active site of yeast RNA polymerase II(B) by mutagenesis
1992
Structural basis for transcription inhibition by tagetitoxin
2005
Structural Organization of the RNA Polymerase-Promoter Open Complex
2000
Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS
2004
Dynamics of DNA Methylation in Recent Human and Great Ape Evolution
2013
In vivo evidence for back and forth oscillations of the transcription elongation complex
1999
Promoter Proximal Sequences Modulate RNA Polymerase II Elongation by a Novel Mechanism
1996
RNA Polymerase as a Molecular Motor
1998
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
The thumb subdomain of yeast mitochondrial RNA polymerase is involved in processivity, transcript fidelity and mitochondrial transcription factor binding
2015
Structure and Function of Lineage-specific Sequence Insertions in the Bacterial RNA Polymerase β′ Subunit
2005
Structural Basis of Transcription Inhibition by Antibiotic Streptolydigin
2005
The Role of Chromatin during Transcription
2007 Standout
Nascent transcript sequencing visualizes transcription at nucleotide resolution
2011 Nature
Synergistic Functions of SII and p300 in Productive Activator-Dependent Transcription of Chromatin Templates
2006
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Mutations in and Monoclonal Antibody Binding to Evolutionary Hypervariable Region of Escherichia coli RNA Polymerase β′ Subunit Inhibit Transcript Cleavage and Transcript Elongation
1998
Nucleosome Assembly Protein 1 Exchanges Histone H2A-H2B Dimers and Assists Nucleosome Sliding
2004
Transcriptional activation via DNA-looping: visualization of intermediates in the activation pathway of E. coli RNA polymerase·σ54 holoenzyme by scanning force microscopy
1997
A model for the mechanism of polymerase translocation 1 1Edited by A. R. Fersht
1997
RSC Exploits Histone Acetylation to Abrogate the Nucleosomal Block to RNA Polymerase II Elongation
2006
Structural Organization of Bacterial RNA Polymerase Holoenzyme and the RNA Polymerase-Promoter Open Complex
2002
Transcriptional fidelity and proofreading in Archaea and implications for the mechanism of TFS‐induced RNA cleavage
2004
A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase
2018 StandoutNobel
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
2014 Standout
Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?
2004
T7 RNA polymerase elongation complex structure and movement
2000
Elongation by RNA polymerase II: the short and long of it
2004
A Ratchet Mechanism of Transcription Elongation and Its Control
2005
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Mapping of Rpb3 and Rpb5 contact sites on two large subunits, Rpb1 and Rpb2, of the RNA polymerase II from fission yeast
1998
Transcription elongation: structural basis and mechanisms
1999
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice
2010
The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase
2004 StandoutNobel
NTP concentration effects on initial transcription by T7 RNAP indicate that translocation occurs through passive sliding and reveal that divergent promoters have distinct NTP concentration requirements for productive initiation 1 1Edited by R. Ebright
1998
Applications for atomic force microscopy of DNA
1995
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Transcriptional Pausing at +62 of the HIV-1 Nascent RNA Modulates Formation of the TAR RNA Structure
1998
Nucleosomes Can Form a Polar Barrier to Transcript Elongation by RNA Polymerase II
2006
Electron Crystal Structure of an RNA Polymerase II Transcription Elongation Complex
1999 StandoutNobel
Structure and Function of the Transcription Elongation Factor GreB Bound to Bacterial RNA Polymerase
2003
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
The RNA Polymerase II Trigger Loop Functions in Substrate Selection and Is Directly Targeted by α-Amanitin
2008 Nobel
Transcriptional Fidelity and Proofreading by RNA Polymerase II
1998
The RSC chromatin remodelling ATPase translocates DNA with high force and small step size
2011
Mechanistic Model of the Elongation Complex of Escherichia coli RNA Polymerase
1998
Swing-Gate Model of Nucleotide Entry into the RNA Polymerase Active Center
2002
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Evidence for Eviction and Rapid Deposition of Histones upon Transcriptional Elongation by RNA Polymerase II
2004
Stimulation of Transcription by Mutations Affecting Conserved Regions of RNA Polymerase II
1998
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Protein-RNA interactions in the active center of transcription elongation complex.
1996
The Structure of a Transcribing T7 RNA Polymerase in Transition from Initiation to Elongation
2008 StandoutScienceNobel
Mapping of a contact for the RNA 3' terminus in the largest subunit of RNA polymerase.
1991
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
The RNA polymerase II general elongation factors
1996
A Structural Model of Transcription Elongation
2000 Science
An Integrated Model of the Transcription Complex in Elongation, Termination, and Editing
1998 Science
OPTICAL DETECTION OF SINGLE MOLECULES
1997
Transcription Against an Applied Force
1995 Science
Quality Control by DNA Repair
1999 StandoutScienceNobel
Increased accommodation of nascent RNA in a product site on RNA polymerase II during arrest.
1996
Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II
2004 StandoutScienceNobel
Spatial Organization of Transcription Elongation Complex in Escherichia coli
1998 Science
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Interactions between synaptic vesicle fusion proteins explored by atomic force microscopy
2003
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution
2001 StandoutScienceNobel
Probing conformational changes in T7 RNA polymerase during initiation and termination by using engineered disulfide linkages
2005
BASIC MECHANISMS OF TRANSCRIPT ELONGATION AND ITS REGULATION
1997
Interactions of Escherichia coli σ 70 within the transcription elongation complex
1999
Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily
1999
Mechanism of Transcription Through the Nucleosome by Eukaryotic RNA Polymerase
1997 Science
Mechanism of Polymerase II Transcription Repression by the Histone Variant macroH2A
2006
The RNA Polymerase II Elongation Complex
2003
Mutations in the alpha-amanitin conserved domain of the largest subunit of yeast RNA polymerase III affect pausing, RNA cleavage and transcriptional transitions.
1996
Scanning Force Microscopy in Biology
1995
Illuminating Single Molecules in Condensed Matter
1999 StandoutScienceNobel
Structural Perspective on Mutations Affecting the Function of Multisubunit RNA Polymerases
2006
TFIIS Enhances Transcriptional Elongation through an Artificial Arrest Site In Vivo
2001
Structural basis of transcription inhibition by α-amanitin and implications for RNA polymerase II translocation
2008
Modular organization of the catalytic center of RNA polymerase
1997
Nanotubes as nanoprobes in scanning probe microscopy
1996 StandoutNatureNobel
RNA polymerase II subunit Rpb9 is important for transcriptional fidelity in vivo
2006
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
FACT Facilitates Transcription-Dependent Nucleosome Alteration
2003 Science
Direct atomic force microscope imaging of EcoRI endonuclease site specifically bound to plasmid DNA molecules.
1996 StandoutNobel
Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
2002 StandoutScienceNobel
The T7 RNA Polymerase Intercalating Hairpin Is Important for Promoter Opening during Initiation but Not for RNA Displacement or Transcription Bubble Stability during Elongation
2001
Principles Governing Mg, Ca, and Zn Binding and Selectivity in Proteins
2003
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
2004 StandoutScienceNobel
The initiation–elongation transition: Lateral mobility of RNA in RNA polymerase II complexes is greatly reduced at +8/+9 and absent by +23
2003
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Domain-Wide Displacement of Histones by Activated Heat Shock Factor Occurs Independently of Swi/Snf and Is Not Correlated with RNA Polymerase II Density
2005
Rewriting a genome
2013 StandoutNatureNobel
Human Histone Chaperone Nucleophosmin Enhances Acetylation-Dependent Chromatin Transcription
2005
Single-Molecule Study of Transcriptional Pausing and Arrest by E. coli RNA Polymerase
2000 Science
Transcription Processivity: Protein-DNA Interactions Holding Together the Elongation Complex
1996 Science
Termination-altering amino acid substitutions in the beta' subunit of Escherichia coli RNA polymerase identify regions involved in RNA chain elongation.
1994
Force and Velocity Measured for Single Molecules of RNA Polymerase
1998 Science
Works of Mikhail Kashlev being referenced
Nucleosomal Fluctuations Govern the Transcription Dynamics of RNA Polymerase II
2009 Science
Isolation and Characterization of RNA Polymerase rpoB Mutations That Alter Transcription Slippage during Elongation in Escherichia coli
2012
The Fidelity of Transcription
2012
Crucial Role of the RNA:DNA Hybrid in the Processivity of Transcription
1998
Coupling between transcription termination and RNA polymerase inchworming
1995
CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
2011 Nature
Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides
2012
Nature of the Nucleosomal Barrier to RNA Polymerase II
2005
Shortening of RNA:DNA Hybrid in the Elongation Complex of RNA Polymerase Is a Prerequisite for Transcription Termination
2002
Histidine-tagged RNA polymerase: dissection of the transcription cycle using immobilized enzyme
1993
Bacterial Polymerase and Yeast Polymerase II Use Similar Mechanisms for Transcription through Nucleosomes
2003
The 8-Nucleotide-long RNA:DNA Hybrid Is a Primary Stability Determinant of the RNA Polymerase II Elongation Complex
2000
Interaction of RNA Polymerase II Fork Loop 2 with Downstream Non-template DNA Regulates Transcription Elongation
2011
Histidine-tagged RNA polymerase of Escherichia coli and transcription in solid phase
1996
RNA Polymerase Switches between Inactivated and Activated States By Translocating Back and Forth along the DNA and the RNA
1997
Motion and enzymatic degradation of DNA in the atomic force microscope
1994
Nucleosome Remodeling Induced by RNA Polymerase II
2002
Overextended RNA:DNA hybrid as a negative regulator of RNA polymerase II processivity 1 1Edited by R. Ebright
2000
Strategies and Methods of Cross-Linking of RNA Polymerase Active Center
2003
Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner
2007 Nature
Transcriptional arrest: Escherichia coli RNA polymerase translocates backward, leaving the 3′ end of the RNA intact and extruded
1997
Discontinuous Mechanism of Transcription Elongation
1994 Science
Escherichia coli RNA Polymerase Activity Observed Using Atomic Force Microscopy
1997
Mapping of the priming substrate contacts in the active center of Escherichia coli RNA polymerase.
1991
Bacteriophage T4 Alc protein: A transcription termination factor sensing local modification of DNA
1993
A non-essential domain of Escherichia coli RNA polymerase required for the action of the termination factor Alc.
1994
A beta subunit mutation disrupting the catalytic function of Escherichia coli RNA polymerase.
1991
Assembly of functional Escherichia coli RNA polymerase containing beta subunit fragments.
1995
Mapping of trypsin cleavage and antibody-binding sites and delineation of a dispensable domain in the beta subunit of Escherichia coli RNA polymerase.
1991
Mapping of Catalytic Residues in the RNA Polymerase Active Center
1996 Science
Active center rearrangement in RNA polymerase initiation complex.
1993
Dissection of the beta subunit in the Escherichia coli RNA polymerase into domains by proteolytic cleavage.
1992
Functional topography of nascent RNA in elongation intermediates of RNA polymerase
1998
Mechanism of sequence-specific pausing of bacterial RNA polymerase
2009
Topology of the RNA polymerase active center probed by chimeric rifampicin-nucleotide compounds.
1994
Blocking of the Initiation-to-Elongation Transition by a Transdominant RNA Polymerase Mutation
1990 Science
Mutations in the Saccharomyces cerevisiae RPB1 Gene Conferring Hypersensitivity to 6-Azauracil
2006