Standout Papers
Citation Impact
Citing Papers
Recent Molecular Genetic Explorations of Caenorhabditis elegans MicroRNAs
2018 StandoutNobel
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines
2007 StandoutNobel
Identification of Let-7–Regulated Oncofetal Genes
2008
The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25
2006 StandoutNobel
MicroRNA Gene Expression Deregulation in Human Breast Cancer
2005 Standout
Sequence Variations of MicroRNAs in Human Cancer: Alterations in Predicted Secondary Structure Do Not Affect Processing
2006
Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers
2013 StandoutScienceNobel
Characterization of MicroRNA Expression Levels and Their Biological Correlates in Human Cancer Cell Lines
2007 StandoutNobel
A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis
2005
A microRNA expression signature of human solid tumors defines cancer gene targets
2006 Standout
miRNA-34 Prevents Cancer Initiation and Progression in a Therapeutically Resistant K-ras and p53-Induced Mouse Model of Lung Adenocarcinoma
2012
Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells
2007
miR-15 and miR-16 induce apoptosis by targeting BCL2
2005 Standout
A Polycistronic MicroRNA Cluster, miR-17-92 , Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation
2005
Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells
2005 Science
The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function
2007
Systematic analysis of dynamic miRNA-target interactions during C. elegans development
2009 StandoutNobel
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
2005
Selective Blockade of MicroRNA Processing by Lin28
2008 Science
MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation
2005
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
2012
Hallmarks of Cancer: The Next Generation
2011 Standout
A Cellular Micro-RNA, let-7i, Regulates Toll-like Receptor 4 Expression and Contributes to Cholangiocyte Immune Responses against Cryptosporidium parvum Infection
2007
A 3′-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysis
2011
Systematic identification of microRNA functions by combining target prediction and expression profiling
2006
MicroRNA function in animal development
2005
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
2008
Solution structure of a let-7 miRNA: lin-41 mRNA complex from C. elegans
2008
mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein–enriched transcripts
2008 StandoutNobel
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
2007
The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs
2009 Nature
The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2
2009
Mammalian microRNAs: a small world for fine-tuning gene expression
2006
The Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3′UTR-mediated repression of the let-7 microRNA target gene, hbl-1
2007
A C. elegans genome-scale microRNA network contains composite feedback motifs with high flux capacity
2008 StandoutNobel
Spatial preferences of microRNA targets in 3' untranslated regions
2007
Regulatory Mutations of mir-48, a C. elegans let-7 Family MicroRNA, Cause Developmental Timing Defects
2005
How microRNAs control cell division, differentiation and death
2005
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
2009
The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional Repressors ZEB1 and ZEB2
2008
STAT3 Activation of miR-21 and miR-181b-1 via PTEN and CYLD Are Part of the Epigenetic Switch Linking Inflammation to Cancer
2010
Targeting microRNAs in cancer: rationale, strategies and challenges
2010
Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?
2005
A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans
2010
Small non-coding RNAs in animal development
2008
Chronic myeloid leukaemia as a model of disease evolution in human cancer
2007
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence
2012 StandoutNatureNobel
nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans
2009 StandoutNobel
Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets
2013
The Diverse Functions of MicroRNAs in Animal Development and Disease
2006 Standout
Post‐embryonic expression of C. elegans microRNAs belonging to the lin‐4 and let‐7 families in the hypodermis and the reproductive system
2005
The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
2007
Misexpression of the Caenorhabditis elegans miRNA let-7 Is Sufficient to Drive Developmental Programs
2006 StandoutNobel
Potent effect of target structure on microRNA function
2007 StandoutNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54
2006
The let-7 microRNA Directs Vulval Development through a Single Target
2015
Slicer function of Drosophila Argonautes and its involvement in RISC formation
2005
The mir-34 microRNA is required for the DNA damage response in vivo in C. elegans and in vitro in human breast cancer cells
2009
LNA-modified oligonucleotides mediate specific inhibition of microRNA function
2006
MicroRNA Function and Mechanism: Insights from Zebra Fish
2006
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA
2011 StandoutNobel
A Whole-Genome RNAi Screen for C. elegans miRNA Pathway Genes
2007 StandoutNobel
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Therapeutic targeting of microRNAs: current status and future challenges
2014
Lin28: A MicroRNA Regulator with a Macro Role
2010
Epigenetics in Cancer
2008 Standout
MicroRNAs as oncogenes
2005
A genetic interactome of the let-7 microRNA in C. elegans
2015
MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease
2008
An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation
2009
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
An elegant miRror: microRNAs in stem cells, developmental timing and cancer
2009
Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans
2011
A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors
2006
Systemic Delivery of Tumor Suppressor microRNA Mimics Using a Neutral Lipid Emulsion Inhibits Lung Tumors in Mice
2011
Differential Regulation of microRNAs by p53 Revealed by Massively Parallel Sequencing: miR-34a is a p53 Target That Induces Apoptosis and G1-arrest
2007
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
2005
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
2011
Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells
2007
miR-58 family and TGF-β pathways regulate each other inCaenorhabditis elegans
2015
MicroRNA biogenesis pathways in cancer
2015 Standout
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
The essence of senescence: Figure 1.
2010 Standout
Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity
2008 StandoutNobel
U1 snRNP regulates cancer cell migration and invasion in vitro
2020 Standout
Oncomirs — microRNAs with a role in cancer
2006 Standout
Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans
2009
Extensive post-transcriptional regulation of microRNAs and its implications for cancer
2006
A Genome-Wide Map of Conserved MicroRNA Targets in C. elegans
2006
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
2017 Standout
MicroRNAs in cell proliferation, cell death, and tumorigenesis
2006
LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
2009
Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
2010
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
2008 Standout
LIN-42, the Caenorhabditis elegans PERIOD homolog, Negatively Regulates MicroRNA Transcription
2014
Genomics of microRNA
2006
MicroRNA signatures in human cancers
2006 Standout
Deletion of microRNA-80 Activates Dietary Restriction to Extend C. elegans Healthspan and Lifespan
2013
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
2006
MicroRNAs Both Promote and Antagonize Longevity in C. elegans
2010
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Revealing the world of RNA interference
2004 StandoutNatureNobel
The Developmental Timing Regulator AIN-1 Interacts with miRISCs and May Target the Argonaute Protein ALG-1 to Cytoplasmic P Bodies in C. elegans
2005
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver
2007
The let-7 family of microRNAs
2008
MicroRNA expression profiles classify human cancers
2005 StandoutNatureNobel
let-7 regulates Dicer expression and constitutes a negative feedback loop
2008
Gene regulation by microRNAs
2006
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
2006 Standout
let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells
2007 Standout
MicroRNA deregulation in human thyroid papillary carcinomas
2006
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
miR-34 – a microRNA replacement therapy is headed to the clinic
2012
Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells
2009
Camels and zebrafish, viruses and cancer: a microRNA update
2005
A New Role for the GARP Complex in MicroRNA-Mediated Gene Regulation
2013
The microRNA pathway controls germ cell proliferation and differentiation in C. elegans
2012
Most Caenorhabditis elegans microRNAs Are Individually Not Essential for Development or Viability
2007 StandoutNobel
The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Prodifferentiation Genes
2013 Nobel
The mir-51 Family of microRNAs Functions in Diverse Regulatory Pathways in Caenorhabditis elegans
2012
Inference of miRNA targets using evolutionary conservation and pathway analysis
2007
The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation
2008
The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans
2005 StandoutNobel
Functional Genomic Analysis of the let-7 Regulatory Network in Caenorhabditis elegans
2013
Autophagy modulates miRNA‐mediated gene silencing and selectively degrades AIN‐1/GW182 in C. elegans
2013
The ribosomal protein RACK1 is required for microRNA function in both C. elegans and humans
2011
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Targeted CML therapy: controlling drug resistance, seeking cure
2005
RNA–protein analysis using a conditional CRISPR nuclease
2013 StandoutNobel
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
MicroRNA functions in animal development and human disease
2005
microRNAs exhibit high frequency genomic alterations in human cancer
2006
miRNA Deregulation in Cancer Cells and the Tumor Microenvironment
2016
A role for Dicer in immune regulation
2006 StandoutNobel
Understanding the molecular basis of imatinib mesylate therapy in chronic myelogenous leukemia and the related mechanisms of resistance. Commentary re: A. N. Mohamed et al., The effect of imatinib mesylate on patients with Philadelphia chromosome-positive chronic myeloid leukemia with secondary chromosomal aberrations. Clin. Cancer Res., 9: 1333-1337, 2003.
2003
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
2009 StandoutNobel
The role of microRNA genes in papillary thyroid carcinoma
2005 Standout
Let-7 expression defines two differentiation stages of cancer
2007
The Temporal Patterning MicroRNA let-7 Regulates Several Transcription Factors at the Larval to Adult Transition in C. elegans
2005
Sizing up miRNAs as cancer genes
2005
Combinatorial Action of MicroRNAs let-7 and miR-34 Effectively Synergizes with Erlotinib to Suppress Non-small Cell Lung Cancer Cell Proliferation
2015
Human let-7a miRNA blocks protein production on actively translating polyribosomes
2006
MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors Are Associated With Distinctive Pathologic Features and Clinical Behavior
2006
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Distance constraints between microRNA target sites dictate efficacy and cooperativity
2007
Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1
2015
The regulation of genes and genomes by small RNAs
2007 StandoutNobel
Myogenic factors that regulate expression of muscle-specific microRNAs
2006
let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells
2006
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
Micro-RNA Regulation of the Mammalian lin-28 Gene during Neuronal Differentiation of Embryonal Carcinoma Cells
2005
MicroRNA-Cancer Connection: The Beginning of a New Tale
2006
microRNA Functions
2007 Standout
Disrupting the Pairing Between let-7 and Hmga2 Enhances Oncogenic Transformation
2007 Science
MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
2008
Proteomic and functional analysis of Argonaute‐containing mRNA–protein complexes in human cells
2007
Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets
2009 StandoutNobel
Caenorhabditis elegans microRNAs of the let-7 family act in innate immune response circuits and confer robust developmental timing against pathogen stress
2015 StandoutNobel
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
Works of Mike Byrom being referenced
The let-7 MicroRNA Represses Cell Proliferation Pathways in Human Cells
2007
BCR/ABL activates mdm2 mRNA translation via the La antigen
2003
RAS Is Regulated by the let-7 MicroRNA Family
2005 Standout