Citation Impact
Citing Papers
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
2001 StandoutScience
Diversity of the Human Intestinal Microbial Flora
2005 StandoutScience
Promoter Choice Determines Splice Site Selection in Protocadherin α and γ Pre-mRNA Splicing
2002 StandoutNobel
CYP2A6: genetics, structure, regulation, and function
2012
Cytochrome P450 2B6: function, genetics, and clinical relevance
2012
Glutathione-S-transferase family of enzymes
2001
CYP2A6Polymorphisms and Risk for Tobacco-Related Cancers
2008
Technology platforms for pharmacogenomic diagnostic assays
2004
A Systematic Comparison of the Properties of Clinically Used Angiotensin II Type 1 Receptor Antagonists
2013
The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test
2009
No association between CYP2D6 polymorphism and Alzheimer's disease in an Italian population
2005
SIFT web server: predicting effects of amino acid substitutions on proteins
2012 Standout
CNVs of human genes and their implication in pharmacogenetics
2008
Targeting hypoxia in cancer therapy
2011 Standout
In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function
2009
Phenotype prediction of deleterious nonsynonymous single nucleotide polymorphisms in human alcohol metabolism-related genes: a bioinformatics study
2010
Identification of a Novel Polymorphic Enhancer of the Human CYP3A4 Gene
2004
Studies on the inhibition of human cytochromes P450 by selenocysteine Se -conjugates
2003
Microbial tryptophan catabolites in health and disease
2018 Standout
CYP2A6: a human coumarin 7-hydroxylase
2000
Cytochrome P450: taming a wild type enzyme
2011 StandoutNobel
Orphans in the Human Cytochrome P450 Superfamily: Approaches to Discovering Functions and Relevance in Pharmacology
2011
Vascularized and functional human liver from an iPSC-derived organ bud transplant
2013 StandoutNature
Epigenetics and the environment: emerging patterns and implications
2012 Standout
Profiling gene expression of whole cytochrome P450 superfamily in human bronchial and peripheral lung tissues: Differential expression in non-small cell lung cancers
2009
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants
2003
Use of doping agents, particularly anabolic steroids, in sports and society
2008 Standout
Interindividual Variability and Tissue-Specificity in the Expression of Cytochrome P450 3A mRNA
2002
Regulation of CYP3A genes in the human respiratory tract
2005
Cytochrome P-450 Polymorphisms and Response to Clopidogrel
2008 Standout
Effects of Prototypical Microsomal Enzyme Inducers on Cytochrome P450 Expression in Cultured Human Hepatocytes
2003
Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide
2010
Impact of CYP2A6 genotype on pretreatment smoking behaviour and nicotine levels from and usage of nicotine replacement therapy
2006
Cytochrome P450-mediated metabolism in the human gut wall
2009
A genome-wide comparison of recent chimpanzee and human segmental duplications
2005 StandoutNatureNobel
Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism
2002
Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction
2011
CYP2D6 in the Metabolism of Opioids for Mild to Moderate Pain
2011
Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data
2002
Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function
2012
Hepatic microsomal metabolism of indole to indoxyl, a precursor of indoxyl sulfate
2001
A compendium of proteins that interact with HIF-1α
2017 StandoutNobel
Genetic contribution to variable human CYP3A-mediated metabolism
2002
Be smart, exercise your heart: exercise effects on brain and cognition
2007 Standout
Inflammatory bowel disease: cause and immunobiology
2007 Standout
Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
2007
A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds
2009 StandoutNobel
Synergistically Enhanced CYP2B6 Inducibility between a Polymorphic Mutation in CYP2B6 Promoter and Pregnane X Receptor Activation
2010
Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China
2008
A Novel Duplication Type of CYP2A6 Gene in African-American Population
2007
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Positive selection in the evolution of cancer
2006
Functional Characterization of CYP2B6 Allelic Variants in Demethylation of Antimalarial Artemether
2011
Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene
2008
Discriminative Quantification of Cytochrome P4502D6 and 2D7/8 Pseudogene Expression by TaqMan Real-Time Reverse Transcriptase Polymerase Chain Reaction
2002
Will tomorrow's medicines work for everyone?
2004
CYP3A5 GENETIC POLYMORPHISMS IN DIFFERENT ETHNIC POPULATIONS
2005
The Epidemiology of Pancreatitis and Pancreatic Cancer
2013 Standout
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
Co-Regulation of CYP3A4 and CYP3A5 and Contribution to Hepatic and Intestinal Midazolam Metabolism
2002
Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
2009
Molecular Genetics of Nicotine Metabolism
2009
INVOLVEMENT OF HEPATOCYTE NUCLEAR FACTOR 4α IN THE DIFFERENT EXPRESSION LEVEL BETWEEN CYP2C9 AND CYP2C19 IN THE HUMAN LIVER
2006
Clinical Pharmacokinetics and Pharmacodynamics of Tacrolimus in Solid Organ Transplantation
2004 Standout
Genetic Polymorphism in CYP2E1: Population Distribution of CYP2E1 Activity
2009
Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors
2009
Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism
2007
Segmental Duplications and Copy-Number Variation in the Human Genome
2005
Metabolism of Antidepressant and Neuroleptic Drugs by Cytochrome P450s: Clinical and Interethnic Aspects
2007
Suggestions for the nomenclature of human alleles: relevance to ecogenetics, pharmacogenetics and molecular epidemiology
2000
Functional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)
2008
Three haplotypes associated with CYP2A6 phenotypes in Caucasians
2005
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
2001 Standout
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity
2004
Polymorphisms of CYP2A6 and its practical consequences
2001
A Novel Promoter Element Containing Multiple Overlapping Xenobiotic and Hypoxia Response Elements Mediates Induction of Cytochrome P4502S1 by Both Dioxin and Hypoxia
2007
Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
2009
Gut flora in health and disease
2003 Standout
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
2013 StandoutNobel
Induction of Human CYP2A6 Is Mediated by the Pregnane X Receptor with Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α
2006
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry
2004
Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19
2001
Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues
2007
Significance of the Minor Cytochrome P450 3A Isoforms
2006
CYP1B1 genotype and risk of cardiovascular disease, pulmonary disease, and cancer in 50 000 individuals
2009
Genetic epidemiology and public health: hope, hype, and future prospects
2005
Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation
2003
Dexamethasone-Mediated Up-Regulation of Human CYP2A6 Involves the Glucocorticoid Receptor and Increased Binding of Hepatic Nuclear Factor 4α to the Proximal Promoter
2007
Intergenic mRNA Molecules Resulting fromtrans-Splicing
2002
New function ofTSGA10gene in angiogenesis and tumor metastasis: a response to a challengeable paradox
2015
A Natural CYP2B6 TATA Box Polymorphism (–82T→ C) Leading to Enhanced Transcription and Relocation of the Transcriptional Start Site
2005
The Transcriptional Regulation of the Human CYP2C Genes
2009
The gut microbiota — masters of host development and physiology
2013 Standout
Intestinal IgA synthesis: regulation of front-line body defences
2003 StandoutNobel
Determinants of the rate of nicotine metabolism and effects on smoking behavior
2006
Polymorphic Cytochrome P450 2D6: Humanized Mouse Model and Endogenous Substrates
2004
Effects of cigarette smoking and carbon monoxide on chlorzoxazone and caffeine metabolism
2003
Inhibition of Mutated, Activated BRAF in Metastatic Melanoma
2010 Standout
The genetic determinants of the CYP3A5 polymorphism
2001
REGULATION OF CYP2B6 IN PRIMARY HUMAN HEPATOCYTES BY PROTOTYPICAL INDUCERS
2004
CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation
2006
A Novel Distal Enhancer Module Regulated by Pregnane X Receptor/Constitutive Androstane Receptor Is Essential for the Maximal Induction of CYP2B6 Gene Expression
2003
Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.
2001
Cytochrome P450 ω-Hydroxylase Pathway of Tocopherol Catabolism
2002 Standout
COMPARATIVE ANALYSIS OF CYP3A EXPRESSION IN HUMAN LIVER SUGGESTS ONLY A MINOR ROLE FOR CYP3A5 IN DRUG METABOLISM
2003
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
Molecular Mechanisms of Polymorphic CYP3A7 Expression in Adult Human Liver and Intestine
2002
Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine
2004
Cancer as an evolutionary and ecological process
2006 Standout
Inhibition and induction of human cytochrome P450 (CYP) enzymes
1998
Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme
2008
The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine
2003
Selective Induction of Human Hepatic Cytochromes P450 2B6 and 3A4 by Metamizole
2007
Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region
2009
Sequence diversity and haplotype structure at the human CYP3A cluster
2005
CYP2D6 genotyping strategy based on gene copy number determination by TaqMan real-rime PCR
2003
Characterization of the biochemical and structural phenotypes of four CYP1B1 mutations observed in individuals with primary congenital glaucoma
2008
Interactions between commensal intestinal bacteria and the immune system
2004 Standout
Potential Genetic Causes of Heterogeneity of Treatment Effects
2007
Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study
2006 Standout
The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z‐4‐hydroxy‐tamoxifen in human liver
2002
The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice
2011 Standout
Xenobiotic metabolizing enzymes in the central nervous system: Contribution of cytochrome P450 enzymes in normal and pathological human brain
2007
A Genetic Polymorphism in the Regulatory Sequences of HumanCYP2E1:Association with Increased Chlorzoxazone Hydroxylation in the Presence of Obesity and Ethanol Intake
1998
Pharmacogenetics and adverse drug reactions
2000
Sequencing technologies — the next generation
2009 Standout
Mammalian Cytochrome P450 Enzymes Catalyze the Phenol-coupling Step in Endogenous Morphine Biosynthesis
2009
DNA Microarray Technology in the Clinical Environment:The AmpliChip CYP450 Test for CYP2D6 and CYP2C19 Genotyping
2009
Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk
2012
Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations
2006
Pharmacogenetics of Neonatal Opioid Toxicity Following Maternal Use of Codeine During Breastfeeding: A Case–Control Study
2008
Homology Modeling of Rat and Human Cytochrome P450 2D (CYP2D) Isoforms and Computational Rationalization of Experimental Ligand-Binding Specificities
2002
Gut Microbiota in Health and Disease
2010 Standout
Significant Effect of Polymorphisms inCYP2D6andABCC2on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Breast Cancer Patients
2010
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
2014 Standout
Fine-scale structural variation of the human genome
2005
Origins of P450 diversity
2013
Human Pharmacogenomic Variations and Their Implications for Antifungal Efficacy
2006
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation
2008
Pharmacogenomics of Tamoxifen Therapy
2009
The Cytochrome P450 Engineering Database: integration of biochemical properties
2009
Commensal Host-Bacterial Relationships in the Gut
2001 StandoutScience
Docking and scoring in virtual screening for drug discovery: methods and applications
2004 Standout
MOLECULAR MECHANISMS OF GENETIC POLYMORPHISMS OF DRUG METABOLISM
1997
NewCYP2A6Gene Deletion and Conversion Variants in a Population of Black African Descent
2010
57 Varieties: The Human Cytochromes P450
2004
Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
2011 Standout
Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America
2016 Standout
Cytochrome P450-mediated metabolism in the human gut wall
2009
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
2007 Standout
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
2012 StandoutNobel
Identification of Variants of CYP3A4 and Characterization of Their Abilities to Metabolize Testosterone and Chlorpyrifos
2001
Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts
2003
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
The gut microbiota as an environmental factor that regulates fat storage
2004 Standout
Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures
2010 StandoutNobel
REGULATION OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS IN INFLAMMATION
2005
Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications
2007
Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6
2001
Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics
1999 StandoutScience
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Organoselenium and Organotellurium Compounds: Toxicology and Pharmacology
2004 Standout
PolymorphicCYP2B6: Molecular Mechanisms and Emerging Clinical Significance
2007
Genetic Variability inCYP2A6and the Pharmacokinetics of Nicotine
2007
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Mikael Oscarson being referenced
Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.
1994
Pharmacogenetics of Drug Metabolising Enzymes: Importance for Personalised Medicine
2003
Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine
2006
Cloning and Tissue Distribution of a Novel Human Cytochrome P450 of the CYP3A Subfamily, CYP3A43
2001
Functional Analysis of Six Different Polymorphic CYP1B1 Enzyme Variants Found in an Ethiopian Population
2002
Identification of a Single Nucleotide Polymorphism in the TATA Box of the CYP2A6 Gene: Impairment of Its Promoter Activity
2001
Effects of rifampicin on global gene expression in human small intestine
2007
Transcriptional Regulation of the Human CYP2A6 Gene
2005
Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians
1997
A nicotineC-oxidase gene (CYP2A6) polymorphism important for promoter activity
2004
Genetic polymorphisms of cytochrome P450 2A6 in a case-control study on lung cancer in a French population.
2001
Polymorphic NF-Y dependent regulation of human nicotine C-oxidase (CYP2A6)
2004
Structural and Functional Characterization of the 5′-Flanking Region of the Rat and Human Cytochrome P450 2E1 Genes: Identification of a Polymorphic Repeat in the Human Gene
1999
TSGA10 – A Target for Autoantibodies in Autoimmune Polyendocrine Syndrome Type 1 and Systemic Lupus Erythematosus
2010
CYPalleles: A Web Page for Nomenclature of Human Cytochrome P450 Alleles
2002
Characterization and tissue distribution of a novel human cytochrome P450—CYP2U1
2004
Characterization of a Human GlutathioneS-Transferase μ Cluster Containing a DuplicatedGSTM1 Gene that Causes Ultrarapid Enzyme Activity
1997
Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C‐oxidase
1998
Characterization of a novelCYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity
2002
Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment
1999
Characterization and Functional Analysis of Two Common Human Cytochrome P450 1B1 Variants
2000
Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism
1999
Identification and Tissue Distribution of the Novel Human Cytochrome P450 2S1 (CYP2S1)
2001
A Combination of Mutations in the CYP2D6*17(CYP2D6Z) Allele Causes Alterations in Enzyme Function
1997
Human CYP allele database: Submission criteria procedures and objectives
2002
Characterisation and PCR‐based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population
1999
Role of CYP2C9 polymorphism in losartan oxidation.
2001
Genetic polymorphisms in the cytochrome P450 2A6 (CYP2A6) gene: implications for interindividual differences in nicotine metabolism.
2001
Genetic Polymorphism of Human CYP2E1: Characterization of Two Variant Alleles
1997
CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes.
2001