Standout Papers

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unex... 2012 2026 2016 2021 1.1k
  1. Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial (2012)
    Wolfgang Hueber, Bruce E. Sands et al. Gut

Citation Impact

Citing Papers

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
2013 Standout
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis
2015
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
2013
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis
2018 StandoutNobel
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis
2019
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
2019 StandoutNobel
Cytokines in inflammatory bowel disease
2014 Standout
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
2013
Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell–dependent IgA responses
2013
Distinct Profiles of Effector Cytokines Mark the Different Phases of Crohn’s Disease
2013
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
The IL-17 Family of Cytokines in Psoriasis: IL-17A and Beyond
2018
Immunopathology of inflammatory bowel disease
2014
New concepts in the generation and functions of IgA
2012
Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis
2013 Standout
NF-κB signaling in inflammation
2017 Standout
Interactions between the microbiota, immune and nervous systems in health and disease
2017 Standout
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
2014
Rheumatoid arthritis
2016 Standout
The microbiota in adaptive immune homeostasis and disease
2016 StandoutNature
Ulcerative Colitis
2011 Standout
The IL-17 Family of Cytokines in Health and Disease
2019
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
2019 Standout
A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility
2016 Standout
Immunopathogenesis of IBD: current state of the art
2015
Dysbiosis and the immune system
2017
ATP-Gated Ionotropic P2X7 Receptor Controls Follicular T Helper Cell Numbers in Peyer’s Patches to Promote Host-Microbiota Mutualism
2014
Type I interferons in infectious disease
2015 Standout
Tildrakizumab versus placebo or etanercept for chronic plaque psoriasis (reSURFACE 1 and reSURFACE 2): results from two randomised controlled, phase 3 trials
2017
Guselkumab versus secukinumab for the treatment of moderate-to-severe psoriasis (ECLIPSE): results from a phase 3, randomised controlled trial
2019
Psoriasis
2021 Standout
Structure-guided mutagenesis of a mucin-selective metalloprotease from Akkermansia muciniphila alters substrate preferences
2022 StandoutNobel
Psoriasis: Which therapy for which patient
2018
The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells
2019
Interaction between microbiota and immunity in health and disease
2020 Standout
Genetics of Inflammatory Bowel Diseases
2015
IL-6 as a keystone cytokine in health and disease
2015 Standout
Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences
2013 Standout
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity
2015 Standout
Clinical management of psoriatic arthritis
2018
Molecular and cellular mechanisms of liver fibrosis and its regression
2020
Rheumatoid arthritis therapy reappraisal: strategies, opportunities and challenges
2015
Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study
2019 Standout
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions
2015
Crohn's disease
2016 Standout
Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota
2015
Current understanding of the human microbiome
2018 Standout
Ulcerative colitis
2016 Standout
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
2018 Standout
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
2014 Standout
The dichotomous nature of T helper 17 cells
2017
Targeting IL-17 and TH17 cells in chronic inflammation
2012
Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies
2015
Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
2013 Standout
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
2015
Resurrection of endogenous retroviruses in antibody-deficient mice
2012 Nature
Host-directed therapies for bacterial and viral infections
2017
Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine
2015
Gut microbiota, metabolites and host immunity
2016 Standout
Emerging cell and cytokine targets in rheumatoid arthritis
2013
Innate lymphoid cells — a proposal for uniform nomenclature
2013 Standout
Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila
2017
Neutrophils in cancer: neutral no more
2016 Standout
How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy
2013
Revisiting STAT3 signalling in cancer: new and unexpected biological functions
2014 Standout
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases
2011
Genetic insights into common pathways and complex relationships among immune-mediated diseases
2013
Gut microbiota in human metabolic health and disease
2020 Standout
The human microbiome: at the interface of health and disease
2012 Standout
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
2013
Enhanced SARS-CoV-2 neutralization by dimeric IgA
2020 StandoutNobel
Regulatory T Cells and Human Disease
2020 StandoutNobel
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
2017
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice
2016 StandoutNobel
Type I IFNs Regulate Effector and Regulatory T Cell Accumulation and Anti-Inflammatory Cytokine Production during T Cell–Mediated Colitis
2013
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade
2018 Standout
CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22
2014
Innate immune signalling at the intestinal epithelium in homeostasis and disease
2012
Microbiota, Disease, and Back to Health: A Metastable Journey
2012
Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease
2018
Plastic and Human Health: A Micro Issue?
2017 Standout
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
The effects of the microbiota on the host immune system
2014
Impaired T cell receptor signaling and development of T cell–mediated autoimmune arthritis
2020 StandoutNobel
Pathophysiology, Clinical Presentation, and Treatment of Psoriasis
2020 Standout
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel

Works of Michael Yao being referenced

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
2012 Standout
IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis
2014
Suppression of inflammation in ulcerative colitis by interferon-β-1a is accompanied by inhibition of IL-13 production
2010
Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism
2016
Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut
2011
Decreases in Colonic and Systemic Inflammation in Chronic HIV Infection after IL-7 Administration
2014
Rankless by CCL
2026