Standout Papers
Citation Impact
Citing Papers
Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo
2006
Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.
1996
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo
2001 Science
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
2015 StandoutScienceNobel
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
2008
Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
2010
Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE
1996
Hallmarks of Cancer: The Next Generation
2011 Standout
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding
1998
NALPs: a novel protein family involved in inflammation
2003
ICEBERG
2000
Apoptosis in the nervous system
2000 StandoutNature
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
1997 Standout
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
1997 Nature
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
2011 Standout
Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE
1998
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
M-Ras/R-Ras3, a Transforming Ras Protein Regulated by Sos1, GRF1, and p120 Ras GTPase-activating Protein, Interacts with the Putative Ras Effector AF6
1999
Molecular Ordering of Apoptotic Mammalian CED-3/ICE-like Proteases
1996
Selected comparison of immune and nervous system development
2001
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
1999
Target Cell Lysis by CTL Granule Exocytosis Is Independent of ICE/Ced-3 Family Proteases
1997
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Interaction between hepatitis C virus proteins and host cell factors
2002 StandoutNobel
Inhibition of hypoxia/reoxygenation-induced apoptosis by an antisense oligonucleotide targeted to JNK1 in human kidney cells
2000
Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1
2006
Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis
2000
The Inflammasome
2002 Standout
Substrate Specificities of Caspase Family Proteases
1997
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
1998
Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH2-terminal kinases
1999
X-linked IAP is a direct inhibitor of cell-death proteases
1997 StandoutNature
Growth and folding of the mammalian cerebral cortex: from molecules to malformations
2014
Neural-Tube Defects
1999 Standout
ICE/CED-3 proteasesin apoptosis
1996
The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy
1999
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
1999
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
1999 Nature
Evolution of the neocortex: a perspective from developmental biology
2009
The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding
2002
BCL-2 family members and the mitochondria in apoptosis
1999 Standout
Necrotic death as a cell fate
2006
IB1 Reduces Cytokine-induced Apoptosis of Insulin-secreting Cells
2000
An Amino-terminal Amphipathic α-Helix Mediates Membrane Association of the Hepatitis C Virus Nonstructural Protein 5A
2002
Unresponsiveness of MyD88-Deficient Mice to Endotoxin
1999 Standout
A conserved docking motif in MAP kinases common to substrates, activators and regulators
2000
Complex Formation of NS5B with NS3 and NS4A Proteins of Hepatitis C Virus
1998
Determinants for Membrane Association of the Hepatitis C Virus RNA-dependent RNA Polymerase
2001 StandoutNobel
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.
1996 StandoutNobel
Cell Death in Development
1999
Caspase Functions in Cell Death and Disease
2013 Standout
Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development
1998
Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzymea
1998
Protease activation during apoptosis: Death by a thousand cuts?
1995 Standout
Cortical Gyrification Induced by Fibroblast Growth Factor 2 in the Mouse Brain
2013
Molecular Ordering of the Cell Death Pathway
1996
Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production
1997 Nature
Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)
2000
Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
1998
A License to Kill
1996
Taking dendritic cells into medicine
2007 StandoutNatureNobel
A pancreatic islet-specific microRNA regulates insulin secretion
2004 StandoutNature
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Proteases to die for
1998
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
1995 Standout
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
2004 StandoutNature
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis
2010
Caspases: killer proteases
1997 Standout
The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
1999
A novel recombinant single‐chain hepatitis C virus ns3‐ns4a protein with improved helicase activity
1999
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
The Hepatitis C Virus Nonstructural Protein 4B Is an Integral Endoplasmic Reticulum Membrane Protein
2001 StandoutNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Function of Nod‐like receptors in microbial recognition and host defense
2008
Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme
2011
Structural biology of hepatitis C virus
2004
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
The cell-death machine
1996
Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties
2000 StandoutNobel
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Viral and cellular RNA helicases as antiviral targets
2005
Transcriptional regulation of the IL-2 gene
1995
Inhibition of death receptor signals by cellular FLIP
1997 StandoutNature
Novel Insights into Hepatitis C Virus Replication and Persistence
2004
Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3
1999 StandoutNobel
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Caspases: Intracellular Signaling by Proteolysis
1997 Standout
Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice
1998
Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation
2000
Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo
1998
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
1996 StandoutNature
The ced-8 Gene Controls the Timing of Programmed Cell Deaths in C. elegans
2000 StandoutNobel
Apoptosis and the maintenance of homoeostasis in the immune system
1996
Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1
2001
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
Replication of hepatitis C virus
2007 StandoutNobel
Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2
1998 StandoutNobel
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Apoptosis induction resulting from proteasome inhibition
1996
Replication of hepatitis C virus
2000
Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions
2000
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
2000 StandoutScience
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans
2000 StandoutNatureNobel
Subcellular Localization, Stability, and trans -Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines
2000 StandoutNobel
Lamin proteolysis facilitates nuclear events during apoptosis.
1996
Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model
2000 Science
Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35
1995 Science
Neural progenitors, neurogenesis and the evolution of the neocortex
2014
REVIEW ■ : Keeping Neurons Alive: The Molecular Control of Apoptosis (Part I
1996
Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia
1998
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Efficient Initiation of HCV RNA Replication in Cell Culture
2000 StandoutScienceNobel
The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication
2007 StandoutNobel
Fire and ICE: the role of pyrin domain-containing proteins in inflammation and apoptosis.
2003
Rearranging Views on Neurogenesis
1999
Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.
1996 StandoutNobel
Apoptosis-Associated Speck-Like Protein Containing a Caspase Recruitment Domain Is a Regulator of Procaspase-1 Activation
2003
BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases
1999
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.
1996
Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
1996
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Mice Deficient in Interleukin-1 Converting Enzyme are Resistant to Neonatal Hypoxic-Ischemic Brain Damage
1999
Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.
1996 Nobel
IL-1β-converting enzyme (caspase-1) in intestinal inflammation
2001
Hyperphosphorylation of the Hepatitis C Virus NS5A Protein Requires an Active NS3 Protease, NS4A, NS4B, and NS5A Encoded on the Same Polyprotein
1999
Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak
1997
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Salmonella-Induced Caspase-2 Activation in Macrophages
2000
Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity
1997
High Glucose–Induced Apoptosis in Human Endothelial Cells Is Mediated by Sequential Activations of c-Jun NH 2 -Terminal Kinase and Caspase-3
2000
Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase
2000 StandoutScience
Human hepatic glyceraldehyde-3-phosphate dehydrogenase binds to the poly(U) tract of the 3′ non-coding region of hepatitis C virus genomic RNA
1999
The Hepatitis C Virus NS4B Protein Can trans -Complement Viral RNA Replication and Modulates Production of Infectious Virus
2008
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
2003
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
2006
Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells
1997
A bacterial invasin induces macrophage apoptosis by binding directly to ICE.
1996
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
2010
Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B
1999
Caspases: Enemies Within
1998 StandoutScience
Multiple Enzymatic Activities Associated with Recombinant NS3 Protein of Hepatitis C Virus
1998
Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons.
1996
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
2000
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
The Pro-Apoptotic Proteins, Bid and Bax, Cause a Limited Permeabilization of the Mitochondrial Outer Membrane That Is Enhanced by Cytosol
1999
Works of Michael Su being referenced
Cleavage of Poly(ADP-ribose) Polymerase by Interleukin-1β Converting Enzyme and Its Homologs TX and Nedd-2
1995
Crystal Structure of p38 Mitogen-activated Protein Kinase
1996
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
1997
Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
1998
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis
1998
The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation
1994
Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32
1996
Chemogenomic approaches to drug discovery
2001
Processing and Activation of CMH-1 by Granzyme B
1996
Interleukin-1β-induced Rat Pancreatic Islet Nitric Oxide Synthesis Requires Both the p38 and Extracellular Signal-regulated Kinase 1/2 Mitogen-activated Protein Kinases
1998
Interleukin-18 (IFNgamma-inducing factor) induces IL-8 and IL-1beta via TNFalpha production from non-CD14+ human blood mononuclear cells.
1998
Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
1995 Science
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
1997 Science
The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins
1997
Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors
1997
Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells
1997
Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.
1995
Interleukin 18 stimulates HIV type 1 in monocytic cells
1998