Citation Impact
Citing Papers
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
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Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
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Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole
2006
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
Ionotropic and metabotropic glutamate receptor structure and pharmacology
2005
Target engagement imaging of PARP inhibitors in small-cell lung cancer
2018
Challenges and successes in developing new therapies for hepatitis C
2005 Nature
Nucleoside Analog Inhibitors of Hepatitis C Virus Replication
2006
In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance
2006
Effectiveness of Antipsychotic Drugs in Patients with Chronic Schizophrenia
2005 Standout
Hypothalamic regulation of sleep and circadian rhythms
2005 StandoutNature
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs
2004
Dynamic Covalent Chemistry
2002 StandoutNobel
Predicting plasma protein binding of drugs: a new approach
2002
A Novel Series of 2-Carboxytetrahydroquinolines Provides New Insights into the Eastern Region of Glycine Site NMDA Antagonists
2000
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain
2008
Fluorine in Medicinal Chemistry
2015
Small‐Molecule Inhibitors of the Hedgehog Signaling Pathway as Cancer Therapeutics
2010
1,3,4-Oxadiazole: A Privileged Structure in Antiviral Agents
2011
Carboxylic Acid (Bio)Isosteres in Drug Design
2013
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Structure-Function Relationships Among RNA-Dependent RNA Polymerases
2007
Estimation of Blood-Brain Barrier Crossing of Drugs Using Molecular Size and Shape, and H-Bonding Descriptors
1998
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
3‐Fluoropiperidines and N‐Methyl‐3‐fluoropiperidinium Salts: The Persistence of Axial Fluorine
2005
NMDA receptor subunits: diversity, development and disease
2001
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
2008
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
2011 Standout
Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A
2012
Phosphoramidites: Privileged Ligands in Asymmetric Catalysis
2010 StandoutNobel
Hepatitis C Virus-Specific Directly Acting Antiviral Drugs
2013
Hepatitis C Virus Entry
2007 StandoutNobel
The many roles of histone deacetylases in development and physiology: implications for disease and therapy
2008 Standout
New developments in the discovery of small molecule Hedgehog pathway antagonists
2010
Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity
2012
The Polar Hydrophobicity of Fluorinated Compounds
2004
A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase
2018 StandoutNobel
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells
2009
Catalytic Enantioselective Addition of Dialkylzinc Reagents to N‐Acylpyridinium Salts
2009 StandoutNobel
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
2002 Standout
Carbon-Fluorine Bond Formation for the Synthesis of Aryl Fluorides
2010
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
2013 StandoutNature
Allostery in Disease and in Drug Discovery
2013
The way forward in HCV treatment — finding the right path
2007 StandoutNobel
Fluorine in medicinal chemistry
2007 Standout
Diagnosis and Management of the Metabolic Syndrome
2005 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Carbon-fluorine bond formation.
2008
Medicinal Chemistry of hERG Optimizations: Highlights and Hang-Ups
2006
Silylcupration of Allenes and Subsequent Electrophilic Trapping by Allylic Phosphates. A Novel Approach to Silylated 1,4-Diene Systems
2000
Organic Photoredox Catalysis
2016 Standout
Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus
2006
Functionalised Allylsilanes from Silylcopper Reagents and Allene. A Useful Strategy for Cyclopentane Annulations
2000
Postsynaptic N -methyl- d -aspartate receptor function requires α-neurexins
2004 StandoutNobel
Ultrastructural analysis of hepatitis C virus particles
2013 StandoutNobel
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
A Century of Alzheimer's Disease
2006 StandoutScience
Ligand Tuning in Asymmetric Hydrovinylation of 1,3-Dienes: A Stereoselective Route to Either Steroid-C20 (S) or -C20 (R) Derivatives
2008
Synthesis of piperidines
2004
Recent synthetic developments in a powerful imino Diels–Alder reaction (Povarov reaction): application to the synthesis of N-polyheterocycles and related alkaloids
2008 Standout
The regiochemistry of the stannylcupration of allenes: synthesis of allylstannanes using the lower order cuprate (Bu3Sn)CuCNLi
2004
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Recent progress in the synthesis of 1,2,3,4,-tetrahydroquinolines
1996 Standout
Design, Synthesis, and Pharmacological Evaluation of Conformationally Constrained Analogues of N,N‘-Diaryl- and N-Aryl-N-aralkylguanidines as Potent Inhibitors of Neuronal Na+ Channels
1998
Efficient Long-Range Stereochemical Communication and Cooperative Effects in Self-Assembled Fe4L6 Cages
2012 StandoutNobel
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
The stereochemistry of the silyl-cupration of allenes
1991
Solid-Phase Synthesis of 1,2-Diheterocyclic-Substituted (E)-Olefins from a Supported Selenium Resin
2005
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
New findings on the regiochemistry of the silylcupration of allene
1994
Silylcupration of allenes followed by reaction with enones. A new strategy for the synthesis of methylenecyclopentanols
1999
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules
2006 Standout
Pentacenequinone derivatives for preparation of gold nanoparticles: facile synthesis and catalytic application
2014
Allylsilanes and Vinylsilanes from Silylcupration of Carbon−Carbon Multiple Bonds: Scope and Synthetic Applications
2004
Review HCV Antiviral Resistance: The Impact of in vitro Studies on the Development of Antiviral Agents Targeting the Viral NS5B Polymerase
2005
Intramolecular Cyclization of tert-Butyldiphenylallylsilane Units and Carbonyl Groups: Allylsilane Terminated Cyclization versus the Ene Reaction
2001
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
Single-electron transmetalation in organoboron cross-coupling by photoredox/nickel dual catalysis
2014 Science
The synthesis of allylstannanes and, vinylstannanes by the stannyl-cupration of allenes
1990
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease
2006
Enantiomeric Recognition of Amine Compounds by Chiral Macrocyclic Receptors
1997
Der Stand der Totalsynthese zu Beginn des 21. Jahrhunderts
2000
Dynamic Inversion of Stereoselective Phosphate Binding to a Bisurea Receptor Controlled by Light and Heat
2015 StandoutNobel
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450 BM3 demethylases
2009 StandoutNobel
Regio- and stereo-selective aza-Diels–Alder reaction of ethyl glyoxylate 4-methoxyphenylimine with 1,3-dienes in the presence of BF3·Et2O. Evidence for a non-concerted mechanism
2006
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Use of Quinolinium Salts in Parallel Synthesis for the Preparation of 4-Amino-2-alkyl-1,2,3,4-tetrahydroquinoline
2005
Deracemizing α‐Branched Carboxylic Acids by Catalytic Asymmetric Protonation of Bis‐Silyl Ketene Acetals with Water or Methanol
2019 StandoutNobel
Synthesis of Hexahydrobenzo[b]pyrimido[4,5-h][1,6]naphthyridines via an Intramolecular Hetero-Diels−Alder Reaction
2010
Synthesis of substituted 1,2,3,4-tetrahydroquinones by the Povarov reaction. New potentials of the classical reaction
2008
Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products
2017
Zirconocene-promoted stereoselective bicyclization of 1,6- and 1,7-dienes to produce trans-zirconabicyclo[3.3.0]octanes and cis-zirconabicyclo[4.3.0]nonanes
1989 StandoutNobel
The reaction of tert-butyldiphenylsilylcuprates with allenes
1991
Synthesis of allylstannanes and vinylstannanes by the stannyl-cupration of allenes
1992
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro
2005
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Strong and Confined Acids Enable a Catalytic Asymmetric Nazarov Cyclization of Simple Divinyl Ketones
2019 StandoutNobel
Some Typical Advances in the Synthetic Applications of Allenes
2005 Standout
Synthesis of the CETP Inhibitor Torcetrapib: The Resolution Route and Origin of Stereoselectivity in the Iminium Ion Cyclization
2006
Synthesis and Structure−Activity Relationships of 1,2,3,4-Tetrahydroquinoline-2,3,4-trione 3-Oximes: Novel and Highly Potent Antagonists for NMDA Receptor Glycine Site
1996
In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse
1999 StandoutScience
Analysis of GABAA Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics
2004
An odyssey from stoichiometric carbotitanation of alkynes to zirconium-catalysed enantioselective carboalumination of alkenes
1996 StandoutNobel
Works of Michael Rowley being referenced
Crucial points at diagnosis. Type 2 diabetes or slow type 1 diabetes.
1999
Allosteric inhibitors of hepatitis C virus NS5B polymerase thumb domain site II: Structure-based design and synthesis of new templates
2010
N-(4-Fluorobenzyl)-3-hydroxy-9,9-dimethyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidine-2-carboxamides a novel class of potent HIV-1 integrase inhibitors
2009
3'-(Arylmethyl)- and 3'-(Aryloxy)-3-phenyl-4-hydroxyquinolin- 2(1H)-ones: Orally Active Antagonists of the Glycine Site on the NMDA Receptor
1994
Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor
1998
2-Trifluoroacetylthiophenes, a novel series of potent and selective class II histone deacetylase inhibitors
2008
N-(Indol-3-ylglyoxylyl)piperidines: high affinity agonists of human GABA-A receptors containing the α1 subunit
2000
3-Acyl-4-hydroxyquinolin-2(1H)-ones. Systemically active anticonvulsants acting by antagonism at the glycine site of the N-methyl-D-aspartate receptor complex
1993
3-(1-Piperazinyl)-4,5-dihydro-1H-benzo[g]indazoles: high affinity ligands for the human dopamine D4 receptor with improved selectivity over ion channels
1998
Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture
2009
Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small Molecule Inhibitors Bound to a Novel Allosteric Site
2005
Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway
2009
2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors
2008
Neighboring Group Participation of the Indole Nucleus: An Unusual DAST-Mediated Rearrangement Reaction
2000
Mechanismof Action and Antiviral Activity of Benzimidazole-Based AllostericInhibitors of the Hepatitis C Virus RNA-Dependent RNAPolymerase
2003
Effect of Plasma Protein Binding on in Vivo Activity and Brain Penetration of Glycine/NMDA Receptor Antagonists
1997
Novel Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease Featuring a 2-Amino-1,3-thiazole as a P4 Carbamate Replacement
2009
The silyl-cupration and stannyl-cupration of allenes
1989
The stereochemistry of the intramolecular electrophilic attack of an aldehyde on a carbon-tin bond
1986
ChemInform Abstract: 3‐(4‐Fluoropiperidin‐3‐yl)‐2‐phenylindoles as High Affinity, Selective, and Orally Bioavailable h5‐HT2A Receptor Antagonists.
2001
5-(4-Chlorophenyl)-4-methyl-3-(1-(2- phenylethyl)piperidin-4-yl)isoxazole: A Potent, Selective Antagonist at Human Cloned Dopamine D4 Receptors
1996
3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as High Affinity, Selective, and Orally Bioavailable h5-HT2A Receptor Antagonists
2001
Development and Preliminary Optimization of Indole-N-Acetamide Inhibitors of Hepatitis C Virus NS5B Polymerase
2005
Current and Novel Approaches to the Drug Treatment of Schizophrenia
2001
Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors
2009
Total synthesis of (+)-ophiobolin C
1989
Dihydroxypyrimidine-4-carboxamides as Novel Potent and Selective HIV Integrase Inhibitors
2007
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases
2008
Synthesis of cis and trans 4-amido 2-carboxytetrahydroquinolines, high affinity ligands at the glycine site of the NMDA receptor
1992
Stabilization of a Cis Amide Bond in a Host−Guest Complex
1996
A Novel Series of Potent and Selective Ketone Histone Deacetylase Inhibitors with Antitumor Activity in Vivo
2008
3-Heteroaryl-2-pyridones: Benzodiazepine Site Ligands with Functional Selectivity for α2/α3-Subtypes of Human GABAA Receptor-Ion Channels
2002
Potent Inhibitors of Subgenomic Hepatitis C Virus RNA Replication through Optimization of Indole-N-Acetamide Allosteric Inhibitors of the Viral NS5B Polymerase
2005