Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Limits of long-term selection against Neandertal introgression
2019 StandoutNobel
Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society
2016 Standout
Mapping of sudden infant death with dysgenesis of the testes syndrome (SIDDT) by a SNP genome scan and identification of TSPYL loss of function
2004
The UK Biobank resource with deep phenotyping and genomic data
2018 StandoutNature
An integrated map of genetic variation from 1,092 human genomes
2012 StandoutNature
A unified mixed-model method for association mapping that accounts for multiple levels of relatedness
2005 Standout
Two-dimensional crystallization of the ryanodine receptor Ca2+ release channel on lipid membranes
2004
Characteristics and function of Ca2+ — and inositol 1,4,5-trisphosphate-releasable stores of Ca2+ in neurons
1992
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Identification of Hyperreactive Cysteines within Ryanodine Receptor Type 1 by Mass Spectrometry
2004
Structural Basis for Gating and Activation of RyR1
2016 StandoutNobel
Dissecting autoimmune diabetes through genetic manipulation of non-obese diabetic mice
2003
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
2020 Standout
An Icelandic example of the impact of population structure on association studies
2004
Identification of ATP-Binding Regions in the RyR1 Ca2+ Release Channel
2012
Properties of Structured Association Approaches to Detecting Population Stratification
2004
Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle
1993 StandoutScience
Calmodulin activation and inhibition of skeletal muscle Ca2+ release channel (ryanodine receptor)
1995
Autosomal Recessive Familial Exudative Vitreoretinopathy Is Associated with Mutations in LRP5
2004
Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway
2001
Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass
2005
Disease Mutations in the Ryanodine Receptor Central Region: Crystal Structures of a Phosphorylation Hot Spot Domain
2012
Pharmacogenetics of the human beta-adrenergic receptors
2006
Primer3—new capabilities and interfaces
2012 Standout
A Ca2+-Binding Domain in RyR1 that Interacts with the Calmodulin Binding Site and Modulates Channel Activity
2005
The fine-scale genetic structure of the British population
2015 Nature
Updating the East Asian mtDNA phylogeny: a prerequisite for the identification of pathogenic mutations
2006
Efficient Coalescent Simulation and Genealogical Analysis for Large Sample Sizes
2016
Demonstrating stratification in a European American population
2005
Understanding the recent evolution of the human genome: insights from human-chimpanzee genome comparisons
2006
Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein
1994
Tolerance and Autoimmunity
2001
Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution
2014 Nature
Postulated Role of Interdomain Interaction within the Ryanodine Receptor in Ca2+ Channel Regulation
2000
Architecture and conformational switch mechanism of the ryanodine receptor
2014 Nature
Role of Amino-terminal Half of the S4-S5 Linker in Type 1 Ryanodine Receptor (RyR1) Channel Gating
2011
PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
2007 Standout
Structure of the Skeletal Muscle Calcium Release Channel Activated with Ca2+ and AMP-PCP
1999
Localization of calmodulin binding sites on the ryanodine receptor from skeletal muscle by electron microscopy
1994
The power and promise of population genomics: from genotyping to genome typing
2003
Principal components analysis corrects for stratification in genome-wide association studies
2006 Standout
Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating
2009
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Detecting the number of clusters of individuals using the software structure : a simulation study
2005 Standout
Population structure, differential bias and genomic control in a large-scale, case-control association study
2005
A model for familial exudative vitreoretinopathy caused by LPR5 mutations
2008 StandoutNobel
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
1998 StandoutNatureNobel
The Pore Structure of the Closed RyR1 Channel
2005
Inositol 1,4,5-Trisphosphate receptor causes formation of ER cisternal stacks in transfected fibroblasts and in cerebellar purkinje cells
1994 StandoutNobel
Mutations in LRP5 or FZD4 Underlie the Common Familial Exudative Vitreoretinopathy Locus on Chromosome 11q
2004
Ligand Binding and Cooperative Interactions among the Subunits of the Tetrameric Ca2+ Release Channel Complex of Sarcoplasmic Reticulum
1992
Ryanodine receptors: how many, where and why?
1993
Inositol trisphosphate and calcium signalling
1993 StandoutNature
Prescribing Personalized Nutrition for Cardiovascular Health: Are We Ready?
2014 Standout
arrow encodes an LDL-receptor-related protein essential for Wingless signalling
2000 Nature
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
A Review of Chemotherapy Trials for Malignant Mesothelioma
1998
Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway
2005
Genome-wide association studies for common diseases and complex traits
2005 Standout
An LDL-receptor-related protein mediates Wnt signalling in mice
2000 Nature
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
Nonvalidation of Reported Genetic Risk Factors for Acute Coronary Syndrome in a Large-Scale Replication Study
2007
Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle
2005
Differential confounding of rare and common variants in spatially structured populations
2012
Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM
2005
Obesity and Female Gender Increase Breath Ethanol Concentration: Potential Implications for The Pathogenesis of Nonalcoholic Steatohepatitis
2001
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
Genome-Wide Analysis of Single Nucleotide Polymorphisms Uncovers Population Structure in Northern Europe
2008
Genetics of autoimmune diseases in humans and in animal models
2002
Human-Specific Transcriptional Networks in the Brain
2012
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Structure and function of inositol triphosphate receptors
1991
Cardiac excitation–contraction coupling
2002 StandoutNature
Fast model-based estimation of ancestry in unrelated individuals
2009 Standout
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain
2014
Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.
1990
DNA analysis of an early modern human from Tianyuan Cave, China
2013 StandoutNobel
Expression of calreticulin in Escherichia coli and identification of its Ca2+ binding domains.
1991
Block of Ca 2+ Wave and Ca 2+ Oscillation by Antibody to the Inositol 1,4,5-Trisphosphate Receptor in Fertilized Hamster Eggs
1992 StandoutScienceNobel
Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma
2003 Standout
Structural determination of the phosphorylation domain of the ryanodine receptor
2012
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
2002
Separating endogenous ancient DNA from modern day contamination in a Siberian Neandertal
2014 StandoutNobel
Localization of the high and low affinity [3H]ryanodine binding sites on the skeletal muscle Ca2+ release channel.
1994
Differential immunohistochemical localization of inositol 1,4,5- trisphosphate- and ryanodine-sensitive Ca2+ release channels in rat brain
1993
Expression of a Ryanodine Receptor-Ca 2+ Channel that is Regulated by TGF-β
1992 Science
Intracellular Ca2+ stores in chicken Purkinje neurons: differential distribution of the low affinity-high capacity Ca2+ binding protein, calsequestrin, of Ca2+ ATPase and of the ER lumenal protein, Bip.
1991
The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor.
1990 StandoutNobel
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Topology of the Ca 2+ release channel of skeletal muscle sarcoplasmic reticulum (RyR1)
2002
Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin
1992
Molecular Basis of Ca2+ Activation of the Mouse Cardiac Ca2+ Release Channel (Ryanodine Receptor)
2001
Population Structure and Eigenanalysis
2006 Standout
Cancer Pharmacogenomics: Early Promise, But Concerted Effort Needed
2013 Science
Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel
2008
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
2004
Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations
2018 StandoutScienceNobel
Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.
1982 StandoutNobel
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Interdependence of ryanodine binding, oligomeric receptor interactions, and Ca2+ release regulation in junctional sarcoplasmic reticulum
1991
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2band dose-dependent requirement of H-2g7for diabetes in NOD mice
2008 StandoutNobel
Genetic legacy of state centralization in the Kuba Kingdom of the Democratic Republic of the Congo
2018 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
THE NOD MOUSE: A Model of Immune Dysregulation
2004
Structure of a novel InsP3 receptor.
1991 StandoutNobel
Single-particle selection and alignment with heavy atom cluster-antibody conjugates
1998 StandoutNobel
Surface topography analysis of the ryanodine receptor/junctional channel complex based on proteolysis sensitivity mapping.
1990
Photoaffinity labeling of the ryanodine receptor/Ca2+ release channel with an azido derivative of ryanodine.
1994
Phosphorylation-Dependent Regulation of Ryanodine Receptors
2001
Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development
2012 StandoutNobel
Structure and expression of the rat inositol 1,4,5-trisphosphate receptor.
1990 StandoutNobel
Links between genetics and pathophysiology in the autism spectrum disorders
2011
THE MAMMALIAN LOW-DENSITY LIPOPROTEIN RECEPTOR FAMILY
1999
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Reconstitution of the skeletal muscle ryanodine receptor-Ca2+ release channel protein complex into proteoliposomes.
1994
Effects of Rapamycin on Ryanodine Receptor/Ca 2+ -Release Channels From Cardiac Muscle
1996
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
NMR structure of the calreticulin P-domain
2001 StandoutNobel
Logistic regression protects against population structure in genetic association studies
2005
Admixture into and within sub-Saharan Africa
2016
Works of Michael Phillips being referenced
The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia.
1992
Optimus Primer: A PCR enrichment primer design program for next-generation sequencing of human exonic regions
2010
The NOD Idd9 Genetic Interval Influences the Pathogenicity of Insulitis and Contains Molecular Variants of Cd30, Tnfr2, and Cd137
2000
Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children
2011
β-adrenergic Receptor Polymorphisms and Responses during Titration of Metoprolol Controlled Release/extended Release in Heart Failure*
2005
Cloning of a novel member of the low-density lipoprotein receptor family
1998
Endogenous breath ethanol concentrations in abstinent alcohol abusers and normals
1988
Prevalence and Risk Factors for Acquisition of Carbapenem-Resistant Enterobacteriaceae in the Setting of Endemicity
2013
De Novo Mutations in FOXP1 in Cases with Intellectual Disability, Autism, and Language Impairment
2010
Large-scale genotyping of complex DNA
2003
The substitution of Arg for Gly2433 in the human skeletal muscle ryanodine receptor is associated with malignant hyperthermia
1994
The effects of human population structure on large genetic association studies
2004
A mutation in the human ryanodine receptor gene associated with central core disease
1993
Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy
2009
Malignant Hyperthermia
1992 Science
Detection of endogenous ethanol and other compounds in the breath by gas chromatography with on-column concentration of sample
1987
Mapping by Genetic Interaction
2001
Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.
1990
Randomized comparison of cyclophosphamide, imidazole carboxamide, and adriamycin versus cyclophosphamide and adriamycin in patients with advanced stage malignant mesothelioma: a Sarcoma Intergroup Study.
1987