Standout Papers
Citation Impact
Citing Papers
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
2010
Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE
1996
Hallmarks of Cancer: The Next Generation
2011 Standout
Infectivity of visna virus DNA
1976
NALPs: a novel protein family involved in inflammation
2003
ICEBERG
2000
ASC is essential for LPS‐induced activation of procaspase‐1 independently of TLR‐associated signal adaptor molecules
2004
A novel family of variable region genes of the human immunoglobulin heavy chain
1987 StandoutNobel
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
1997 Standout
Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE
1998
Cryopyrin activates the inflammasome in response to toxins and ATP
2006 StandoutNature
ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis
1996
Apoptosis by Death Factor
1997 Standout
Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus
1993 StandoutNobel
The Dynamic Nature of the Antibody Repertoire
1988 Nobel
Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1
2006
The Inflammasome
2002 Standout
Substrate Specificities of Caspase Family Proteases
1997
From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair
1997
ICE Family Proteases: Mediators of All Apoptotic Cell Death?
1996
The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias
1988
Protease Activity of in Vitro Transcribed and Translated Caenorhabditis elegans Cell Death Gene (ced-3) Product
1996
ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B
1996
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
ICE-like proteases in apoptosis
1995
Necrotic death as a cell fate
2006
the Viral and Cellular Forms of the Abelson (Dbl) Oncogene
1988
An interleukin‐1β‐converting enzyme‐like protease is a common mediator of apoptosis in thymocytes
1995
Contenders in FasL/TNF death signaling
1995
The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization
1989 Nobel
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.
1996 StandoutNobel
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
1996 Standout
Complete sequence of the genes encoding the VH and VL regions of low- and high- affinity monoclonal lgM and lgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient
1991
Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype.
1991 StandoutNobel
Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA
1988 StandoutNature
Antibody diversity: Somatic hypermutation of rearranged VH genes
1981
Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzymea
1998
A new human immunoglobulin VH family preferentially rearranged in immature B-cell tumours
1988 Nature
Protease activation during apoptosis: Death by a thousand cuts?
1995 Standout
Structural Analyses of Human Developmentally Regulated Vh3 Genes
1990
Molecular Ordering of the Cell Death Pathway
1996
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
1995 Standout
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
2004 StandoutNature
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
Non-canonical inflammasome activation targets caspase-11
2011 StandoutNature
Biosynthesis of the reverse transcriptase of hepatitis B viruses involves de novo translational initiation not ribosomal frameshifting
1989 StandoutNatureNobel
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
1988 Standout
The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism
1988
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
Function of Nod‐like receptors in microbial recognition and host defense
2008
The cell-death machine
1996
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
1992 Standout
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
1996 Nature
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein
1989 Standout
Caspases: Intracellular Signaling by Proteolysis
1997 Standout
CD4+CD25+ Immunoregulatory T Cells
2002
Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1
2001
Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases
1995
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
1995 Nature
Organization of four mouse lambda light chain immunoglobulin genes.
1981 StandoutNobel
Defectiveness of avian erythroblastosis virus: synthesis of a 75K gag-related protein
1979
The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters.
1988
Enhanced transformation by a simian virus 40 recombinant virus containing a Harvey murine sarcoma virus long terminal repeat.
1983
Virus-specific RNAs in cells infected by avian myelocytomatosis virus and avian erythroblastosis virus: Modes of oncogene expression
1981 StandoutNobel
Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups.
1983
Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.
1983
Somatic generation of antibody diversity.
1976 StandoutNobel
Preferential utilization of conserved immunoglobulin heavy chain variable gene segments during human fetal life.
1990
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
1986
Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus
1982 Nobel
Selective cleavage in the avian retroviral long terminal repeat sequence by the endonuclease associated with the alpha beta form of avian reverse transcriptase.
1983
Human heavy-chain variable region gene family nonrandomly rearranged in familial chronic lymphocytic leukemia.
1987
Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors.
1985 StandoutNobel
The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes
1985
Two Pairs of Recombination Signals Are Sufficient to Cause Immunoglobulin V-(D)-J Joining
1987 Science
Retrovirus-like particles containing RNA homologous to the transposable element copia in Drosophila melanogaster
1983 Nature
Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions
2000
Conservation and divergence of immunoglobulin VH pseudogenes.
1983
V(D)J recombination: a functional definition of the joining signals.
1989
Polymorphism of germ‐line immunoglobulin VH genes correlates with allotype and idiotype markers
1981
Organization and evolution of variable region genes of the human immunoglobulin heavy chain
1986 StandoutNobel
Induction of Chronic Myelogenous Leukemia in Mice by the P210 bcr/abl Gene of the Philadelphia Chromosome
1990 StandoutScienceNobel
Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase
1981 Nobel
Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.
1988
Analysis of a 5′ leader sequence on murine leukemia virus 21S RNA: Heteroduplex mapping with long reverse transcriptase products
1978 Nobel
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals
1987
The mouse carbonic anhydrase I gene contains two tissue-specific promoters.
1989
Avian Retrovirus pp32 DNA-Binding Protein I. Recognition of Specific Sequences on Retrovirus DNA Terminal Repeats
1982
An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity
1984
Specific RNA sequences and gene products of MC29 avian acute leukemia virus
1978
Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35
1995 Science
Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.
1995
Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation
1979 Nature
The physical organization of the human immunoglobulin heavy chain gene complex.
1990
mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification
1983 StandoutNatureNobel
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein.
1989 StandoutNobel
Organization and evolution of immunoglobulin VH gene subgroups.
1982
Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase
1986
Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme
1997 Science
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments
1985
Correct integration of retroviral DNA in vitro
1987 StandoutNobel
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration.
1984 StandoutNobel
Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes.
1984 StandoutNobel
Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma.
1988
Intramolecular integration within Moloney murine leukemia virus DNA
1981 Nobel
Analysis of antibody diversity: V-D-J mRNA nucleotide sequence of four anti-GAT monoclonal antibodies. A paucigene system using alternate D-J recombinations to generate functionally similar hypervariable regions.
1983 StandoutNobel
Immunoglobulin Structure-Function Correlates: Antigen Binding and Idiotypes
1983
Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse.
1981 Nobel
Structure, organization, and somatic rearrangement of T cell gamma genes
1985
Nucleotide sequence of cloned unintegrated avian sarcoma virus DNA: viral DNA contains direct and inverted repeats similar to those in transposable elements.
1981 StandoutNobel
Novel Proteinaceous Infectious Particles Cause Scrapie
1982 StandoutScienceNobel
The CML-Specific P210 bcr / abl Protein, Unlike v- abl , Does Not Transform NIH/3T3 Fibroblasts
1987 ScienceNobel
The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy.
1995
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
1993 Standout
Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements.
1989
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments.
1982 StandoutNobel
Requirement of an ICE-Like Protease for Induction of Apoptosis and Ceramide Generation by REAPER
1996 Science
The internally located telomeric sequences in the germ-line chromosomes of tetrahymena are at the ends of transposon-like elements
1985 StandoutNobel
The structure, rearrangement and expression of Dβ gene segments of the murine T-cell antigen receptor
1984 Nature
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains
1984 Nature
The human t cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene
1984
Molecular thanatopsis: a discourse on the BCL2 family and cell death
1996
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
1986 StandoutNobel
Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
1996
Early Restriction of the Human Antibody Repertoire
1987 Science
Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.
1988 Nobel
In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome.
1987
Functional macrophage cell lines transformed by abelson leukemia virus
1978
A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.
1986
Molecular basis of a mouse strain-specific anti-hapten response
1983 Nobel
Salmonella Exploits Caspase-1 to Colonize Peyer's Patches in a Murine Typhoid Model
2000
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
1984 StandoutNatureNobel
Salmonella-Induced Caspase-2 Activation in Macrophages
2000
No apparent nucleotide sequence specificity in cellular DNA juxtaposed to retrovirus proviruses.
1980 Nobel
A catalogue of splice junction sequences
1982 Standout
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.
1982
λ5, a new light-chain-related locus selectively expressed in pre-B lymphocytes
1986 Nature
Significance analysis of microarrays applied to the ionizing radiation response
2001 Standout
Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene.
1989
The genetic basis of antibody production: The dominant anti‐arsonate idiotype response of the strain a mouse
1982
Molecular Characterization of the Lymphoid V(D) J Recombination Activity
1989
Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.
1991 Nobel
Selective Transformation of Primitive Lymphoid Cells by the BCR/ABL Oncogene Expressed in Long-Term Lymphoid or Myeloid Cultures
1988
Nucleotide sequence of acceptor site and termini of integrated avian endogenous provirus ev1: Integration creates a 6 bp repeat of host DNA
1981
The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining
1985 Science
Unusual association of V, J and C regions in a mouse immunoglobulin λ chain
1982 Nature
Regulation of Genome Rearrangement Events during Lymphocyte Differentiation
1986
Replacing the complementarity-determining regions in a human antibody with those from a mouse
1986 StandoutNatureNobel
The integrated genome of murine leukemia virus
1978
Two closely linked but separable promoters for human neuronal nitric oxide synthase gene transcription.
1995 StandoutNobel
In vitro transformation of lymphoid cells by Abelson murine leukemia virus.
1975 StandoutNobel
Nucleotide sequence of Moloney murine leukaemia virus
1981 Nature
RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene.
1981
A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene
1987 StandoutNatureNobel
Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains.
1984 StandoutNobel
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.
1996
Amino acid sequence diversity within the family of antibodies bearing the major antiarsonate cross-reactive idiotype of the A strain mouse.
1983
The smaller human VH gene families display remarkably little polymorphism.
1989
Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties.
1985
A Rous sarcoma virus provirus is flanked by short direct repeats of a cellular DNA sequence present in only one copy prior to integration.
1981 StandoutNobel
Nucleotide sequences at host–proviral junctions for mouse mammary tumour virus
1981 Nature
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Immunoglobulin V region variants in hybridoma cells. I. Isolation of a variant with altered idiotypic and antigen binding specificity.
1982
Adaptation of a retrovirus as a eucaryotic vector transmitting the herpes simplex virus thymidine kinase gene.
1982
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.
1989 StandoutNobel
Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: Studies with cloned viral DNA
1980 Nobel
Targeted gene disruption of the endogenous c-abl locus by homologous recombination with DNA encoding a selectable fusion protein.
1990
Restricted association of V and J-C gene segments for mouse lambda chains.
1984 StandoutNobel
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.
1985
Expression and rearrangement of the alpha, beta, and gamma chain genes of the T cell receptor in cloned murine large granular lymphocyte lines. No correlation with the cytotoxic spectrum.
1986 StandoutNobel
The Fv-1 Gene of the Mouse and its Control of Murine Leukemia Virus Replication
1979
Works of Michael Paskind being referenced
Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production
1997 Nature
Molecular Cloning of SLAP-130, an SLP-76-associated Substrate of the T Cell Antigen Receptor-stimulated Protein Tyrosine Kinases
1997
Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP
1999
Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
1995
Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases
1995
Four murine c-abl mRNAs arise by usage of two transcriptional promoters and alternative splicing.
1988 Nobel
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells
1984 NatureNobel
The First Intron in the Human c-abl Gene Is at Least 200 Kilobases Long and Is a Target for Translocations in Chronic Myelogenous Leukemia
1987 Nobel
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines
1984 NatureNobel
Structure of a cloned circular Moloney murine leukemia virus DNA molecule containing an inverted segment: implications for retrovirus integration.
1980 Nobel
Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.
1986
Somatic variants of murine immunoglobulin λ light chains
1982 NatureNobel
Structure of Cloned Retrovirus Circular DNAs: Implications for Virus Integration
1981 Nobel
Mechanism of Induction of RNA Tumor Viruses by Halogenated Pyrimidines
1974 StandoutNobel
Alternative 5′ exons in c-abl mRNA
1986 Nobel
Cloning and analysis of reverse transcript P160 genomes of Abelson murine leukemia virus
1983 Nobel
Structure of the abelson murine leukemia virus genome
1979 Nobel
Dual expression of λ genes in the MOPC-315 plasmacytoma
1981 NatureNobel
The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia.
1987 Nobel
Measurement of the Sequence Complexity of Cloned Moloney Murine Leukemia Virus 60 to 70 S RNA: Evidence for a Haploid Genome
1974
Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells.
1978 Nobel
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable region
1981 Nobel