Citation Impact
Citing Papers
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
2016 Science
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts
2010 StandoutNobel
Tumor-specific Th17-polarized cells eradicate large established melanoma
2008
Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma
2013 StandoutNobel
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints
2014
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype
2012
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity
2015
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1
2015
The emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy
2023
T-cell exhaustion in the tumor microenvironment
2015
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses
2016
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
2017
An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction
2015
T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?
2014
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway
2016
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade
2018
A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells
2016
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade
2016
T cell exhaustion
2011 Standout
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
2015
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
2019 Standout
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
2014 StandoutNature
The biology and management of non-small cell lung cancer
2018 StandoutNature
Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family
2016
Hallmarks of aging: An expanding universe
2023 Standout
The Principles of Engineering Immune Cells to Treat Cancer
2017
T Cell Factor 1-Expressing Memory-like CD8+ T Cells Sustain the Immune Response to Chronic Viral Infections
2016
Microbiome and Anticancer Immunosurveillance
2016
Type I interferons in infectious disease
2015 Standout
T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection
2014
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
2016 Nature
The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
2014
Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging
2020
T cell exhaustion in protozoan disease
2012
Complementary Role of HCV and HIV in T-Cell Activation and Exhaustion in HIV/HCV Coinfection
2013
The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
2016
Transcriptional control of effector and memory CD8+ T cell differentiation
2012
Inhibitory Receptors Beyond T Cell Exhaustion
2015
Inhibitory Receptor Expression Depends More Dominantly on Differentiation and Activation than “Exhaustion” of Human CD8 T Cells
2013
Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade
2016
Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo
2018
TCF1 in T cell immunity: a broadened frontier
2021
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Role of the gut microbiota in immunity and inflammatory disease
2013 Standout
Adoptive immunotherapy of cancer using CD4+ T cells
2009
Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers
2022
Regulation of mature T cell responses by the Wnt signaling pathway
2012
T cell exhaustion during persistent viral infections
2015
PD-1 marks dysfunctional regulatory T cells in malignant gliomas
2016
Prevention of VTE in Nonorthopedic Surgical Patients
2012 Standout
Overcoming T cell exhaustion in infection and cancer
2015
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease
2016
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells
2018
Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model
2015
Molecular mechanisms of T cell co-stimulation and co-inhibition
2013 Standout
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 + T Cell Effector Function
2014
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
2016 Standout
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
2016
Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer
2017 StandoutNobel
Regulation of type I interferon responses
2013 Standout
AKT/PKB Signaling: Navigating the Network
2017 Standout
Eomesodermin is required for antitumor immunity mediated by 4-1BB-agonist immunotherapy
2014
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Inhibitory Phenotype of HBV-Specific CD4+ T-Cells Is Characterized by High PD-1 Expression but Absent Coregulation of Multiple Inhibitory Molecules
2014
Compartmentalized and systemic control of tissue immunity by commensals
2013
Molecular and cellular insights into T cell exhaustion
2015 Standout
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease
2016
Liver Environment and HCV Replication Affect Human T-Cell Phenotype and Expression of Inhibitory Receptors
2013
T cell metabolic fitness in antitumor immunity
2015
Microbiota-mediated colonization resistance against intestinal pathogens
2013
Innate immune signaling and regulation in cancer immunotherapy
2016
Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+T-Cell Population in Elite Controllers
2015
The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
2015
Molecular regulation of effector and memory T cell differentiation
2014
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
2013 Standout
Hyperprogressive disease: recognizing a novel pattern to improve patient management
2018
Microbial Programming of Systemic Innate Immunity and Resistance to Infection
2014
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Coinhibitory Pathways in Immunotherapy for Cancer
2016
Adoptive cell transfer as personalized immunotherapy for human cancer
2015 StandoutScience
Defective mitochondria disrupt CD8+ T cells
2016
Immune-Related Adverse Events Associated with Immune Checkpoint Blockade
2018 Standout
Innate Immune Recognition of Cancer
2015
Disparate Individual Fates Compose Robust CD8 + T Cell Immunity
2013 Science
mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
2015
Fundamental Mechanisms of Immune Checkpoint Blockade Therapy
2018 StandoutNobel
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
2016
The epigenetic landscape of T cell exhaustion
2016 Science
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients
2018 StandoutScience
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C
2013
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Immunosuppressive CD71+ erythroid cells compromise neonatal host defence against infection
2013 Nature
Genetic and Epigenetic Regulation of PD-1 Expression
2016
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Helper T‐cell identity and evolution of differential transcriptomes and epigenomes
2013
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
CAR T cell immunotherapy for human cancer
2018 StandoutScience
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Michael Paley being referenced
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
2011
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
2016
Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity
2012
Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory
2012
Major bleeding complicating deep sternal infection after cardiac surgery
2003
Cutting Edge: B Cell–Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection
2016
Progenitor and Terminal Subsets of CD8 + T Cells Cooperate to Contain Chronic Viral Infection
2012 Science
Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche
2010
IFN-γ Mediates the Death of Th1 Cells in a Paracrine Manner
2008
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
2015
Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes
2012