Citation Impact
Citing Papers
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response
2013 StandoutNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
2005
IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice.
1999
Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9
2008 StandoutNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity
1998
Functional diversity of helper T lymphocytes
1996 StandoutNature
Cloning of a new cytokine that induces IFN-γ production by T cells
1995 StandoutNature
Expression of IL-12 and IL-13 mRNA in asthma and their modulation in response to steroid therapy.
1997
lnterleukin-13 is a new human lymphokine regulating inflammatory and immune responses
1993 Nature
Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ
2005
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
1998 StandoutNature
Interleukin-12 and the regulation of innate resistance and adaptive immunity
2003 Standout
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
2003 StandoutNature
Synergistic Regulation of the Human Interleukin-12 p40 Promoter by NFκB and Ets Transcription Factors in Epstein-Barr Virus-transformed B Cells and Macrophages
1998
Regulation of Experimental Autoimmune Encephalomyelitis by Interleukin‐12
1996
Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens
2000
Interleukin-12 in anti-tumor immunity and immunotherapy
2002
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Structure and chromosomal location of the mouse interleukin‐12 p35 and p40 subunit genes
1996
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
2008 StandoutNature
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
2017 Standout
Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome
1995
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
2007 StandoutNature
Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β
1995
Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?
1992
Role of interleukin-12 family cytokines in the cellular response to mycobacterial disease
2009
Interleukin 6 and its Receptor: Ten Years Later
1998
Interleukin-18: A Novel Cytokine That Augments Both Innate and Acquired Immunity
1998
Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene.
1998
IL-12 in Autoimmunity
1998
Transforming growth factor-β induces development of the TH17 lineage
2006 StandoutNature
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
2006 StandoutNature
The urokinase-type plasminogen activator system in cancer metastasis: A review
1997 Standout
IL-12 Acts Directly on DC to Promote Nuclear Localization of NF-κB and Primes DC for IL-12 Production
1998
The microenvironment of the tumour–host interface
2001 StandoutNature
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
2003
Murine splenocytes produce inflammatory cytokines in a MyD88-dependent response to Bacillus anthracis spores
2006
Interleukin-12 Induces Tyrosine Phosphorylation of an 85-kDa Protein Associated with the Interleukin-12 Receptor β1 Subunit
1998
Taking dendritic cells into medicine
2007 StandoutNatureNobel
New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
2005
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
2002 Standout
Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice
1995
Tumor Cell Responses to IFNγ Affect Tumorigenicity and Response to IL-12 Therapy and Antiangiogenesis
1998
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
1996 Nature
Homeostasis in Mice with Genetically Decreased Angiotensinogen Is Primarily by an Increased Number of Renin-producing Cells
1999 StandoutNobel
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
2010 StandoutNature
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
2008 StandoutNature
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses
1996
Cytokines in the generation of immune responses to, and resolution of, virus infection
1994
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
CD40 ligand is a T cell growth factor
1993 StandoutNobel
Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist
1995
Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation
1992
Prorenin and Other Large Molecular Weight Forms of Renin*
1980
Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.
1996
Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes
1995
A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo
2008
Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.
1995
Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients.
1992
Impaired interleukin 12 production in human immunodeficiency virus-infected patients.
1994
Sequential processing of insulin by cultured kidney cells.
1995
The Role of Cellular Accumulation in Determining Sensitivity to Platinum-Based Chemotherapy
2007
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
1997
Interferon-γ–Dependent Inducible Expression of the Human Interleukin-12 p35 Gene in Monocytes Initiates From a TATA-Containing Promoter Distinct From the CpG-Rich Promoter Active in Epstein-Barr Virus-Transformed Lymphoblastoid Cells
1998
Peptidolytic monoclonal antibody elicited by a neuropeptide.
1992 StandoutNobel
Response of human natural killer (NK) cells to NK cell stimulatory factor (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF.
1992
A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits
1996
STATs and Gene Regulation
1997 StandoutScience
Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site
1995
Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.
1991
Interleukin-12–Activated Natural Killer Cells Recognize B7 Costimulatory Molecules on Tumor Cells and Autologous Dendritic Cells
1998
Roles of Interleukin-12 and Gamma Interferon in MurineChlamydia pneumoniaeInfection
2000
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.
1995 StandoutNobel
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
2010 StandoutNobel
Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones.
1994
Role of Interleukin-12 in Primary Influenza Virus Infection
1998
Requirement for IL-13 Independently of IL-4 in Experimental Asthma
1998 StandoutScience
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
2003
IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
2007 Standout
Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present
2002
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.
1991
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.
1993
Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells
2002 StandoutNobel
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.
1993 Standout
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
1993 StandoutScience
Functions of Ceramide in Coordinating Cellular Responses to Stress
1996 StandoutScience
Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract
2005 StandoutScience
IL-12 Is Dysregulated in Macrophages from IRF-1 and IRF-2 Knockout Mice
1999
Cleavage of vasoactive intestinal peptide at multiple sites by autoantibodies
1991
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.
1995
Magnesium and lipids in cardiovascular disease.
1986
Control Selection for RNA Quantitation
2000
Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit
1999
Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
2005 StandoutNobel
Expression and Function of IL-12 and IL-18 Receptors on Human Tonsillar B Cells
2000
Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.
1995
Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10
1998
Regulation of IL-12 p40 Promoter Activity in Primary Human Monocytes: Roles of NF-κB, CCAAT/Enhancer-Binding Protein β, and PU.1 and Identification of a Novel Repressor Element (GA-12) That Responds to IL-4 and Prostaglandin E2
2001
Purification of a factor which provides a costimulatory signal for gamma interferon production
1993
Interleukin 12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells.
1994
IL-12 Is Required to Maintain a Th1 Response DuringLeishmania majorInfection
2000
Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.
1990
Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice
1998
B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
1994
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.
1992
Interleukin 12: A key modulator of immune function
1994
Interferon-γ–Dependent Inducible Expression of the Human Interleukin-12 p35 Gene in Monocytes Initiates From a TATA-Containing Promoter Distinct From the CpG-Rich Promoter Active in Epstein-Barr Virus-Transformed Lymphoblastoid Cells
1998
Antibodies Against IL-12 Prevent Superantigen-Induced and Spontaneous Relapses of Experimental Autoimmune Encephalomyelitis
1998
A Protective and Agonistic Function of IL-12p40 in Mycobacterial Infection
2001
Interleukin-12 primes human CD4 and CD8 T cell clones for high production of both interferon-gamma and interleukin-10.
1996
Requirement for V α 14 NKT Cells in IL-12-Mediated Rejection of Tumors
1997 Science
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.
1993
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Interleukin-13: Central Mediator of Allergic Asthma
1998 StandoutScience
The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.
1996
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
1993
Regulation of interleukin-12 production in antigen-presenting cells
2001
Antitumor and antimetastatic activity of interleukin 12 against murine tumors.
1993
IL-12: Initiation Cytokine for Cell-Mediated Immunity
1993 Science
Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity.
1994 StandoutNobel
Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.
1994
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Mechanism of inhibition of LPS-induced IL-12p40 production by IL-10 and TGF-β in ANA-1 cells
1998
An IFN-γ-Inducible Transcription Factor, IFN Consensus Sequence Binding Protein (ICSBP), Stimulates IL-12 p40 Expression in Macrophages
2000
Regulation of Nuclear Gamma Interferon Gene Expression by Interleukin 12 (IL-12) and IL-2 Represents a Novel Form of Posttranscriptional Control
2002
Innate or Adaptive Immunity? The Example of Natural Killer Cells
2011 StandoutScience
Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production.
1995
Contribution of the CXC chemokines IP-10 and Mig to the antitumor effects of IL-12
1998
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
1999 StandoutNobel
Biosynthesis and Posttranslational Regulation of Human IL-12
2000
Works of Michael P. Ryan being referenced
The nephrotoxicity, cytotoxicity and renal handling of a cisplatin-methionine complex in male Wistar rats
1994
Induced expression of p52(PAI‐1) in normal rat kidney cells by the microfilament‐disrupting agent cytochalasin D
1994
pH-Independent inhibition of plasma angiotensin i degradation: Implications for renin assay
1979
Effects of Diuretics on the Renal Handling of Magnesium
1984
Complex regulation of plasminogen activator inhibitor type-1 (PAI-1) gene expression by serum and substrate adhesion
1996
High Performance Liquid Chromatographic Analysis of Insulin Degradation by Rat Skeletal Muscle Insulin Protease*
1986
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.
1989 Standout
The renal metabolism of insulin
1984