Citation Impact
Citing Papers
The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy
2005
Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat
2005 StandoutScienceNobel
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Genetic variability: The key problem in the prevention and therapy of RNA‐based virus infections
2003
A stomatin-like protein necessary for mechanosensation in C. elegans
1995 StandoutNatureNobel
Commensal–dendritic-cell interaction specifies a unique protective skin immune signature
2014 Nature
Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity
1994
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Amphipathic, α-helical antimicrobial peptides
2000
Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design
1996
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Naturally occurring mutations associated with resistance to HCV NS5B polymerase and NS3 protease inhibitors in treatment-naïve patients with chronic hepatitis C
2015
The microbiota in adaptive immune homeostasis and disease
2016 StandoutNature
The Refined Crystal Structure of Cowpea Mosaic Virus at 2.8 Å Resolution
1999
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Prosthetic-Joint Infections
2004 Standout
How bacteria talk to each other: regulation of gene expression by quorum sensing
1999
Atopic dermatitis
2015 Standout
Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus
1998 StandoutNobel
The importance of resistance to direct antiviral drugs in HCV infection in clinical practice
2015
AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication
2014
Defensins: antimicrobial peptides of innate immunity
2003 Standout
Rapid gating and anion permeability of an intracellular aquaporin
1999 StandoutNatureNobel
A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
1995 Standout
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain
1995 StandoutNobel
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
SNAREpins: Minimal Machinery for Membrane Fusion
1998 StandoutNobel
Distinct Pathogenesis and Host Responses during Infection of C. elegans by P. aeruginosa and S. aureus
2010
Crystal structure of Thermus aquaticus DNA polymerase
1995 StandoutNatureNobel
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans
1994 StandoutNatureNobel
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia
2004
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
2002 StandoutNatureNobel
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
UCSF Chimera—A visualization system for exploratory research and analysis
2004 Standout
Two physically distinct pores in the dimeric CIC-0 chloride channel
1996 Nature
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease
2014
Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine
1995
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
2005 Standout
Resistance to nucleotide analogue inhibitors of hepatitis C virus NS5B: mechanisms and clinical relevance
2014
Predicting Drug‐Resistant Mutations of HIV Protease
2007 StandoutNobel
Hydration and DNA Recognition by Homeodomains
1996 StandoutNobel
Recombining the structures of HIV integrase, RuvC and RNase H
1995 StandoutNobel
Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides
1998
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin
2015 StandoutNobel
Pore-forming segments in voltage-gated chloride channels
1997 Nature
Glycosylation in health and disease
2019
Update on hepatitis C virus resistance to direct-acting antiviral agents
2014
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
2007 StandoutNatureNobel
Illuminating the dark conformational space of macrocycles using dominant rotors
2021
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
How Do Viruses Enter Cells? The HIV Coreceptors Teach Us a Lesson of Complexity
1997
Programmed population control by cell–cell communication and regulated killing
2004 StandoutNatureNobel
Protein–ligand docking: Current status and future challenges
2006
The CLC chloride channel family
1999
Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion
1995 Nature
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
2002 StandoutNatureNobel
Primate defensins
2004
Mutational Analysis Demonstrates That ClC-4 and ClC-5 Directly Mediate Plasma Membrane Currents
1999
A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans
1994 Nature
A synthetic multicellular system for programmed pattern formation
2005 StandoutNatureNobel
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
2009 Standout
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
2002 Standout
Structural features and biological activities of the cathelicidin-derived antimicrobial peptides
2000
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Accurate design of megadalton-scale two-component icosahedral protein complexes
2016 StandoutScienceNobel
Multimeric structure of ClC-1 chloride channel revealed by mutations in dominant myotonia congenita (Thomsen).
1994
Inhibitors of the Tick-Borne, Hemorrhagic Fever-Associated Flaviviruses
2014
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Human immunodeficiency virus type 1 proteinase resistance to symmetric cyclic urea inhibitor analogs
1997
Water as an Active Constituent in Cell Biology
2007 Standout
Ordered water in macromolecular structure
1994
Thermodynamic Contributions of the Ordered Water Molecule in HIV-1 Protease
2003
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains
2012
Quorum Sensing in Bacteria
2001 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Clinical evidence and bioinformatics characterization of potential hepatitis C virus resistance pathways for sofosbuvir
2014
The Canyon Hypothesis
1989
Molecular Structure and Physiological Function of Chloride Channels
2002
Ion permeation and selectivity in ClC-type chloride channels
2001
Inward Rectification in ClC-0 Chloride Channels Caused by Mutations in Several Protein Regions
1997
Synthesis of Native Proteins by Chemical Ligation
2000
Structure-Based Strategies for Drug Design and Discovery
1992 Science
Degradation of Human Antimicrobial Peptide LL-37 by Staphylococcus aureus -Derived Proteinases
2004
Organic Chemistry on Solid Supports
1996
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Organische Chemie an fester Phase
1996
Examining methods for calculations of binding free energies: LRA, LIE, PDLD-LRA, and PDLD/S-LRA calculations of ligands binding to an HIV protease
2000 StandoutNobel
Capsule Polysaccharide Mediates Bacterial Resistance to Antimicrobial Peptides
2004
Natural and Synthetic Small Boron-Containing Molecules as Potential Inhibitors of Bacterial and Fungal Quorum Sensing
2010
Mathematical Modeling of Subgenomic Hepatitis C Virus Replication in Huh-7 Cells
2006 StandoutNobel
Characterization of the Early Steps of Hepatitis C Virus Infection by Using Luciferase Reporter Viruses
2006
Competing and noncompeting activities of miR-122 and the 5′ exonuclease Xrn1 in regulation of hepatitis C virus replication
2012
A mutation in autosomal dominant myotonia congenita affects pore properties of the muscle chloride channel
1997
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
DMP 323, a nonpeptide cyclic urea inhibitor of human immunodeficiency virus (HIV) protease, specifically and persistently blocks intracellular processing of HIV gag polyprotein
1994
Internal Disequilibria and Phenotypic Diversification during Replication of Hepatitis C Virus in a Noncoevolving Cellular Environment
2017 StandoutNobel
MprF-Mediated Lysinylation of Phospholipids in Staphylococcus aureus Leads to Protection against Oxygen-Independent Neutrophil Killing
2002
Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
1998 Standout
Barrier-Independent, Fitness-Associated Differences in Sofosbuvir Efficacy against Hepatitis C Virus
2016 StandoutNobel
Works of Michaël Otto being referenced
Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: New role for the NADPH oxidase in host defense
2004
Structure–function relationships in the tryptophan‐rich, antimicrobial peptide indolicidin
2001
Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system
2004
Clevudine: a potent inhibitor of hepatitis B virusin vitroandin vivo
2006
Quorum‐Sensing Control of Biofilm Factors inStaphylococcus epidermidis
2003
A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes
2015
Staphylococcus δ-toxin induces allergic skin disease by activating mast cells
2013 Nature
The role of virulence determinants in community-associated MRSA pathogenesis
2008
Inactivation of the dlt Operon inStaphylococcus aureus Confers Sensitivity to Defensins, Protegrins, and Other Antimicrobial Peptides
1999
Inhibition of virulence factor expression in Staphylococcus aureus by the Staphylococcus epidermidis agr pheromone and derivatives
1999
Structure of the pheromone peptide of the Staphylococcus epidermidis agr system
1998
Looking toward basic science for potential drug discovery targets against community‐associated MRSA
2009
Virulence factors of the coagulase-negative staphylococci
2004
Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus
2012
The Mechanism of Action of β- d -2′-Deoxy-2′-Fluoro-2′- C -Methylcytidine Involves a Second Metabolic Pathway Leading to β- d -2′-Deoxy-2′-Fluoro-2′- C -Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase
2007
Confirmation of linkage of hyperkalaemic periodic paralysis to chromosome 17.
1991
Multiple Mutations in the Human Immunodeficiency Virus Protease Gene Are Responsible for Decreased Susceptibility to Protease Inhibitors
1995
Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues
2002
Evidence for genetic homogeneity in autosomal recessive generalised myotonia (Becker).
1993
The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents That Inhibit Uncoating
1986 Science
Staphylococcus epidermidis pan-genome sequence analysis reveals diversity of skin commensal and hospital infection-associated isolates
2012
In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor
1993
Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d -2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine
2011
Improved cyclic urea inhibitors of the HIV-1 protease: synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450
1996
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl)phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating
1987
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
2012
Staphylococcus aureus Resistance to Human Defensins and Evasion of Neutrophil Killing via the Novel Virulence Factor Mprf Is Based on Modification of Membrane Lipids with l -Lysine
2001
An Assay for HIV RNA in Infected Cell Lysates, and its use for the Rapid Evaluation of Antiviral Efficacy
1994
Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors
1994 Science
Common cold viruses
1987
Dynamics of Subgenomic Hepatitis C Virus Replicon RNA Levels in Huh-7 Cells after Exposure to Nucleoside Antimetabolites
2003
Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication
1997
The Skeletal Muscle Chloride Channel in Dominant and Recessive Human Myotonia
1992 Science
Discovery of a β-d -2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
2010
The d -Alanine Residues of Staphylococcus aureus Teichoic Acids Alter the Susceptibility to Vancomycin and the Activity of Autolytic Enzymes
2000
Design, Synthesis, and Antiviral Activity of 2‘-Deoxy-2‘-fluoro-2‘-C-methylcytidine, a Potent Inhibitor of Hepatitis C Virus Replication
2005
Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA
2011
Inhibition of Hepatitis C Replicon RNA Synthesis by β-D-2′-deoxy-2′-fluoro-2′-C-Methylcytidine: A Specific Inhibitor of Hepatitis C Virus Replication
2006