Standout Papers
Citation Impact
Citing Papers
Complement and microglia mediate early synapse loss in Alzheimer mouse models
2016 StandoutScience
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
2005 StandoutNobel
A New Triggering Receptor Expressed on Myeloid Cells (Trem) Family Member, Trem-Like 4, Binds to Dead Cells and Is a DNAX Activation Protein 12-Linked Marker for Subsets of Mouse Macrophages and Dendritic Cells
2009 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
1996 Standout
Neuronal localization of C1q in preclinical Alzheimer's disease
2003
Two-dimensional crystallization technique for imaging macromolecules, with application to antigen–antibody–complement complexes
1983 StandoutNatureNobel
Distinct expression of C1q‐like family mRNAs in mouse brain and biochemical characterization of their encoded proteins
2010
Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature
2011
Role of Complement and Other Innate Immune Mechanisms in the Removal of Apoptotic Cells
2005
Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity
1999
Function of Rho family proteins in actin dynamics during phagocytosis and engulfment
2000
Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer
2006
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Adiponectin modulates inflammatory reactions via calreticulin receptor–dependent clearance of early apoptotic bodies
2007
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
2007 StandoutNobel
Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9
2005
Pathways for bradykinin formation and inflammatory disease
2002
Complement: a unique innate immune sensor for danger signals
2004
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
2006
Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function
1999
Phagocytosis of apoptotic cells in homeostasis
2015
Ro’s Role in RNA Reconnaissance
2005 StandoutNobel
Regulated portals of entry into the cell
2003 StandoutNature
The cell cycle inhibitor p21 controls T-cell proliferation and sex-linked lupus development
2000
Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice
2003
C1q and its growing family
2006
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Innate recognition systems in insect immunity and development: new approaches in
2000
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity
2012
Features of systemic lupus erythematosus in Dnase1-deficient mice
2000
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
2006 StandoutNature
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
NMR Solution Structure of Complement-like Repeat CR3 from the Low Density Lipoprotein Receptor-related Protein
2000
Function and Specificity of T Cell Subsets in the Mouse
1987
Inefficient Clearance of Dying Cells and Autoreactivity
2006
Toll-Like Receptors and Activation of Autoreactive B Cells
2002
Arthritis Critically Dependent on Innate Immune System Players
2002
Complement Deficiency and Autoimmunitya
1997
C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation
2008
Immunity, Inflammation, and Cancer
2010 Standout
C1q and tumor necrosis factor superfamily: modularity and versatility
2004
The Classical Complement Cascade Mediates CNS Synapse Elimination
2007 Standout
Lupus Erythematosus Associated With Genetically Determined Deficiency of the Second Component of the Complement
2000
DNaseI in pathogenesis of systemic lupus erythematosus
2004
Genetics of Systemic Autoimmunity in Mouse Models of Lupus
2000
Origin and physiological roles of inflammation
2008 StandoutNature
Complement inhibitors: a resurgent concept in anti-inflammatory therapeutics
2000
A blast from the past: clearance of apoptotic cells regulates immune responses
2002
Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
2017
Genetic dissection of systemic lupus erythematosus
1999
Complement
2001
The Ro 60�kDa autoantigen: insights into cellular function and role in autoimmunity
2004
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
A Dominant Complement Fixation Pathway for Pneumococcal Polysaccharides Initiated by SIGN-R1 Interacting with C1q
2006 StandoutNobel
The complement‐derived anaphylatoxin C5a increases microglial GLT‐1 expression and glutamate uptake in a TNF‐α‐independent manner
2009
A Dramatic Increase of C1q Protein in the CNS during Normal Aging
2013
Points of control in inflammation
2002 StandoutNature
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Localization of the binding site for the human high-affinity Fc receptor on IgG
1988 StandoutNatureNobel
The binding site for C1q on IgG
1988 StandoutNatureNobel
Chromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
2002 StandoutNature
Recognizing death: the phagocytosis of apoptotic cells
1998
Susceptibility genes in the pathogenesis of murine lupus.
2002
APOPTOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS
2000
Engulfment of apoptotic cells: signals for a good meal
2007
Intracellular mammalian DNA stimulates myeloid dendritic cells to produce type I interferons predominantly through a toll‐like receptor 9–independent pathway
2006
Spontaneous Autoimmune Disease in FcγRIIB-Deficient Mice Results from Strain-Specific Epistasis
2000
Autoimmune disease: why and where it occurs
2001
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Biochemical and functional characterization of the interaction between pentraxin 3 and C1q
2003
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Impaired apoptosis, extended duration of immune responses, and a lupus-like autoimmune disease in IEX-1-transgenic mice
2002 StandoutNobel
Emerging Marine Diseases--Climate Links and Anthropogenic Factors
1999 Science
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Complement Activation Contributes to Hypoxic-Ischemic Brain Injury in Neonatal Rats
2003
Cutting Edge: Ectopic Expression of CD40 Ligand on B Cells Induces Lupus-Like Autoimmune Disease
2002 StandoutNobel
Immunostimulatory CpG-DNA Activates Murine Microglia
2002
Binding of complement subcomponent Clq to mouse IgGl, IgG2a AND IgG2b: A novel Clq binding assay
1984
Serpin Structure, Mechanism, and Function
2002 Standout
Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer
2003
Expression of CD4 in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex.
1991 StandoutNobel
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Immunoglobulin G: Functional sites
1985
Tolerance induction by thymic medullary epithelium.
1992 StandoutNobel
Historical Overfishing and the Recent Collapse of Coastal Ecosystems
2001 StandoutScience
AN APPETITE FOR APOPTOTIC CELLS? CONTROVERSIES AND CHALLENGES
2000
Central Role of Complement in Passive Protection by Human IgG1 and IgG2 Anti-pneumococcal Antibodies in Mice
2003
Immunologically Active Autoantigens: The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease
2007
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide ofStreptococcus pneumoniaein the marginal zone of mouse spleen
2003 StandoutNobel
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Kinetics of reaction of human C-inhibitor with the human complement system proteases Cr and Cs
1980
Complement Component 1Q (C1Q) Upregulation in Retina of Murine, Primate, and Human Glaucomatous Eyes
2006
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease
2005 StandoutNobel
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
The classical pathway is the dominant complement pathway required for innate immunity toStreptococcus pneumoniaeinfection in mice
2002
Mannose-Binding Lectin-Deficient Mice Display Defective Apoptotic Cell Clearance but No Autoimmune Phenotype
2005
Interleukin 5, a T-cell-derived B-cell differentiation factor also induces cytotoxic T lymphocytes.
1987 StandoutNobel
Complement-dependent Clearance of Apoptotic Cells by Human Macrophages
1998
Chemical analysis and electron microscopy studies of human C1q prepared by different methods
1975
Cutting Edge: The Wiskott-Aldrich Syndrome Protein Is Required for Efficient Phagocytosis of Apoptotic Cells
2001
Characterization of soluble factors that induce the cytolytic activity and the expression of T cell growth factor receptors of a T cell hybrid.
1984
Genetic Influences on the End-Stage Effector Phase of Arthritis
2001
Association of CD4+CD25+T Cells with Prevention of Severe Destructive Arthritis inBorrelia burgdorferi-Vaccinated and Challenged Gamma Interferon-Deficient Mice Treated with Anti-Interleukin-17 Antibody
2004
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Complement C4 Inhibits Systemic Autoimmunity through a Mechanism Independent of Complement Receptors Cr1 and Cr2
2000
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
2005
A Hierarchical Role for Classical Pathway Complement Proteins in the Clearance of Apoptotic Cells in Vivo
2000
THE ENGULFMENT PROCESS OF PROGRAMMED CELL DEATH INCAENORHABDITIS ELEGANS
2004 Nobel
Pyridinedicarboxylates, the first mechanism-derived inhibitors for prolyl 4-hydroxylase, selectively suppress cellular hydroxyprolyl biosynthesis. Decrease in interstitial collagen and Clq secretion in cell culture
1987
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
Apoptotic cells induce Mer tyrosine kinase–dependent blockade of NF-κB activation in dendritic cells
2006
Characterization of the Calcium Site in Two Complement-like Domains from the Low-Density Lipoprotein Receptor-Related Protein (LRP) and Comparison with a Repeat from the Low-Density Lipoprotein Receptor
1998
Legionella PneumophilaPathogenesis: A Fateful Journey from Amoebae to Macrophages
2000
C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells
2001
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes
2004
Nucleosomes Are Exposed at the Cell Surface in Apoptosis
2004
BIOCHEMISTRY OF INSECT VENOMS
1982
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
The immunobiology of TSE diseases
2001
Physiology of Microglia
2011 Standout
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Works of Michael Loos being referenced
Isolation and Characterization of the Kininogen-binding Protein p33 from Endothelial Cells
1996
Expression of C1q, a subcomponent of the rat complement system, is dramatically enhanced in brains of rats with either Borna disease or experimental allergic encephalomyelitis
1995
Isolation, sequence analysis and characterization of cDNA clones coding for the C chain of mouse C1q
1992
Disulfide bridge formation between C1q and IgG in vitro
1990
C1 Inhibitor-C 1 ¯ s
1997
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
1998 Standout
Complement component C1 and the collectins: parallels between routes of acquired and innate immunity
1998
Complement component C1 and the collectins – first-line defense molecules in innate and acquired immunity
2002
Differential Expression of the Murine Mannose-Binding Lectins A and C in Lymphoid and Nonlymphoid Organs and Tissues
2003
Autoantibodies against C1q: view on clinical relevance and pathogenic roles
1999
Modulation of mRNA expression and secretion of C1q in mouse macrophages by anti-inflammatory drugs and cAMP: evidence for the partial involvement of a pathway that includes cyclooxygenase, prostaglandin E2 and adenylate cyclase.
1995
Isolation and partial characterization of a polysaccharide in ant venom (Pseudomyrmex sp.) that activates the classical complement pathway
1979
Autoantibodies to the collagenous region of C1q occur in three strains of lupus-prone mice
1996
Molecular basis of a new type of C1q-deficiency associated with a non-functional low molecular weight (LMW) C1q: parallels and differences to other known genetic C1q-defects
1997
Intracoronary Application of C1 Esterase Inhibitor Improves Cardiac Function and Reduces Myocardial Necrosis in an Experimental Model of Ischemia and Reperfusion
1997
Activation of the first component of complement evidence for an internal activation step.
1972
Interaction of DNP-Antigens with the First Component of Complement (C1)
1977
Gene expression of the A- and B-chain of mouse C1q in different tissues and the characterization of the recombinant A-chain
1991
The functions of endogenous C1q, a subcomponent of the first component of complement, as a receptor on the membrane of macrophages
1982
The inactivator from guinea pig serum — III
1972
The biosynthesis of C1q, the collagen-like and Fc-recognizing molecule of the complement system.
1989
Complement C1q Is Dramatically Up-Regulated in Brain Microglia in Response to Transient Global Cerebral Ischemia
2000
Activation of the First Component of Complement
1972
Follicular dendritic cells, interdigitating cells, and cells of the monocyte-macrophage lineage are the C1q-producing sources in the spleen. Identification of specific cell types by in situ hybridization and immunohistochemical analysis.
1995
Reversible inhibition of C1q release from guinea pig macrophages by 2,2′‐dipyridyl
1978
Collagen-like complement component C1q is a membrane protein of human monocyte-derived macrophages that mediates endocytosis
1995
The role of accessory cells in polyclonal T cell activation. I. Both induction of interleukin 2 production and of interleukin 2 responsiveness by concanavalin A are accessory cell dependent
1983
Autoantibody-Mediated Acquired Deficiency of C1 Inhibitor
1987
Trinitrophenylated Red Cells (E-TNP) as a Model for Antibody-Independent Activation of the Complement System via the Classical Pathway
1978
A 66-kilodalton heat shock protein of Salmonella typhimurium is responsible for binding of the bacterium to intestinal mucus
1992
Component Deficiencies 1. The First Component: Clq, Clr, Cls
2015
IL-17 regulates gene expression and protein synthesis of the complement system, C3 and factor B, in skin fibroblasts
2000
Antibody-independent binding of the first component of complement (C1) and its subcomponent C1q to the S and R forms of Salmonella minnesota
1981
Biosynthesis of the First Component of Complement by Human and Guinea Pig Peritoneal Macrophages: Evidence for an Independent Production of the C1 Subunits
1978