Standout Papers
Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo
2006
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
A small-molecule switch for Golgi sulfotransferases
2004 StandoutNobel
Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction
2010 StandoutScienceNobel
Copper-free click chemistry in living animals
2010 StandoutNobel
Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents
2010
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Affinity mass spectrometry from a tailored porous silicon surfaceElectronic supplementary information (ESI) available: synthesis and characterization of new compounds, experimental details. See http://www.rsc.org/suppdata/cc/b4/b408200a/
2004
Evolution of a designed retro-aldolase leads to complete active site remodeling
2013 StandoutNobel
Synthesis of 3-(1,2,3-triazol-1-yl)- and 3-(1,2,3-triazol-4-yl)-substituted pyrazolo[3,4-d]pyrimidin-4-amines via click chemistry: potential inhibitors of the Plasmodium falciparum PfPK7 protein kinase
2009
Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance
2005 StandoutNobel
Chemical and biochemical strategies for the randomization of protein encoding DNA sequences: library construction methods for directed evolution
2004
Biological functions of fucose in mammals
2017
The chemistry and biology of mucin-type O-linked glycosylation
2005 StandoutNobel
Chemical Technologies for Probing Glycans
2006 StandoutNobel
A two stage click-based library of protein tyrosine phosphatase inhibitors
2006
Enzyme (re)design: lessons from natural evolution and computation
2009
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
PRODRG: a tool for high-throughput crystallography of protein–ligand complexes
2004 Standout
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Heterogeneous Catalysis through Microcontact Printing
2008 StandoutNobel
The Structures of Four Macrolide Antibiotics Bound to the Large Ribosomal Subunit
2002 StandoutNobel
Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design
2011 StandoutNobel
Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design
2013 StandoutNobel
Design and synthesis of β-methoxyacrylate analogues via click chemistry and biological evaluations
2007
Preparation of triazole-linked glycosylated α-ketocarboxylic acid derivatives as new PTP1B inhibitors
2010
Click chemistry: a new facile and efficient strategy for preparation of functionalized HPLC packings
2006
The Origin of Stereoselectivity in Primary Amino Acid Catalyzed Intermolecular Aldol Reactions
2005
Use of Click Chemistry to Define the Substrate Specificity of Leishmania β‐1,2‐Mannosyltransferases
2006
Computational Enzyme Design
2013 StandoutNobel
Mechanism of the Ligand‐Free CuI‐Catalyzed Azide–Alkyne Cycloaddition Reaction
2005
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Fluorous click chemistry as a practical tagging method
2005
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
Amino Acid Catalyzed Neogenesis of Carbohydrates: A Plausible Ancient Transformation
2005
Click chemistry reactions in medicinal chemistry: Applications of the 1,3‐dipolar cycloaddition between azides and alkynes
2007
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome
2012
Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions
2010
The growing applications of click chemistry
2007 Standout
Analysis of the Class I Aldolase Binding Site Architecture Based on the Crystal Structure of 2-Deoxyribose-5-phosphate Aldolase at 0.99 Å Resolution
2004
The involvement of RNA in ribosome function
2002 StandoutNatureNobel
Direct Amino Acid Catalyzed Asymmetric Synthesis of Polyketide Sugars
2004
Glycans in cancer and inflammation — potential for therapeutics and diagnostics
2005 StandoutNobel
Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: Novel construction of PTP1B inhibitors on a sugar scaffold
2011
Direct Asymmetric Intermolecular Aldol Reactions Catalyzed by Amino Acids and Small Peptides
2006
The growing impact of click chemistry on drug discovery
2003 StandoutNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics
2007
Metabolic Labeling of Glycans with Azido Sugars for Visualization and Glycoproteomics
2006 StandoutNobel
Chemical remodelling of cell surfaces in living animals
2004 StandoutNatureNobel
Chemoenzymatic synthesis of oligosaccharides and glycoproteins
2004
Microtiter plate based chemistry and in situ screening: a useful approach for rapid inhibitor discovery
2006
X-ray observation of a transient hemiaminal trapped in a porous network
2009 Nature
Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase
2016 StandoutNobel
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
Towards Organo‐Click Chemistry: Development of Organocatalytic Multicomponent Reactions Through Combinations of Aldol, Wittig, Knoevenagel, Michael, Diels–Alder and Huisgen Cycloaddition Reactions
2004
“Click” synthesis of small-molecule inhibitors targeting caspases
2008
The use of click chemistry in the emerging field of catalomics
2010
Fluorogenic 1,3‐Dipolar Cycloaddition within the Hydrophobic Core of a Shell Cross‐Linked Nanoparticle
2006
High-throughput synthesis of azide libraries suitable for direct “click” chemistry and in situ screening
2009
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Peptidomimetics via copper-catalyzed azide–alkyne cycloadditions
2007
A Rationally Designed Aldolase Foldamer
2008
Design and synthesis of O-GlcNAcase inhibitors via ‘click chemistry’ and biological evaluations
2011
The Organic Approach to Asymmetric Catalysis
2006 StandoutScienceNobel
Rapid synthesis of Abelson tyrosine kinase inhibitors using click chemistry
2009
Mechanism of the Class I KDPG aldolase
2006
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Synthesis of azide/alkyne-terminal polymers and application for surface functionalisation through a [2 + 3] Huisgen cycloaddition process, “click chemistry”
2007
Organic Azides: An Exploding Diversity of a Unique Class of Compounds
2005 Standout
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
The small peptide-catalyzed direct asymmetric aldol reaction in water
2005
Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates
2004 StandoutNobel
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Synthetic utility of glycosyl triazoles in carbohydrate chemistry
2006
An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket
2009
Direct Observation of an Enamine Intermediate in Amine Catalysis
2009
A new solvent system for efficient synthesis of 1,2,3-triazoles
2006
Versatile 5‘-Functionalization of Oligonucleotides on Solid Support: Amines, Azides, Thiols, and Thioethers via Phosphorus Chemistry
2004
New mechanistic studies on the proline-catalyzed aldol reaction
2004 StandoutNobel
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
2008 StandoutScienceNobel
Quantum Mechanical Design of Enzyme Active Sites
2008
Amino Acid‐Catalyzed Asymmetric Carbohydrate Formation: Organocatalytic One‐Step De Novo Synthesis of Keto and Amino Sugars
2006
Solid phase synthesis of peptidotriazoles with multiple cycles of triazole formation
2005
Development of Small Designer Aldolase Enzymes: Catalytic Activity, Folding, and Substrate Specificity
2005
Reusable Polymer-Supported Catalyst for the [3+2] Huisgen Cycloaddition in Automation Protocols
2006
Chiral Primary Amine Catalyzed Asymmetric Direct Cross‐Aldol Reaction of Acetaldehyde
2011
Samarium(II)-Iodide-Mediated Cyclizations in Natural Product Synthesis
2004 Standout
Copper-free click chemistry for dynamic in vivo imaging
2007 StandoutNobel
Well‐controlled polymerization of 2‐azidoethyl methacrylate at near room temperature and click functionalization
2007
Synthesis of 1,4,5-trisubstituted-1,2,3-triazoles by copper-catalyzed cycloaddition-coupling of azides and terminal alkynes
2006
Harnessing Protein Symmetry for Enzyme Design
2012
Click-Chemistry-Derived Triazole Ligands of Arginine−Glycine−Aspartate (RGD) Integrins with a Broad Capacity To Inhibit Adhesion of Melanoma Cells and Both in Vitro and in Vivo Angiogenesis
2010
Organocatalytic Direct Asymmetric Aldol Reactions in Water
2005
The Simplest "Enzyme"
2002 Science
Synthesis of hemicyanine dyes for ‘click’ bioconjugation
2005
Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules
2009
Synthesis of Sugar Arrays in Microtiter Plate
2002
‘Click chemistry’ on polysaccharides: a convenient, general, and monitorable approach to develop (1→3)-β-d-glucans with various functional appendages
2005
Copper‐in‐Charcoal‐Catalyzed, Tandem One‐Pot Diazo Transfer‐Click Reactions
2009
An Efficient Approach to the Discovery of Potent Inhibitors against Glycosyltransferases
2010
Discovery and Protein Engineering of Biocatalysts for Organic Synthesis
2011
C−C Bond-Forming Lyases in Organic Synthesis
2011
Primary amine catalyzed direct asymmetric aldol reaction assisted by water
2005
Activation Energies and Reaction Energetics for 1,3‐Dipolar Cycloadditions of Hydrazoic Acid with CC and CN Multiple Bonds from High‐Accuracy and Density Functional Quantum Mechanical Calculations
2005
Gerichtete Evolution stereoselektiver Enzyme: Eine ergiebige Katalysator‐Quelle für asymmetrische Reaktionen
2010
Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I.
1990
A direct intramolecular asymmetric catalytic aldol cyclodehydration of meso-3,4-disubstituted-1,6-dialdehydes
2004
Confined acids catalyze asymmetric single aldolizations of acetaldehyde enolates
2018 StandoutScienceNobel
The Application of “Click Chemistry” for the Decoration of 2(1H)-Pyrazinone Scaffold: Generation of Templates
2005
Organocatalytic Direct Asymmetric Aldol Reactions in Water.
2006
Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)
2010
Imaging the glycome
2008 StandoutNobel
Click Chemistry on Curdlan: A Regioselective and Quantitative Approach to Develop Artificial β-1,3-Glucans with Various Functional Appendages
2005
High-throughput identification of fucosyltransferase inhibitors using carbohydrate microarrays
2004
Click chemistry in materials synthesis. 1. Adhesive polymers from copper‐catalyzed azide‐alkyne cycloaddition
2004 StandoutNobel
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
The Chemistry and Applications of Metal-Organic Frameworks
2013 StandoutScienceNobel
Recent Advances in Aldolase‐Catalyzed Asymmetric Synthesis
2007
Click for PET: rapid preparation of [18F]fluoropeptides using CuI catalyzed 1,3-dipolar cycloaddition
2006
Catalytic “Click” Rotaxanes: A Substoichiometric Metal-Template Pathway to Mechanically Interlocked Architectures
2006
Mechanism of the Ligand‐Free CuI‐Catalyzed Azide–Alkyne Cycloaddition Reaction
2005
Proline-catalyzed asymmetric reactions
2002 StandoutNobel
Catalytic Versatility, Stability, and Evolution of the (βα)8-Barrel Enzyme Fold
2005
A Novel Potent Nicotinamide Phosphoribosyltransferase Inhibitor Synthesized via Click Chemistry
2009
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Asymmetric Enamine Catalysis
2007 StandoutNobel
CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective
2005
Chemical Glycoproteomics
2016 StandoutNobel
Application of copper(I)-catalysed azide/alkyne cycloaddition (CuAAC) ‘click chemistry’ in carbohydrate drug and neoglycopolymer synthesis
2010
Application of Designed Enzymes in Organic Synthesis
2011
Design of Acid−Base Catalysis for the Asymmetric Direct Aldol Reaction
2004
Indium(III) triflate catalyzed tandem azidation/1,3-dipolar cycloaddition reaction of ω,ω-dialkoxyalkyne derivatives with trimethylsilyl azide
2005
Works of Michael L. Mitchell being referenced
Observation of Covalent Intermediates in an Enzyme Mechanism at Atomic Resolution
2001 Science
Directed evolution of N-acetylneuraminic acid aldolase to catalyze enantiomeric aldol reactions
2003
Australine, a pyrrolizidine alkaloid that inhibits amyloglucosidase and glycoprotein processing
1989
Synthesis and Evaluation of Transition-State Analogue Inhibitors of α-1,3-Fucosyltransferase This work was supported by the NIH and the Skaggs Institute. M.L.M. acknowledges fellowships from UNCFâMerck Science Initiative and Skaggs Predoctoral Fellows Program.
2002
Chemical-Enzymatic Synthesis of Iminocyclitol Phosphonic Acids
2001
A Potent and Highly Selective Inhibitor of Human α-1,3-Fucosyltransferase via Click Chemistry
2003 StandoutNobel
Synthesis and evaluation of six-membered GDP-iminocyclitol
2002
The effect of lithium bromide and lithium chloride on the reactivity of SmI2 in THF
1997