Michael Kiffe

Epothilones – A fascinating family of microtubule stabilizing antitumor agents

3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters

Therapeutic potential of resveratrol: the in vivo evidence

Natural products: A continuing source of novel drug leads

Natural products: An evolving role in future drug discovery

The merger of natural product synthesis and medicinal chemistry: on the chemistry and chemical biology of epothilones

Catalytic Antibody Route to the Naturally Occurring Epothilones: Total Synthesis of Epothilones A-F

Anticancer drugs from nature—natural products as a unique source of new microtubule-stabilizing agents

Natural products for cancer chemotherapy

Natural products to drugs: natural product-derived compounds in clinical trials

Studies on the Biosynthesis of Epothilones: The Biosynthetic Origin of the Carbon Skeleton.

Hormesis: from marginalization to mainstream

Profiling drug-like properties in discovery research

Targeted protein degradation as a powerful research tool in basic biology and drug target discovery

Synthesis of Furano‐Epothilone D

High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis

PROTAC targeted protein degraders: the past is prologue

Recent developments in the chemistry, biology and medicine of the epothilones

The Chemistry and Biology of Epothilones—The Wheel Keeps Turning

Synthesis of natural-product-based compound libraries

Targeting ferroptosis as a vulnerability in cancer

Myxobacterial secondary metabolites: bioactivities and modes-of-action

Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

Genotoxicity and anti-genotoxicity of some traditional medicinal herbs

Biological effects of essential oils – A review

Shifting Native Chemical Ligation into Reverse through N→S Acyl Transfer

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

Antitubulin agents for the treatment of cancer – a medicinal chemistry update

Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway

Synthesis of Epothilone 16,17‐Alkyne Analogs by Replacement of the C13−C15(O)‐Ring Segment of Natural Epothilone C

Seven Post-synthetic Covalent Reactions in Tandem Leading to Enzyme-like Complexity within Metal–Organic Framework Crystals

Iterative catalyst controlled diastereodivergent synthesis of polypropionates

Oxadiazoles in Medicinal Chemistry

Transition Metal-Catalyzed Organometallic Reactions that Have Revolutionized Organic Synthesis

Catalytic Enantioselective Addition of Allylic Organometallic Reagents to Aldehydes and Ketones

Multicomponent reactions: advanced tools for sustainable organic synthesis

Advances in Fmoc solid‐phase peptide synthesis

The Binding Mode of Epothilone A on α,ß-Tubulin by Electron Crystallography

Epothilones: new tubulin polymerization agents in preclinical and clinical development

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis

A Novel Application of a Pd(0)-Catalyzed Nucleophilic Substitution Reaction to the Regio- and Stereoselective Synthesis of Lactam Analogues of the Epothilone Natural Products

Total Synthesis and Antitumor Activity of 12,13-Desoxyepothilone F:  An Unexpected Solvolysis Problem at C15, Mediated by Remote Substitution at C21

Amino Acid-Protecting Groups

Fmoc-Based Synthesis of Peptide α-Thioesters Using an Aryl Hydrazine Support

Biphasic Dose Response in Low Level Light Therapy

An Efficient Total Synthesis of (−)-Epothilone B

A Combinatorial Synthesis of a Macrosphelide Library Utilizing a Palladium‐Catalyzed Carbonylation on a Polymer Support

Hydroxymethylfurfural, A Versatile Platform Chemical Made from Renewable Resources

Targeted inhibition of the COP9 signalosome for treatment of cancer

Derivatization of the C12 C13 functional groups of epothilones A, B and C

Oxidative and reductive transformations of epothilone A

Characterization of cytotoxic and genotoxic effects of different compounds in CHO K5 cells with the comet assay (single-cell gel electrophoresis assay)

N-Oxidation of Epothilone A-C andO-Acyl Rearrangement to C-19- and C-21-Substituted Epothilones

N-Oxidation von Epothilon A–C undO-Acylumlagerung zu C-19- und C-21-substituierten Epothilonen

SAR and pH Stability of Cyano-Substituted Epothilones

N-Oxidation von Epothilon A–C und O-Acylumlagerung zu C-19- und C-21-substituierten Epothilonen

New mild acid‐labile protecting groups for the guanidino function of N^α‐fluorenylmethoxycarbonyl‐l‐arginine in solid‐phase peptide synthesis: 10, 11‐dihydro‐5H‐dibenzo[a, d]. cyclohepten‐5‐yl, 2‐methoxy‐10, 11‐dihydoro‐5H‐dibenzo[a, d]. cyclohepten‐5‐yl and 5H‐dibenzo[a, d]. cyclohepten‐5‐yl groups

Antibiotics from Gliding Bacteria, LXXIX. – Chemical Modification of the Antifungal Macrolide Soraphen A_1α: Deoxygenation in the South‐East Ring Segment