Standout Papers
Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body
2004 Science
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
A Phase I Study of the AKT Inhibitor MK-2206 in Combination with Hormonal Therapy in Postmenopausal Women with Estrogen Receptor–Positive Metastatic Breast Cancer
2016
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
2003
Redox Regulation of Forkhead Proteins Through a p66shc -Dependent Signaling Pathway
2002 Science
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
PKB/AKT: functional insights from genetic models
2001
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
2001
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
2011
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
The Plasticity of Aging: Insights from Long-Lived Mutants
2005
PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy
2002
Allosteric Modulation of Muscarinic Acetylcholine Receptors
2007
A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity
2008
Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy
2004 Standout
Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1)
2004
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
2001 StandoutNobel
FOXO transcription factors: key regulators of cellular quality control
2014
Apoptosis in the nervous system
2000 StandoutNature
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
2000
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
1999
Survival Factor-Mediated BAD Phosphorylation Raises the Mitochondrial Threshold for Apoptosis
2002
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
2003
AKT/PKB Signaling: Navigating Downstream
2007 Standout
S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt
2006
Tyrosine Phosphorylation of p85 Relieves Its Inhibitory Activity on Phosphatidylinositol 3-Kinase
2001
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B
1999
PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization
2002
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Negative Regulation of the Forkhead Transcription Factor FKHR by Akt
1999
Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice
1995 StandoutNatureNobel
The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes
2002
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
2012
Phosphatidylinositol 3-Kinase Signaling Inhibits DAF-16 DNA Binding and Function via 14-3-3-dependent and 14-3-3-independent Pathways
2001 StandoutNobel
FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts
2003
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
TOR, a Central Controller of Cell Growth
2000 Standout
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
2001
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
2001
Akt-dependent transformation: there is more to growth than just surviving
2005
Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting
2005
Cellular survival: a play in three Akts
1999 Standout
Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16
2003
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
2002 StandoutNature
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans
1999 StandoutNobel
Structural Basis for DNA Recognition by FoxO1 and Its Regulation by Posttranslational Modification
2008
Increased AKT Activity Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and Diminishing p27Kip1 Expression
2000
Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic
1995
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Reward and aversion in a heterogeneous midbrain dopamine system
2013
Opposing Roles for Akt1 and Akt2 in Rac/Pak Signaling and Cell Migration
2006
The Akt-regulated Forkhead Transcription Factor FOXO3a Controls Endothelial Cell Viability through Modulation of the Caspase-8 Inhibitor FLIP
2004
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
BCL-2 family members and the mitochondria in apoptosis
1999 Standout
In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation
2003
A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR
2002
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
The Protooncogene TCL1 Is an Akt Kinase Coactivator
2000
Phosphorylation of Serine 256 by Protein Kinase B Disrupts Transactivation by FKHR and Mediates Effects of Insulin on Insulin-like Growth Factor-binding Protein-1 Promoter Activity through a Conserved Insulin Response Sequence
1999
FoxO6, a Novel Member of the FoxO Class of Transcription Factors with Distinct Shuttling Dynamics
2003
14‐3‐3 suppresses the nuclear localization of threonine 157‐phosphorylated p27Kip1
2004
SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling
2000
A distributional code for value in dopamine-based reinforcement learning
2020 StandoutNatureNobel
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
2009
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
2000
Signaling—2000 and Beyond
2000 Standout
Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane
2001
Inhibition of PI3K/mTOR Leads to Adaptive Resistance in Matrix-Attached Cancer Cells
2012
Use of RNA Interference-mediated Gene Silencing and Adenoviral Overexpression to Elucidate the Roles of AKT/Protein Kinase B Isoforms in Insulin Actions
2003
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
2006
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway
2003
A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation
2009
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
A TRP Channel that Senses Cold Stimuli and Menthol
2002 StandoutNobel
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
2000 Nature
Phosphatidylinositol (3,4,5)P3 Is Essential but Not Sufficient for Protein Kinase B (PKB) Activation; Phosphatidylinositol (3,4)P2 Is Required for PKB Phosphorylation at Ser-473
2002
The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors
2004 Standout
Insulin Stimulates Phosphorylation of the Forkhead Transcription Factor FKHR on Serine 253 through a Wortmannin-sensitive Pathway
1999
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
2001
The mosaic that is our genome
2003 StandoutNatureNobel
Regulation of Phosphoenolpyruvate Carboxykinase and Insulin-like Growth Factor-binding Protein-1 Gene Expression by Insulin
2000
Insulin Inhibits the Activation of Transcription by a C-terminal Fragment of the Forkhead Transcription Factor FKHR
2000
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Foxo Transcription Factors Control Regulatory T Cell Development and Function
2010
A novel family of genes encoding putative pheromone receptors in mammals
1995 StandoutNobel
Expressionof Drosophila FOXO regulates growth and can phenocopy starvation
2003
Forkhead transcription factors are targets of signalling by the proto‐oncogene PKB (C‐AKT)
2000
Genetic pathways that regulate ageing in model organisms
2000 Nature
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation
2004
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
2003 Nature
AKT/PKB Signaling: Navigating the Network
2017 Standout
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
1999 Nature
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
Binding and Phosphorylation of Par-4 by Akt Is Essential for Cancer Cell Survival
2005
Regulation of Oxidative Stress by the Anti-aging Hormone Klotho*♦
2005
Peptide and Protein Library Screening Defines Optimal Substrate Motifs for AKT/PKB
2000
Signaling pathways controlling skeletal muscle mass
2013
Molecular evolution of FOXP2, a gene involved in speech and language
2002 StandoutNatureNobel
A motif-based profile scanning approach for genome-wide prediction of signaling pathways
2001
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
1999 StandoutNature
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
2016
Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1
2006
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
2002
Brain angiotensin receptor subtypes in the control of physiological and behavioral responses
1994
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
The Extending Network of FOXO Transcriptional Target Genes
2010
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
2001
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons
2003
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)
1999 Science
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Dopamine Induces a PI3-Kinase-Independent Activation of Akt in Striatal Neurons: A New Route to cAMP Response Element-Binding Protein Phosphorylation
2002
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Neurotrophins: Roles in Neuronal Development and Function
2001 Standout
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
2009
Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1
2001
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal
2002
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
A VAMP-Binding Protein from Aplysia Required for Neurotransmitter Release
1995 StandoutScienceNobel
Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B
1999
The PI3K‒PDK1 connection: more than just a road to PKB
2000
Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation
2016
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
14-3-3 Proteins and Survival Kinases Cooperate to Inactivate BAD by BH3 Domain Phosphorylation
2000
Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27KIP1
2000
Insulin-Like Growth Factor-Mediated Muscle Cell Survival: Central Roles for Akt and Cyclin-Dependent Kinase Inhibitor p21
2000
F‐domain valency determines outcome of signaling through the angiopoietin pathway
2021 StandoutNobel
The Amount of Scurfin Protein Determines Peripheral T Cell Number and Responsiveness
2001 StandoutNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo
2000
Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells
2002
Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation
2003
Somatic and behavioural postnatal effects of fetal injections of nerve growth factor antibodies in the rat
1981 StandoutNatureNobel
The role of nerve-growth factor (NGF) in the central nervous system
1976
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
Activation of Akt (Protein Kinase B) in Mammary Epithelium Provides a Critical Cell Survival Signal Required for Tumor Progression
2001
The Developmental Biology of Brain Tumors
2001
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
A MOLECULAR DESCRIPTION OF NERVE TERMINAL FUNCTION
1983
A Dual Role for Src Homology 2 Domain–Containing Inositol-5-Phosphatase (Ship) in Immunity
2000
mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
2009
Hepatic Akt Activation Induces Marked Hypoglycemia, Hepatomegaly, and Hypertriglyceridemia With Sterol Regulatory Element Binding Protein Involvement
2003
Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors
2002
Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN
2000
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
1999 StandoutScience
Modulation of Akt kinase activity by binding to Hsp90
2000
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein
2002 Science
Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)
2001
Regulation of insulin-like growth factor–dependent myoblast differentiation by Foxo forkhead transcription factors
2003
Neurally Mediated Increase in Dopamine-β-Hydroxylase Activity
1970 StandoutNobel
Connections of the corticomedial amygdala in the golden hamster. I. Efferents of the “vomeronasal amygdala”
1981
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
2001
Targeted Investigation of the Neandertal Genome by Array-Based Sequence Capture
2010 StandoutScienceNobel
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
1999
The PI3K–PDK1 connection: more than just a road to PKB
2000
Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR
2000
The Many Forks in FOXO's Road
2003
Works of Michael J. Zigmond being referenced
Lesions of the dopaminergic nigrostriatal system in neonatal rats: effects on the electrophysiological activity of striatal neurons recorded during adulthood
1990
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
1999 Standout
Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex
1989
Characterization of the impaired feeding behavior in rats given haloperidol or dopamine-depleting brain lesions
1990
Animal Models of Parkinsonism Using Selective Neurotoxins: Clinical and Basic Implications
1989
Regulation of dopamine synthesis in striatal synaptosomes during depolarization
1979
A Role for α-Synuclein in the Regulation of Dopamine Biosynthesis
2002
Deficits in Feeding Behavior after Intraventricular Injection of 6-Hydroxydopamine in Rats
1972 Science
Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections.
1996
The effect of McN‐A‐343 on muscarinic receptors in the cerebral cortex and heart
1983
Recovery of Feeding and Drinking by Rats after Intraventricular 6-Hydroxydopamine or Lateral Hypothalamic Lesions
1973 Science
Disruption of copulation in male rats after hypothalamic lesions: A behavioral, anatomical and neurochemical analysis
1973
ENZYMATIC CONVERSION OF NOREPINEPHRINE TO EPINEPHRINE BY THE BRAIN
1969
A role for alpha-synuclein in the regulation of dopamine biosynthesis.
2002
Effects on homeostasis of intraventricular injections of 6-hydroxydopamine in rats.
1974