Citation Impact
Citing Papers
Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations
2014
Development and Characterization of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma Tumorgrafts
2012
PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials
2012
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
2005 StandoutScience
mTOR Inhibition Induces Upstream Receptor Tyrosine Kinase Signaling and Activates Akt
2006 Standout
Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle
2015
Development of siRNA Payloads to Target KRAS -Mutant Cancer
2014
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
Calcium-dependent Regulation of Protein Kinase D Revealed by a Genetically Encoded Kinase Activity Reporter
2006 StandoutNobel
Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5
2003
Targeted glycan degradation potentiates the anticancer immune response in vivo
2020 StandoutNobel
Oncogenic KRAS signalling in pancreatic cancer
2014
Imaging beyond the proteome
2012 StandoutNobel
Insulin-stimulated GLUT4 Translocation in Adipocytes Is Dependent upon Cortical Actin Remodeling
2001
Spatio-temporal Dynamics of Protein Kinase B/Akt Signaling Revealed by a Genetically Encoded Fluorescent Reporter
2004 StandoutNobel
mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes
2005
cGMP-dependent Protein Kinase Inhibits Serum-response Element-dependent Transcription by Inhibiting Rho Activation and Functions
2002
Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
2014 Standout
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
Cancer nanomedicine: progress, challenges and opportunities
2016 Standout
Mechanism and medical implications of mammalian autophagy
2018 Standout
Forces in Tissue Morphogenesis and Patterning
2013 Standout
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
2009 Standout
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
2008 Standout
PDK1, the master regulator of AGC kinase signal transduction
2004
Malignant astrocytic glioma: genetics, biology, and paths to treatment
2007 Standout
Patient-derived tumour xenografts as models for oncology drug development
2012
Hepatocellular carcinoma
2021 Standout
CRISPR-Cas9 screens identify regulators of antibody–drug conjugate toxicity
2019 StandoutNobel
Effects of extracellular matrix viscoelasticity on cellular behaviour
2020 StandoutNature
Survivors of childhood and adolescent cancer: life-long risks and responsibilities
2013 Standout
Regulation of Insulin Action by Ceramide
2004
Getting personalized cancer genome analysis into the clinic: the challenges in bioinformatics
2012
The Structure and Function of PKN, a Protein Kinase Having a Catalytic Domain Homologous to That of PKC
2003
Rho GTPases in cell biology
2002 StandoutNature
Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila
2002
PTEN, more than the AKT pathway
2007
Role of the cytoskeleton during leukocyte responses
2004
Attenuated T Cell Responses to a High-Potency Ligand In Vivo
2010 StandoutNobel
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
2001
Phosphatidylinositol 3‐kinases in tumor progression
2001
A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumors
2013
Role of Rho family GTPases in epithelial morphogenesis
2002
Mechanisms of resistance to therapies targeting BRCA-mutant cancers
2013
Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production
2005
Apoptosis
2002 Standout
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
2006 Standout
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function
2006
Challenges and opportunities in childhood cancer drug development
2012
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Defining the Role of mTOR in Cancer
2007 Standout
Targeting autophagy in cancer
2017 Standout
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Crosstalk in NF-κB signaling pathways
2011 Standout
Targeting ferroptosis as a vulnerability in cancer
2022 Standout
Prospects for MEK inhibitors for treating cancer
2014
Advanced methodologies to formulate nanotheragnostic agents for combined drug delivery and imaging
2011
AKT/PKB Signaling: Navigating the Network
2017 Standout
The functions and regulation of the PTEN tumour suppressor
2012 Standout
Protein Kinase C θ (PKCθ)-dependent Phosphorylation of PDK1 at Ser504 and Ser532 Contributes to Palmitate-induced Insulin Resistance
2008
The PI3K Pathway in Human Disease
2017 Standout
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
2009 StandoutNobel
Predictive in vivo animal models and translation to clinical trials
2012
Novel patient-derived preclinical models of liver cancer
2020
Recent advances in the protein kinase B signaling pathway
2005
Integrating cell-signalling pathways with NF-κB and IKK function
2006 Standout
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
2018 Standout
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
2006 Standout
Liver organoids: from basic research to therapeutic applications
2019
Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction
2006 Standout
FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes
2005
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
2005 Standout
T cell receptor for antigen induces linker for activation of T cell–dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2
2006
Phosphoflow Protocol for Signaling Studies in Human and Murine B Cell Subpopulations
2020
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Fluorescent Sensors for Measuring Metal Ions in Living Systems
2014 Standout
Patient-Derived Tumor Xenografts: Transforming Clinical Samples into Mouse Models
2013
Critical nodes in signalling pathways: insights into insulin action
2006 Standout
Mechanisms of Diabetic Complications
2013 Standout
Ca2+Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase
2003 Standout
IκB kinase β phosphorylates Dok1 serines in response to TNF, IL-1, or γ radiation
2004
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Regulation of insulin and type 1 insulin‐like growth factor signaling and action by the G rb10/14 and SH 2B 1/B 2 adaptor proteins
2012
Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications
2012 Standout
Cellular uptake of nanoparticles: journey inside the cell
2017 Standout
Photothermal Adjunctive Cytoreductive Surgery for Treating Peritoneal Metastasis of Gastric Cancer
2018
Primary Human Non‐Small Cell Lung and Pancreatic Tumorgraft Models—Utility and Applications in Drug Discovery and Tumor Biology
2013
T Cell Activation
2009 Standout
Works of Michael J. Wick being referenced
The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer
2012
A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced Cancer
2011
Efficacy of Weekly Docetaxel and Bevacizumab in Mesenchymal Chondrosarcoma: A New Theranostic Method Combining Xenografted Biopsies with a Mathematical Model
2008
SLC46A3 as a Potential Predictive Biomarker for Antibody–Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads
2018
Insulin Receptor-mediated p62dok Tyrosine Phosphorylation at Residues 362 and 398 Plays Distinct Roles for Binding GTPase-activating Protein and Nck and Is Essential for Inhibiting Insulin-stimulated Activation of Ras and Akt
2001
Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092
2015
Mouse 3-Phosphoinositide-dependent Protein Kinase-1 Undergoes Dimerization and trans-Phosphorylation in the Activation Loop
2003
Substitution of the Autophosphorylation Site Thr516with a Negatively Charged Residue Confers Constitutive Activity to Mouse 3-Phosphoinositide-dependent Protein Kinase-1 in Cells
2002
Mechanism of Phosphorylation of Protein Kinase B/Akt by a Constitutively Active 3-Phosphoinositide-dependent Protein Kinase-1
2000
Prioritizing Phase I Treatment Options Through Preclinical Testing on Personalized Tumorgraft
2011
Nuclear translocation of 3′-phosphoinositide-dependent protein kinase 1 (PDK-1): A potential regulatory mechanism for PDK-1 function
2003
Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton
2000
Abstract 2764: Effect of PNT2258 combinations with docetaxel, dacarbazine, or vemurafenib on the A375 melanoma xenograft
2012