Standout Papers
- Nucleotide sequence of bacteriophage φX174 DNA (1977)
- Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding (1982)
- Role of arginine-38 in regulation of the cytochrome c oxidation-reduction equilibrium (1989)
- DNA sequence at the C termini of the overlapping genes A and B in bacteriophage φX174 (1977)
Citation Impact
Citing Papers
Identification of functional similarities between proteins using directed evolution
2003 StandoutNobel
[57] Sequencing end-labeled DNA with base-specific chemical cleavages
1980 StandoutNobel
Dissecting the catalytic triad of a serine protease
1988 Nature
Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine·guanine base pairs
1987 StandoutNobel
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains
1988 StandoutScience
The development of mechanistic enzymology in the 20th century
2001
Electrostatic control of charge separation in bacterial photosynthesis
1990 StandoutNobel
Calculation of the Redox Potentials of Iron-Sulfur Proteins: The 2-/3- Couple of [Fe4S4Cys4] Clusters in Peptococcus aerogenes Ferredoxin, Azotobacter vinelandii Ferredoxin I, and Chromatium vinosum High-Potential Iron Protein
1994 StandoutNobel
HIV infection does not require endocytosis of its receptor, CD4
1988 StandoutNobel
Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb
1989 StandoutNobel
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing
1987
[2] New M13 vectors for cloning
1983 Standout
Deletion of the cytoplasmic domain of the polymeric immunoglobulin receptor prevents basolateral localization and endocytosis
1986
Rat epidermal growth factor: complete amino acid sequence
1985
A gene which encodes a predicted protein kinase can restore some functions of the ras gene in fission yeast.
1988
[60] Computer analysis of nucleic acids and proteins
1980
Nucleotide sequence and topography of chicken c-fps
1985 StandoutNobel
Characterization of yeast iso-1-cytochrome c mRNA.
1980
Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone
1977 Nature
Homology between the ran1+ gene of fission yeast and protein kinases.
1986
Basis of biological specificity
1984
Construction of heterodimer tyrosyl-tRNA synthetase shows tRNATyr interacts with both subunits.
1986 StandoutNobel
Improved oligonudeotide site-directed rautagenesis using M13 vectors
1985 StandoutNobel
Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme
1989
An E. coli gene coding for a protamine-like protein
1981 StandoutNobel
Protein kinase activity of FSV (Fujinami sarcoma virus) P130gag-fps shows a strict specificity for tyrosine residues.
1986
[29] Hybridization with synthetic oligonucleotides
1979 StandoutNobel
Number and distribution of polyadenylated RNA sequences in yeast
1977 StandoutNobel
Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes
1981
Purification of adenovirus messenger ribonucleic acid by an aqueous polymer two-phase system
1976
The Catalytic Role of the Active Site Aspartic Acid in Serine Proteases
1987 Science
Assembly of the mitochondrial membrane system: sequences of yeast mitochondrial valine and an unusual threonine tRNA gene
1979
At least 104 nucleotides are transposed from the 5′ terminus of the avian sarcoma virus genome to the 5′ termini of smaller viral mrnas
1978 StandoutNobel
The Amino Acid Sequence of the Tyrosy1-tRNA Synthetase from Bacillus stearothermophilus
1983 StandoutNobel
Transformation of mammalian cells with genes from procaryotes and eucaryotes
1979 StandoutNobel
Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase.
1985
Complete nucleotide sequence of the 5′ noncoding region of human α- and β-globin mRNA
1977
Inhibition of restriction endonuclease Nel I cleavage by phosphorothioate groups and its application to oligonucleotide-directed mutagenesis
1986
Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation
1987
Molecular analysis of the unc-54 myosin heavy-chain gene of Caenorhabditis elegans
1981 StandoutNatureNobel
Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum
1984 StandoutNatureNobel
Probing histidine-substrate interactions in tyrosyl-tRNA synthetase using asparagine and glutamine replacements
1985 StandoutNobel
Cloning of human mitochondrial DNA in Escherichia coli
1980
Identification of two anti-parallel beta-sheet conformations in the solution structure of murine epidermal growth factor by proton magnetic resonance.
1986 StandoutNobel
[27] Modification of enzyme catalysis by engineering surface charge
1991
Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts.
1986 Nobel
Charon Phages: Safer Derivatives of Bacteriophage Lambda for DNA Cloning
1977 StandoutScienceNobel
Analysis of a 5′ leader sequence on murine leukemia virus 21S RNA: Heteroduplex mapping with long reverse transcriptase products
1978 Nobel
Assembly of the mitochondrial membrane system. The DNA sequence of a mitochondrial ATPase gene in Saccharomyces cerevisiae.
1979
Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src
1983 StandoutNobel
Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms
1986
Deletion mapping of sequences essential for in vivo transcription of the iso-1-cytochrome c gene.
1981
Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region
1987 StandoutNatureNobel
Adenosine deaminase: characterization and expression of a gene with a remarkable promoter.
1985
G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.
1990 StandoutNobel
A lysine in the ATP-binding site of P130gag-fps is essential for protein-tyrosine kinase activity.
1986
The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)
1984 StandoutNobel
The ovalbumin gene - sequence of putative control regions
1980
Mutagenesis in vitro by DNA polymerase from an RNA tumour virus
1979 Nature
Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site
1987
The genes for fifteen ribosomal proteins of Saccharomyces cerevisiae.
1981
Complete sequence of constant and 3′ noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing
1978 StandoutNobel
DNA sequencing with chain-terminating inhibitors
1977 StandoutNobel
Initiation by Yeast RNA Polymerase II at the Adenoviral Major Late Promoter in Vitro
1989 StandoutScienceNobel
Expression of a beta-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna2 mutation of yeast.
1983 StandoutNobel
Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis
1985 Nature
Distinctive sequence of human mitochondrial ribosomal RNA genes
1980 Nature
Deletion mutagenesis using an ‘M13 splint’: the N-terminal structural domain of tyrosyl-tRNA synthetase (B. stearothermophilus) catalyses the formation of tyrosyl adenylate.
1983 StandoutNobel
Introduction of homologous DNA sequences into mammalian cells induces mutations in the cognate gene
1986 StandoutNatureNobel
The reactivation of developmentally inert 5S genes in somatic nuclei injected into Xenopus oocytes
1981 StandoutNatureNobel
Oligonucleotide directed mutagenesis of the human β-globin gene: a general method for producing specific point mutations in cloned DNA
1981
The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers
1982 Standout
Noncoding nucleotide sequence in the 3'-terminal region of a mouse immunoglobulin .kappa. chain messenger RNA determined by analysis of complementary DNA
1977
Generation of cDNA Probes Directed by Amino Acid Sequence: Cloning of Urate Oxidase
1988 Science
Fine structure of the human hypoxanthine phosphoribosyltransferase gene.
1986
Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNA
1978
Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis
1985 Nature
Isolation and structure of a rat cytochrome c gene.
1981
DNA sequence of a mutation in the leader region of the yeast iso-1-cytochrome c mRNA
1981 StandoutNobel
Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene
1986
Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.
1977 StandoutNobel
Transformation of yeast.
1978 Standout
Gene K, a new overlapping gene in bacteriophage G4
1978 StandoutNatureNobel
Accurate initiation at RNA polymerase II promoters in extracts from Saccharomyces cerevisiae.
1987 StandoutNobel
Specific Interactions in RNA Enzyme-Substrate Complexes
1989 StandoutScienceNobel
Protein Control of Redox Potentials of Iron−Sulfur Proteins
1996 StandoutNobel
Site-Specific Mutagenesis of cdc2+, a Cell Cycle Control Gene of the Fission Yeast Schizosaccharomyces pombe
1986
Rous sarcoma virus genome is terminally redundant: the 3' sequence.
1977
Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure
1977 StandoutNobel
Sequence and organization of the human mitochondrial genome
1981 StandoutNatureNobel
Activation of yeast RNA polymerase II transcription by a thymidine-rich upstream element in vitro.
1989 StandoutNobel
Rapid gel sequencing of RNA by primed synthesis with reverse transcriptase
1977
Isolation and sequence of the gene for actin in Saccharomyces cerevisiae.
1980
Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene.
1986
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
A model of synthetase/transfer RNA interaction as deduced by protein engineering
1986 StandoutNatureNobel
Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.
1986
A system for shotgun DNA sequencing
1981 Standout
DNA sequence of a T4 transfer RNA gene cluster
1980
cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.
1983 StandoutNobel
Sequence analysis of the 3′ non-coding regions of rabbit α- and β-globin messenger RNAs
1976
Characterization of an activated human ros gene.
1986
Promoter-specific activation of RNA polymerase II transcription by Sp1
1986
Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme
1985 StandoutNobel
Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src.
1986
A different genetic code in human mitochondria
1979 Nature
Quantitative analysis of structure–activity relationships in engineered proteins by linear free-energy relationships
1986 Nature
Use of directed mutagenesis to probe the role of tyrosine 198 in the catalytic mechanism of carboxypeptidase A.
1987
The use of thin acrylamide gels for DNA sequencing
1978 StandoutNobel
Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene
1980
tRNA punctuation model of RNA processing in human mitochondria
1981 StandoutNature
Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP
1989 StandoutScienceNobel
Overlapping genes in bacteriophage φX174
1976 Nature
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose
1986
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
1986 StandoutNobel
Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae.
1980
How Enzymes Work: Analysis by Modern Rate Theory and Computer Simulations
2004 Science
A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene
1987 StandoutNatureNobel
Solution structure of murine epidermal growth factor: determination of the polypeptide backbone chain-fold by nuclear magnetic resonance and distance geometry.
1987 StandoutNobel
Sequence of chicken ovalbumin mRNA
1978 Nature
Genes and spacers of cloned sea urchin histone DNA analyzed by sequencing
1978 StandoutNobel
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
1988 StandoutNatureNobel
Mutants of yeast initiating translation of Iso-1-cytochrome c within a region spanning 37 nucleotides
1980
Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor
1986 StandoutNobel
Isolation of yeast histone genes H2A and H2B
1979 StandoutNobel
p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.
1987
A large increase in enzyme–substrate affinity by protein engineering
1984 StandoutNatureNobel
Bacteriophage phiX174: gene A overlaps gene B.
1977
Assembly of the mitochondrial membrane system. Sequence of the oxi 2 gene of yeast mitochondrial DNA.
1980
Nucleotide sequence of bacteriophage G4 DNA
1978 StandoutNature
Hydrogen bonding and biological specificity analysed by protein engineering
1985 StandoutNatureNobel
Rapid synthesis of oligodeoxyribonucleotides II1. Machine-aided solid-phase syntheses of two nonanucleotides and an octanucleotide
1977
Examination of the role of arginine-143 in the human copper and zinc superoxide dismutase by site-specific mutagenesis.
1987
Transition-state stabilization in the mechanism of tyrosyl-tRNA synthetase revealed by protein engineering.
1985 StandoutNobel
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction.
1989 StandoutNobel
[20] Improved oligonucleotide-directed mutagenesis using M13 vectors
1987
Electrostatic complementarity within the substrate-binding pocket of trypsin.
1988
The gapped duplex DNA approach to oligonucleotide-directed mutation construction
1984
Site-directed mutagenesis as a probe of enzyme structure and catalysis: tyrosyl-tRNA synthetase cysteine-35 to glycine-35 mutation
1983 StandoutNobel
Mechanism of mitochondrial DNA replication in mouse L-cells: Localization and sequence of the light-strand origin of replication
1979
Fine Structure of the Human Hypoxanthine Phosphoribosyltransferase Gene
1986
The DNA Binding Domain of the Rat Liver Nuclear Protein C/EBP Is Bipartite
1989 Science
Analysis of Enzyme Structure and Activity by Protein Engineering
1984 StandoutNobel
Works of Michael J. Smith being referenced
Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template
1984
Role of arginine-38 in regulation of the cytochrome c oxidation-reduction equilibrium
1989 StandoutNobel
Hyperexpression of a synthetic gene encoding a high potential iron sulfur protein
1994
Isolation and sequence of the gene for iso-2-cytochrome c in Saccharomyces cerevisiae.
1980
Repetitive and non-repetitive sequence in sea urchin heterogeneous nuclear RNA
1974
Mutagenesis of Fujinami Sarcoma Virus: Evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity
1984
In vitrogeneration of specific deletions in DNA cloned In M13 vectors using synthetic oligodeoxyribonucleotides: mutants in the 5′-flanking region of the yeast alcohol dehydrogenase II gene
1984
Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding
1982 StandoutNatureNobel
Nucleotide sequence of the 3′ terminal third of rabbit α-globin messenger RNA: Comparison with human α-globin messenger RNA
1977
Mutations at the yeast SUP4 tRNATyr locus: DNA sequence changes in mutants lacking suppressor activity
1980
Immunoglobulin‐like messenger RNA in a mouse T cell lymphoma
1977
Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis
1984
Sequence of the gene for iso-l-cytochrome c in saccharomyces cerevisiae
1979
The sequence of a region of bacteriophage φX174 DNA coding for parts of genes A and B
1977
Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation.
1988
Enzymatic synthesis of deoxyribo-oiigonucleotides of defined sequence. Deoxyribo-oligonucleotide synthesis
1974
Identification and isolation of the yeast cytochrome c gene
1978
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: I. Optimum conditions and minimum oligodeoxyribonucleotide length
1979
Enzymatic synthesis of oligodeoxyribonucleotides of defined sequence.
1978
Site-directed mutagenesis
1982
Mutagenesis at a specific position in a DNA sequence.
1978
Defined transversion mutations at a specific position in DNA using synthetic oligodeoxyribonucleotides as mutagens
1979
Sequence analysis of the 3′ non-coding region of mouse immunoglobulin light chain messenger RNA
1977
DNA sequence at the C termini of the overlapping genes A and B in bacteriophage φX174
1977 StandoutNatureNobel
Site specific endonuclease from Fusobacterium nucleatum
1979
Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA
1982
The 3′ terminal sequence of chicken ovalumin messenger RNA and its comparison with other messenger RNA molecules
1976
The Mapping and sequence determination of the single site in φX174am3 replicative form DNA cleaved by restriction endonuclease Pst I
1976
Transcription initiation of the Saccharomyces cerevisiae iso-1-cytochrome c gene
1986
Sequence complexity of heterogeneous nuclear RNA in sea urchin embryos
1975
Enzymatic synthesis of oligonucleotides of defined sequence: synthesis of a segment of yeast iso-1-cytochrome c gene.
1977
Mutations of the yeast SUP4 tRNATyr Locus: Transcription of the mutant genes in vitro
1980
Site-specific mutagenesis using synthetic oligodeoxyribonucleotide primers: II. In vitro selection of mutant DNA
1979
[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors
1983
Structure of the 3′ hairpin termini of four rodent parvovirus genomes: Nucleotide sequence homology at origins of DNA replication
1979
Biologically active synthetic fragments of epidermal growth factor: localization of a major receptor-binding region.
1984
The distal transcription signals of the herpesvirus tk gene share a common hexanucleotide control sequence
1984
Nucleotide sequence of the yeast alcohol dehydrogenase II gene.
1983
DNA sequences of two yeast promoter-up mutants
1983 Nature
Nucleotide sequence of bacteriophage φX174 DNA
1977 StandoutNatureNobel