Standout Papers
Citation Impact
Citing Papers
Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1
2008
TRPA1 acts as a cold sensor in vitro and in vivo
2009
TRP Channels as Potential Drug Targets
2017
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
2019
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
2011 StandoutNobel
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
A primer on ankyrin repeat function in TRP channels and beyond
2008
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
2014 Standout
A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome
2010
The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions
2008
Calmodulin is responsible for Ca2+-dependent regulation of TRPA1 Channels
2017
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
2014 Nature
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Molecular Basis Determining Inhibition/Activation of Nociceptive Receptor TRPA1 Protein
2014
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
In-cell Selectivity Profiling of Serine Protease Inhibitors by Activity-based Proteomics
2008
Mining the active proteome in plant science and biotechnology
2010
Chemical Proteomic Probes for Profiling Cytochrome P450 Activities and Drug Interactions In Vivo
2007
Requirement of a Soluble Intracellular Factor for Activation of Transient Receptor Potential A1 by Pungent Chemicals: Role of Inorganic Polyphosphates
2007
Characterization of a Ligand Binding Site in the Human Transient Receptor Potential Ankyrin 1 Pore
2013
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
2007
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo
2010
Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress
2008
TRPA1 is a major oxidant sensor in murine airway sensory neurons
2008
Piezo2 is required for Merkel-cell mechanotransduction
2014 StandoutNatureNobel
Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane
2009 StandoutNobel
The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation
2009
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
An Ion Channel Essential for Sensing Chemical Damage
2007 StandoutNobel
Honey Bee Thermal/Chemical Sensor, AmHsTRPA, Reveals Neofunctionalization and Loss of Transient Receptor Potential Channel Genes
2010
Prostaglandin-Induced Activation of Nociceptive Neurons via Direct Interaction with Transient Receptor Potential A1 (TRPA1)
2007
Structure–functional intimacies of transient receptor potential channels
2009
Transient receptor potential channels: targeting pain at the source
2008 StandoutNobel
The Outer Pore and Selectivity Filter of TRPA1
2016
Small molecule microarray-facilitated screening of affinity-based probes (AfBPs) for γ-secretase
2009
Thymol and related alkyl phenols activate the hTRPA1 channel
2008
Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels
2008 StandoutNobel
TRPV1 Is Activated by Both Acidic and Basic pH
2009 StandoutNobel
Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels
2008
An immunochemical, ultrastructural, and developmental characterization of the horizontal basal cells of rat olfactory epithelium
1995
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Protein Organic Chemistry and Applications for Labeling and Engineering in Live‐Cell Systems
2013
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception
2010 Nature
TRPA1 antagonists as potential analgesic drugs
2011
Identification of Molecular Determinants for a Potent Mammalian TRPA1 Antagonist by Utilizing Species Differences
2013
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
Bimodal Action of Menthol on the Transient Receptor Potential Channel TRPA1
2007
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
TRPA1 Contributes to Cold Hypersensitivity
2010 StandoutNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
Transient Receptor Potential Channels in Sensory Neurons Are Targets of the Antimycotic Agent Clotrimazole
2008
Activation of TRPA1 by Farnesyl Thiosalicylic Acid
2008
Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments
2009
Common pitfalls in preclinical cancer target validation
2017 StandoutNobel
A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic
2008
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Intracellular alkalization causes pain sensation through activation of TRPA1 in mice
2008
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Disparate proteome reactivity profiles of carbon electrophiles
2008
Irritating channels: the case of TRPA1
2010
A clickable inhibitor reveals context-dependent autoactivation of p90 RSK
2007
Transient receptor potential A1 mediates an osmotically activated ion channel
2008
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Chemical Probes Identify a Role for Histone Deacetylase 3 in Friedreich's Ataxia Gene Silencing
2009
The use of click chemistry in the emerging field of catalomics
2010
Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel
2019
Programmed population control by cell–cell communication and regulated killing
2004 StandoutNatureNobel
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
2009
Molecular Architecture and Subunit Organization of TRPA1 Ion Channel Revealed by Electron Microscopy
2011
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Selective and diagnostic labelling of serine hydrolases with reactive phosphonate inhibitors
2007
Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain
2012
Proteomic methods for drug target discovery
2008
Thermosensory and Nonthermosensory Isoforms of Drosophila melanogaster TRPA1 Reveal Heat-Sensor Domains of a ThermoTRP Channel
2012
Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six
2014 StandoutNobel
Caenorhabditis elegans TRPA-1 functions in mechanosensation
2007 StandoutNobel
Nociceptors—Noxious Stimulus Detectors
2007
β‐Lactones as Privileged Structures for the Active‐Site Labeling of Versatile Bacterial Enzyme Classes
2008
Agonist-Induced Changes in Ca2+ Permeation through the Nociceptor Cation Channel TRPA1
2010
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
DrosophilaPainless Is a Ca2+-Requiring Channel Activated by Noxious Heat
2008
A Genetic Program Promotes C. elegans Longevity at Cold Temperatures via a Thermosensitive TRP Channel
2013
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
Seeing small molecules in action with bioorthogonal chemistry
2008
The Met268Pro Mutation of Mouse TRPA1 Changes the Effect of Caffeine from Activation to Suppression
2010
Ion channels involved in cold detection in mammals: TRP and non-TRP mechanisms
2009
Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)—a general method for mapping sites of probe modification in proteomes
2007
Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
1988 StandoutScienceNobel
Strategies for Discovering and Derisking Covalent, Irreversible Enzyme Inhibitors
2010
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Clues from cell metabolism
2010 StandoutNatureNobel
Functional Profiling, Identification, and Inhibition of Plasmepsins in Intraerythrocytic Malaria Parasites
2009
HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity
2008
Functional Proteomic and Structural Insights into Molecular Recognition in the Nitrilase Family Enzymes
2008
Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation
2010
A Role of TRPA1 in Mechanical Hyperalgesia is Revealed by Pharmacological Inhibition
2007 StandoutNobel
Chemical probes for profiling fatty acid-associated proteins in living cells
2008
Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling
2011
Molecular and Cellular Limits to Somatosensory Specificity
2008
The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1
2016
Click Chemistry and Bioorthogonal Reactions: Unprecedented Selectivity in the Labeling of Biological Molecules
2009
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
1986 StandoutNatureNobel
Species-Specific Pharmacology of Trichloro(Sulfanyl)ethyl Benzamides as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists
2007
TRP Channels and Pain
2013 StandoutNobel
Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation
2009
Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
2013
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4
2009 StandoutNobel
Unexpectedly Large Size of Globin Messenger Ribonucleic Acid
1971
Investigating the Proteome Reactivity and Selectivity of Aryl Halides
2014
Programmed Death in Bacteria
2000
TRPA1 mediates formalin-induced pain
2007 StandoutNobel
In situclick chemistry: a powerful means for lead discovery
2006 StandoutNobel
Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels
2008
Organische Proteinchemie und ihre Anwendung für Markierungen und Engineering in Lebendzellsystemen
2013
Optimization of Activity-Based Probes for Proteomic Profiling of Histone Deacetylase Complexes
2008
Three abundance classes in HeLa cell messenger RNA
1974 StandoutNatureNobel
Cutaneous Nociception Evoked by 15-delta PGJ2 via Activation of Ion Channel TRPA1
2008
Showdomycin as a Versatile Chemical Tool for the Detection of Pathogenesis-Associated Enzymes in Bacteria
2010
TRPA1: A Gatekeeper for Inflammation
2012
The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1
2010
Deficiency of vitamin E in the alveolar fluid of cigarette smokers. Influence on alveolar macrophage cytotoxicity.
1986
Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry
2008
Mechanism-Based Probe for the Analysis of Cathepsin Cysteine Proteases in Living Cells
2006
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene
1987 StandoutNatureNobel
In vitro Synthesis of DNA Components of Human Genes for Globins
1972
Chemical activation of the mechanotransduction channel Piezo1
2015 StandoutNobel
Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose
1972 Standout
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
1985 StandoutNatureNobel
Molecular cloning of cDNA encoding human interleukin-2 receptor
1984 StandoutNatureNobel
Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain
2014
Polymodal Ligand Sensitivity of TRPA1 and Its Modes of Interactions
2009
Determinants of carboxyl-terminal domain translocation during prion protein biogenesis
1994 StandoutNobel
Works of Michael J. Evans being referenced
The Effects of Dietary Antioxidants on NO2- Induced Injury to Type 1 Alveolar Cells
1981
Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling
2005
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
The Penetration of Antibiotics into Aggregates of Mucoid and Non-mucoid Pseudomonas aeruginosa
1989
Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides
2007
The Role of Basal Cells in Attachment of Columnar Cells to the Basal Lamina of the Trachea
1989
Mechanism-Based Profiling of Enzyme Families
2006
Do the ear's links link?
1992 Nature
Hemoglobin messenger ribonucleic acid. Synthesis of 9 S and ribosomal ribonucleic acid during erythroid cell development
1969
Overcoming mutation-based resistance to antiandrogens with rational drug design
2013
Hemoglobin messenger ribonucleic acid. Distribution of the 9S ribonucleic acid in polysomes of different sizes
1969