Citation Impact
Citing Papers
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
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Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
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The Tumor Suppressor Smad4 Is Required for Transforming Growth Factor β–Induced Epithelial to Mesenchymal Transition and Bone Metastasis of Breast Cancer Cells
2006
High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells
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Disruption of Transforming Growth Factor-β Signaling in ELF β-Spectrin-Deficient Mice
2003 Science
Kruppel-Like Factor 8 Induces Epithelial to Mesenchymal Transition and Epithelial Cell Invasion
2007
Fate-determining mechanisms in epithelial–myofibroblast transition: major inhibitory role for Smad3
2010
Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity
2005 Science
Cell size and invasion in TGF-β–induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
2007
Hallmarks of Cancer: The Next Generation
2011 Standout
Engineered receptors for soluble cellular communication and disease sensing
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Zyxin Is a Transforming Growth Factor-β (TGF-β)/Smad3 Target Gene That Regulates Lung Cancer Cell Motility via Integrin α5β1
2012
Discovering Hematopoietic Mechanisms through Genome-wide Analysis of GATA Factor Chromatin Occupancy
2009
Inflammation and EMT: an alliance towards organ fibrosis and cancer progression
2009
Serine Phosphorylation, Chromosomal Localization, and Transforming Growth Factor-β Signal Transduction by Human
1996
Metastasis is driven by sequential elevation of H-ras and Smad2 levels
2002
Transforming growth factor β (TGFβ) signalling in palatal growth, apoptosis and epithelial mesenchymal transformation (EMT)
2004
Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
2003
MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling
1996
Inflammation and cancer
2002 StandoutNature
Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling
2003
Epithelial-mesenchymal transition and its implications for fibrosis
2003 Standout
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
Integration of TGF‐β/Smad and Jagged1/Notch signalling in epithelial‐to‐mesenchymal transition
2004
Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration
2000
Mechanisms of TGF-β signaling in regulation of cell growth and differentiation
2002
Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses
2003
Extracellular Signal-regulated Kinase and the Small GTP-binding Protein, Rac, Contribute to the Effects of Transforming Growth Factor-β1 on Gene Expression
1996
Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
2003
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
2003 Standout
TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A
2011
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Molecular mechanisms of epithelial–mesenchymal transition
2014 Standout
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Evidence for a Role of the JNK Cascade in Smad7-mediated Apoptosis
2001
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
1998
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
LIM-kinase 2 and Cofilin Phosphorylation Mediate Actin Cytoskeleton Reorganization Induced by Transforming Growth Factor-β
2005
TGF-β1-mediated alterations of renal proximal tubular epithelial cell phenotype
2003
A Novel Mechanism for Regulating Transforming Growth Factor β (TGF-β) Signaling
2001
TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
2002
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
2006
Regulation of cell proliferation by Smad proteins
2002
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
2015 StandoutNature
MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways
1996
TGFβ‐mediated RhoA expression is necessary for epithelial‐mesenchymal transition in the embryonic chick heart
2006
TGFβ signalling in control of T-cell-mediated self-reactivity
2007
The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
2005
Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL
2003
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Interaction of Transforming Growth Factor-β Receptor I with Farnesyl-protein Transferase-α in Yeast and Mammalian Cells
1996
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
FKBP-12 Recognition Is Dispensable For Signal Generation by Type I Transforming Growth Factor-β Receptors
1996
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
1997 StandoutNature
TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease
2007 Standout
Integrin β1 Signaling Is Necessary for Transforming Growth Factor-β Activation of p38MAPK and Epithelial Plasticity
2001
Transforming Growth Factor-β Signaling during Epithelial-Mesenchymal Transformation: Implications for Embryogenesis and Tumor Metastasis
2005
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
A crucial function of PDGF in TGF-β-mediated cancer progression of hepatocytes
2006
TGFβ: the molecular Jekyll and Hyde of cancer
2006
Mechanisms in Epithelial Plasticity and Metastasis: Insights from 3D Cultures and Expression Profiling
2002
Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
2001
TGF-β and epithelial-to-mesenchymal transitions
2005
Mapping and analysis of chromatin state dynamics in nine human cell types
2011 StandoutNature
Rho GTPases in cell biology
2002 StandoutNature
Inhibition of TGFβ signaling in cancer therapy
2005
Transforming growth factor-β induces development of the TH17 lineage
2006 StandoutNature
Mechanism of TGFβ receptor inhibition by FKBP12
1997
Loss of TGFβ Signaling Destabilizes Homeostasis and Promotes Squamous Cell Carcinomas in Stratified Epithelia
2007
Emergence of the Phosphoinositide 3-Kinase-Akt- Mammalian Target of Rapamycin Axis in Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition
2010
TGF- β signaling in cancer – a double-edged sword
2001
Epithelial–mesenchymal transitions in tumour progression
2002 Standout
G Protein-coupled Receptors
1998 StandoutNobel
Filamin Associates with Smads and Regulates Transforming Growth Factor-β Signaling
2001
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
1996 StandoutNature
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
TGF-β receptor signaling
1997
ERK5/MAPK is activated by TGFβ in hepatocytes and required for the GSK-3β-mediated Snail protein stabilization
2008
Transient activation of NF-κB through a TAK1/IKK kinase pathway by TGF-β1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
2003
Role of Rho family GTPases in epithelial morphogenesis
2002
Immunity, Inflammation, and Cancer
2010 Standout
Characterization of the Interaction of FKBP12 with the Transforming Growth Factor-β Type I Receptor in Vivo
1996
The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway
2001
EMT, the cytoskeleton, and cancer cell invasion
2009
The Activity of Guanine Exchange Factor NET1 Is Essential for Transforming Growth Factor-β-mediated Stress Fiber Formation
2001
TGFβ in Cancer
2008 Standout
Fibroblasts Derive from Hepatocytes in Liver Fibrosis via Epithelial to Mesenchymal Transition
2007
Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial–mesenchymal transition of lens epithelium in mice
2004
Requirement of Ras/MAPK Pathway Activation by Transforming Growth Factor β for Transforming Growth Factor β1Production in a Smad-dependent Pathway
2000
Activation of the Erk Pathway Is Required for TGF-β1-Induced EMT In Vitro
2004
A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif
2000
Functional Roles for the Cytoplasmic Domain of the Type III Transforming Growth Factor β Receptor in Regulating Transforming Growth Factor β Signaling
2001
Transforming Growth Factor-β1 (TGF-β1) and TGF-β2 Decrease Expression of CD36, the Type B Scavenger Receptor, through Mitogen-activated Protein Kinase Phosphorylation of Peroxisome Proliferator-activated Receptor-γ
2000
The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion
2013
Role of Transforming Growth Factor-beta Signaling in Cancer
2000
The basics of epithelial-mesenchymal transition
2009 Standout
The Type II Transforming Growth Factor (TGF)-β Receptor-interacting Protein TRIP-1 Acts as a Modulator of the TGF-β Response
1998
Clonal evolution in cancer
2012 StandoutNature
The Inhibitory Effects of Transforming Growth Factor-Beta-1 (TGF-β1) in Autoimmune Diseases
2000
Matrix metalloproteinases in tumor–host cell communication
2002
How cells read TGF-β signals
2000 Standout
Identification of STRAP, a Novel WD Domain Protein in Transforming Growth Factor-β Signaling
1998
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Mechanisms of metastasis: Epithelial‐to‐mesenchymal transition and contribution of tumor microenvironment
2007
NCAM‐induced focal adhesion assembly: a functional switch upon loss of E‐cadherin
2008
The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
1997
Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion
1998
Cancer-related inflammation
2008 StandoutNature
Smad3 Potentiates Transforming Growth Factor β (TGFβ)-induced Apoptosis and Expression of the BH3-only Protein Bim in WEHI 231 B Lymphocytes
2003
JNK Regulates Autocrine Expression of TGF-β1
2004
Altered Transforming Growth Factor β Signaling in Epithelial Cells when Ras Activation Is Blocked
1996
TGF-β-induced epithelial to mesenchymal transition
2009 Standout
Chromosomal Region Maintenance 1 (CRM1)-dependent Nuclear Export of Smad Ubiquitin Regulatory Factor 1 (Smurf1) Is Essential for Negative Regulation of Transforming Growth Factor-β Signaling by Smad7
2003
Cell Adhesion, Cellular Tension, and Cell Cycle Control
2007
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
2007 StandoutNature
Conditional inactivation of the TGF‐β type II receptor using Cre:Lox
2002
Transforming Growth Factor-β Stimulates Parathyroid Hormone-related Protein and Osteolytic Metastases via Smad and Mitogen-activated Protein Kinase Signaling Pathways
2002
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
Role of tissue stroma in cancer cell invasion
2003
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
1997
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
Tumor suppressor activity of the TGF-β pathway in human cancers
1996
Regulation of epithelial–mesenchymal and mesenchymal–epithelial transitions by microRNAs
2013
p38 mitogen-activated protein kinase is required for TGFβ-mediated fibroblastic transdifferentiation and cell migration
2002
Controlling TGF-β signaling
2000
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
Differential Regulation of Epithelial and Mesenchymal Markers by δEF1 Proteins in Epithelial–Mesenchymal Transition Induced by TGF-β
2007
Meeting Report: Signaling Schemes for TGF-βA review of the meeting "The TGF-β Superfamily: Signaling and Development," FASEB Summer Research Conference, Tucson, Arizona, 7 to 12 July 2001.
2001
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
2005
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.
1996
Cell-Type-Specific Activation of PAK2 by Transforming Growth Factor β Independent of Smad2 and Smad3
2003
Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4
1997
Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer
2016
Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line.
2001
Smad regulation in TGF-β signal transduction
2001
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
Inactivation of Smad-Transforming Growth Factor β Signaling by Ca2+-Calmodulin-Dependent Protein Kinase II
2000
Targeted disruption of TGF-β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
2003
A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation
1999 StandoutNobel
The Calpain System
2003 Standout
Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins
1996
The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis.
2003
Non-Smad TGF-β signals
2005 Standout
Transforming Growth Factor-β–induced Mobilization of Actin Cytoskeleton Requires Signaling by Small GTPases Cdc42 and RhoA
2002
Squamous cell carcinoma and mammary abscess formation through squamous metaplasia inSmad4/Dpc4conditional knockout mice
2003
Dynamic actin remodeling during epithelial–mesenchymal transition depends on increased moesin expression
2011
Dual Role of SnoN in Mammalian Tumorigenesis
2006
TGF-β signal transduction and mesangial cell fibrogenesis
2003
STRAP and Smad7 Synergize in the Inhibition of Transforming Growth Factor β Signaling
2000
Signal Transduction by the TGF-β Superfamily
2002 StandoutScience
SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
2005 Standout
Transforming growth factor-β and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes
2002
Tumor Necrosis Factor-α Stimulates the Epithelial-to-Mesenchymal Transition of Human Colonic Organoids
2003
Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling
2007
TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES
2005 Standout
TGF-β-induced activation of mTOR complex 2 drives epithelial–mesenchymal transition and cell invasion
2012
Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis
2003
Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells
2013 StandoutScience
Epithelial-mesenchymal transition and its implications for fibrosis
2003 Standout
Mature Vascular Endothelium Can Give Rise to Smooth Muscle Cells via Endothelial-Mesenchymal Transdifferentiation
2002
Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition
2006
Targeted Disruption of Smad4 in Cardiomyocytes Results in Cardiac Hypertrophy and Heart Failure
2005
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
2006 StandoutScience
TGF-β and cancer
2005
Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition
2003
The RhoA Activator GEF-H1/Lfc Is a Transforming Growth Factor-β Target Gene and Effector That Regulates α-Smooth Muscle Actin Expression and Cell Migration
2010
Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses.
1996
TGF-β and the Smad Signaling Pathway Support Transcriptomic Reprogramming during Epithelial-Mesenchymal Cell Transition
2005
Controlling TGF-beta signaling.
2000 Standout
Smad3 Is Essential for TGF-β1 to Suppress IL-2 Production and TCR-Induced Proliferation, but Not IL-2-Induced Proliferation
2004
Alterations in components of the TGF-β superfamily signaling pathways in human cancer
2005
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Works of Michael E. Engel being referenced
Signal transduction by transforming growth factor-β: A cooperative paradigm with extensive negative regulation
1998
RhoB Is Stabilized by Transforming Growth Factor β and Antagonizes Transcriptional Activation
1998
Interaction of the Transforming Growth Factor-β Type I Receptor with Farnesyl-protein Transferase-α
1995
Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription
1999
Deletion of Mtg16, a Target of t(16;21), Alters Hematopoietic Progenitor Cell Proliferation and Lineage Allocation
2008
Transforming Growth Factor-β1 Mediates Epithelial to Mesenchymal Transdifferentiation through a RhoA-dependent Mechanism
2001