Standout Papers
Citation Impact
Citing Papers
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
2006
Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA
2008
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes
2006
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
The Critical Role of Metabolic Pathways in Aging
2012
Tat-SIRT1 Tango
2008
Regulation of Insulin Secretion by SIRT4, a Mitochondrial ADP-ribosyltransferase
2007
Strong expression of a longevity-related protein, SIRT1, in Bowen’s disease
2006
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation
2015 StandoutNobel
Effectiveness of a hospital-wide programme to improve compliance with hand hygiene
2000 Standout
NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs
2007
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants
2007 StandoutNobel
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy
2013 StandoutNobel
Metabolite of SIR2 Reaction Modulates TRPM2 Ion Channel
2006
SIRT6 protects against pathological damage caused by diet‐induced obesity
2009
Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway
2006
Roles of NAD / NADH and NADP+ / NADPH in Cell Death
2009
Mechanism of Human SIRT1 Activation by Resveratrol
2005
Therapeutic potential of resveratrol: the in vivo evidence
2006 Standout
pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2
2007 StandoutNobel
Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (Wld) mice: Activation of SIRT2, an NAD-dependent tubulin deacetylase
2007
Histone deacetylases and cancer
2007
Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
2005
Combined Immunodeficiencies with Nonfunctional T Lymphocytes
2014
Calorie Restriction— the SIR2 Connection
2005
NAD+ and NADH in cellular functions and cell death
2006
Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
2008
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Sirtuins in Aging and Age-Related Disease
2006
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging
2006
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs
2012
The Sir2 family of protein deacetylases
2005
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity
2013 StandoutNobel
The genetics of ageing
2010 StandoutNature
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
2016
Development and characterization of lysine based tripeptide analogues as inhibitors of Sir2 activity
2009
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
Shared Principles in NF-κB Signaling
2008 Standout
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
2005
Hallmarks of aging: An expanding universe
2023 Standout
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
2008
DBC1 is a negative regulator of SIRT1
2008 Nature
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
2017 StandoutNobel
Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD+ Cosubstrate Specificity of a Sir2 Enzyme
2005
SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons
2008
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
2006
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
2006
Sirtuins, Aging, and Medicine
2011
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
2010 Standout
Sirtuins, Aging, and Metabolism
2011
Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions
2012
The multifaceted functions of sirtuins in cancer
2015
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
2009
The Epigenomics of Cancer
2007 Standout
MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila
2017 StandoutNobel
Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation
2010
SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity
2006
Chimeric antigen receptors: driving immunology towards synthetic biology
2016
Negative regulation of inflammation by SIRT1
2012
Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging
2007
Metabolism of inflammation limited by AMPK and pseudo-starvation
2013 Nature
A therapeutic role for sirtuins in diseases of aging?
2007
Sex and gender: modifiers of health, disease, and medicine
2020 Standout
Blinded by the Light: The Growing Complexity of p53
2009 Standout
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
2012
Substrate-specific Activation of Sirtuins by Resveratrol
2005
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
2012 StandoutNobel
SIRT1 Modulating Compounds from High-Throughput Screening as Anti-Inflammatory and Insulin-Sensitizing Agents
2006
Involvement of mammalian sirtuin 1 in the action of ethanol in the liver
2008
Nampt/PBEF/Visfatin: A regulator of mammalian health and longevity?
2006
Resveratrol attenuates TNF-α-induced activation of coronary arterial endothelial cells: role of NF-κB inhibition
2006
Acetylation and deacetylation of non-histone proteins
2005
Skin Hygiene and Infection Prevention: More of the Same or Different Approaches?
1999 Standout
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells
2004
Motif module map reveals enforcement of aging by continual NF-κB activity
2007
SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes
2005
Epigenetics and aging: the targets and the marks
2007
GITR subverts Foxp3+ Tregs to boost Th9 immunity through regulation of histone acetylation
2015
Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation
2005
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-Associated Tumorigenesis
2008
SirT1 modulates the estrogen–insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
2007
Recent progress in the biology and physiology of sirtuins
2009 Nature
Inhibition of SIRT1 Reactivates Silenced Cancer Genes without Loss of Promoter DNA Hypermethylation
2006
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Transcriptional control of the inflammatory response
2009
Programmed Cell Senescence during Mammalian Embryonic Development
2013 Standout
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
2008
Poly(ADP-ribose) Polymerase-1-dependent Cardiac Myocyte Cell Death during Heart Failure Is Mediated by NAD+ Depletion and Reduced Sir2α Deacetylase Activity
2005
Toward a unified theory of caloric restriction and longevity regulation
2005
Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation
2009
Autophagy and Aging
2011 Standout
SirT1 fails to affect p53‐mediated biological functions
2006
Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity
2009
C. elegans SIR-2.1 Interacts with 14-3-3 Proteins to Activate DAF-16 and Extend Life Span
2006 Nobel
Sirt1 contributes critically to the redox-dependent fate of neural progenitors
2008
Negative regulation of the deacetylase SIRT1 by DBC1
2008 Nature
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
2009
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
2006 Standout
The Hallmarks of Aging
2013 Standout
Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation
2008
Active Regulator of SIRT1 Cooperates with SIRT1 and Facilitates Suppression of p53 Activity
2007
Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines
2009
The NF- B Family of Transcription Factors and Its Regulation
2009 Standout
Sirtuin Catalysis and Regulation
2012
SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
2009
Activation of nuclear factor-kappa B signalling promotes cellular senescence
2011
Spermidine/Spermine N1-Acetyltransferase 2 (SSAT2) functions as a coactivator for NF-κB and cooperates with CBP and P/CAF to enhance NF-κB-dependent transcription
2006
SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease
2008
Sirtuins in neurodegenerative diseases: an update on potential mechanisms
2013
sirt1-null mice develop an autoimmune-like condition
2008
SIRT1 Regulates HIV Transcription via Tat Deacetylation
2005
SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
2009
NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response
2012
SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
2009
Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
2010
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
SIRT1 and SIRT2: emerging targets in neurodegeneration
2013
NAD + /NADH and NADP + /NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences
2007 Standout
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Design, Synthesis, and Biological Evaluation of Sirtinol Analogues as Class III Histone/Protein Deacetylase (Sirtuin) Inhibitors
2005
SIRT1 Is Significantly Elevated in Mouse and Human Prostate Cancer
2007
SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes
2008
IκB Kinase α-Mediated Derepression of SMRT Potentiates Acetylation of RelA/p65 by p300
2005
The Biochemistry of Sirtuins
2006
Regulatory T Cells and Human Disease
2020 StandoutNobel
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms
2010
Deracemization of α-Aryl Hydrocoumarins via Catalytic Asymmetric Protonation of Ketene Dithioacetals
2012 StandoutNobel
Sirtuins in mammals: insights into their biological function
2007
Sirt1 protects against high-fat diet-induced metabolic damage
2008
miR-34a repression of SIRT1 regulates apoptosis
2008
Fluorescence Lifetime Measurements and Biological Imaging
2010 Standout
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage
2005
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
Spermidine in health and disease
2018 StandoutScience
NF-κB RelA Phosphorylation Regulates RelA Acetylation
2005
Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF‐κB‐independent mechanism
2005
Trapping a transition state in a computationally designed protein bottle
2015 StandoutScienceNobel
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function
2010 StandoutNobel
Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis
2009
IP3Receptors, Mitochondria, and Ca2+Signaling: Implications for Aging
2011
SIRT2 regulates NF-κB-dependent gene expression through deacetylation of p65 Lys310
2010
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Sirtuins — novel therapeutic targets to treat age-associated diseases
2008
SirT1 Regulates Adipose Tissue Inflammation
2011
Histone Deacetylases in Herpesvirus Replication and Virus-Stimulated Host Defense
2013
Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1
2009 Science
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Sex differences in the aging human heart: decreased sirtuins, pro-inflammatory shift and reduced anti-oxidative defense
2019
SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity
2008
Prevention of Ocular Inflammation in Endotoxin-Induced Uveitis with Resveratrol by Inhibiting Oxidative Damage and Nuclear Factor–κB Activation
2009
The Structural Basis of Sirtuin Substrate Affinity,
2006
Chromatin Contributions to the Regulation of Innate Immunity
2014
Works of Michael D. Keller being referenced
Graft Versus Leukemia Response Without Graft-versus-host Disease Elicited By Adoptively Transferred Multivirus-specific T-cells
2014
Evaluation of protocol change in burn‐care management using the Cox proportional hazards model with time‐dependent covariates
1993
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
2004 Standout
Combined proteasome and histone deacetylase inhibition in non–small cell lung cancer
2004
Proteasome Inhibition Sensitizes Non–Small-Cell Lung Cancer to Gemcitabine-Induced Apoptosis
2004
T-B+NK+ Severe Combined Immunodeficiency Caused by Complete Deficiency of the CD3zeta Subunit of the T Cell Antigen Receptor Complex
2007
T−B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3ζ subunit of the T-cell antigen receptor complex
2006