Standout Papers
Citation Impact
Citing Papers
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
2019 Science
β-Amyloid accumulation in the human brain after one night of sleep deprivation
2018
Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI
2017
Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits
2015
Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases
2016
Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function
2018
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed
2014
Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence
2014
Paravascular pathways contribute to vasculitis and neuroinflammation after subarachnoid hemorrhage independently of glymphatic control
2016
Cell type-selective secretome profiling in vivo
2020 StandoutNobel
Brain-wide glymphatic enhancement and clearance in humans assessed with MRI
2018
Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study
2018
The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome
2016 Standout
Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation
2016
Interaction between cerebrovascular disease and Alzheimer pathology
2016
Emerging targets in neuroinflammation-driven chronic pain
2014
Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease
2015
Molecular Architecture of the Mouse Nervous System
2018 Standout
Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brains
2020 StandoutNobel
Interactions between the microbiota, immune and nervous systems in health and disease
2017 Standout
The Effect of Body Posture on Brain Glymphatic Transport
2015
Priming the Inflammatory Pump of the CNS after Traumatic Brain Injury
2015
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
The glymphatic pathway in neurological disorders
2018 Standout
Dopamine mediates vagal modulation of the immune system by electroacupuncture
2014
Manipulating the Circadian and Sleep Cycles to Protect Against Metabolic Disease
2015
Voluntary running enhances glymphatic influx in awake behaving, young mice
2017
Glial Cell Development and Function in Zebrafish
2014
Revisiting the Mechanisms of CNS Immune Privilege
2015
The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
2017 Standout
Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease
2016
Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
2017
A meta-analysis of the five-factor model of personality and academic performance.
2009 Standout
White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies
2016
International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and Classification of Adenosine Receptors—An Update
2011 Standout
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
2021 Standout
Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association
2022 Standout
Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
2018 Standout
How Do Astrocytes Participate in Neural Plasticity?
2014
In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
2018 Standout
Cerebrospinal fluid is drained primarily via the spinal canal and olfactory route in young and aged spontaneously hypertensive rats
2014
Sleep and the Price of Plasticity: From Synaptic and Cellular Homeostasis to Memory Consolidation and Integration
2014
Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity
2014
Structural and functional features of central nervous system lymphatic vessels
2015 StandoutNature
Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice
2017
Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
2015 Standout
The Cellular Phase of Alzheimer’s Disease
2016
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal
2016
Glia and pain: Is chronic pain a gliopathy?
2013
Immunopathology of multiple sclerosis
2015 Standout
The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’ system?
2018
Astrocyte physiopathology: At the crossroads of intercellular networking, inflammation and cell death
2015
Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice
2014
A molecular atlas of cell types and zonation in the brain vasculature
2018 Nature
Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain
2013 Standout
The Glymphatic System: A Beginner’s Guide
2015 Standout
Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation
2016
Cortical Spreading Depression Closes Paravascular Space and Impairs Glymphatic Flow: Implications for Migraine Headache
2017
An Optical Neuron-Astrocyte Proximity Assay at Synaptic Distance Scales
2018
IL-10 Cytokine Released from M2 Macrophages Is Crucial for Analgesic and Anti-inflammatory Effects of Acupuncture in a Model of Inflammatory Muscle Pain
2014
Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism
2015
A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans
2015
Aquaporins and blood–brain barrier permeability in early edema development after traumatic brain injury
2015
Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
2015
Small vessel disease: mechanisms and clinical implications
2019 Standout
Reactive Astrocytes: Production, Function, and Therapeutic Potential
2017 Standout
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
What Learning Systems do Intelligent Agents Need? Complementary Learning Systems Theory Updated
2016 StandoutNobel
Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System
2015
Lymphatics in Neurological Disorders: A Neuro-Lympho-Vascular Component of Multiple Sclerosis and Alzheimer’s Disease?
2016
Drowning stars: reassessing the role of astrocytes in brain edema
2014
Glymphatic solute transport does not require bulk flow
2016
Mouse models of human evolution
2014
Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain
2016
Cannula Implantation into the Cisterna Magna of Rodents
2018
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Evolution of the Human Nervous System Function, Structure, and Development
2017
Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden
2018
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Mechanism of depression as a risk factor in the development of Alzheimer’s disease: the function of AQP4 and the glymphatic system
2016
Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts
2017
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Clearance systems in the brain—implications for Alzheimer disease
2015
Diversity of astrocyte functions and phenotypes in neural circuits
2015
The role of inflammation in depression: from evolutionary imperative to modern treatment target
2015 Standout
Adenosine as a Multi-Signalling Guardian Angel in Human Diseases: When, Where and How Does it Exert its Protective Effects?
2016
The amyloid hypothesis of Alzheimer's disease at 25 years
2016 Standout
Neuroinflammation: the devil is in the details
2016 Standout
Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier
2019 StandoutNobel
Reduced spinal cord parenchymal cerebrospinal fluid circulation in experimental autoimmune encephalomyelitis
2018
Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism
2016
Lecanemab in Early Alzheimer’s Disease
2022 Standout
Is There a Cerebral Lymphatic System?
2013
Impairment of the glymphatic system after diabetes
2016
Glymphatic MRI in idiopathic normal pressure hydrocephalus
2017
Omega‐3 polyunsaturated fatty acids promote amyloid‐β clearance from the brain through mediating the function of the glymphatic system
2016
Vascular contributions to cognitive impairment and dementia including Alzheimer's disease
2014
Pain regulation by non-neuronal cells and inflammation
2016 StandoutScience
Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains
2016
The effects of noncoding aquaporin‐4 single‐nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease
2017
Brain Tissue Responses to Neural Implants Impact Signal Sensitivity and Intervention Strategies
2014
Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics
2017
Understanding the role of the perivascular space in cerebral small vessel disease
2018
Hydrogel bioelectronics
2018 Standout
Perivascular spaces, glymphatic dysfunction, and small vessel disease
2017
Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development
2016 StandoutNobel
Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels
2017
Microglia Function in the Central Nervous System During Health and Neurodegeneration
2017 Standout
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Neuropathic Pain: From Mechanisms to Treatment
2020 Standout
Impairment of paravascular clearance pathways in the aging brain
2014 Standout
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
2015 Standout
MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain
2015
Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents
2021 StandoutNobel
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Subarachnoid hemorrhage – Induced block of cerebrospinal fluid flow: Role of brain coagulation factor III (tissue factor)
2017
Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms?
2015
Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer’s disease
2018
Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow
2017
Garbage Truck of the Brain
2013 Science
The glia/neuron ratio: How it varies uniformly across brain structures and species and what that means for brain physiology and evolution
2014
Microglial M1/M2 polarization and metabolic states
2015 Standout
Primary and Secondary School Teachers' Perceptions and Actions Regarding Their Pupils' Emotional Lives
1998
Sleep Health: An Opportunity for Public Health to Address Health Equity
2020
Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery
2017
The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future
2017
Effect of 1 Night of Total Sleep Deprivation on Cerebrospinal Fluid β-Amyloid 42 in Healthy Middle-Aged Men
2014
Inspiration Is the Major Regulator of Human CSF Flow
2015
Glymphatic clearance controls state-dependent changes in brain lactate concentration
2016
Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma
2017
Physiological Roles of Aquaporin-4 in Brain
2013
Molecular characterization of perivascular drainage pathways in the murine brain
2017
Alzheimer’s disease: A matter of blood–brain barrier dysfunction?
2017
Works of Michael Chen being referenced
Sleep Drives Metabolite Clearance from the Adult Brain
2013 StandoutScience
Neuronal Transgene Expression in Dominant-Negative SNARE Mice
2014
Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury
2012
Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice
2013
The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy
2014
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury
2014
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
2010
‘Hit & Run’ Model of Closed-Skull Traumatic Brain Injury (TBI) Reveals Complex Patterns of Post-Traumatic AQP4 Dysregulation
2013
Stigma of school counselling among Israeli adolescents as a function of ethnicity, counselling orientation and contact frequency
1988