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FGF signaling in skeletal development
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[28] Preparation and bioassay of bone morphogenetic protein and polypeptide Fragments
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In VivoStimulation of Endosteal Bone Formation by Basic Fibroblast Growth Factor in Rats
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The generation of diversity and pattern in animal development
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Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation
2000
Fluid shear stress inhibits TNF‐α‐induced apoptosis in osteoblasts: A role for fluid shear stress‐induced activation of PI3‐kinase and inhibition of caspase‐3
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Fibroblast growth factor-2 (FGF-2) increases N-cadherin expression through protein kinase C and Src-kinase pathways in human calvaria osteoblasts
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Regulation of Osteoblast, Chondrocyte, and Osteoclast Functions by Fibroblast Growth Factor (FGF)-18 in Comparison with FGF-2 and FGF-10
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1996
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Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)-β and bone morphogenetic protein (BMP)
2000
Binding of Transforming Growth Factor-β to Cell Surface Proteins Varies with Cell Type
1989
Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation
2000
Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation
1990
TGF-β receptor signaling
1997
Differential expression of fibroblast growth factor receptor-1, -2, and -3 and syndecan-1, -2, and -4 in neonatal rat mandibular condyle and calvaria during osteogenic differentiation in vitro
1999
Regulation of prostatic growth and function by peptide growth factors
1996
The Effects of Short‐Term Application of a Combination of Platelet‐Derived and Insulin‐Like Growth Factors on Periodontal Wound Healing
1991
Cell biology of the osteoclast
1999
Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells
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TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop
1990
TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
2001
Dual Regulation of Stromelysin-3 by Fibroblast Growth Factor-2 in Murine Osteoblasts
1998
In VivoStimulation of Bone Formation by Transforming Growth Factor-β
1989
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
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Immediate Early Gene Responses of NIH 3T3 Fibroblasts and NMuMG Epithelial Cells to TGFβ-1
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Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.
1998
Functional Roles for the Cytoplasmic Domain of the Type III Transforming Growth Factor β Receptor in Regulating Transforming Growth Factor β Signaling
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Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
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Cloning and Characterization of a Novel WD-40 Repeat Protein That Dramatically Accelerates Osteoblastic Differentiation
2001
The Type II Transforming Growth Factor (TGF)-β Receptor-interacting Protein TRIP-1 Acts as a Modulator of the TGF-β Response
1998
Anabolic Actions of Parathyroid Hormone on Bone*
1993
Initiation and enhancement of bone formation: A review
1987
Mechanisms of Bone Metastasis
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Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
1992
Osteogenesis and Bone-Marrow-Derived Cells
2001
Platelet-derived Growth Factor Induces Interleukin-6 Transcription in Osteoblasts through the Activator Protein-1 Complex and Activating Transcription Factor-2
1999
In Vivo Modulation of FGF Biological Activity Alters Cranial Suture Fate
2001
Basic Fibroblast Growth Factor Induces Osteoclast Formation by Reciprocally Regulating the Production of Osteoclast Differentiation Factor and Osteoclastogenesis Inhibitory Factor in Mouse Osteoblastic Cells
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Quantitative angiogenesis assays: Progress and problems
1997
Expression cloning of an activin receptor, a predicted transmembrane serine kinase
1991
The pathogenesis of atherosclerosis: a perspective for the 1990s
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Skeletal Growth Factors Regulate the Synthesis of Insulin-like Growth Factor Binding Protein-5 in Bone Cell Cultures
1995
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
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Effects of bone morphogenetic protein-2 on human neonatal calvaria cell differentiation
1999
Matrix Elasticity Directs Stem Cell Lineage Specification
2006 Standout
Transcriptional Program of Mouse Osteoclast Differentiation Governed by the Macrophage Colony-stimulating Factor and the Ligand for the Receptor Activator of NFκB
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Guanine nucleotide binding-protein coupled signaling pathway regulation of osteoblast-mediated bone formation
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Multilineage Potential of Adult Human Mesenchymal Stem Cells
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Mechanisms of Fibroblast Growth Factor-2 Modulation of Vascular Endothelial Growth Factor Expression by Osteoblastic Cells
2000
Modulation of adipocyte differentiation by tumor necrosis factor and transforming growth factor beta.
1989
Roles of Autocrine TGF-β Receptor and Smad Signaling in Adipocyte Differentiation
2000
Involutional Osteoporosis
1986 Standout
Effect of platelet‐derived growth factor‐BB on bone formation in calvarial defects: an experimental study in rabbits
1997
The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors
1987
Direct and Indirect Actions of Fibroblast Growth Factor 2 on Osteoclastic Bone Resorption in Cultures
2000
Basic Fibroblast Growth Factor Stimulates Collagenase-3 Promoter Activity in Osteoblasts through an Activator Protein-1-Binding Site
2000
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Tissue Engineering
1993 StandoutScience
Phenotypic consequences of lung-specific inducible expression of FGF-3
2001 StandoutNobel
Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse
1992
Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins
1994
Transforming Growth Factor β1 (TGF-β1) Promotes Endothelial Cell Survival during In Vitro Angiogenesis via an Autocrine Mechanism Implicating TGF-α Signaling
2001
Basic fibroblast growth factor regulates IGF-I binding proteins in the clonal osteoblastic cell line MC3T3-E1
1995
Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation.
1996
Expression and regulation of basic fibroblast growth factor mRNA levels in mouse osteoblastic MC3T3-E1 cells.
1994
Bone Resorption by Osteoclasts
2000 StandoutScience
The Effects of Fibroblast Growth Factor-2 on Human Neonatal Calvaria Osteoblastic Cells Are Differentiation Stage Specific
1998
Transforming Growth Factor βs and Fibroblast Growth Factors and Their Receptors: Role in Sutural Biology and Craniosynostosis
1997
Low Dose TGF-β Attenuates IL-12 Responsiveness in Murine Th Cells
1998
Prostaglandins Regulate the Expression of Fibroblast Growth Factor-2 in Bone
1999
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis
2000 Standout
Platelet-derived growth factor stimulates the synthesis of interleukin-6 in cells of the osteoblast lineage.
1995
Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells.
1989
Purification and characterization of other distinct bone-inducing factors.
1988
A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation
1999 StandoutNobel
Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells.
1994
Parathyroid Hormone Regulates the Expression of Fibroblast Growth Factor-2 mRNA and Fibroblast Growth Factor Receptor mRNA in Osteoblastic Cells
1999
Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.
1986
Characterization and Cloning of a Receptor for BMP-2 and BMP-4 from NIH 3T3 Cells
1994
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
Transcriptional regulation of alpha 2(I) collagen gene expression by fibroblast growth factor-2 in MC3T3-E1 osteoblast-like cells
2001
Parathyroid Hormone Stimulates TRANCE and Inhibits Osteoprotegerin Messenger Ribonucleic Acid Expression in Murine Bone Marrow Cultures: Correlation with Osteoclast-Like Cell Formation*
1999
Prostaglandins Regulate the Expression of Fibroblast Growth Factor-2 in Bone
1999
Low dose TGF-beta attenuates IL-12 responsiveness in murine Th cells.
1998
Wound Healing--Aiming for Perfect Skin Regeneration
1997 StandoutScience
Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts
1994
Basic Fibroblast Growth Factor Stimulates Collagenase-3 Promoter Activity in Osteoblasts through an Activator Protein-1-Binding Site*
2000
Effects of endothelial cell growth factor on bone remodelling in vitro.
1987
Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action
1988
Some recent advances in the chemistry and biology of transforming growth factor-beta.
1987
Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro.
1997
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis*
2000 Standout
New Developments in the Pathogenesis and Treatment of Steroid-Induced Osteoporosis
1999
Requirement for Generation of H 2 O 2 for Platelet-Derived Growth Factor Signal Transduction
1995 StandoutScience
Fibroblast Growth Factor-2 Induces Hepatocyte Growth Factor/Scatter Factor Expression in Osteoblasts*
1999
Human Trabecular Bone Cells Are Able to Express Both Osteoblastic and Adipocytic Phenotype: Implications for Osteopenic Disorders
1998
Novel Regulators of Bone Formation: Molecular Clones and Activities
1988 StandoutScience
Angiogenic Factors
1987 StandoutScience
Osteochondrogenic potential of marrow mesenchymal progenitor cells exposed to TGF-β1 or PDGF-BB as assayed in vivo and in vitro
1996
Characterization of the activation of latent TGF-beta by co-cultures of endothelial cells and pericytes or smooth muscle cells: a self-regulating system.
1990
The effect of systemically administered PDGF-BB on the rodent skeleton
1996
Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.
1986
Stimulation of osteoprotegerin production is responsible for osteosclerosis in mice overexpressing TPO
2003
Third-Generation Biomedical Materials
2002 StandoutScience
Colony stimulating factor-1 plays a role in osteoclast formation and function in bone resorption induced by parathyroid hormone and parathyroid hormone-related protein
1996
Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein.
1995
Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.
1987
Basic fibroblast growth factor stimulates expression of interstitial collagenase and inhibitors of metalloproteinases in rat bone cells.
1995
Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development.
1991 Standout
Endothelial cells in physiology and in the pathophysiology of vascular disorders.
1998 Standout
Role of transforming growth factor-beta in the development of the mouse embryo.
1987
The Molecular Biology of Axon Guidance
1996 StandoutScience
PERIOD1-Associated Proteins Modulate the Negative Limb of the Mammalian Circadian Oscillator
2005 StandoutScienceNobel
Extracellular-signal regulated kinase signaling pathway mediates downregulation of type I procollagen gene expression by FGF-2, PDGF-BB, and okadaic acid in osteoblastic cells
2000
Skeletal Growth Factors
2010
Human Aging: Usual and Successful
1987 StandoutScience
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor
1999 Standout
Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I
1993
A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.
1995 StandoutNobel
Works of Michael Centrella being referenced
Macrophage colony-stimulating factor release and receptor expression in bone cells
1993
Expression of Transforming Growth Factor Type III Receptor in Vascular Endothelial Cells Increases Their Responsiveness to Transforming Growth Factor β2
1995
Transforming growth factor beta is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures from fetal rat bone.
1987
Relative binding and biochemical effects of heterodimeric and homodimeric isoforms of platelet‐derived growth factor in osteoblast‐enriched cultures from fetal rat bone
1991
Transforming and nontransforming growth factors are present in medium conditioned by fetal rat calvariae.
1985
Parathyroid Hormone Enhances the Transcript and Polypeptide Levels of Insulin-Like Growth Factor I in Osteoblast-Enriched Cultures from Fetal Rat Bone*
1989
Activation of the Insulin-Like Growth Factor-Binding Protein-5 Promoter in Osteoblasts by Cooperative E Box, CCAAT Enhancer-Binding Protein, and Nuclear Factor-1 Deoxyribonucleic Acid-Binding Sequences1
1999
Further biochemical and molecular characterization of primary rat parietal bone cell cultures
1988
Opposing effects by glucocorticoid and bone morphogenetic protein-2 in fetal rat bone cell cultures
1997
Complex pattern of insulin‐like growth factor binding protein expression in primary rat osteoblast enriched cultures: Regulation by prostaglandin E2, growth hormone, and the insulin‐like growth factors
1994
Regulatory Effects of Insulin-Like Growth Factors I and II on Bone Collagen Synthesis in Rat Calvarial Cultures*
1989
Human Platelet-Derived Transforming Growth Factor-βStimulates Parameters of Bone Growth in Fetal Rat Calvariae*
1986
Transforming Growth Factor-β Gene Family Members and Bone*
1994
Skeletal tissue and transforming growth factor β
1988
Regulation of Insulin-Like Growth Factor-II Production in Bone Cultures*
1991
Transforming growth factor-beta and remodeling of bone.
1991
Determination and expression of platelet-derived growth factor-AA in bone cell cultures.
1992
Tumor Necrosis Factor-α Inhibits Collagen Synthesis and Alkaline Phosphatase Activity Independently of Its Effect on Deoxyribonucleic Acid Synthesis in Osteoblast-Enriched Bone Cell Cultures*
1988
Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.
1996
Parathyroid hormone modulates transforming growth factor beta activity and binding in osteoblast-enriched cell cultures from fetal rat parietal bone.
1988
Regulation of insulin-like growth factor I transcription by cyclic adenosine 3',5'-monophosphate (cAMP) in fetal rat bone cells through an element within exon 1: protein kinase A-dependent control without a consensus AMP response element.
1995
Changes in Bone Morphogenetic Protein Sensitivity Relative to Differentiation in Fetal Rat Bone Cell Cultures
1996
Receptors for Insulin-Like Growth Factors-I and -II in Osteoblast-Enriched Cultures from Fetal Rat Bone*
1990
Platelet-Derived Growth Factor Enhances Deoxyribonucleic Acid and Collagen Synthesis in Osteoblast-Enriched Cultures from Fetal Rat Parietal Bone*
1989
Cyclic AMP induces insulin-like growth factor I synthesis in osteoblast-enriched cultures.
1990
Rapid Flux in Transforming Growth Factor-β Receptors on Bone Cells
1996
Insulin-like growth factor I mediates selective anabolic effects of parathyroid hormone in bone cultures.
1989
Effects of basic fibroblast growth factor on bone formation in vitro.
1988
Multiple regulatory effects by transforming growth factor-beta on type I collagen levels in osteoblast-enriched cultures from fetal rat bone.
1992
Insulin-Like Growth Factor I Has Independent Effects on Bone Matrix Formation and Cell Replication*
1988
Local Regulators of Skeletal Growth: A Perspective*
1985
Effects of Fibroblast Growth Factors on Deoxyribonucleic Acid and Collagen Synthesis in Rat Parietal Bone Cells*
1989
Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone.
1992
Effect of Partially Purified Bone Morphogenetic Protein on DNA Synthesis and Cell Replication in Calvarial and Fibroblast Cultures
1985
Mitogenesis in fetal rat bone cells simultaneously exposed to type β transforming growth factor and other growth regulators
1987
Glucocorticoid regulation of transforming growth factor beta 1 activity and binding in osteoblast-enriched cultures from fetal rat bone.
1991
Activin-A Binding and Biochemical Effects in Osteoblast-Enriched Cultures from Fetal-Rat Parietal Bone
1991
Independent Changes in Type I and Type II Receptors for Transforming Growth Factor β Induced by Bone Morphogenetic Protein 2 Parallel Expression of the Osteoblast Phenotype
1995
Functional Cooperation between CCAAT/Enhancer-Binding Proteins and the Vitamin D Receptor in Regulation of 25-Hydroxyvitamin D3 24-Hydroxylase
2004
Role of platelet derived growth factor in bone cell function.
1992
Cloning, characterization, and expression of the transforming growth factor-beta type I receptor promoter in fetal rat bone cells.
1996
Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone.
1991
Recombinant Transforming Growth Factor Type β3: Biological Activities and Receptor-Binding Properties in Isolated Bone Cells
1990
Opposing effects by glucocorticoid and bone morphogenetic protein-2 in fetal rat bone cell cultures.
1997