Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues
2018 StandoutNobel
Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart
1989
Pharmacology of nootropics and metabolically active compounds in relation to their use in dementia
1990
Abdominal obesity and metabolic syndrome
2006 StandoutNature
Occurence and partition of the β-carboline norharman in rat organs
1993
QM/MM Methods for Biomolecular Systems
2009 Standout
Characterization of the cyclic nucleotide phosphodiesterase isoenzymes present in rat epididymal fat cells
1992
Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE 3 gene family)
1995
Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
2005 Standout
Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives
2004 Standout
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
2006 Standout
Psychomotor-stimulant effects of 3-isobutyl-1-methylxanthine: Comparison with caffeine and 7-(2-chloroethyl) theophylline
1989
Interrelationships of Cyclic GMP, Inositol Phosphates, and Calcium
1994 StandoutNobel
Selection of boron reagents for Suzuki–Miyaura coupling
2013 Standout
Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors
1990 Standout
The Pictet–Spengler Reaction in Nature and in Organic Chemistry
2011 Standout
Phosphodiesterase inhibitory profile of some related xanthine derivatives pharmacologically active on the peripheral microcirculation
1994
Effect of Oral Milrinone on Mortality in Severe Chronic Heart Failure
1991 Standout
Intake of Garlic and Its Bioactive Components
2001 Standout
Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function
1991
Phosphodiesterase inhibitors: new opportunities for the treatment of asthma.
1991
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review
2003 Standout
Simple indole alkaloids and those with a nonrearranged monoterpenoid unit
2010 Standout
Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations
1988 Standout
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
2010 Standout
Catalytic Functionalization of Indoles in a New Dimension
2009 Standout
Biology of Anxiety
1988
Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)
1997
Benzyl vinylogous amide substituted aryldihydropyridazinones and aryldimethylpyrazolones as potent and selective PDE3B inhibitors
2003
Cardiac cGMP-stimulated cyclic nucleotide phosphodiesterases: effects of cGMP analogues and drugs
1991
Behavioral and physiological effects of xanthines in nonhuman primates
1997
β-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO)
2009 Standout
8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) ? a selective high affinity antagonist radioligand for A1 adenosine receptors
1987
Clarifying the Real Bioactive Constituents of Garlic
2006 Standout
Subclasses of cyclic AMP phosphodiesterase in cardiac muscle
1987
Characterization of a Catalytic Ligand Bridging Metal Ions in Phosphodiesterases 4 and 5 by Molecular Dynamics Simulations and Hybrid Quantum Mechanical/Molecular Mechanical Calculations
2006
Crystal Structures of the Catalytic Domain of Phosphodiesterase 4B Complexed with AMP, 8-Br-AMP, and Rolipram
2004
Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY‐5445, vinpocetine and 1‐methyl‐3‐isobutyl‐8‐(methylamino)xanthine
1989
Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects
1992 Standout
The Isoenzyme Selectivity of AH 21–132 as an Inhibitor of Cyclic Nucleotide Phosphodiesterase Activity
1991
Cyclic guanosine 3',5'‐monophosphate regulates the calcium current in single cells from frog ventricle.
1987
Ribozyme catalysis: not different, just worse
2005 StandoutNobel
N‐acyliminium intermediates in solid‐phase synthesis
2010 StandoutNobel
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
1998 StandoutNobel
The mRNA encoding a high-affinity cAMP phosphodiesterase is regulated by hormones and cAMP.
1989
Pathophysiology of Human Visceral Obesity: An Update
2013 Standout
3d Transition Metals for C–H Activation
2018 Standout
Solid-Phase Intramolecular N-Acyliminium Pictet−Spengler Reactions as Crossroads to Scaffold Diversity
2004 StandoutNobel
Receptors for Purines and Pyrimidines
1998 Standout
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Use of the Pictet–Spengler reaction for the synthesis of 1,4-disubstituted-1,2,3,4-tetrahydro-β-carbolines and 1,4-disubstituted-β-carbolines: formation of γ-carbolines
2008
Current Status of Benzodiazepines
1983
Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells
1986 Nature
Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues
2018 StandoutNobel
4-Trifloxy-9-SEM-β-Carboline: Preparation and Synthetic Utility
1999
Palladium-catalyzed tandem C,N-arylation of immobilized enamine for solid phase indole synthesisElectronic supplementary information (ESI) available: experimental procedures. See http://www.rsc.org/suppdata/p1/b2/b206378f/
2002
Advances in Transition Metal (Pd,Ni,Fe)-Catalyzed Cross-Coupling Reactions Using Alkyl-organometallics as Reaction Partners
2011 Standout
Synthesis and Functionalization of Indoles Through Palladium-catalyzed Reactions
2005 Standout
Solid-Phase Synthesis of Indolecarboxylates Using Palladium-Catalyzed Reactions
2003
Phosphine Organocatalysis
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Recent developments in indole ring synthesis—methodology and applications
2000 Standout
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
A versatile route to benzocanthinones
2005
Regional variation in adipose tissue metabolism of severely obese premenopausal women.
1995
Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand.
1987
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
1995 Standout
Tetrahydro-β-carboline micro-injected into the hippocampus induces an anxiety-like state in the rat
1986
Pictet-Spengler reaction on solid support: Synthesis of 1,2,3,4-tetrahydro-β-carboline libraries
1996
Boron Reagents in Process Chemistry: Excellent Tools for Selective Reductions
2006
Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use
1999 Standout
Pyridazine derivatives. Part 33: Sonogashira approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones
2003
The interaction of natural products with cellular signalling mechanisms
1987
Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity
2000 Science
Green and Sustainable Solvents in Chemical Processes
2018 Standout
Phosphodiesterase 4D is required for β 2 adrenoceptor subtype-specific signaling in cardiac myocytes
2005 StandoutNobel
Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors
2005
Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast.
1992
Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome
2000 Standout
First Computational Evidence for a Catalytic Bridging Hydroxide Ion in a Phosphodiesterase Active Site
2001
Synthesis of 3-Substituted Quinolines via Transition-Metal-Catalyzed Reductive Cyclization of o-Nitro Baylis−Hillman Acetates
2003
N-Terminal Peptide Aldehydes as Electrophiles in Combinatorial Solid Phase Synthesis of Novel Peptide Isosteres
2000 StandoutNobel
Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets
1986
Direct biocatalytic synthesis of functionalized catechols: a green alternative to traditional methods with high effective mass yield
2000
Novel Selective PDE IV Inhibitors as Antiasthmatic Agents. Synthesis and Biological Activities of a Series of 1-Aryl-2,3-bis(hydroxymethyl)naphthalene Lignans
1996
Selective oxidation of canthines to canthin-6-ones with triethylbenzylammonium permanganate
1994
Stereospecificity in the Pictet-Spengler reaction kinetic vs thermodynamic control
1991
A practical synthesis of 1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid derivatives from pyrrole-2-carboxaldehydes
1993
Receptors for Purines and Pyrimidines
2012 Standout
Construction of the Benzindenoazepine Skeleton via Cyclopentannulation of Fischer Aminocarbene Complexes: Total Synthesis of Bulgaramine
2005
Advances in the Baylis–Hillman reaction-assisted synthesis of cyclic frameworks
2008 Standout
The Neuropsychology of Anxiety
2003 Standout
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
2001 Standout
Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes.
1989
C–H Alkylations of (Hetero)Arenes by Maleimides and Maleate Esters through Cobalt(III) Catalysis
2017
Subclasses of cyclic AMP-specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility.
1987
The Nature of Recollection and Familiarity: A Review of 30 Years of Research
2002 Standout
Antinociceptive action of nitrous oxide is mediated by stimulation of noradrenergic neurons in the brainstem and activation of [alpha]2B adrenoceptors.
2000 StandoutNobel
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
2007 Standout
Heterocyclic Nanographenes and Other Polycyclic Heteroaromatic Compounds: Synthetic Routes, Properties, and Applications
2016 Standout
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
2013 StandoutNobel
One-Pot Phosphine-Catalyzed Syntheses of Quinolines
2012
Mechanism driven trans stereospecificity in the Pictet-Spengler reaction. Stereospecific formation of trans-1,2,3-trisubstituted-tetrahydro β- carbolines by condensation of Nb-diphenylmethyl tryptophan isopropyl esters wtm aldehydes
1992
The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors
1987
Antitumor Agents. 207. Design, Synthesis, and Biological Testing of 4β-Anilino-2-fluoro-4‘-demethylpodophyllotoxin Analogues as Cytotoxic and Antiviral Agents
2001
Syhthesis of pentacyclic β-carbolike and 1,4-benzodiazepine hybrid molecules by dehydrogenatioh-trahsamidation of quinazolino-tetrahydro-β-carbolines
1987
Towards control of χ-space: Conformationally constrained analogues of Phe, Tyr, Trp and His
1999
Benzodiazepine Receptors and Their Relationship to the Treatment of Epilepsy
1986
Works of Michael Cain being referenced
Synthesis of 5,6-methylenedioxy-1-tetralone. An aryl grignard approach from guaiacol
1995
3-Hydroxymethyl-β-carboline antagonizes some pharmacologic actions of diazepam
1981
Cardiotonic agents. 4. Synthesis and biological evaluation of N-substituted 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones: rigid structures derived from CI-930 and analogs
1986
Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists, Ro 15-1788 and CGS 8216
1982
A New Generation of Phosphodiesterase Inhibitors: Multiple Molecular Forms of Phosphodiesterase and the Potential for Drug Selectivity
1985
Biomimetic approach to potential benzodiazepine receptor agonists and antagonists
1984
A Scalable Process for the Novel Antidepressant ABT-200
1998
A Benzodiazepine Receptor Antagonist Decreases Sleep and Reverses the Hypnotic Actions of Flurazepam
1983 Science
.beta.-Carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors
1982