Citation Impact
Citing Papers
The Hepatitis C Virus NS3 Protein: A Model RNA Helicase and Potential Drug Target
2007
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
Neutralizing antibody response during acute and chronic hepatitis C virus infection
2004 StandoutNobel
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
2008 StandoutNobel
Structural inference of native and partially folded RNA by high-throughput contact mapping
2008 StandoutNobel
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target.
2007
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
NS3 Helicase from the Hepatitis C Virus Can Function as a Monomer or Oligomer Depending on Enzyme and Substrate Concentrations
2008
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Functional Properties of a Monoclonal Antibody Inhibiting the Hepatitis C Virus RNA-dependent RNA Polymerase
2002
Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things
1998
Challenges and successes in developing new therapies for hepatitis C
2005 Nature
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding
1998
The ϕ29 DNA polymerase:protein‐primer structure suggests a model for the initiation to elongation transition
2006 StandoutNobel
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
ATP Binding Modulates the Nucleic Acid Affinity of Hepatitis C Virus Helicase
2003
The Nonstructural Protein 3 Protease/Helicase Requires an Intact Protease Domain to Unwind Duplex RNA Efficiently
2004
Development of novel therapies for hepatitis C
2010
The Helicase from Hepatitis C Virus Is Active as an Oligomer
1999
Mechanism of autoproteolysis at the NS2–NS3 junction of the hepatitis C virus polyprotein
1998
A Novel Mechanism to Ensure Terminal Initiation by Hepatitis C Virus NS5B Polymerase
2001
Treatment triumphs
2014 StandoutNatureNobel
RecA-like motor ATPases—lessons from structures
2004
A Common Core RNP Structure Shared between the Small Nucleoar Box C/D RNPs and the Spliceosomal U4 snRNP
2000 StandoutNobel
Quaternary Polymorphism of Replicative Helicase G40P: Structural Mapping and Domain Rearrangement
2006
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Two Novel Conserved Motifs in the Hepatitis C Virus NS3 Protein Critical for Helicase Action
2003
A mechanism for initiating RNA-dependent RNA polymerization
2001 Nature
Molecular virology of hepatitis C virus.
1997
RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP
2006 Nature
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
2003
Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase
1999
Product Release Is the Major Contributor tok cat for the Hepatitis C Virus Helicase-catalyzed Strand Separation of Short Duplex DNA
1998
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Mechanistic Basis of 5′-3′ Translocation in SF1B Helicases
2009
Hepatitis C: an update
2001
Hepatitis C Virus Proteins: From Structure to Function
2013
Internal Processing of Hepatitis C Virus NS3 Protein
1999
The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding
2002
Chapter 2 Cutting the Gordian Knot-Development and Biological Relevance of Hepatitis C Virus Cell Culture Systems
2008
Determinants for Membrane Association of the Hepatitis C Virus RNA-dependent RNA Polymerase
2001 StandoutNobel
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
2005 StandoutNature
DNA Structure and Aspartate 276 Influence Nucleotide Binding to Human DNA Polymerase β
2001
Escherichia coli DNA Helicase II Is Active as a Monomer
1999
DEAD-box proteins: the driving forces behind RNA metabolism
2004
The Serine Protease Domain of Hepatitis C Viral NS3 Activates RNA Helicase Activity by Promoting the Binding of RNA Substrate
2007
NMR structure of the N-terminal domain of E. coli DnaB helicase: implications for structure rearrangements in the helicase hexamer
1999
RNA helicases — one fold for many functions
2007
Crystal Structure of the Helicase Domain from the Replicative Helicase-Primase of Bacteriophage T7
1999
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
1999
Hydrophobic Groups Stabilize the Hydration Shell of 2′-O-Methylated RNA Duplexes
2001
Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A
2012
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Hepatitis C Virus-Specific Directly Acting Antiviral Drugs
2013
A novel recombinant single‐chain hepatitis C virus ns3‐ns4a protein with improved helicase activity
1999
Crystal Structure of RNA Helicase from Genotype 1b Hepatitis C Virus
1998
From Structure to Function: New Insights into Hepatitis C Virus RNA Replication
2005
Structural biology of hepatitis C virus
2004
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
2014 Standout
Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties
2000 StandoutNobel
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Host sphingolipid biosynthesis as a target for hepatitis C virus therapy
2005
A surprising simplicity to protein folding
2000 StandoutNatureNobel
Viral and cellular RNA helicases as antiviral targets
2005
Novel Insights into Hepatitis C Virus Replication and Persistence
2004
What Are the Promising New Therapies in the Field of Chronic Hepatitis C After the First-Generation Direct-Acting Antivirals?
2012
New therapeutic strategies for hepatitis C
2002 StandoutNobel
25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end
2013
Crystal Structures of Complexes of PcrA DNA Helicase with a DNA Substrate Indicate an Inchworm Mechanism
1999
Flexibility of the Rings: Structural Asymmetry in the DnaB Hexameric Helicase
2002
Parallels among positive-strand RNA viruses, reverse-transcribing viruses and double-stranded RNA viruses
2006
Replication of hepatitis C virus
2007 StandoutNobel
Hepatitis C Virus RNA Functionally Sequesters miR-122
2015 StandoutNobel
Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
2003 StandoutNobel
Initiation of viral RNA-dependent RNA polymerization
2004
The Structure of a Transcribing T7 RNA Polymerase in Transition from Initiation to Elongation
2008 StandoutScienceNobel
A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity
2005 StandoutNobel
Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line
1999 StandoutScience
Replication of hepatitis C virus
2000
A cis -Acting Replication Element in the Sequence Encoding the NS5B RNA-Dependent RNA Polymerase Is Required for Hepatitis C Virus RNA Replication
2004 StandoutNobel
Mechanism of action of a pestivirus antiviral compound
2000 StandoutNobel
Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides
2002
[68] Benzophenone-ATP: A photoaffinity label for the active site of ATPases
1986
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Viral Proteomics
2007
Ultrastructural analysis of hepatitis C virus particles
2013 StandoutNobel
Subcellular Localization, Stability, and trans -Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines
2000 StandoutNobel
Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains
2012
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
2012 StandoutNobel
ESR spin-label studies of lipid-protein interactions in membranes
1982
Structure-Based Mutagenesis Study of Hepatitis C Virus NS3 Helicase
1999
Biochemical and structural analysis of the NS5B RNA‐dependent RNA polymerase of the hepatitis C virus
2000
The Hepatitis C Virus NS3 Proteinase: Structure and Function of a Zinc-Containing Serine Proteinase
1998
Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA Polymerase
2002
A bacterial Argonaute with noncanonical guide RNA specificity
2016 StandoutNobel
cis -Acting RNA Signals in the NS5B C-Terminal Coding Sequence of the Hepatitis C Virus Genome
2004
Hepatitis C Virus Subgenomic Replicon Requires an Active NS3 RNA Helicase
2005
Studying Hepatitis C Virus: Making the Best of a Bad Virus
2007 StandoutNobel
Mutations That Affect Dimer Formation and Helicase Activity of the Hepatitis C Virus Helicase
2001 StandoutNobel
Specific Interaction of Hepatitis C Virus Protease/Helicase NS3 with the 3′-Terminal Sequences of Viral Positive- and Negative-Strand RNA
2001
Simulations of RNA base pairs in a nanodroplet reveal solvation-dependent stability
2007 StandoutNobel
Cloning of a Subunit of Yeast RNA Oolymerase II Transcription Factor b and CTD Kinase
1992 StandoutScienceNobel
Computer simulations of protein functions: Searching for the molecular origin of the replication fidelity of DNA polymerases
2005 StandoutNobel
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Mutational analysis of the hepatitis C virus RNA helicase
1997
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs
2002 StandoutNobel
Characterization of Soluble Hepatitis C Virus RNA-Dependent RNA Polymerase Expressed in Escherichia coli
1999
Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders
2005 StandoutNobel
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
2003
Structure of Hexameric DnaB Helicase and Its Complex with a Domain of DnaG Primase
2007 StandoutScienceNobel
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Protein Displacement by DExH/D "RNA Helicases" Without Duplex Unwinding
2004 Science
Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation
2004 StandoutNobel
Multiple Enzymatic Activities Associated with Recombinant NS3 Protein of Hepatitis C Virus
1998
Structure-Based Mutational Analysis of the Hepatitis C Virus NS3 Helicase
2001
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication
2004 StandoutNobel
Membrane Association of the RNA-Dependent RNA Polymerase Is Essential for Hepatitis C Virus RNA Replication
2004
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Michael Cable being referenced
Structure of the hepatitis C virus RNA helicase domain
1997
Spin-labeled cardiolipin: preferential segregation in the boundary layer of cytochrome c oxidase
1980
Probing the Relationship between RNA-Stimulated ATPase and Helicase Activities of HCV NS3 Using 2‘-O-Methyl RNA Substrates
2000
Cardiolipin: a stereospecifically spin-labeled analogue and its specific enzymic hydrolysis.
1978
1999
Labeling the adenine nucleotide binding domain of the sarcoplasmic reticulum Ca,Mg-ATPase with photoaffinity analogs of ATP.
1984