Standout Papers
Citation Impact
Citing Papers
Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice
2003
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus
2018
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
2002 StandoutNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Locus control regions: coming of age at a decade plus
1999
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Beta-globin locus activation regions: conservation of organization, structure, and function.
1990
Human gamma- to beta-globin gene switching in transgenic mice.
1990
Paraspeckles
2002
Precursor RNAs Harboring Nonsense Codons Accumulate Near the Site of Transcription
2001
The Influence of Chromosomal Location on the Expression of Two Transgenes in Mice
1999 StandoutNobel
Recent advances in understanding and managing adenosine deaminase and purine nucleoside phosphorylase deficiencies
2013
KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading
2010
Locus control regions of mammalian β-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights
1997
The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation
2008
The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner
1989
Focal Spots of Size λ / 23 Open Up Far-Field Florescence Microscopy at 33 nm Axial Resolution
2002 StandoutNobel
Alternative isoform regulation in human tissue transcriptomes
2008 StandoutNature
A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy
1998
Replication and transcription: Shaping the landscape of the genome
2005
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Problems and paradigms: Induction mechanism of a single gene molecule: Stochastic or deterministic?
1992
Early Formation of mRNP
2003 StandoutNobel
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
2009 StandoutNature
A Block to mRNA Nuclear Export in S. cerevisiae Leads to Hyperadenylation of Transcripts that Accumulate at the Site of Transcription
2001 StandoutNobel
Gene Transfer into Hematopoietic Stem Cells
1992
Negative regulation of transcriptional initiation in eukaryotes
1990
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Quality control of mRNA 3′-end processing is linked to the nuclear exosome
2001 StandoutNatureNobel
Mammalian microRNAs predominantly act to decrease target mRNA levels
2010 StandoutNature
An extensive network of coupling among gene expression machines
2002 Nature
Studies on the role of NonA in mRNA biogenesis
2006
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2017 StandoutNature
Lethal α–thalassaemia created by gene targeting in mice and its genetic rescue
1995
Production of recombinant protein therapeutics in cultivated mammalian cells
2004 Standout
High resolution protein localization using soft X‐ray microscopy
2001
The Polymyositis-Scleroderma Autoantigen Interacts with the Helix-Loop-Helix Proteins E12 and E47
1997
2 The regulation of human globin gene expression
1993
The β-Globin LCR Is Not Necessary for an Open Chromatin Structure or Developmentally Regulated Transcription of the Native Mouse β-Globin Locus
1998
Genome-wide MyoD Binding in Skeletal Muscle Cells: A Potential for Broad Cellular Reprogramming
2010
An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells
2000 Nature
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
2007 StandoutNature
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Protein folding and misfolding
2003 StandoutNature
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
A 5′ element of the chicken β-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila
1993
The yin and yang of the exosome
2002
T7 RNA polymerase-directed transcripts are processed in yeast and link 3??? end formation to mRNA nuclear export
2002 StandoutNobel
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
A locus control region in the T cell receptor α/δ locus
1994
A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript
2004 StandoutNobel
Regulation of β-globin gene expression: straightening out the locus
1996
Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3′-end formation of nascent transcripts
2001
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells
2009
3′‐end formation signals modulate the association of genes with the nuclear periphery as well as mRNP dot formation
2006 StandoutNobel
Nuclear export of mRNA
2001
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice
1990 Nature
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Zinc fingers are sticking together
1998
Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells.
1995 StandoutNobel
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Functional Analysis of the Human Adenosine Deaminase Gene Thymic Regulatory Region and Its Ability To Generate Position-Independent Transgene Expression
1992
Extinction of the tumor necrosis factor locus, and of genes encoding the lipopolysaccharide signaling pathway.
1993 StandoutNobel
RanGTP-mediated nuclear export of karyopherin α involves its interaction with the nucleoporin Nup153
1997 StandoutNobel
The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells
1998
PROTOFIBRILS , PORES , FIBRILS, AND NEURODEGENERATION : Separating the Responsible Protein Aggregates from The Innocent Bystanders
2003
Eukaryotic mRNA Decapping
2004
Two distinct classes of Ran-binding sites on the nucleoporin Nup-358
1999 StandoutNobel
Rad51 expression and localization in B cells carrying out class switch recombination.
1996
Quality Control by DNA Repair
1999 StandoutScienceNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Total Chemical Synthesis of the Integral Membrane Protein Influenza A Virus M2: Role of Its C-Terminal Domain in Tetramer Assembly
1999
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
Formation of mRNA 3′ Ends in Eukaryotes: Mechanism, Regulation, and Interrelationships with Other Steps in mRNA Synthesis
1999
Mass spectrometry-based proteomics
2003 StandoutNature
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
1996
On the importance of being co-transcriptional
2002
The connection between transcription and genomic instability
2002
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
2000 StandoutNobel
Polypyrimidine Tract Binding Protein Modulates Efficiency of Polyadenylation
2004
Human globin locus activation region (LAR): role in temporal control
1990
The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives
2003
A genetically clamped renin transgene for the induction of hypertension
2002 StandoutNobel
Stochastic Gene Expression in a Single Cell
2002 StandoutScience
Inactivation of the human beta-globin gene by targeted insertion into the beta-globin locus control region.
1992
Semisynthesis and Folding of the Potassium Channel KcsA
2002 StandoutNobel
SRm160 Splicing Coactivator Promotes Transcript 3′-End Cleavage
2002
Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position-independent transgene expression.
1992
Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.
1995
Chromatin modification by DNA tracking
1999
Transport Between the Cell Nucleus and the Cytoplasm
1999 Standout
Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.
1993 StandoutNobel
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
1997 StandoutScience
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
TAPping into mRNA Export
2001 StandoutScienceNobel
Genomic analysis of orthologous mouse and human olfactory receptor loci
2001 StandoutNobel
RNA TRANSPORT
1997
Coupling of Termination, 3′ Processing, and mRNA Export
2002
Tracking Col1a1 RNA in Osteogenesis Imperfecta
2000
Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation
2011 StandoutNobel
Characterization of the DNase I hypersensitive site 3' of the human beta globin gene domain
1993
Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors
2011
A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation
2006 StandoutNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions.
1990
Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation
2004 StandoutNobel
High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human hemoglobin in murine erythrocytes.
1989
Conservation of sequence and structure flanking the mouse and human β-globin loci: The β-globin genes are embedded within an array of odorant receptor genes
1999 StandoutNobel
A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.
1990
Works of Michael Antoniou being referenced
CpG-island fragments from the HNRPA2B1/CBX3genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells
2005
TBP binding and the rate of transcription initiation from the human β-globin gene
1995
Transcriptional activation by hypersensitive site three of the human β-globin locus control region in murine erythroleukemia cells
1994
LCR/MEL: A versatile system for high-level expression of heterologous proteins in erythroid cells
1992
Correlation of DNA Methylation with Histone Modifications Across the HNRPA2B1-CBX3 Ubiquitously-Acting Chromatin Open Element (UCOE)
2007
Transgenes encompassing dual-promoter CpG islands from the human TBP and HNRPA2B1 loci are resistant to heterochromatin-mediated silencing
2003
An interaction between U2AF 65 and CF Im links the splicing and 3′ end processing machineries
2006
The β-Globin Locus Control Region in Combination With the EF1α Short Promoter Allows Enhanced Lentiviral Vector-mediated Erythroid Gene Expression With Conserved Multilineage Activity
2012
Inefficient processing impairs release of RNA from the site of transcription
1999
A dominant control region from the human β-globin locus conferring integration site-independent gene expression
1989 Nature
Efficient 3'-end formation of human beta-globin mRNA in vivo requires sequences within the last intron but occurs independently of the splicing reaction
1998
The human desmin locus: Gene organization and LCR-mediated transcriptional control
2006
Muscle-Specific Locus Control Region Activity Associated with the Human Desmin Gene
1998
Induction of Erythroid-Specific Expression in Murine Erythroleukemia (MEL) Cell Lines
2003
A Ubiquitous Chromatin Opening Element (UCOE) Confers Resistance to DNA Methylation–mediated Silencing of Lentiviral Vectors
2010
Protease-resistant prion protein produced in vitro lacks detectable infectivity.
1999
GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes.
1996
In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of β-thalassemia
2008
Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.
1990
Nuclear organization of splicing snRNPs during differentiation of murine erythroleukemia cells in vitro.
1993
Beta-globin gene promoter generates 5′ truncated transcripts in the embryonic/fetal erythrold environment
1987
beta-globin dominant control region interacts differently with distal and proximal promoter elements.
1990
Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells.
1996
β-Globin gene promoter generates 5′ truncated transcripts in the embryonic/fetal erythroid environment
1986
Splicing- and cleavage-independent requirement of RNA polymerase II CTD for mRNA release from the transcription site
2007
A novel function for the U2AF 65 splicing factor in promoting pre‐mRNA 3′‐end processing
2002
Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells
2007
Analysis of intergenic transcription in the human IL-4/IL-13 gene cluster
2004