Standout Papers
Citation Impact
Citing Papers
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
2010
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
2006
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
Serotonin Transporter Genetic Variation and the Response of the Human Amygdala
2002 StandoutScience
Targeting bile-acid signalling for metabolic diseases
2008
The human fatty acid-binding protein family: Evolutionary divergences and functions
2011
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor
2002
The Hypolipidemic Natural Product Guggulsterone Acts as an Antagonist of the Bile Acid Receptor
2002
Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism
2001
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
2005 Standout
Suppression of sterol 12α-hydroxylase transcription by the short heterodimer partner: insights into the repression mechanism
2001
Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice
2014
Inflammation and metabolic disorders
2006 StandoutNature
FOR, a Novel Orphan Nuclear Receptor Related to Farnesoid X Receptor
2002
HDL-cholesterol and cardiovascular disease
2015
Effects of Torcetrapib in Patients at High Risk for Coronary Events
2007 Standout
Loss of Nuclear Receptor SHP Impairs but Does Not Eliminate Negative Feedback Regulation of Bile Acid Synthesis
2002
Disruption of the Sterol 27-Hydroxylase Gene in Mice Results in Hepatomegaly and Hypertriglyceridemia
2000
The Negative Effects of Bile Acids and Tumor Necrosis Factor-α on the Transcription of Cholesterol 7α-Hydroxylase Gene (CYP7A1) Converge to Hepatic Nuclear Factor-4
2001
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
2006 StandoutNature
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
2014 StandoutNature
Orphan Nuclear Receptors as eLiXiRs and FiXeRs of Sterol Metabolism
2001
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
2007
27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells
2001
Liver X receptors as integrators of metabolic and inflammatory signaling
2006
Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors
2000
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice
2005
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
2012
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation
2009
The changing landscape of atherosclerosis
2021 StandoutNature
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
2009
Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor
2002
Macrophage death and defective inflammation resolution in atherosclerosis
2009
Farnesoid X receptor is essential for normal glucose homeostasis
2006
Bile acid sequestrants
2011
Regulation of Complement C3 Expression by the Bile Acid Receptor FXR
2004
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Redundant Pathways for Negative Feedback Regulation of Bile Acid Production
2002
Farnesoid X-Activated Receptor Induces Apolipoprotein C-II Transcription: a Molecular Mechanism Linking Plasma Triglyceride Levels to Bile Acids
2001
Independent Repression of Bile Acid Synthesis and Activation of c-Jun N-terminal Kinase (JNK) by Activated Hepatocyte Fibroblast Growth Factor Receptor 4 (FGFR4) and Bile Acids
2005
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
PRDM16 controls a brown fat/skeletal muscle switch
2008 StandoutNature
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
2000 Standout
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
LXRβ Is Required for Adipocyte Growth, Glucose Homeostasis, and β Cell Function
2005
Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR
2007
Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho
2005
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Transcriptional Regulation of the Human Sterol 12α-Hydroxylase Gene (CYP8B1)
2001
3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV
2008
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
2004 Standout
The Effect of Interleukin-1 Receptor Antagonist on Arteries and Cholesterol Metabolism
2006
Combinatorial roles of nuclear receptors in inflammation and immunity
2005
FXR Agonists as Therapeutic Agents for Non-alcoholic Fatty Liver Disease
2015
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
2012
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
2013
Down-regulation of Cholesterol 7α-Hydroxylase (CYP7A1) Gene Expression by Bile Acids in Primary Rat Hepatocytes Is Mediated by the c-Jun N-terminal Kinase Pathway
2001
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism
2016 Standout
Enterohepatic Circulation of Bile Salts in Farnesoid X Receptor-deficient Mice
2003
The BDNF val66met Polymorphism Affects Activity-Dependent Secretion of BDNF and Human Memory and Hippocampal Function
2003 Standout
Transcriptional regulation of hepatic lipogenesis
2015
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
2004
Klotho converts canonical FGF receptor into a specific receptor for FGF23
2006 StandoutNature
Bile acids as regulatory molecules
2009
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
AKT/PKB Signaling: Navigating the Network
2017 Standout
Methotrexate Conjugates: A Molecular In Vivo Protein Tag
2004
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
2003
Adipocyte differentiation from the inside out
2006 Standout
Phospholipid Transfer Protein Is Regulated by Liver X Receptors in Vivo
2002
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
2006 Standout
Dual Mechanisms for Repression of the Monomeric Orphan Receptor Liver Receptor Homologous Protein-1 by the Orphan Small Heterodimer Partner
2002
The Hallmarks of Aging
2013 Standout
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
2003
Tumor Necrosis Factor α-dependent Up-regulation of Lrh-1 and Mrp3(Abcc3) Reduces Liver Injury in Obstructive Cholestasis
2003
Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
2002
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation
2001
Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms
2003
The Amino Acid Residues Asparagine 354 and Isoleucine 372 of Human Farnesoid X Receptor Confer the Receptor with High Sensitivity to Chenodeoxycholate
2002
Human Bile Salt Export Pump Promoter Is Transactivated by the Farnesoid X Receptor/Bile Acid Receptor
2001
A Nuclear Receptor Atlas: 3T3-L1 Adipogenesis
2005
HDL as a target in the treatment of atherosclerotic cardiovascular disease
2005
Crosstalk between LXR and Toll-like Receptor Signaling Mediates Bacterial and Viral Antagonism of Cholesterol Metabolism
2003
Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8
2003
Dietary Cholesterol Fails to Stimulate the Human Cholesterol 7α-Hydroxylase Gene (CYP7A1) in Transgenic Mice
2002
Bifidobacteria can protect from enteropathogenic infection through production of acetate
2011 StandoutNature
Bile acid receptors as targets for drug development
2013
Tissue-specific function of farnesoid X receptor in liver and intestine
2011
Inflammasomes in health and disease
2012 StandoutNature
Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP
2005
A Chemical, Genetic, and Structural Analysis of the Nuclear Bile Acid Receptor FXR
2003
Catechol-o-Methyltransferase, Cognition, and Psychosis: Val158Met and Beyond
2006
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
A catechol- O -methyltransferase that is essential for auditory function in mice and humans
2008 StandoutNobel
The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity
2009
Regulation of bile acid synthesis under reconstructed enterohepatic circulation in rats
2004
De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters
2014 StandoutNobel
Regulatory circuits controlling white versus brown adipocyte differentiation
2006
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
Identification of Farnesoid X Receptor β as a Novel Mammalian Nuclear Receptor Sensing Lanosterol
2003 StandoutNobel
Autoregulation of the Human Liver X Receptor α Promoter
2001
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
2003 Standout
Targeted inactivation of sister of P-glycoprotein gene ( spgp ) in mice results in nonprogressive but persistent intrahepatic cholestasis
2001
Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor.
2001
Apoptotic Regulation by the Crk Adapter Protein Mediated by Interactions with Wee1 and Crm1/Exportin
2002
A Lewis Acid Mediated Schmidt Reaction of Benzylic Azide: Synthesis of Sterically Crowded Aromatic Tertiary Amines
2011
A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP
2002
Modulation of insulin-like growth factor-II/mannose 6-phosphate receptors and transforming growth factor-beta 1 during liver regeneration.
1991
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 Nobel
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
2001
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
2001
BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
2002
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Liver Regeneration
1997 StandoutScience
Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor γ Expression
2004
Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
2002
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
The Caenorhabditis elegans Nuclear Receptor Gene nhr-25 Regulates Epidermal Cell Development
2004
Microarray Analyses during Adipogenesis: Understanding the Effects of Wnt Signaling on Adipogenesis and the Roles of Liver X Receptor α in Adipocyte Metabolism
2002
A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle
2010 StandoutNobel
Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR
2000
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
2001 Standout
Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells
2003
The Hypolipidemic Natural Product Guggulsterone Acts as an Antagonist of the Bile Acid Receptor
2002
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
2002
Structural insights into gene repression by the orphan nuclear receptor SHP
2013
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
2004 StandoutScience
Works of Michael A. Watson being referenced
Liver X receptors are regulators of adipocyte gene expression but not differentiation
2004
Expression of c‐raf‐1 and A‐raf‐1 during regeneration of rat liver following surgical partial hepatectomy
1989
A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid Biosynthesis
2000 Standout
Direct and Indirect Mechanisms for Regulation of Fatty Acid Synthase Gene Expression by Liver X Receptors
2002
Liver X Receptor (LXR) Regulation of the LXRα Gene in Human Macrophages
2001
Differential Regulation of Rat and HumanCYP7A1by the Nuclear Oxysterol Receptor Liver X Receptor-α
2003
Sterol Regulatory Element-binding Protein-1c Is Responsible for Cholesterol Regulation of Ileal Bile Acid-binding Protein Gene in Vivo
2002
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor
2002
Synthetic LXR ligand inhibits the development of atherosclerosis in mice
2002
An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.
1997
Identification of a Nonsteroidal Liver X Receptor Agonist through Parallel Array Synthesis of Tertiary Amines
2002
Vectors Encoding Alternative Antibiotic Resistance for Use in the Yeast Two-Hybrid System
1996
Pharmacophore Analysis of the Nuclear Oxysterol Receptor LXRα
2001