Standout Papers
Citation Impact
Citing Papers
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Transmembrane Protein 16A (TMEM16A) Is a Ca2+-regulated Cl– Secretory Channel in Mouse Airways
2009
Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)
1992
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation
1991 Nature
Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508delCFTR
2015 Standout
New animal models of cystic fibrosis
2011
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
1994 Standout
Long-term uncoupling of chloride secretion from intracellular calcium levels by lns(3,4,5,6)P4
1994 StandoutNatureNobel
Understanding how cystic fibrosis mutations disrupt CFTR function: From single molecules to animal models
2014
Calcium-activated potassium channels expressed from cloned complementary DNAs
1992 StandoutNobel
Generation and characterization of a ΔF508 cystic fibrosis mouse model
1995 StandoutNobel
Targeting genes for self-excision in the germ line
1999 StandoutNobel
Bicarbonate secretion in rabbit ileum: Electrogenicity, ion dependence, and effects of cyclic nucleotides
1993
Targeting the mouse genome: a compendium of knockouts (part I)
1995
Influence of gender, menstrual phase, and oral contraceptive use on immunological changes in response to prolonged cycling
2005
The intrinsic Cl - conductance of mouse kidney cortex brush-border membrane vesicles is not related to CFTR
1997 StandoutNobel
Characteristics and roles of the volume-sensitive outwardly rectifying (VSOR) anion channel in the central nervous system
2014
Chloride channels and anion fluxes in a human colonic epithelium (HCA‐7)
1992
Structure of Dengue Virus
2002 Standout
Small-Molecule Screen Identifies Inhibitors of a Human Intestinal Calcium-Activated Chloride Channel
2007
N-Glycosylation Is Essential for Vesicular Targeting of Synaptotagmin 1
2004 StandoutNobel
Bicarbonate permeability of the outwardly rectifying anion channel
1989
Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease
2011
Production of a severe cystic fibrosis mutation in mice by gene targeting
1993 StandoutNobel
Ion modulation of membrane permeability: Effect of cations on intact cells and on cells and phospholipid bilayers treated with pore-forming agents
1988
Time-domain fluorescence lifetime imaging for intracellular pH sensing in living tissues
2008
Identification and regulation of the cystic fibrosis transmembrane conductance regulator-generated chloride channel.
1991
Acute Pancreatitis
2016 Standout
Mitochondria: In Sickness and in Health
2012 Standout
A functional CFTR protein is required for mouse intestinal cAMP‐, cGMP‐ and Ca2+‐dependent HCO3− secretion
1997 StandoutNobel
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung
2012 Nature
Mechanically Activated Ion Channels
2015 StandoutNobel
G Protein-coupled Receptor Kinase 6A Phosphorylates the Na+/H+ Exchanger Regulatory Factor via a PDZ Domain-mediated Interaction
1999 StandoutNobel
Mouse pancreatic acinar/ductlar tissue gives rise to epithelial cultures that are morphologically, biochemically, and functionally indistinguishable from interlobular duct cell cultures
1994
Processing of CFTR: Traversing the cellular maze—How much CFTR needs to go through to avoid cystic fibrosis?
2005
Bicarbonate permeability of epithelial chloride channels
1991
Tracking and Elucidating Alphavirus-Host Protein Interactions
2006 StandoutNobel
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
Regulation of membrane chloride currents in rat bile duct epithelial cells.
1993
Cystic fibrosis genetics: from molecular understanding to clinical application
2014 Standout
Striatal Expression of a Calmodulin Fragment Improved Motor Function, Weight Loss, and Neuropathology in the R6/2 Mouse Model of Huntington's Disease
2009
Localization of the cystic fibrosis transmembrane conductance regulator in pancreas.
1991
Disease-associated Mutations in the Fourth Cytoplasmic Loop of Cystic Fibrosis Transmembrane Conductance Regulator Compromise Biosynthetic Processing and Chloride Channel Activity
1996
Cystic fibrosis: molecular biology and therapeutic implications
1992 StandoutScience
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Airway Mucus Function and Dysfunction
2010 Standout
The Multifunctional Fish Gill: Dominant Site of Gas Exchange, Osmoregulation, Acid-Base Regulation, and Excretion of Nitrogenous Waste
2004 Standout
twine, a cdc25 homolog that functions in the male and female germline of drosophila
1992 StandoutNobel
Expression of the cystic fibrosis gene in non-epithelial invertebrate cells produces a regulated anion conductance
1991
CFTR: Development of high- affinity antibodies and localization in sweat gland
1991
Fibre optic sensor for the detection of potassium using fluorescence energy transfer
1990
Degradation of CFTR by the ubiquitin-proteasome pathway
1995 Standout
A mouse model for the delta F508 allele of cystic fibrosis.
1995 StandoutNobel
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
1996 StandoutNature
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
2008 Standout
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
1993 StandoutNatureNobel
Phosphorylation-regulated CI− channel in CHO cells stably expressing the cystic fibrosis gene
1991 Nature
An Apical PDZ Protein Anchors the Cystic Fibrosis Transmembrane Conductance Regulator to the Cytoskeleton
1998
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
Effect of secretion on intracellular pH regulation in isolated rat bile duct epithelial cells.
1993
Volume-activated Cl− channels
1996
Genetic Risk Factors for Pancreatic Disorders
2013
An Animal Model for Cystic Fibrosis Made by Gene Targeting
1992 StandoutScienceNobel
Anion Transport in Heart
2000
Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates.
1993
The alphaviruses: gene expression, replication, and evolution
1994 Standout
Fluorescence ratio imaging of cytosolic free Na+ in individual fibroblasts and lymphocytes
1989 StandoutNobel
REGULATION OF NORMAL AND CYSTIC FIBROSIS AIRWAY SURFACE LIQUID VOLUME BY PHASIC SHEAR STRESS
2005
Generation of cAMP-Activated Chloride Currents by Expression of CFTR
1991 Science
Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands
1997 StandoutNobel
Inhibition of the Endogenous Volume-regulated Anion Channel (VRAC) in HEK293 Cells by Acidic Di-Aryl-Ureas
2003
Defective Epithelial Chloride Transport in a Gene-Targeted Mouse Model of Cystic Fibrosis
1992 StandoutScienceNobel
Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis
2014
New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
2009 Standout
Multi-State Regulation of the Dihydrogen Phosphate Binding Affinity to a Light- and Heat-Responsive Bis-Urea Receptor
2014 StandoutNobel
Carrier-Based Ion-Selective Electrodes and Bulk Optodes. 1. General Characteristics
1997 Standout
Restoration by intratracheal gene transfer of bicarbonate secretion in cystic fibrosis mouse gallbladder
1998 StandoutNobel
Regulation of bicarbonate-dependent ductular bile secretion assessed by lumenal micropuncture of isolated rodent intrahepatic bile ducts.
1993
Molecular Background of Leak K+Currents: Two-Pore Domain Potassium Channels
2010
Molecular Structure and Physiological Function of Chloride Channels
2002
Na+, K+, and H+/HCO3− Transport in Submandibular Salivary Ducts
1995
Alphavirus-based expression vectors: strategies and applications.
1996 StandoutNobel
Abnormal regulation of ion channels in cystic fibrosis epithelia
1990
Electrogenic bicarbonate secretion in mouse gallbladder
1998
The multidrug resistance and cystic fibrosis genes have complementary patterns of epithelial expression.
1992
Cl- channel activity in Xenopus oocytes expressing the cystic fibrosis gene.
1991
Secretin Promotes Osmotic Water Transport in Rat Cholangiocytes by Increasing Aquaporin-1 Water Channels in Plasma Membrane
1997 StandoutNobel
The silent codon change I507‐ATC→ATT contributes to the severity of the ΔF508 CFTR channel dysfunction
2013
Pathophysiology of Gene-Targeted Mouse Models for Cystic Fibrosis
1999
Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA
1989 StandoutScience
Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator.
1994
Cystic fibrosis: a disease in electrolyte transport
1990
Role of myokines in exercise and metabolism
2007
Protein Kinase Activity Closely Associated with a Reconstituted Calcium-Activated Potassium Channel
1991 Science
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Channelling our thoughts
1991 Nature
Chloride channels in the apical membrane of normal and cystic fibrosis airway and intestinal epithelia
1992
Impaired cell volume regulation in intestinal crypt epithelia of cystic fibrosis mice.
1995 StandoutNobel
Apical sorting of a voltage- and Ca 2+ -activated K + channel α-subunit in Madin-Darby canine kidney cells is independent of N-glycosylation
2000
The anti-inflammatory effect of exercise
2005 Standout
Noncytopathic Sindbis virus RNA vectors for heterologous gene expression
1998 StandoutNobel
Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism.
1992
Activation of a heterologously expressed octopamine receptor coupled only to adenylyl cyclase produces all the features of presynaptic facilitation inAplysiasensory neurons
2000 StandoutNobel
Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism.
1994 StandoutNobel
Genistein activates CFTR-mediated Cl−secretion in the murine trachea and colon
2000 StandoutNobel
cAMP-inducible chloride conductance in mouse fibroblast lines stably expressing the human cystic fibrosis transmembrane conductance regulator.
1991
Works of Michael A. Gray being referenced
Full-Length Human Mutant Huntingtin with a Stable Polyglutamine Repeat Can Elicit Progressive and Selective Neuropathogenesis in BACHD Mice
2008
Bradykinin regulation of salt transport across mouse inner medullary collecting duct epithelium involves activation of a Ca2+‐dependent Cl− conductance
2000
Volume-sensitive chloride currents in primary cultures of human fetal vas deferens epithelial cells
1996
The Swelling-Activated Anion Conductance in the Mouse Renal Inner Medullary Collecting Duct Cell Line mIMCD-K2
2000
Regulation of maxi-K+ channels on pancreatic duct cells by cyclic AMP-dependent phosphorylation
1990
Dynamic Regulation of CFTR Bicarbonate Permeability by [Cl−]i and Its Role in Pancreatic Bicarbonate Secretion
2010
Maxi K+ channels on human vas deferens epithelial cells
1994
Calcium-activated chloride conductance is not increased in pancreatic duct cells of CF mice
1995 StandoutNobel
Calcium-activated chloride conductance in a pancreatic adenocarcinoma cell line of ductal origin (HPAF) and in freshly isolated human pancreatic duct cells
1998
Novel Role for Pendrin in Orchestrating Bicarbonate Secretion in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-expressing Airway Serous Cells
2011
Measurement of Intracellular pH in Pancreatic Duct Cells
2004
Characterization of vectorial chloride transport pathways in the human pancreatic duct adenocarcinoma cell line HPAF
2003
Volume-activated chloride currents in pancreatic duct cells
1995
Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells
1988
Effect of Vesicular Stomatitis Virus and Semliki Forest Virus on Uptake of Nutrients and Intracellular Cation Concentration
1983
cAMP-regulated whole cell chloride currents in pancreatic duct cells
1993
Regulation of Murine Airway Surface Liquid Volume by CFTR and Ca2+-activated Cl− Conductances
2002
CFTR and calcium-activated chloride currents in pancreatic duct cells of a transgenic CF mouse
1994
Increased sensitivity of virus-infected cells to inhibitors of protein synthesis does not correlate with changes in plasma membrane permeability
1986
Two types of chloride channel on duct cells cultured from human fetal pancreas
1989
Oxonol dyes as monitors of membrane potential: The effect of viruses and toxins on the plasma membrane potential of animal cells in monolayer culture and in suspension
1985
Protein Synthesis in Semliki Forest Virus-infected Cells is Not Controlled by Permeability Changes
1983
Correction of delF508-CFTR activity with benzo(c)quinolizinium compounds through facilitation of its processing in cystic fibrosis airway cells
2001
Protein kinase C regulates the magnitude and stability of CFTR currents in pancreatic duct cells
1995
Chloride channels and cystic fibrosis of the pancreas
1995
Anion selectivity and block of the small-conductance chloride channel on pancreatic duct cells
1990
Protein synthesis in cells infected with Semliki Forest virus is not controlled by intracellular cation changes
1983