Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues
2009
Endothelial Progenitor Cells for Vascular Regeneration
2002
Phenotypic Overlap Between Hematopoietic Cells with Suggested Angioblastic Potential and Vascular Endothelial Cells
2002
Transplantation ofex vivoexpanded endothelial progenitor cells for therapeutic neovascularization
2000 Standout
Decreasing Intracellular Superoxide Corrects Defective Ischemia-induced New Vessel Formation in Diabetic Mice
2008
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial
2002
Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia
2001
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
2001 Standout
Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1
2000 StandoutNobel
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
2001 Standout
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Monocytes coexpress endothelial and macrophagocytic lineage markers and form cord-like structures in Matrigel® under angiogenic conditions
2001
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α
2001
Molecular mechanisms of lymphangiogenesis in health and disease
2002
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Impaired angiogenesis in the aging kidney: Vascular endothelial growth factor and Thrombospondin-1 in renal disease
2001
Molecular mechanisms of blood vessel growth
2001
HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
2001
Induction of Renoprotective Gene Expression by Cobalt Ameliorates Ischemic Injury of the Kidney in Rats
2003
Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells
2003
Regulation of angiogenesis by the aging suppressor gene klotho
2002
Age-Related Changes in Parathyroid Hormone-Related Protein and Vascular Endothelial Growth Factor in Human Osteoblastic Cells
2002
Angiopoietin 2 expression in the retina: upregulation during physiologic and pathologic neovascularization
2000
Molecular basis of the VHL hereditary cancer syndrome
2002 StandoutNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Diabetes impairs progenitor cell mobilisation after hindlimb ischaemia–reperfusion injury in rats
2006
Telomere states and cell fates
2000 StandoutNatureNobel
Circulating Endothelial Progenitor Cells Are Reduced in Peripheral Vascular Complications of Type 2 Diabetes Mellitus
2005
The Hallmarks of Cancer
2000 Standout
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice
2004
Janus face of vascular endothelial growth factor: The obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension
2002
A New Weapon for Attacking Tumor Blood Vessels
2008 StandoutNobel
Angiogenesis in health and disease
2003 Standout
Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1α
2007
Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity
2000 StandoutNobel
How oxygen makes its presence felt: Figure 1.
2002 StandoutNobel
Transplanted cord blood–derived endothelial precursor cells augment postnatal neovascularization
2000
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
2004 Standout
Endothelial Progenitor Cells
2004
Aging and Survival of Cutaneous Microvasculature
2002
The synergism of age and db/db genotype impairs wound healing☆
2007
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?
2002
Increased endogenous angiogenic response and hypoxia-inducible factor-1α in human critical limb ischemia
2006
Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth
2003 StandoutNobel
Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo
2006 StandoutNobel
Expression of constitutively stable hybrid hypoxia-inducible factor-1α protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury
2004
Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo
2001
Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice
2000
Intramyocardial injection of naked DNA encoding HIF-1 /VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat
2002
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
2001 StandoutNobel
Hypoxia-Inducible Factor 1α Polymorphism and Coronary Collaterals in Patients With Ischemic Heart Disease
2005 StandoutNobel
Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells
1999
The efficacy of a ‘master switch gene’ HIF-1α in a porcine model of chronic myocardial ischaemia
2005
Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetes
2008
Molecular regulation of vessel maturation
2003 Standout
Circulating Endothelial Progenitor Cells, Vascular Function, and Cardiovascular Risk
2003 Standout
Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders
2003
Switching and Signaling at the Telomere
2001 StandoutNobel
HMG-CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells
2001
Impaired collateral vessel development in diabetes: potential cellular mechanisms and therapeutic implications
2001
Telomerized human microvasculature is functional in vivo
2001
Clinical applications of angiogenic growth factors and their inhibitors
1999
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Adult hematopoietic stem cells provide functional hemangioblast activity during retinal neovascularization
2002
The von Hippel–Lindau protein, HIF hydroxylation, and oxygen sensing
2005 StandoutNobel
Induction of angiogenesis in a mouse model using engineered transcription factors
2002
Mechanisms of angiogenesis and arteriogenesis
2000 Standout
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
2010
Neovascularization of ischemic myocardium by human bone-marrow–derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
2001 Standout
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
The anti-angiogenic basis of metronomic chemotherapy
2004 Standout
The function of hypoxia‐inducible factor 1 (HIF‐1) is impaired in senescent mice
1999
Vascular Growth in Ischemic Limbs: A Review of Mechanisms and Possible Therapeutic Stimulation
2008
Origins of circulating endothelial cells and endothelial outgrowth from blood
2000
A Role for Hematopoietic Stem Cells in Promoting Angiogenesis
2000
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
2009
Angiogenesis as a therapeutic target
2005 StandoutNature
Human Endothelial Cell Life Extension by Telomerase Expression
1999
Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel‐Lindau gene and hypoxia
2002
VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
1999 Standout
Myocardial gene therapy
2002 Nature
Impairment in Ischemia-Induced Neovascularization in Diabetes
2004
VEGFs, receptors and angiogenesis
1999
Arteriogenesis The Development and Growth of Collateral Arteries
2003
Vascular Progenitors From Biology to Treatment
2002
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
2003
Endothelial Progenitor Cells and Vascular Biology in Diabetes Mellitus: Current Knowledge and Future Perspectives
2005
VEGFR-1–Selective VEGF Homologue PlGF Is Arteriogenic
2003
HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
2001
Endothelial Progenitor Thrombospondin-1 Mediates Diabetes-Induced Delay in Reendothelialization Following Arterial Injury
2006
Angiogenesis
2005
HMG-CoA reductase inhibitor mobilizes bone marrow–derived endothelial progenitor cells
2001
The well-tempered vessel
2001
Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells
2001
Endothelial PAS Domain Protein 1 Gene Promotes Angiogenesis Through the Transactivation of Both Vascular Endothelial Growth Factor and Its Receptor, Flt-1
2004
Effect of Hypoxia-Inducible Factor-1α Gene Therapy on Walking Performance in Patients With Intermittent Claudication
2011
The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer.
2001
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
2004 Standout
Use of a Constitutively Active Hypoxia-Inducible Factor-1α Transgene as a Therapeutic Strategy in No-Option Critical Limb Ischemia Patients
2007
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
2002 StandoutNobel
Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures
2002
Constitutively active HIF-1α improves perfusion and arterial remodeling in an endovascular model of limb ischemia
2005 StandoutNobel
Direct Evidence for Tumor Necrosis Factor-α Signaling in Arteriogenesis
2002
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
Endothelial Progenitor Cell Vascular Endothelial Growth Factor Gene Transfer for Vascular Regeneration
2002
Polymeric system for dual growth factor delivery
2001
Potential Role of the Angiopoietin/Tie2 System in Ischemia-Induced Retinal Neovascularization
2003
Peripheral Blood “Endothelial Progenitor Cells” Are Derived From Monocyte/Macrophages and Secrete Angiogenic Growth Factors
2003 Standout
Therapeutic Angiogenesis
2006 StandoutNobel
Therapeutic coronary angiogenesis: a fronte praecipitium a tergo lupi?
2001
A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy
2003
Oxidative Stress and Diabetic Complications
2010 Standout
Therapeutic Potential of Ex Vivo Expanded Endothelial Progenitor Cells for Myocardial Ischemia
2001
Vascular Trauma Induces Rapid but Transient Mobilization of VEGFR2 + AC133 + Endothelial Precursor Cells
2001
Transdifferentiation of Blood-Derived Human Adult Endothelial Progenitor Cells Into Functionally Active Cardiomyocytes
2003
Inhibition of Prolyl Hydroxylase Domain Proteins Promotes Therapeutic Revascularization
2009
Endothelial progenitor cells as putative targets for angiostatin.
1999
Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A.
2001
Critical Roles of Muscle-Secreted Angiogenic Factors in Therapeutic Neovascularization
2006
Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease
2001 Standout
Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
2010 StandoutScienceNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Cell Type–Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1
2003 StandoutNobel
Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
2002 Standout
Angiogenesis in Ischemic Disease
1999
Combination of Antiangiogenic Therapy With Other Anticancer Therapies: Results, Challenges, and Open Questions
2005
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Relevance of Monocytic Features for Neovascularization Capacity of Circulating Endothelial Progenitor Cells
2003
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
Regulation of Bone Marrow-Derived Vascular Progenitor Cell Mobilization and Maintenance
2010
Angiogenic Growth Factor Messenger Ribonucleic Acids in Uterine Natural Killer Cells1
2001
Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease
2004
Statin Therapy Accelerates Reendothelialization
2002
Endothelial Progenitor Cells
2004 Standout
Angiopoietin-1 Protects Against the Development of Cardiac Allograft Arteriosclerosis
2003
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice
2009 StandoutNobel
HIF-1 and human disease: one highly involved factor
2000 StandoutNobel
Therapeutic Angiogenesis and Vasculogenesis for Ischemic Disease
2004
Bone Marrow-Derived Cells Do Not Incorporate Into the Adult Growing Vasculature
2003
Signaling and Functions of Angiopoietin-1 in Vascular Protection
2006
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration
2003
Role ofVHLGene Mutation in Human Cancer
2004 StandoutNobel
Increase in Circulating Endothelial Progenitor Cells by Statin Therapy in Patients With Stable Coronary Artery Disease
2001
Contribution of marrow-derived progenitors to vascular and cardiac regeneration
2002
Blood monocyte concentration is critical for enhancement of collateral artery growth
2002
Benfotiamine Counteracts Glucose Toxicity Effects on Endothelial Progenitor Cell Differentiation via Akt/FoxO Signaling
2006
Angiopoietin-1 Regulates Endothelial Cell Survival Through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway
2000
Works of Meredith Magner being referenced
Bone Marrow Origin of Endothelial Progenitor Cells Responsible for Postnatal Vasculogenesis in Physiological and Pathological Neovascularization
1999 Standout
Rescue of Diabetes-Related Impairment of Angiogenesis by Intramuscular Gene Therapy with Adeno-VEGF
1999
Intramyocardial Gene Therapy with Naked DNA Encoding Vascular Endothelial Growth Factor Improves Collateral Flow to Ischemic Myocardium
1999
Vascular Endothelial Growth Factor-C (VEGF-C/VEGF-2) Promotes Angiogenesis in the Setting of Tissue Ischemia
1998
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
1999 Standout
Direct Intramuscular Injection of Plasmid DNA Encoding Angiopoietin-1 but not Angiopoietin-2 Augments Revascularization in the Rabbit Ischemic Hindlimb
1998
Impaired Collateral Vessel Development Associated With Reduced Expression of Vascular Endothelial Growth Factor in ApoE −/− Mice
1999
Tie2 Receptor Ligands, Angiopoietin-1 and Angiopoietin-2, Modulate VEGF-Induced Postnatal Neovascularization
1998
Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1α/VP16 Hybrid Transcription Factor
2000
Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy
2000
Age-Dependent Impairment of Angiogenesis
1999
Lower-Extremity Edema Associated with Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor
2000
Antibody Blockade of Thrombospondin Accelerates Reendothelialization and Reduces Neointima Formation in Balloon-Injured Rat Carotid Artery
1999