Citation Impact
Citing Papers
Phase III Study Comparing Cisplatin Plus Gemcitabine With Cisplatin Plus Pemetrexed in Chemotherapy-Naive Patients With Advanced-Stage Non–Small-Cell Lung Cancer
2008 Standout
Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer
2000 Standout
Guidelines for the welfare and use of animals in cancer research
2010 Standout
The Human Multidrug Resistance Protein MRP5 Transports Folates and Can Mediate Cellular Resistance against Antifolates
2005
Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331
2000
Perspectives on cancer therapy-induced mucosal injury
2004 Standout
Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression
2003
Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells
1996
Separation methods for methotrexate, its structural analogues and metabolites
2001
Molecular mechanisms of drug resistance
2005
Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)
1998
Cancer drug resistance: an evolving paradigm
2013 Standout
The resurgence of platinum-based cancer chemotherapy
2007 Standout
A review of stimuli-responsive nanocarriers for drug and gene delivery
2008 Standout
New approaches to molecular cancer therapeutics
2006
‘Tomudex’ (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia
1995
Comparative pO2 measurements in cell spheroids cultured with different techniques
1987
Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells
1994
Modification of cell proliferation with inhibitors
1992
Resistance to antifolates
2003
Dendrimers in biomedical applications—reflections on the field
2005 Standout
Targeting multidrug resistance in cancer
2006 Standout
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
2016 StandoutNobel
Chemotherapy and the war on cancer
2005 Standout
Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review
2018 Standout
Magnetic nanoparticles in MR imaging and drug delivery
2008 Standout
Karnofsky memorial lecture. Ode to methotrexate.
1993
Analysis of anticancer drugs: A review
2011 Standout
5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods
2002 Standout
Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil
1995
The methotrexate story: A paradigm for development of cancer chemotherapeutic agents
1994
5-Fluorouracil: mechanisms of action and clinical strategies
2003 Standout
Intrinsic and Acquired Resistance to Methotrexate in Acute Leukemia
1996
Cell cycle control and cancer chemotherapy
1994 StandoutNobel
Organic Azides: An Exploding Diversity of a Unique Class of Compounds
2005 Standout
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
2005 Standout
Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications
1994
Final results of a randomised trial comparing ‘Tomudex’® (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer
1996
Multicellular spheroids
1987
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
2012 Standout
The role of thymidylate synthase induction in modulating p53-regulated gene expression in response to 5-fluorouracil and antifolates.
2002
Current understanding of methotrexate pharmacology and efficacy in acute leukemias. Use of newer antifolates in clinical trials.
2001
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.
1999
Carboxylic acid bioisosteres of γ-linked dipeptide analogues of the folate-based thymidylate synthase (TS) inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)
1996
Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma
2003 Standout
1-Protected 5-amido 1,2,3-triazoles via ruthenium-catalyzed [3+2] cycloaddition of azides and ynamides
2007
Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates
2000
Synthesis and Porous Properties of Chromium Azolate Porous Coordination Polymers
2014 StandoutNobel
Ynamides: A Modern Functional Group for the New Millennium
2010 Standout
Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors.
2001
Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates
2015
Cell and Environment Interactions in Tumor Microregions: The Multicell Spheroid Model
1988 StandoutScience
Mechanisms of Cancer Drug Resistance
2002 Standout
Chemotherapy for the Treatment of Patients with Metastatic Colorectal Cancer: An Overview
1997
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
1997
Antifolate Activity of Epigallocatechin Gallate against Stenotrophomonas maltophilia
2005 Standout
Randomized Trial of Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy and Palliative Surgery in Patients With Peritoneal Carcinomatosis of Colorectal Cancer
2003 Standout
Small-Molecule H-Bond Donors in Asymmetric Catalysis
2007 Standout
In situclick chemistry: a powerful means for lead discovery
2006 StandoutNobel
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
2009 StandoutScience
Panning phage antibody libraries on cells: isolation of human Fab fragments against ovarian carcinoma using guided selection.
1998 StandoutNobel
Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application
2018 Standout
Influence of the oxygen pressure in the culture medium on the oxygenation of different types of multicellular spheroids
1985
Regulation of growth saturation and development of necrosis in EMT6/Ro multicellular spheroids by the glucose and oxygen supply.
1986
Tethering: Fragment-Based Drug Discovery
2004
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Cytoreductive Surgery Combined With Perioperative Intraperitoneal Chemotherapy for the Management of Peritoneal Carcinomatosis From Colorectal Cancer: A Multi-Institutional Study
2004 Standout
DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base–base mismatch repair
1997 StandoutNobel
5‐Substituted 1H‐Tetrazoles as Carboxylic Acid Isosteres: Medicinal Chemistry and Synthetic Methods
2003 Standout
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Works of Melody Brown being referenced
The Role of the Reduced-Folate Carrier and Metabolism to Intracellular Polyglutamates for the Activity of ICI D1694
1993
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines
1995
Quinazoline-based thymidylate synthase inhibitors: relationship between structural modifications and polyglutamation.
1995
A system for determining the pharmacology of indirect radiation sensitizer drugs on multicellular spheroids.
1981
Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors
1999
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
1991