Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
S6K1 −/− / S6K2 −/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway
2004
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
2005 StandoutScience
Where CD4 + CD25 + T reg cells impinge on autoimmune diabetes
2005
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
2007 Standout
Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8 + T Lymphocytes
2008 StandoutScienceNobel
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
2004 StandoutScience
Akt1 Ablation Inhibits, whereas Akt2 Ablation Accelerates, the Development of Mammary Adenocarcinomas in Mouse Mammary Tumor Virus (MMTV)-ErbB2/Neu and MMTV-Polyoma Middle T Transgenic Mice
2007
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
2010 Standout
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
Multiple Antitumor Mechanisms Downstream of Prophylactic Regulatory T-Cell Depletion
2010 StandoutNobel
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
PTEN-Deficient Tumors Depend on AKT2 for Maintenance and Survival
2014
Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/β-Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth
2009
PKB/AKT: functional insights from genetic models
2001
A2A Adenosine Receptor May Allow Expansion of T Cells Lacking Effector Functions in Extracellular Adenosine-Rich Microenvironments
2009
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
Cancer Cell Metabolism
2011
Opportunities and challenges in the development of kinase inhibitor therapy for cancer
2003
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy
2004 Standout
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
2020 Standout
Mitochondrial Complex III ROS Regulate Adipocyte Differentiation
2011
Loss of Akt1 Leads to Severe Atherosclerosis and Occlusive Coronary Artery Disease
2007
Specific Killing of Rb Mutant Cancer Cells by Inactivating TSC2
2010
Isoform-specific Regulation of Insulin-dependent Glucose Uptake by Akt/Protein Kinase B
2003
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
2005 Standout
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKBβ
2003
Posttranslational regulation of Akt in human cancer
2014
Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase
2004
Genetic analysis of insulin signaling in Drosophila
2002
Imaging in the era of molecular oncology
2008 StandoutNature
Regulatory T Cells in Cancer
2010
Phosphoproteomics Screen Reveals Akt Isoform-Specific Signals Linking RNA Processing to Lung Cancer
2014
A cytokine-mediated link between innate immunity, inflammation, and cancer
2007 Standout
PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms
2007
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
2012
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Malignant astrocytic glioma: genetics, biology, and paths to treatment
2007 Standout
The Human T Cell Response to Melanoma Antigens
2006
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Modulation of oxidative stress as an anticancer strategy
2013 Standout
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Akt-dependent transformation: there is more to growth than just surviving
2005
Regulatory T cells in transplantation
2006
CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells
2006
Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling
2009
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity
2009
Oncogenic PI3K and its role in cancer
2005
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
2005
TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
2010
Upstream and downstream of mTOR
2004 Standout
Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression
2009
Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis
2008
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Regulatory T cells, tumour immunity and immunotherapy
2006 Standout
The effect Akt2 deletion on tumor development in Pten+/− mice
2011
Akt1/protein kinase B is critical for ischemic and VEGF-mediated angiogenesis
2005
Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation
2004
Regulation of cancer cell metabolism
2011 Standout
Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner
2003
Advances in protein kinase B signalling: AKTion on multiple fronts
2004
A Near-Infrared Cell Tracker Reagent for Multiscopic In Vivo Imaging and Quantification of Leukocyte Immune Responses
2007
TGF-beta as a T cell regulator in colitis and colon cancer
2005
Nutritional stress in eukaryotic cells: Oxidative species and regulation of survival in time of scarceness
2011
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin
2006
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Portrait of PTEN: Messages from mutant mice
2008 StandoutNobel
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
2005
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
2008
The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo
2015
Akt2 Is Required for Hepatic Lipid Accumulation in Models of Insulin Resistance
2009
ROS Are Required for Mouse Spermatogonial Stem Cell Self-Renewal
2013
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Akt3 Deficiency in Macrophages Promotes Foam Cell Formation and Atherosclerosis in Mice
2012
Defining the Role of mTOR in Cancer
2007 Standout
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner
2006
PTEN function in mammalian cell size regulation
2002
AKT/PKB Signaling: Navigating the Network
2017 Standout
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Regulation of cardiac hypertrophy by intracellular signalling pathways
2006 Standout
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
2004
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Polarized immune responses differentially regulate cancer development
2008
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
2006
Mechanisms of suppression by suppressor T cells
2005
Dendritic Cells and CD4+CD25+ T Regulatory Cells: Crosstalk Between Two Professionals in Immunity versus Tolerance
2006
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles
2006
Regulatory T Cells Reversibly Suppress Cytotoxic T Cell Function Independent of Effector Differentiation
2006
Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice
2014
Infiltration of a Mesothelioma by IFN-γ-Producing Cells and Tumor Rejection after Depletion of Regulatory T Cells
2007
Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster
2003
Interleukin-2-Dependent Mechanisms of Tolerance and Immunity In Vivo
2006
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Attenuation of CD8+ T-Cell Function by CD4+CD25+ Regulatory T Cells in B-Cell Non-Hodgkin's Lymphoma
2006
Dendritic cells with TGF-β1 differentiate naïve CD4+CD25−T cells into islet-protective Foxp3+regulatory T cells
2007 StandoutNobel
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3 high regulatory T cells in humans
2015 StandoutNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Mechanism and Management of AKT Inhibitor-Induced Hyperglycemia
2008
Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection
2015
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
2007
Physiological roles of PKB/Akt isoforms in development and disease
2007
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Differential Effects of Protein Kinase B/Akt Isoforms on Glucose Homeostasis and Islet Mass
2009
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
Immunologic and clinical effects of antibody blockade of cytotoxic T lymphocyte-associated antigen 4 in previously vaccinated cancer patients
2008 StandoutNobel
CD4+regulatory cells as a potential immunotherapy
2005 StandoutNobel
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Essential role of protein kinase Bγ (PKBγ/Akt3) in postnatal brain development but not in glucose homeostasis
2005
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Unique potential of 4-1BB agonist antibody to promote durable regression of HPV + tumors when combined with an E6/E7 peptide vaccine
2015 StandoutNobel
Critical nodes in signalling pathways: insights into insulin action
2006 Standout
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
2004
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
2010
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
Akt isoforms differentially regulate neutrophil functions
2010
Regulatory T Cells Control Dendritic Cell/NK Cell Cross-Talk in Lymph Nodes at the Steady State by Inhibiting CD4+ Self-Reactive T Cells
2008
O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling
2011
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice
2002
Transduction of Growth or Mitogenic Signals into Translational Activation of TOP mRNAs Is Fully Reliant on the Phosphatidylinositol 3-Kinase-Mediated Pathway but Requires neither S6K1 nor rpS6 Phosphorylation
2002
Life with a Single Isoform of Akt: Mice Lacking Akt2 and Akt3 Are Viable but Display Impaired Glucose Homeostasis and Growth Deficiencies
2006
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization
2012
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Immune Therapy for Cancer
2008
Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size
2005
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
2014
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Akt1 and Akt2 are required for αβ thymocyte survival and differentiation
2007
Works of Mei-Ling Chen being referenced
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo
2004
Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
2001
The deficiency of Akt1 is sufficient to suppress tumor development in Pten +/− mice
2006
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
2003
Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis
2008
Detection of Severe Acute Respiratory Syndrome Coronavirus RNA in Plasma during the Course of Infection
2005
Leptin Deficiency and Beta-Cell Dysfunction Underlie Type 2 Diabetes in Compound Akt Knockout Mice
2009