Citation Impact
Citing Papers
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
1992
Small GTP-Binding Proteins
1992
A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins
1990
PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex
1990
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Proteins regulating Ras and its relatives
1993 StandoutNature
S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein
1990
Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein
1990
Stimulation of p21ras upon T-cell activation
1990 Nature
Ras interaction with the GTPase‐activating protein (GAP)
1989
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2013 StandoutNature
Cloning of bovine GAP and its interaction with oncogenic ras p21
1988 Nature
ras and GAP—Who's controlling whom?
1990
PDGF induction of tyrosine phosphorylation of GTPase activating protein
1989 Nature
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
1992 Standout
The PH domain: a common piece in the structural pathcwork of signalling proteins
1993
Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1
1995
The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product
1988 Nature
The GTPase superfamily: a conserved switch for diverse cell functions
1990 StandoutNature
Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products
1990
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae
1990
ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein
1991
Mammalian Ras interacts directly with the serine/threonine kinase raf
1993 Standout
The neurofibromatosis type 1 gene encodes a protein related to GAP
1990 Standout
Rabbit intestine contains a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein
1989
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21
1990
A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family
1993 Nature
Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
1991
Structure of the recA protein–ADP complex
1992 StandoutNatureNobel
Regulators and Effectors of ras Proteins
1991
Drosophila larval neuromuscular junction: Molecular components and mechanisms underlying synaptic plasticity
2000
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation
1989 Nature
Tumor suppressor genes
1991 Standout
Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus
1992
Conformational changes involved in the activation of ras p21: Implications for related proteins
1990
Suppression of c-ras transformation by GTPase-activating protein
1990 Nature
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
Phosphatidylinositol-3-OH kinase direct target of Ras
1994 StandoutNature
GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
1989 Nature
let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein
1990
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
1994 Standout
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Association between GTPase activators for Rho and Ras families
1992 Nature
The C. elegans genome sequencing project: a beginning
1992 StandoutNatureNobel
The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
1991
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
C2-domains, Structure and Function of a Universal Ca2+-binding Domain
1998 StandoutNobel
Genetic analysis of mammalian GAP expressed in yeast
1989
Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules
1990
COPII–cargo interactions direct protein sorting into ER-derived transport vesicles
1998 StandoutNatureNobel
Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGF
1993
Molecular themes in oncogenesis
1991 StandoutNobel
A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase
1992
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Chromosome localization and cDNA sequence of murine and human genes forras p21 GTPase activating protein (GAP)
1989
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
1994 Standout
The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
1990 Nature
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER
1993 StandoutNatureNobel
Cellular and Molecular Biology of the Presynaptic Nerve Terminal
1991
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
1990
Somatic mutations in the neurofibromatosis 1 gene in human tumors
1992
Neurofibromatosis type 1 gene mutations in neuroblastoma
1993
Disassembly of RanGTP-Karyopherin β Complex, an Intermediate in Nuclear Protein Import
1997 StandoutNobel
SH3 — an abundant protein domain in search of a function
1992
ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels
1990
Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein
1993 StandoutNatureNobel
Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1
1991
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
1990 Nature
Agonist-induced association of the p21rasGTPase-activating protein with phosphatidylinositol 3-kinase
1992
cDNA cloning of the type 1 neurofibromatosis gene: Complete sequence of the NF1 gene product
1991
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain
1988
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria
1994 StandoutNatureNobel
Phospholipase C-β1 is a GTPase-activating protein for Gq/11, its physiologic regulator
1992
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Identification and partial purification of GTPase‐activating proteins from yeast and mammalian cells that preferentially act on Ypt1/Rab1 proteins
1991
CRYSTAL STRUCTURE OF THE SH3 DOMAIN IN HUMAN FYN; COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF SH3 DOMAINS IN TYROSINE KINASES AND SPECTRIN
1993
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
1991 StandoutScience
Enhancement of the GDP-GTP Exchange of RAS Proteins by the Carboxyl-Terminal Domain of SCD25
1990 Science
Mutations in the GTP-binding site of GSα alter stimulation of adenylyl cyclase
1989
Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae.
1989
Identification and structure of four yeast genes (SLY) that are able to suppress the functional loss of YPT1, a member of the RAS superfamily.
1991
sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1.
1991
Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
1990
GTP hydrolysis by ADP-ribosylation factor is dependent on both an ADP-ribosylation factor GTPase-activating protein and acid phospholipids.
1994
IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein.
1990
Guanosine Triphosphatase Activating Protein (GAP) Interacts with the p21 ras Effector Binding Domain
1988 Science
A Cytosolic Protein Catalyzes the Release of GDP from p21 ras
1990 Science
A C-terminal domain of GAP is sufficient to stimulate ras p21 GTPase activity.
1989
Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation
1990
Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.
1990
Functional classification of interferon-stimulated genes identified using microarrays
2001
Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis.
1992
Dominant inhibitory mutations in the Mg(2+)-binding site of RasH prevent its activation by GTP.
1991
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
1994
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
1990
Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function.
1991
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH.
1991
Identification of the SH3 Domain of GAP as an Essential Sequence for Ras-GAP-Mediated Signaling
1993 Science
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.
1990
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.
1991 Nobel
Presence of SH2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor.
1992
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.
1992
Gap Domains Responsible for Ras P21-Dependent Inhibition of Muscarinic Atrial K + Channel Currents
1992 Science
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.
1993
Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic.
1989
Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain.
1990
The Mechanism of Guanosine Nucleotide Hydrolysis by p21 c-Ha-ras
1989
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Function of Ras as a molecular switch in signal transduction.
1992
Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code
1993 Science
Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors.
1992
Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP
1988
Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins
1989
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator.
1992
Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction.
1988
Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors
1990 Science
Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.
1990
Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.
1991
p21H-ras-induced morphological transformation and increases in c-myc expression are independent of functional protein kinase C.
1989
Synthesis in Escherichia coli of GTPase-deficient mutants of Gsα
1989 StandoutNobel
Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF
1992 StandoutNatureNobel
A possible target protein for smg-25A/rab3A small GTP-binding protein.
1992
The ras oncogene--an important regulatory element in lower eucaryotic organisms
1989
SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes.
1992
Proteins with SH2 domains: transducers in the tyrosine kinase signaling pathway.
1992
The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits.
1992 StandoutNobel
Purification and Characterization from Bovine Brain Cytosol of Two Gtpase-Activating Proteins Specific for smg p21, a GTP-binding Protein Having the Same Effector Domain as c-ras p21s
1989
Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product
1990 Science
Identification of a nucleotide exchange-promoting activity for p21ras.
1990
Identification and Structure of Four Yeast Genes (SLY) That Are Able To Suppress the Functional Loss of YPT1, a Member of the RAS Superfamily
1991
X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.
1992
Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the same putative effector domain as ras p21s.
1990
Guanosine triphosphatase stimulation of oncogenic Ras mutants
1999
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.
1991
Cells that overproduce protein kinase C are more susceptible to transformation by an activated H-ras oncogene.
1989
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.
1991
ADP-ribosylation factor is functionally and physically associated with the Golgi complex.
1990
Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras.
1993
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
The Cellular Functions of Small GTP-Binding Proteins
1990 Science
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
2006 StandoutScienceNobel
Molecular cloning and characterization of a novel type of regulatory protein (GDI) for smg p25A, a ras p21-like GTP-binding protein.
1990
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.
1989
Characterization of a guanine nucleotide-releasing factor and a GTPase-activating protein that are specific for the ras-related protein p25rab3A.
1992
Binding and hydrolysis of guanine nucleotides by Sec4p, a yeast protein involved in the regulation of vesicular traffic.
1990
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-
1991 StandoutNobel
Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase
1989
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase-activating protein.
1991
Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant.
1989
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae.
1989
Purification and characterization of SAR1p, a small GTP-binding protein required for transport vesicle formation from the endoplasmic reticulum.
1993 StandoutNobel
Dominant Inhibitory Mutations in the Mg2+-Binding Site of RasH Prevent Its Activation by GTP
1991
Purification and characterization from bovine brain cytosol of a novel regulatory protein inhibiting the dissociation of GDP from and the subsequent binding of GTP to rhoB p20, a ras p21-like GTP-binding protein.
1990
Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.
1992 Nobel
GTP cleavage by the small GTP-binding protein Rab3A is associated with exocytosis of synaptic vesicles induced by alpha-latrotoxin.
1994
Src homology region 2 domains direct protein-protein interactions in signal transduction.
1990
Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins
1990 Science
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
Relationship Among Guanine Nucleotide Exchange, GTP Hydrolysis, and Transforming Potential of Mutated ras Proteins
1988
Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae.
1992
β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
1990 StandoutScienceNobel
Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins
1990 Science
Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C.
1991
Efficient selection for high-expression transfectants with a novel eukaryotic vector
1991 Standout
Kinetic analysis of the hydrolysis of GTP by p21N-ras. The basal GTPase mechanism.
1988
Binding of GAP to Activated PDGF Receptors
1990 Science
Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.
1992
Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.
1992
GDP dissociation inhibitor prevents intrinsic and GTPase activating protein-stimulated GTP hydrolysis by the Rac GTP-binding protein.
1993
Purification and characterization from bovine brain cytosol of a protein that inhibits the dissociation of GDP from and the subsequent binding of GTP to smg p25A, a ras p21-like GTP-binding protein.
1990
Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae.
1992
GTPase-Activating Protein SH2-SH3 Domains Induce Gene Expression in a Ras-Dependent Fashion
1992
Cloning of a 67-kD Neutrophil Oxidase Factor with Similarity to a Noncatalytic Region of p60 c-src
1990 Science
Works of Meg Trahey being referenced
Interaction of ras p21 Proteins with GTPase Activating Protein
1988
Inducible Expression of Amplified Human Beta Interferon Genes in CHO Cells
1984
Biochemical and biological properties of the human N-ras p21 protein.
1987
Molecular Cloning of Two Types of GAP Complementary DNA from Human Placenta
1988 Science
Cyclophilin C-associated protein: A normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responsesin vivo
1999
Inducible expression of amplified human beta interferon genes in CHO cells.
1984
A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants
1987 Science