Citation Impact
Citing Papers
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
2012 Standout
Structure of a Synaptic γδ Resolvase Tetramer Covalently Linked to Two Cleaved DNAs
2005 StandoutScienceNobel
Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants
2008
Docking of Protein−Protein Complexes on the Basis of Highly Ambiguous Intermolecular Distance Restraints Derived from 1 H N / 15 N Chemical Shift Mapping and Backbone 15 N− 1 H Residual Dipolar Couplings Using Conjoined Rigid Body/Torsion Angle Dynamics
2003
Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance
2007
Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair
2008
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines
2010
Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay
2006
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery
2005
Mechanisms of Camptothecin Resistance by Human Topoisomerase I Mutations
2004
Hereditary ataxia SCAN1 cells are defective for the repair of transcription-dependent topoisomerase I cleavage complexes
2006 Nobel
Construction of Robust Bio‐nanotubes using the Controlled Self‐Assembly of Component Proteins of Bacteriophage T4
2010 StandoutNobel
Bacterial competition: surviving and thriving in the microbial jungle
2009 Standout
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
2005 Standout
Poly(ADP-ribose) Reactivates Stalled DNA Topoisomerase I and Induces DNA Strand Break Resealing
2004
Enhanced Killing of Cancer Cells by Poly(ADP-ribose) Polymerase Inhibitors and Topoisomerase I Inhibitors Reflects Poisoning of Both Enzymes
2011
What Really Prevents Proton Transport through Aquaporin? Charge Self-Energy versus Proton Wire Proposals
2003 StandoutNobel
DNA topoisomerases: harnessing and constraining energy to govern chromosome topology
2008
Visualizing polynucleotide polymerase machines at work
2006 StandoutNobel
Marine natural products
1990 Standout
The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics
2008 Standout
DNA cleavage assay for the identification of topoisomerase I inhibitors
2008
SURVEY AND SUMMARY: The morph server: a standardized system for analyzing and visualizing macromolecular motions in a database framework
2000
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity
2006
Engineering Teams Up with Computer-Simulation and Visualization Tools to Probe Biomolecular Mechanisms
2003
Molecular drug design, synthesis and structure elucidation of a new specific target peptide based metallo drug for cancer chemotherapy as topoisomerase I inhibitor
2012
Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
2006
Dividing the large glycoside hydrolase family 13 into subfamilies: towards improved functional annotations of -amylase-related proteins
2006
Defective Mre11-dependent Activation of Chk2 by Ataxia Telangiectasia Mutated in Colorectal Carcinoma Cells in Response to Replication-dependent DNA Double Strand Breaks
2006
Constructing Azide-Labeled Cell Surfaces Using Polysaccharide Biosynthetic Pathways
2003 StandoutNobel
The carbohydrate-active enzymes database (CAZy) in 2013
2013 Standout
Novel Stable Camptothecin Derivatives Replacing the E-Ring Lactone by a Ketone Function Are Potent Inhibitors of Topoisomerase I and Promising Antitumor Drugs
2007
The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis
2011 StandoutNobel
Zinc coordination sphere in biochemical zinc sites
2001
Can Morphing Methods Predict Intermediate Structures?
2008 StandoutNobel
SCAN1 mutant Tdp1 accumulates the enzyme–DNA intermediate and causes camptothecin hypersensitivity
2005
Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors
2004
Myocardial Substrate Metabolism in the Normal and Failing Heart
2005 Standout
Early Effects of Topoisomerase I Inhibition on RNA Polymerase II Along Transcribed Genes in Human Cells
2006
Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy
2008 Standout
Protein–Protein Docking with Backbone Flexibility
2007 StandoutNobel
Scalable molecular dynamics with NAMD
2005 Standout
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin
2006
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
2007 Standout
Inducer exclusion and the regulation of sugar transport
1996
Insights into Multistep Phosphorelay from the Crystal Structure of the C-Terminal HPt Domain of ArcB
1997
Targeting DNA topoisomerase II in cancer chemotherapy
2009 Standout
Antitumour drugs impede DNA uncoiling by topoisomerase I
2007 Nature
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
2010 Standout
Phosphohistidines in bacterial signaling
1997
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin
2003
AMPK β Subunit Targets Metabolic Stress Sensing to Glycogen
2003
Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors
2004
AMPK: a nutrient and energy sensor that maintains energy homeostasis
2012 Standout
Mechanisms of Selectivity in Channels and Enzymes Studied with Interactive Molecular Dynamics
2003
Topoisomerase I inhibitors: camptothecins and beyond
2006 Standout
Synthesis of benz[d]indeno[1,2-b]pyran-5,11-diones: Versatile intermediates for the design and synthesis of topoisomerase I inhibitors
2006
Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals
2004
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Repair of Topoisomerase I‐Mediated DNA Damage
2006
Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA−Enzyme−Inhibitor Complex As Determined by X-ray Crystallographic Analysis
2005
Synthesis and Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Substituted with Nitrogen Heterocycles
2006
Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters
2007
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
New Mechanistic and Functional Insights into DNA Topoisomerases
2013
Specificity Modulation of Barley α-Amylase through Biased Random Mutagenesis Involving a Conserved Tripeptide in β → α Loop 7 of the Catalytic (β/α)8-Barrel Domain
2001
A New Strategy To Improve the Metabolic Stability of Lactone: Discovery of (20S,21S)-21-Fluorocamptothecins as Novel, Hydrolytically Stable Topoisomerase I Inhibitors
2013
DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity
2017
Inhibition of DNA Topoisomerases I and II, and Growth Inhibition of Breast Cancer MCF-7 Cells by Ouabain, Digoxin and Proscillaridin A
2006
DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition
2009 Standout
Molecular Determinants of Topoisomerase I Poisoning by Lamellarins: Comparison with Camptothecin and Structure−Activity Relationships
2005
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Preparation of a Cross-Linked Porous Protein Crystal Containing Ru Carbonyl Complexes as a CO-Releasing Extracellular Scaffold
2014 StandoutNobel
Synthesis and Biological Evaluation of Bisindenoisoquinolines as Topoisomerase I Inhibitors
2006
Synthesis and Anticancer Activity of Simplified Indenoisoquinoline Topoisomerase I Inhibitors Lacking Substituents on the Aromatic Rings
2004
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Design, Synthesis, and Biological Evaluation of 14-Substituted Aromathecins as Topoisomerase I Inhibitors
2008
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
An Evolutionary View of the Mechanism for Immune and Genome Diversity
2012 StandoutNobel
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
2006 Nobel
Two-Component Signal Transduction
2000 Standout
Investigation of the Lactam Side Chain Length Necessary for Optimal Indenoisoquinoline Topoisomerase I Inhibition and Cytotoxicity in Human Cancer Cell Cultures
2007
Internal Coordinates for Molecular Dynamics and Minimization in Structure Determination and Refinement
2001
Total Synthesis and Biological Evaluation of 22-Hydroxyacuminatine
2006
Mechanisms of iron regulation in mycobacteria: role in physiology and virulence
2003
Fluorescent Sensors for Measuring Metal Ions in Living Systems
2014 Standout
The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives
2009
Design, Synthesis, and Biological Evaluation of Cytotoxic 11-Alkenylindenoisoquinoline Topoisomerase I Inhibitors and Indenoisoquinoline−Camptothecin Hybrids
2003
Macromolecular Modeling with Rosetta
2008 StandoutNobel
Artificial Molecular Machines
2015 Standout
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Drugging Topoisomerases: Lessons and Challenges
2012
Lamellarin D: a novel potent inhibitor of topoisomerase I.
2003
ATM Mediates Cytotoxicity of a Mutant Telomerase RNA in Human Cancer Cells
2008 StandoutNobel
A Systematic Study of Nitrated Indenoisoquinolines Reveals a Potent Topoisomerase I Inhibitor
2006
Intracellular Carbon Fluxes in Riboflavin-Producing Bacillus subtilis during Growth on Two-Carbon Substrate Mixtures
2002 StandoutNobel
Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach
2008 StandoutNobel
Determination of the Structures of Symmetric Protein Oligomers from NMR Chemical Shifts and Residual Dipolar Couplings
2011 StandoutNobel
Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and RebC on Chromopyrrolic Acid
2006
Nitrated Indenoisoquinolines as Topoisomerase I Inhibitors: A Systematic Study and Optimization
2007
Advances in Copper Complexes as Anticancer Agents
2013 Standout
On the Binding of Indeno[1,2-c]isoquinolines in the DNA−Topoisomerase I Cleavage Complex
2005
Bacterial Iron Sources: From Siderophores to Hemophores
2004
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
2012 StandoutNobel
Cytotoxicity of the traditional chinese medicine (TCM) plumbagin in its copper chemistry
2009
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Synthesis and Structure−Activity Relationship Study of Potent Cytotoxic Analogues of the Marine Alkaloid Lamellarin D
2006
Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.
2003 Nobel
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
2011 StandoutScience
Lamellarins and Related Pyrrole-Derived Alkaloids from Marine Organisms
2007 Standout
Peptide and Protein Building Blocks for Synthetic Biology: From Programming Biomolecules to Self-Organized Biomolecular Systems
2008
Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen
2003
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Works of M.D. Feese being referenced
Escherichia coli Glycerol Kinase: Role of a Tetramer Interface in Regulation by Fructose 1,6-Bisphosphate and Phosphotransferase System Regulatory Protein IIIglc
1994
Glycerol kinase from Escherichia coli and an Ala65→Thr mutant: the crystal structures reveal conformational changes with implications for allosteric regulation
1998
Crystal structure of glycosyltrehalose trehalohydrolase from the hyperthermophilic archaeum Sulfolobus solfataricus 1 1Edited by D. Rees
2000
Crystal Structure of the Iron-dependent Regulator from Mycobacterium tuberculosis at 2.0-Å Resolution Reveals the Src Homology Domain 3-like Fold and Metal Binding Function of the Third Domain
2001
Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex
2005
Cation-promoted association of a regulatory and target protein is controlled by protein phosphorylation.
1994
The mechanism of topoisomerase I poisoning by a camptothecin analog
2002
Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment
2004
Structural Studies of the Escherichia coli Signal Transducing Protein IIAGlc: Implications for Target Recognition,
1997