Citation Impact
Citing Papers
Imbalance of the interleukin 1 system in colonic mucosa—association with intestinal inflammation and interleukin 1 receptor agonist genotype 2
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Reconstituting Organ-Level Lung Functions on a Chip
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Cytochrome P450 and Non–Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics
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Multidrug resistance in cancer: role of ATP–dependent transporters
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Environmental exposures that affect the endocrine system: Public health implications
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In vitro analysis of a hepatic device with intrinsic microvascular-based channels
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Developmental neurotoxicity of industrial chemicals
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Role of Vitamin D Receptor in the Lithocholic Acid-Mediated CYP3A Induction in Vitro and in Vivo
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Some Aspects of Genetic Polymorphism in the Biotransformation of Antidepressants
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Developmental Expression of Human Hepatic CYP2C9 and CYP2C19
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Nanotechnology for environmentally sustainable electromobility
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Simultaneous Absolute Protein Quantification of Transporters, Cytochromes P450, and UDP-Glucuronosyltransferases as a Novel Approach for the Characterization of Individual Human Liver: Comparison with mRNA Levels and Activities
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Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation
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The Pharmacogenetics of Immunosuppression for Organ Transplantation
2003
Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries
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Drugs as CYP3A Probes, Inducers, and Inhibitors
2007
Kinetics of Cytochrome P450 2E1-Catalyzed Oxidation of Ethanol to Acetic Acid via Acetaldehyde
1999
Identification of a Novel Polymorphic Enhancer of the Human CYP3A4 Gene
2004
Enzyme-Catalyzed Activation of Anticancer Prodrugs
2004
Induction of CYP2E1 activity in liver transplant patients as measured by chlorzoxazone 6-hydroxylation*
1998
CYP2A6: a human coumarin 7-hydroxylase
2000
Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans
2007
The missing linkage: what pharmacogenetic associations are left to find inCYP3A?
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Vascularized and functional human liver from an iPSC-derived organ bud transplant
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THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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Cytochrome P450 3A
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Drug Interactions of Clinical Significance with Selective Serotonin Reuptake Inhibitors
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CYP2E1 and risk of chemically mediated cancers
2010
Profiling gene expression of whole cytochrome P450 superfamily in human bronchial and peripheral lung tissues: Differential expression in non-small cell lung cancers
2009
Molecular Mechanism of Basal CYP3A4 Regulation by Hepatocyte Nuclear Factor 4α: Evidence for Direct Regulation in the Intestine
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INTERACTIONS OF TWO MAJOR METABOLITES OF PRASUGREL, A THIENOPYRIDINE ANTIPLATELET AGENT, WITH THE CYTOCHROMES P450
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Use of doping agents, particularly anabolic steroids, in sports and society
2008 Standout
Drug Metabolites in Safety Testing
2002
Cytochrome P-450 Polymorphisms and Response to Clopidogrel
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Association Between CYP2C9 Genetic Variants and Anticoagulation-Related Outcomes During Warfarin Therapy
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Identification of the human cytochromes P450 involved in the oxidative metabolism of “Ecstasy”-related designer drugs
2000
Cytochrome P450-mediated metabolism in the human gut wall
2009
Facile and General Synthesis of Photoactivatable Xanthene Dyes
2011 StandoutNobel
In vitro oxidative metabolism study of (−)-rhazinilam
2005
Gene-Specific Effects of Inflammatory Cytokines on Cytochrome P450 2C, 2B6 and 3A4 mRNA Levels in Human Hepatocytes
2007
Human Liver Expression of CYP2C8: Gender, Age, and Genotype Effects
2010
Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19
2001
Genetic variability of drug-metabolizing enzymes: the dual impact on psychiatric therapy and regulation of brain function
2012
Onset of xenobiotic metabolism in children: Toxicological implications
1998
Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans
2008
Drug-Induced Hepatotoxicity
2003 Standout
Emergency Hospitalizations for Adverse Drug Events in Older Americans
2011 Standout
In vivo effects of interleukin-10 on human cytochrome P450 activity
2000
The Influence of Age and Sex on the Clearance of Cytochrome P450 3A Substrates
2005
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*
1997 Standout
Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites
2007
Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms*
1995
Aging Biology and Geriatric Clinical Pharmacology
2004
In Vitro and In Vivo Evaluations of Cytochrome P450 1A2 Interactions with Duloxetine
2008
Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation*
1996
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
2000 Nature
Effective targeted gene ‘knockdown’ in zebrafish
2000 Standout
The importance of cytochrome P450 2B6 in the human metabolism of environmental chemicals
2006
The Chemistry of Small-Molecule Fluorogenic Probes
2012
CYP3A4 Polymorphisms--Potential Risk Factors for Breast and Prostate Cancer: A HuGE Review
2004
Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity
2002
Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene
2008
Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)
1990 Standout
Progesterone and Testosterone Hydroxylation by Cytochromes P450 2C19, 2C9, and 3A4 in Human Liver Microsomes
1997
Fish Intake, Contaminants, and Human Health
2006 Standout
The Serotonin Syndrome
2005 Standout
Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian populations
1996
Pharmacokinetic-Pharmacodynamic Crisis in the Elderly
2006
Mass spectrometry‐based absolute quantification of microsomal cytochrome P450 2D6 in human liver
2009
INVOLVEMENT OF HEPATOCYTE NUCLEAR FACTOR 4α IN THE DIFFERENT EXPRESSION LEVEL BETWEEN CYP2C9 AND CYP2C19 IN THE HUMAN LIVER
2006
The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6 Catalytic Activity
2003
Genetic Polymorphism in CYP2E1: Population Distribution of CYP2E1 Activity
2009
Phenotypic polymorphism and gender‐related differences of CYP1A2 activity in a Chinese population
2000
Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors
2009
Genome-wide association study reveals a complex genetic architecture underpinning-induced CYP3A4 enzyme activity
2012
Hepatic metabolism of diallyl disulphide in rat and man
2003
Real-Time Polymerase Chain Reaction Analysis of CYP1B1 Gene Expression in Human Liver
2003
The role of human cytochrome P450 enzymes in the metabolism of anticancer agents: implications for drug interactions.
1995
Structures of cytochrome P450 3A4
2004
Three haplotypes associated with CYP2A6 phenotypes in Caucasians
2005
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
2001 Standout
Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes
2009
Ontogeny of Hepatic and Renal Systemic Clearance Pathways in Infants
2002
Interindividual Differences in Hepatic Expression of CYP3A4: Relationship to Genetic Polymorphism in the 5′-Upstream Regulatory Region
1999
Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
2009
Human CYP2E1 is regulated by miR-378
2009
The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-Å Resolution
2004
Developmental Changes in Human Liver CYP2D6 Expression
2008
Phenotype–genotype variability in the human CYP3A locus as assessed by the probe drug quinine and analyses of variant CYP3A4 alleles
2005
Population distribution and effects on drug metabolism of a genetic variant in the 5′ promotor region of CYP3A4
1999
Induction of Human CYP2A6 Is Mediated by the Pregnane X Receptor with Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α
2006
Cytochrome P4502C9: an enzyme of major importance in human drug metabolism
1998
Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies
2007
Reverse transcriptase-PCR quantification of mRNA levels from cytochrome (CYP)1, CYP2 and CYP3 families in 22 different human tissues
2007
Significance of the Minor Cytochrome P450 3A Isoforms
2006
Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes
1999
Role of polymorphic human CYP2B6 in cyclophosphamide bioactivation
2003
Gastric cancer
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Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.
1997
Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression
2010
The ChEMBL database in 2017
2016 Standout
Immunomodulatory functions of type I interferons
2012
Metabolism of warfarin enantiomers in Japanese patients with heart disease having different CYP2C9 and CYP2C19 genotypes*
1998
Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype
2006
CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzyme
2010
Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors
1997
Amodiaquine Metabolism is Impaired by Common Polymorphisms in CYP2C8: Implications for Malaria Treatment in Africa
2007
Simultaneous Absolute Quantification of 11 Cytochrome P450 Isoforms in Human Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry with In Silico Target Peptide Selection
2010
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
REGULATION OF CYP2B6 IN PRIMARY HUMAN HEPATOCYTES BY PROTOTYPICAL INDUCERS
2004
The Ontogeny of Human Drug-Metabolizing Enzymes: Phase I Oxidative Enzymes
2002
Extensive genetic polymorphism in the human CYP2B6 gene with impact on expression and function in human liver.
2001
Cytochrome P450 ω-Hydroxylase Pathway of Tocopherol Catabolism
2002 Standout
Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs
2010
COMPARATIVE ANALYSIS OF CYP3A EXPRESSION IN HUMAN LIVER SUGGESTS ONLY A MINOR ROLE FOR CYP3A5 IN DRUG METABOLISM
2003
Formation of 20-Hydroxyeicosatetraenoic Acid, a Vasoactive and Natriuretic Eicosanoid, in Human Kidney
2000
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver
2010
Molecular Mechanisms of Polymorphic CYP3A7 Expression in Adult Human Liver and Intestine
2002
Novel CYP2C9 Promoter Variants and Assessment of Their Impact on Gene Expression
2008
Immunosuppressive Drugs for Kidney Transplantation
2004 Standout
Inhibition and induction of human cytochrome P450 (CYP) enzymes
1998
New perspectives on the impact of cytochrome P450 3A expression for pediatric pharmacology
2006
The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine
2003
Expression of CYP3A in the Human Liver — Evidence that the Shift between CYP3A7 and CYP3A4 Occurs Immediately After Birth
1997
Perfluoroalkyl sulfonic and carboxylic acids: A critical review of physicochemical properties, levels and patterns in waters and wastewaters, and treatment methods
2009
Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers
2009
Electrochemistry of cytochrome P450 enzyme on nanoparticle-containing membrane-coated electrode and its applications for drug sensing
2007
Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver
2008 Standout
Developmental Expression of CYP2E1 in the Human Liver
1996
Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants
2004
A Genetic Polymorphism in the Regulatory Sequences of HumanCYP2E1:Association with Increased Chlorzoxazone Hydroxylation in the Presence of Obesity and Ethanol Intake
1998
Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450
2000
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
2000 StandoutNature
Inter-individual variation of cytochrome P4502J2 expression and catalytic activities in liver microsomes from Japanese and Caucasian populations
2006
Human health implications of environmental contaminants in Arctic Canada: a review
1999 Standout
Developmental Pharmacology — Drug Disposition, Action, and Therapy in Infants and Children
2003 Standout
Human Cytochrome P450 Maximal Activities In Pediatric versus Adult Liver
2000
Detection of Cytochrome P4503A (CYP3A) in Human Hepatic Stellate Cells
1997
Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products
2010 Standout
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity
2000
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
2013 StandoutNobel
Effect of a New FunctionalCYP3A4Polymorphism on Calcineurin Inhibitors‘ Dose Requirements and Trough Blood Levels in Stable Renal Transplant Patients
2011
Sex Differences in Pharmacokinetics and Pharmacodynamics
2004
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.
1998
Occurrence of per- and polyfluoroalkyl substances (PFAS) in source water and their treatment in drinking water
2019
Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
2002 Standout
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
2000 Standout
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
2000
Sex Is A Major Determinant of Cyp3a4 Expression in Human Liver
2003
Differential expression and function of CYP2C isoforms in human intestine and liver
2003
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Cytochrome P450-mediated metabolism in the human gut wall
2009
Is the Role of the Small Intestine in First-Pass Metabolism Overemphasized?
1999
Gold Nanoparticles in Chemical and Biological Sensing
2012 Standout
Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism
1997
Interleukin-10 and the Interleukin-10 Receptor
2001 Standout
Roles of Cytochromes P450 1A2, 2A6, and 2C8 in 5-Fluorouracil Formation from Tegafur, an Anticancer Prodrug, in Human Liver Microsomes
2000
Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
2008
Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9
2011 StandoutNobel
c-Myc Antisense Limits Rat Liver Regeneration and Indicates Role for c-Myc in Regulating Cytochrome P-450 3A Activity
2000
Human Extrahepatic Cytochromes P450: Function in Xenobiotic Metabolism and Tissue-Selective Chemical Toxicity in the Respiratory and Gastrointestinal Tracts
2003
Cytochrome P-450 mRNAs Are Modulated by Dehydroepiandrosterone, Nafenopin, and Triiodothyronine
1999
Antimicrobial activity of flavonoids
2005 Standout
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 Standout
Clinical impact of patient population differences and genomic variation in efavirenz therapy
2008
Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.
2004
Per- and polyfluoroalkyl substances in the environment
2022 StandoutScience
Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6
2001
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Intrinsic Sexually Dimorphic Expression of the Principal Human CYP3A4 Correlated with Suboptimal Activation of GH/Glucocorticoid-Dependent Transcriptional Pathways in Men
2011
P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans.
1996
Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging
2017 StandoutNobel
Variation in CYP1A2 Activity and its Clinical Implications: Influence of Environmental Factors and Genetic Polymorphisms
2008
Bright Ideas for Chemical Biology
2008
A New Functional CYP3A4 Intron 6 Polymorphism Significantly Affects Tacrolimus Pharmacokinetics in Kidney Transplant Recipients
2011
Structure and Chemistry of Cytochrome P450
2005 Standout
Works of Mayumi Mimura being referenced
Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
1994 Standout
In vivo and in vitro characterization of CYP2E1 activity in Japanese and Caucasians.
1996
Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes.
1994
Catalytic roles of rat and human cytochrome P450 2A enzymes in testosterone 7α- and coumarin 7-hydroxylations
1994
Anti-MRSA activity of sophoraflavanone G and synergism with other antibacterial agents
1998
Activation of trans-l,2-dihydro-l,2-dihydroxy-6-aminochrysene to genotoxic metabolites by rat and human cytochromes P450
1994
Perfluorooctanesulfonate and perfluorooctanoate in raw and treated tap water from Osaka, Japan
2008
7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes
1996
Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans
1997
Characterization of cytochrome P-450 2B6 in human liver microsomes.
1993
Evaluation of biological effects of polychlorinated compounds found in contaminated cooking oil responsible for the disease “Yusho”
1991
Exacerbation of Ulcerative Colitis during Alpha-Interferon Therapy for Chronic Hepatitis C.
1993
PCDDs, PCDFs, PCBs, coplanar PCBs and organochlorinated pesticides in human adipose tissue in Japan
1989
Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.
1996
PCDDs, PCDFs and coplanar PCBs in coastal and marketing fishes in Japan.
1991
Study on polychlorinated dibenzo‐p‐dioxins and dibenzofurans in rivers and estuaries in Osaka Bay in Japan
1988