Citation Impact
Citing Papers
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers
2013 StandoutScienceNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
2000 StandoutScience
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Crystal Structure of Cone Arrestin at 2.3Å: Evolution of Receptor Specificity
2005
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
β-Arrestin-dependent Constitutive Internalization of the Human Chemokine Decoy Receptor D6
2004 StandoutNobel
Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.
1991
Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans
1995 StandoutNatureNobel
Transition of Arrestin into the Active Receptor-binding State Requires an Extended Interdomain Hinge
2002
The Third Intracellular Loop of α2-Adrenergic Receptors Determines Subtype Specificity of Arrestin Interaction
2002
The Active Conformation of β-Arrestin1
2007 StandoutNobel
Hot Spots for Allosteric Regulation on Protein Surfaces
2011
G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer
2006 StandoutNobel
G protein coupled receptor structure and activation
2006 StandoutNobel
lin-35 Rb Acts in the Major Hypodermis to Oppose Ras-Mediated Vulval Induction in C. elegans
2005
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
Multiple Switches in G Protein-Coupled Receptor Activation
2009
Visual Arrestin Binding to Microtubules Involves a Distinct Conformational Change
2006
Mapping the Arrestin-Receptor Interface
2004
Mutation of the Fourth Cytoplasmic Loop of Rhodopsin Affects Binding of Transducin and Peptides Derived from the Carboxyl-terminal Sequences of Transducin α and γ Subunits
2000
Differential Nucleocytoplasmic Shuttling of β-Arrestins
2002
Conformational Changes in Rhodopsin
1999
The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.
1994 StandoutNobel
Signaling States of Rhodopsin
2000
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans
2009 StandoutNobel
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors 1 1Edited by R. Huber
1997
Toward the active conformations of rhodopsin and the β2‐adrenergic receptor
2004
Lessons from constitutively active mutants of G protein-coupled receptors
2002
The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction
1995
Rhodopsin: A Prototypical G Protein-Coupled Receptor
1997
Visual and Both Non-visual Arrestins in Their “Inactive” Conformation Bind JNK3 and Mdm2 and Relocalize Them from the Nucleus to the Cytoplasm
2006
MAP Kinase Signaling Specificity Mediated by the LIN-1 Ets/LIN-31 WH Transcription Factor Complex during C. elegans Vulval Induction
1998
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation
2009
RAS Is Regulated by the let-7 MicroRNA Family
2005 Standout
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains
1992 Nature
The molecular acrobatics of arrestin activation
2004
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Arrangement of rhodopsin transmembrane α-helices
1997 Nature
Structure and function of an irreversible agonist-β2 adrenoceptor complex
2011 StandoutNatureNobel
let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein
1990
Identification of genes expressed in C. elegans touch receptor neurons
2002 StandoutNatureNobel
Rhodopsin structure, dynamics, and activation: A perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking
2003
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Crystal structure of the ligand-free G-protein-coupled receptor opsin
2008 Nature
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Ras pathways in Caenorhabditis elegans
1995
G Protein-coupled Receptors
1998 StandoutNobel
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Conservation of the Phosphate-sensitive Elements in the Arrestin Family of Proteins
2002
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
The gene lin-3 encodes an inductive signal for vulval development in C. elegans
1992 Nature
Combined biophysical and biochemical information confirms arrangement of transmembrane helices visible from the three-dimensional map of frog rhodopsin
1998
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
2011 StandoutNobel
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
2006
Different Levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates
1995
Activation-dependent Conformational Changes in β-Arrestin 2
2004 StandoutNobel
Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3
1995 StandoutNatureNobel
Conformations of the Active and Inactive States of Opsin
2001
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Functional Role of the “Ionic Lock”—An Interhelical Hydrogen-Bond Network in Family A Heptahelical Receptors
2008
Learning about cancer genes through invertebrate genetics
1992
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily
1990 Nature
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
The New Face of Active Receptor Bound Arrestin Attracts New Partners
2003
Subcellular Localization of β-Arrestins Is Determined by Their Intact N Domain and the Nuclear Export Signal at the C Terminus
2003
Conformational Differences Between Arrestin2 and Pre-activated Mutants as Revealed by Hydrogen Exchange Mass Spectrometry
2005
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Visual pigment: G-protein-coupled receptor for light signals
1998
Structure of Bovine Rhodopsin in a Trigonal Crystal Form
2004
Signal transduction during C. elegans vulval induction
1991 StandoutNobel
The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints
1997
C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation
1993 Nature
Pattern formation during C. elegans vulval induction
2001
The interaction with the cytoplasmic loops of rhodopsin plays a crucial role in arrestin activation and binding
2003
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
2004 StandoutNatureNobel
GENETIC CONTROL OF CELL INTERACTIONS IN NEMATODE DEVELOPMENT
1991
Mutation of a Highly Conserved Aspartic Acid in the β2Adrenergic Receptor: Constitutive Activation, Structural Instability, and Conformational Rearrangement of Transmembrane Segment 6
1999
New Roles for β-Arrestins in Cell Signaling: Not Just for Seven-Transmembrane Receptors
2006 StandoutNobel
Signal transduction and cell fate specification during Caenorhabditis elegans vulval development
1994
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
Evolutionarily conserved networks of residues mediate allosteric communication in proteins
2002
G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
2004
Caenorhabditis elegans SUR-5, a Novel but Conserved Protein, Negatively Regulates LET-60 Ras Activity during Vulval Induction
1998
G Protein-coupled Receptors
1998
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.
1994
The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.
1995 StandoutNobel
lin-25, a gene required for vulval induction in Caenorhabditis elegans.
1995
Cutting Edge: Loss of α4 Integrin Expression Differentially Affects the Homing of Th1 and Th17 Cells
2011
Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans
1995
Movement of Retinal Along the Visual Transduction Path
2000 Science
The second extracellular loop of the dopamine D2receptor lines the binding-site crevice
2004
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Independent Photoreceptive Circadian Clocks Throughout Drosophila
1997 StandoutScienceNobel
β-Arrestins and Cell Signaling
2007 StandoutNobel
Agonist-induced conformational changes in the G-protein-coupling domain of the β 2 adrenergic receptor
2001 StandoutNobel
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
2000
Pharmacogenomic and Structural Analysis of Constitutive G Protein–Coupled Receptor Activity
2006
MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.
1995
Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl
1995 Science
Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.
1994
Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans
1995
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
The β-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development
1998
MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL
2006
Role of group-conserved residues in the helical core of β 2 -adrenergic receptor
2007
β-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53
2007
The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.
1994
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein.
1994
A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.
1994 StandoutNobel
The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
1995 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.
1993
ARK-1 Inhibits EGFR Signaling in C. elegans
2000
The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation
1997
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of May Han being referenced
The let-60 locus controls the switch between vulval and nonvulval cell fates in Caenorhabditis elegans.
1990
Partial Agonist Activity of 11-cis-Retinal in Rhodopsin Mutants
1997
T helper type 1 and 17 cells determine efficacy of interferon-β in multiple sclerosis and experimental encephalomyelitis
2010
[18] Assays for activation of recombinant expressed opsins by all-trans-retinals
2000
The steric trigger in rhodopsin activation
1997
Functional Interaction of Transmembrane Helices 3 and 6 in Rhodopsin
1996
High-resolution structural studies of the retinal-Glu113 interaction in rhodopsin
1995
The Effects of Amino Acid Replacements of Glycine 121 on Transmembrane Helix 3 of Rhodopsin
1996
A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction
1999
Crystal Structure of β-Arrestin at 1.9 Å
2001
Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene.
1991
Role of the C9 Methyl Group in Rhodopsin Activation: Characterization of Mutant Opsins with the Artificial Chromophore 11-cis-9-Demethylretinal
1998
Rhodopsin: Structural Basis of Molecular Physiology
2001
The C9 methyl group of retinal interacts with glycine-121 in rhodopsin
1997
NMR Constraints on the Location of the Retinal Chromophore in Rhodopsin and Bathorhodopsin
1995
Constitutive Activation of Opsin by Mutation of Methionine 257 on Transmembrane Helix 6
1998
Localization of the retinal protonated Schiff base counterion in rhodopsin
1993