Citation Impact
Citing Papers
Bridging the gaps in design methodologies by evolutionary optimization of the stability and proficiency of designed Kemp eliminase KE59
2012 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130
2002 StandoutNobel
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
2000 StandoutNature
Inflammation and cancer
2002 StandoutNature
Regulation of the differentiation and function of osteoclasts
2000
The Cathepsin B Inhibitor z-FA.fmk Inhibits Cytokine Production in Macrophages Stimulated by Lipopolysaccharide
2001
Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis
2002
Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: Effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts
2000
Osteopontin expression and function: Role in bone remodeling
1998
Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: Ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair
1996
Expression of the Osteoblast Differentiation Factor RUNX2 (Cbfa1/AML3/Pebp2αA) Is Inhibited by Tumor Necrosis Factor-α
2002
Regulation of Receptor Activator of NF-κB Ligand-induced Osteoclastogenesis by Endogenous Interferon-β (INF-β) and Suppressors of Cytokine Signaling (SOCS)
2002
Functions of Cathepsin K in Bone Resorption
2002
Calcimimetics and calcilytics—fooling the calcium receptor
2005
Bone metabolism of milk goats and sheep during second pregnancy and lactation in comparison to first lactation
2007
Can the pharmaceutical industry reduce attrition rates?
2004 Standout
Mineralization and Alkaline Phosphatase Activity in Collagen Lattices Populated by Human Osteoblasts
2000
Quantifying Ligand Bias at Seven-Transmembrane Receptors
2011 StandoutNobel
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
A genetic association between juvenile rheumatoid arthritis and a novel interleukin‐1α polymorphism
1995
Mitogen activated protein kinase inhibitors: where are we now and where are we going?
2006
Wnt signaling in osteoblasts and bone diseases
2004
Tumor Necrosis Factor-α Blockade: A Novel Therapy for Rheumatic Disease
2002
Expression of granulocyte‐macrophage colony‐stimulating factor in rheumatoid arthritis: Regulation by tumor necrosis factor‐α
1991
Osteoporosis: now and the future
2011 Standout
Lysosomal cysteine proteases: more than scavengers
2000
Recent developments in biased agonism
2013 Nobel
INHIBITORY EFFECT OF TNF$alpha; ANTIBODIES ON SYNOVIAL CELL INTERLEUKIN-1 PRODUCTION IN RHEUMATOID ARTHRITIS
1989
Therapeutic potential of β-arrestin- and G protein-biased agonists
2010 StandoutNobel
Advances in osteoclast biology: old findings and new insights from mouse models
2011
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Localization of Rat Cathepsin K in Osteoclasts and Resorption Pits: Inhibition of Bone Resorption and Cathepsin K-Activity by Peptidyl Vinyl Sulfones
1999
Drug-induced morphea: Report of a case induced by balicatib and review of the literature
2008
The coming of age of de novo protein design
2016 StandoutNatureNobel
The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
2002 Standout
Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis
1995
Inhibitory action of bisphosphonates on bone resorption does not involve the regulation of RANKL and OPG expression
2002
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
2011 StandoutNobel
Immunity, Inflammation, and Cancer
2010 Standout
Minireview: The role of the vacuolar ATPase in nematodes
2011
Osteopontin: a key cytokine in cell‐mediated and granulomatous inflammation
2000
aziridinyl peptides as inhibitors of cysteine proteases: Effect of a free carboxylic acid function on inhibition
2000
Multiple ligand-specific conformations of the β2-adrenergic receptor
2011 StandoutNobel
Leukaemia Inhibitory Factor and Bone Cell Function
2007
Interleukin 1 Induces Multinucleation and Bone-Resorbing Activity of Osteoclasts in the Absence of Osteoblasts/Stromal Cells
1999
Osteoclast differentiation and activation
2003 StandoutNature
Evaluation and ranking of enzyme designs
2010 StandoutNobel
Polypeptide chain fold of human transforming growth factor .alpha. analogous to those of mouse and human epidermal growth factors as studied by two-dimensional proton NMR
1989
In situ hybridization of interleukin-1 in CD14-positive cells in rheumatoid arthritis
1992
Inhibition of cysteine proteases by peptides containing aziridine-2,3-dicarboxylic acid building blocks
1999
The type I interleukin‐1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF‐transgenic mice
1995
Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex
1997
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Structure-Based Design of Specific Cathepsin Inhibitors and Their Application to Protection of Bone Metastases of Cancer Cells
2002
Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo.
1990
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Effect of the Cathepsin K Inhibitor Odanacatib on Bone Resorption Biomarkers in Healthy Postmenopausal Women: Two Double-Blind, Randomized, Placebo-Controlled Phase I Studies
2009
Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
2001 Standout
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
The Calcium-Sensing Receptor: Physiology, Pathophysiology and Car-Based Therapeutics
2007
The O-glycomap of Lubricin, a Novel Mucin Responsible for Joint Lubrication, Identified by Site-specific Glycopeptide Analysis
2014
Regional expression of transforming growth factor-α mRNA in the rat central nervous system
1991
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
Controlling protein assembly on inorganic crystals through designed protein interfaces
2019 StandoutNatureNobel
Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo
1999
Functional Selectivity and Biased Receptor Signaling
2010
Prevention of the onset and progression of collagen‐induced arthritis in rats by the potent p38 mitogen‐activated protein kinase inhibitor FR167653
2003
Mechanisms of Anabolic Therapies for Osteoporosis
2007
Matrix Elasticity Directs Stem Cell Lineage Specification
2006 Standout
17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.
1992
Facilitative Urea Transporters
2001
Fluorescent light-induced DNA crosslinkage and chromatid breaks in mouse cells in culture.
1978 StandoutNobel
Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.
1986 StandoutNobel
Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor
1987
Human Cathepsin V Functional Expression, Tissue Distribution, Electrostatic Surface Potential, Enzymatic Characterization, and Chromosomal Localization
1999
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
Role of Osteopontin in Bone Remodeling Caused by Mechanical Stress
1999
Immunocytochemical detection of interleukin 1 within stimulated human monocytes.
1986
Osteopontin Facilitates Angiogenesis, Accumulation of Osteoclasts, and Resorption in Ectopic Bone*
2001
Molecular Cloning and Structural and Functional Characterization of Human Cathepsin F, a New Cysteine Proteinase of the Papain Family with a Long Propeptide Domain
1999
Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency
1996 Science
Cachectin and tumour necrosis factor as two sides of the same biological coin
1986 StandoutNatureNobel
Cysteine Proteases and Their Inhibitors
1997
Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor
1986 Science
Perspectives: Interleukin-6: An osteotropic factor?
1992
Expression and characterization of transforming growth factor alpha precursor protein in transfected mammalian cells.
1987
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Bone Resorption by Osteoclasts
2000 StandoutScience
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs
1985 Nature
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
1996 Standout
Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?
2001
Induction of murine interleukin 1: stimuli and responsive primary cells.
1987 StandoutNobel
Estrogen Reduces the Depth of Resorption Pits by Disturbing the Organic Bone Matrix Degradation Activity of Mature Osteoclasts
2001
Tumour necrosis factor α stimulates resorption and inhibits synthesis of proteoglycan in cartilage
1986 Nature
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Bone biology. II: Formation, form, modeling, remodeling, and regulation of cell function.
1996
Azapeptides Structurally Based upon Inhibitory Sites of Cystatins as Potent and Selective Inhibitors of Cysteine Proteases
2002
Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.
1988
Bone Biology
1995
Functional glass slides for in vitro evaluation of interactions between osteosarcoma TE85 cells and mineral-binding ligands
2004 StandoutNobel
Multiple biological activities of human recombinant interleukin 1.
1986
Interleukin 1 stimulates granulocyte macrophage colony-stimulating activity release by vascular endothelial cells.
1986
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
Wound Healing--Aiming for Perfect Skin Regeneration
1997 StandoutScience
Estrogen reduces atherosclerotic lesion development in apolipoprotein E-deficient mice.
1996
Purification of human interleukin 1 from human monocyte culture supernatants and identity of thymocyte comitogenic factor, fibroblast-proliferation factor, acute-phase protein-inducing factor, and endogenous pyrogen
1985
Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain
1988
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
IL-1 mediates TNF-induced osteoclastogenesis
2005 Standout
A Chimeric Form of Osteoprotegerin Inhibits Hypercalcemia and Bone Resorption Induced by IL-1β, TNF-α, PTH, PTHrP, and 1,25(OH)2D3
1999
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
1991
THE LYSOSOMAL CYSTEINE PROTEASES
1999
Update in New Anabolic Therapies for Osteoporosis
2010
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
1989 StandoutScience
New Peptidic Cysteine Protease Inhibitors Derived from the Electrophilic α-Amino Acid Aziridine-2,3-dicarboxylic Acid
1999
Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.
1986
Protease Inhibitors: Current Status and Future Prospects
2000
Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors
1986 Nature
Chimeric tumor necrosis factor receptors with constitutive signaling activity.
1995 StandoutNobel
p38 Mitogen-Activated Protein Kinase Is Crucially Involved in Osteoclast Differentiation But Not in Cytokine Production, Phagocytosis, or Dendritic Cell Differentiation of Bone Marrow Macrophages
2003
Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver
2003 StandoutNobel
Caspases as Targets for Anti-Inflammatory and Anti-Apoptotic Drug Discovery
2000
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
1997 StandoutScience
Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts.
1986
The Chloride Channel Inhibitor NS3736 Prevents Bone Resorption in Ovariectomized Rats Without Changing Bone Formation
2004
Osteopontin
2000 Standout
Secretory products of macrophages.
1987 Standout
Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
1990
Odanacatib, a cathepsin-K inhibitor for osteoporosis: A two-year study in postmenopausal women with low bone density
2009
p38 MAPK-Mediated Signals Are Required for Inducing Osteoclast Differentiation But Not for Osteoclast Function
2002
Interleukin 1: An Immunological Perspective
1985
Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis
1996 StandoutNobel
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
A New Approach to Mineralization of Biocompatible Hydrogel Scaffolds: An Efficient Process toward 3-Dimensional Bonelike Composites
2003 StandoutNobel
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes.
1991
Pig interleukin 1. Purification of two immunologically different leukocyte proteins that cause cartilage resorption, lymphocyte activation, and fever.
1985
Therapeutic Approaches to Bone Diseases
2000 Science
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
U0126 and PD98059, Specific Inhibitors of MEK, Accelerate Differentiation of RAW264.7 Cells into Osteoclast-like Cells
2002
Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice
1999 StandoutNobel
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
2000
Molecular Dynamics Simulations of the Catalytic Pathway of a Cysteine Protease: A Combined QM/MM Study of Human Cathepsin K
2007
Works of Maxine Gowen being referenced
Calcilytic Compounds: Potent and Selective Ca2+Receptor Antagonists That Stimulate Secretion of Parathyroid Hormone
2001
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
2000
Are MG-63 and HOS TE85 human osteosarcoma cell lines representative models of the osteoblastic phenotype?
1994
IL‐1‐ and TNF‐induced bone resorption is mediated by p38 mitogen activated protein kinase*
2001
Proteolytic Activity of Human Osteoclast Cathepsin K
1996
Biosynthesis and processing of cathepsin K in cultured human osteoclasts
2001
Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries
2001
A selective inhibitor of the osteoclastic V-H+-ATPase prevents bone loss in both thyroparathyroidectomized and ovariectomized rats
2000
Genomic Organization and Chromosome Localization of the Human Cathepsin K Gene (CTSK)
1997
Oestradiol inhibits the release of tumour necrosis factor but not interleukin 6 from adult human osteoblasts in vitro
1992
Selectively Engaging β-Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance
2010
Inhibition of cathepsin K - a novel approach to antiresorptive therapy
1997
Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts
1996
Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats
2000
Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow.
1989
FrzB-2: a human secreted frizzled-related protein with a potential role in chondrocyte apoptosis
2000
A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys
2006
The Modulation of the Expression of IL-6 and Its Receptor in Human Osteoblastsin Vitro*
1991
Immunochemical characterization of assay for carboxyterminal telopeptide of human type I collagen: loss of antigenicity by treatment with cathepsin K
2000
First Human Dosing Experience with TRV130, a Biased Ligand at the Mu Opioid Receptor (P02.013)
2013
Expression of osteopontin mRNA by osteoclasts and osteoblasts in modelling adult human bone
1993
Identification and cloning of a human urea transporter HUT11, which is downregulated during adipogenesis of explant cultures of human bone
2000
Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro.
1986
Stimulation of the proliferation of human bone cells in vitro by human monocyte products with interleukin-1 activity.
1985
Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women
1990
An interleukin 1 like factor stimulates bone resorption in vitro
1983 Nature
TRV120027, a β-Arrestin Biased Ligand at the Angiotensin II Type 1 Receptor, Produces Unique Pharmacology and Is a Novel Potential Therapy for Heart Failure
2010
Human recombinant transforming growth factor alpha stimulates bone resorption and inhibits formation in vitro.
1986
Interleukin-6 does not stimulate bone resorption in neonatal mouse calvariae
1991
Cathepsin K mRNA Detection Is Restricted to Osteoclasts During Fetal Mouse Development
1998
An animal model for pycnodysostosis: the role of cathepsin K in bone remodelling
1999
Stimulation by human interleukin 1 of cartilage breakdown and production of collagenase and proteoglycanase by human chondrocytes but not by human osteoblasts in vitro
1984
Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: An in vitro and ex vivo study of remodeling bone
1995
Human osteoblastlike cells do not respond to interleukin-6
1991
Antagonism of the Osteoclast Vitronectin Receptor with an Orally Active Nonpeptide Inhibitor Prevents Cancellous Bone Loss in the Ovariectomized Rat
2001
Cathepsin K Knockout Mice Develop Osteopetrosis Due to a Deficit in Matrix Degradation but Not Demineralization
1999
The four biochemically distinct species of human interleukin 1 all exhibit similar biologic activities.
1985
5-(5,6-Dichloro-2-indolyl)-2-methoxy-2,4-pentadienamides: Novel and Selective Inhibitors of the Vacuolar H+-ATPase of Osteoclasts with Bone Antiresorptive Activity
1998
Osteopontin deposition in remodeling bone: An osteoclast mediated event
1996
Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo
1997
Preferential inhibition of cytokine-stimulated bone resorption by recombinant interferon gamma
1986