Standout Papers
Citation Impact
Citing Papers
The Neural Basis of Economic Decision-Making in the Ultimatum Game
2003 StandoutScience
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Sea-Anemone Toxin ATX-II Elicits A-Fiber-Dependent Pain and Enhances Resurgent and Persistent Sodium Currents in Large Sensory Neurons
2012
Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons
2008 StandoutNobel
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
2011 StandoutNobel
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
2007 StandoutNobel
Dynamic mechanical allodynia in the secondary hyperalgesic area in the capsaicin model—Perceptually similar phenomena as in painful neuropathy?
2011
Role of Tetrodotoxin-Resistant Na+Current Slow Inactivation in Adaptation of Action Potential Firing in Small-Diameter Dorsal Root Ganglion Neurons
2003
The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function
2015
Nociceptors: a phylogenetic view
2009
Dorsal root entry zone microcoagulation for spinal cord injury—related central pain: operative intramedullary electrophysiological guidance and clinical outcome
2002
Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors
2014 StandoutNatureNobel
Pain Phenomena and Sensory Recovery following Brachial Plexus Avulsion Injury and Surgical Repairs
2006
NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury
2018
Painful Hiv-Associated Sensory Neuropathy
2012
Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET
1998
Multiple Sites for Generation of Ectopic Spontaneous Activity in Neurons of the Chronically Compressed Dorsal Root Ganglion
2007
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Sensory Symptom Profiles and Co-Morbidities in Painful Radiculopathy
2011
The Tetrodotoxin‐Resistant Na+ Channel Nav1.8 is Essential for the Expression of Spontaneous Activity in Damaged Sensory Axons of Mice
2003
Mechano-insensitive nociceptors encode pain evoked by tonic pressure to human skin
2000
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Descending control of pain
2002 Standout
Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats
2002
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Phenotyping sensory nerve endings in vitro in the mouse
2009
Aβ-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals
2004
Sensory Transduction in Peripheral Nerve Axons Elicits Ectopic Action Potentials
2008
Temperature-dependent double spikes in C-nociceptors of neuropathic pain patients
2005
Piezo2 is required for Merkel-cell mechanotransduction
2014 StandoutNatureNobel
Translational nociceptor research as guide to human pain perceptions and pathophysiology
2009
Two Types of C Nociceptors in Human Skin and Their Behavior in Areas of Capsaicin-Induced Secondary Hyperalgesia
2004
Double spikes to single electrical stimulation correlates to spontaneous activity of nociceptors in painful neuropathy patients
2011
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Itching for Insight
2009 StandoutNobel
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
What Is Spontaneous Pain and Who Has It?
2012
The vasodilator component of neurogenic inflammation is caused by a special subclass of heat‐sensitive nociceptors in the skin of the pig.
1996
An SCN9A channelopathy causes congenital inability to experience pain
2006 StandoutNature
TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch
2011
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Mechanically Activated Ion Channels
2015 StandoutNobel
Mechanisms of Disease: neuropathic pain—a clinical perspective
2006
Relation between sympathetic vasoconstrictor activity and pain and hyperalgesia in complex regional pain syndromes: a case-control study
2002
Glia and pain: Is chronic pain a gliopathy?
2013
Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment
2010 Standout
A Transient Receptor Potential Vanilloid 4-Dependent Mechanism of Hyperalgesia Is Engaged by Concerted Action of Inflammatory Mediators
2006
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
The TTX‐Resistant Sodium Channel Nav1.8 (SNS/PN3): Expression and Correlation with Membrane Properties in Rat Nociceptive Primary Afferent Neurons
2003
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
Blocking Caspase Activity Prevents Transsynaptic Neuronal Apoptosis and the Loss of Inhibition in Lamina II of the Dorsal Horn after Peripheral Nerve Injury
2005
Models and Mechanisms of Hyperalgesia and Allodynia
2009
Abnormal Function of C-Fibers in Patients with Diabetic Neuropathy
2006
Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
2001
A plethora of painful molecules
2004
A TRP Channel that Senses Cold Stimuli and Menthol
2002 StandoutNobel
Mechanosensation and pain
2004
Mechanotransduction and chemosensitivity of two major classes of bladder afferents with endings in the vicinity to the urothelium
2009
The effect of nerve compression and capsaicin on contact heat-evoked potentials related to Aδ- and C-fibers
2012
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
The induction of pain: an integrative review
1999
The role of the immune system in the generation of neuropathic pain
2012
Slowly conducting afferents activated by innocuous low temperature in human skin
2001
Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus
2007
Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury
2006
Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres
2000
Origin and physiological roles of inflammation
2008 StandoutNature
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
2004 StandoutNobel
Postherpetic neuralgia: Topical lidocaine iseffective in nociceptor–deprived skin
2005
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
Mechanically induced axon reflex and hyperalgesia in human UV‐B burn are reduced by systemic lidocaine
2003
Human cutaneous C fibres activated by cooling, heating and menthol
2009
PIEZO2 in sensory neurons and urothelial cells coordinates urination
2020 StandoutNatureNobel
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
2007 Standout
TRPV1 Unlike TRPV2 Is Restricted to a Subset of Mechanically Insensitive Cutaneous Nociceptors Responding to Heat
2008
Intradermal injection of norepinephrine evokes pain in patients with sympathetically maintained pain
2000
Why are there no drugs indicated for sciatica, the most common chronic neuropathic syndrome of all?
2018
Accumulation of Cav3.2 T-type Calcium Channels in the Uninjured Sural Nerve Contributes to Neuropathic Pain in Rats with Spared Nerve Injury
2018
BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
2005 StandoutNature
Histamine H1, H3 and H4 receptors are involved in pruritus
2011
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
Postherpetic Neuralgia: Irritable Nociceptors and Deafferentation
1998
The inflammatory reflex
2002 StandoutNature
Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms
2014
The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel
2004 StandoutNobel
Peripheral somatosensation: a touch of genetics
2011
Chemical responsiveness and histochemical phenotype of electrophysiologically classified cells of the adult rat dorsal root ganglion
2002
High spontaneous activity of C-nociceptors in painful polyneuropathy
2012
Low-Frequency Stimulation of Silent Nociceptors Induces Secondary Mechanical Hyperalgesia in Human Skin
2018
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms
2012
The neurobiology of itch
2006
Design, fabrication and control of soft robots
2015 StandoutNature
Action potential initiation in the peripheral terminals of cold‐sensitive neurones innervating the guinea‐pig cornea
2009
Residual spinothalamic tract pathways predict development of central pain after spinal cord injury
2008
Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch
2011
Pathological C-fibres in patients with a chronic painful condition
2003
An association between migraine and cutaneous allodynia
2000 Standout
Microneurographic findings of relevance to pain in patients with erythromelalgia and patients with diabetic neuropathy
2009
Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents
2014
Thrombospondin-4 divergently regulates voltage-gated Ca2+ channel subtypes in sensory neurons after nerve injury
2016
Receptive Properties of Embryonic Chick Sensory Neurons Innervating Skin
1997
C-nociceptors sensitized to cold in a patient with small-fiber neuropathy and cold allodynia
2009
Computation identifies structural features that govern neuronal firing properties in slowly adapting touch receptors
2014
Cell Signaling and the Genesis of Neuropathic Pain
2004
HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain
2011 Science
Tuning in C‐nociceptors to reveal mechanisms in chronic neuropathic pain
2018
Pain regulation by non-neuronal cells and inflammation
2016 StandoutScience
The Role of Voltage-Gated Sodium Channels in Pain Signaling
2019
Pungent products from garlic activate the sensory ion channel TRPA1
2005 StandoutNobel
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
Neuropathic Pain: From Mechanisms to Treatment
2020 Standout
Detection of Cold Pain, Cold Allodynia and Cold Hyperalgesia in Freely Behaving Rats
2005
Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States
2002
Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy
2002
Chapter 19 Pathophysiology of nerve injury
2006
Methylglyoxal causes pain and hyperalgesia in human through C-fiber activation
2019
Receptive Properties of Mouse Sensory Neurons Innervating Hairy Skin
1997
The Role of Sodium Channels in Chronic Inflammatory and Neuropathic Pain
2006
Mechanical and Heat Sensitization of Cutaneous Nociceptors After Peripheral Inflammation in The Rat
1999
Emerging Targets in Photopharmacology
2016 StandoutNobel
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
Myelinated Mechanically Insensitive Afferents From Monkey Hairy Skin: Heat-Response Properties
1998
Are Voltage-Gated Sodium Channels on the Dorsal Root Ganglion Involved in the Development of Neuropathic Pain?
2011
Neuronal Plasticity: Increasing the Gain in Pain
2000 StandoutScience
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage
2009
Hyperpolarization-activated cyclic nucleotide–gated channels contribute to spontaneous activity in L4 C-fiber nociceptors, but not Aβ-non-nociceptors, after axotomy of L5-spinal nerve in the rat in vivo
2018
Differential modulation of voltage-gated sodium channels by nerve growth factor in three major subsets of TrkA-expressing nociceptors
2018
Functional Attributes Discriminating Mechano-Insensitive and Mechano-Responsive C Nociceptors in Human Skin
1999
Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release
2017 StandoutNobel
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype
2011 StandoutNobel
Differential pain modulation properties in central neuropathic pain after spinal cord injury
2016
25th Anniversary Article: The Evolution of Electronic Skin (E‐Skin): A Brief History, Design Considerations, and Recent Progress
2013 Standout
Works of Matthias Ringkamp being referenced
Sensitization of insensitive branches of C nociceptors in human skin.
1994
Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves
2017
Activated human platelets in plasma excite nociceptors in rat skin, in vitro
1994
Separate Peripheral Pathways for Pruritus in Man
2008
Activity-dependent slowing of conduction velocity in uninjured L4 C fibers increases after an L5 spinal nerve injury in the rat
2006
Delayed responses to electrical stimuli reflect C-fiber responsiveness in human microneurography
1995
Macrophage-Mediated Dorsal Root Ganglion Damage Precedes Altered Nerve Conduction in SIV-Infected Macaques
2011
Psychophysical and Physiological Evidence for Parallel Afferent Pathways Mediating the Sensation of Itch
2007
Thermoreceptors and thermosensitive afferents
2009
Thermoreceptors and thermosensitive afferents
2008
Limitation of sensitization to injured parts of receptive fields in human skin C-nociceptors
1996
A Role for Polymodal C-Fiber Afferents in Nonhistaminergic Itch
2008
A Role for Nociceptive, Myelinated Nerve Fibers in Itch Sensation
2011
Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like behavior in rats with L5 spinal nerve injury
1999
Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human
2009
Mechanical hyperalgesia after spinal nerve ligation in rat is not reversed by intraplantar or systemic administration of adrenergic antagonists
1999
Nerve growth factor induces sensitization of nociceptors without evidence for increased intraepidermal nerve fiber density
2013
Three functionally distinct classes of C-fibre nociceptors in primates
2014
Local Loperamide Injection Reduces Mechanosensitivity of Rat Cutaneous, Nociceptive C-Fibers
2012
Capsaicin Responses in Heat-Sensitive and Heat-Insensitive A-Fiber Nociceptors
2001
Fatigue and Paradoxical Enhancement of Heat Response in C-Fiber Nociceptors from Cross-Modal Excitation
2003
Early Onset of Spontaneous Activity in Uninjured C-Fiber Nociceptors after Injury to Neighboring Nerve Fibers
2001
Degeneration of Myelinated Efferent Fibers Induces Spontaneous Activity in Uninjured C-Fiber Afferents
2002
Novel classes of responsive and unresponsive C nociceptors in human skin
1995
The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises
2020 Standout
Uninjured C-Fiber Nociceptors Develop Spontaneous Activity and α-Adrenergic Sensitivity Following L6Spinal Nerve Ligation in Monkey
1999
Innervation Territories of Mechanically Activated C Nociceptor Units in Human Skin
1997
Electrophysiological Assessment of the Cutaneous Arborization of Aδ-Fiber Nociceptors
1999
A role for uninjured afferents in neuropathic pain.
2008