Standout Papers
Citation Impact
Citing Papers
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals
2013 Science
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response
2013 StandoutNobel
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
2007 Standout
Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8 + T cells in NOD mice
2008 StandoutNobel
Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
2005 StandoutNobel
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
2002 StandoutScience
Functional specialization of gut CD103 + dendritic cells in the regulation of tissue-selective T cell homing
2005
Constitutive Expression of IDO by Dendritic Cells of Mesenteric Lymph Nodes: Functional Involvement of the CTLA-4/B7 and CCL22/CCR4 Interactions
2009 StandoutNobel
Functional diversity of helper T lymphocytes
1996 StandoutNature
Lymphoid Organogenesis in the Intestine
2005
CCR7 and its ligands: balancing immunity and tolerance
2008
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells
2008
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
2006 Standout
Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses
2003
A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity
1994
Control of intestinal homeostasis by regulatory T cells and dendritic cells
2007
Sensitization to self (virus) antigen by in situ expression of murine interferon-gamma.
1995
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
T cell co-stimulation and in vivo tolerance
1993
Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity
1998
Regulatory T Cells
2000 StandoutNobel
Following a diabetogenic T cell from genesis through pathogenesis
1993
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Plasmacytoid Dendritic Cells Mediate Oral Tolerance
2008
Regulation of T cell production in T cell receptor transgenic mice
1993
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse
2000
Could endogenous self-peptides presented by dendritic cells initiate rheumatoid arthritis?
1996
T-cell tolerance and autoimmunity in transgenic models of central and peripheral tolerance
1994
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Development, organization and function of the thymic medulla in normal, immunodeficient or autoimmune mice
1999
Requirement for Lymphoid Tissue-Inducer Cells in Isolated Follicle Formation and T Cell-Independent Immunoglobulin A Generation in the Gut
2008
Induction of peripheral CD8+ T‐cell tolerance by cross‐presentation of self antigens
1998 StandoutNobel
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells
2006
Oral tolerance
2011
CD4 T Cell Tolerance to Nuclear Proteins Induced by Medullary Thymic Epithelium
1996
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.
1998
Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages
2008
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model
1994
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Inflammation but not autoimmunity occurs in transgenic mice expressing constitutive levels of interleukin‐2 in islet β cells
1992
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
2008 Nature
The microbiome of the lung
2012
The Fas Death Factor
1995 StandoutScience
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Negative selection of lymphocytes
1994
Focal expression of interleukin-2 does not break unresponsiveness to "self" (viral) antigen expressed in beta cells but enhances development of autoimmune disease (diabetes) after initiation of an anti-self immune response.
1995 StandoutNobel
Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance
2001
Self-antigen presentation by thymic stromal cells: a subtle division of labor
2000
Dendritic cells in intestinal immune regulation
2008
Costimulation of T cells for tumor immunity
1993
Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex
1996 Nature
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
2001
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Autoimmune Regulator Is Expressed in the Cells Regulating Immune Tolerance in Thymus Medulla
1999
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
An Immune Atlas of Clear Cell Renal Cell Carcinoma
2017
The Physiological Role of Regulatory T Cells in the Prevention of Autoimmunity: the Function of the Thymus in the Generation of the Regulatory T Cell Subset
1996
Lymphoid Tissue Inducer Cells in Intestinal Immunity
2006
Aire regulates negative selection of organ-specific T cells
2003
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
1997
In vivoblockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
1999 StandoutNobel
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
2009 StandoutNobel
Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles
2011 Science
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Antigen Concentration and Precursor Frequency Determine the Rate of CD8+ T Cell Tolerance to Peripherally Expressed Antigens
1999
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
Dendritic cells with TGF-β1 differentiate naïve CD4+CD25−T cells into islet-protective Foxp3+regulatory T cells
2007 StandoutNobel
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
CD103− and CD103+ Bronchial Lymph Node Dendritic Cells Are Specialized in Presenting and Cross-Presenting Innocuous Antigen to CD4+ and CD8+ T Cells
2007
Organizing a mucosal defense
2005
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.
1995
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
2007 Standout
T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.
1994
Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)
2000
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
T Cell Anergy
2003
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotype.
1995
The Thymus Contains a High Frequency of Cells that Prevent Autoimmune Diabetes on Transfer into Prediabetic Recipients
1996
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2band dose-dependent requirement of H-2g7for diabetes in NOD mice
2008 StandoutNobel
Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells
2001
CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium
1998
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells
2000 StandoutNobel
Ionizing Radiation Selectively Reduces Skin Regulatory T Cells and Alters Immune Function
2014 StandoutNobel
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes
2002
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
2007 StandoutNobel
Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells
1997
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
2009 StandoutNobel
Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.
1994
Medullary Thymic Epithelium: A Mosaic of Epithelial “Self”?
1998
Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
2012
Works of Matthias Hoffmann being referenced
Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells
2006
Cryptopatches and isolated lymphoid follicles: dynamic lymphoid tissues dispensable for the generation of intraepithelial lymphocytes
2004
Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection
2016
Autoimmune diabetes as a consequence of locally produced interleukin-2
1992 Nature
A Transgenic Approach to the Study of Peripheral T‐Cell Tolerance
1991 StandoutNobel
T Cell Tolerance and Autoimmunity
2007 StandoutNobel
A nondeletional mechanism of peripheral tolerance in T-cell receptor transgenic mice.
1991
Tolerance induction by thymic medullary epithelium.
1992 StandoutNobel
Avidity for antigen can influence the helper dependence of CD8+ T lymphocytes.
1993
Deletion of high-avidity T cells by thymic epithelium.
1995